STRINGSTRING
KLLA0_E17227g KLLA0_E17227g LOC1 LOC1 KLLA0_E14191g KLLA0_E14191g KLLA0_E13575g KLLA0_E13575g KLLA0_E13025g KLLA0_E13025g HEK2 HEK2 KLLA0_E11067g KLLA0_E11067g KLLA0_E09087g KLLA0_E09087g CSN12 CSN12 KLLA0_E04665g KLLA0_E04665g KLLA0_E02751g KLLA0_E02751g KLLA0_D16775g KLLA0_D16775g KLLA0_D14806g KLLA0_D14806g KLLA0_D13420g KLLA0_D13420g KLLA0_D10659g KLLA0_D10659g KLLA0_D09526g KLLA0_D09526g SHE3 SHE3 KLLA0_D08305g KLLA0_D08305g KLLA0_D04818g KLLA0_D04818g KLLA0_D03674g KLLA0_D03674g PAB1 PAB1 SEC13 SEC13 DHH1 DHH1 KLLA0_C16115g KLLA0_C16115g KLLA0_C15587g KLLA0_C15587g KLLA0_C15235g KLLA0_C15235g KLLA0_C14157g KLLA0_C14157g KLLA0_C12771g KLLA0_C12771g KLLA0_C09801g KLLA0_C09801g KLLA0_C08415g KLLA0_C08415g KLLA0_C06589g KLLA0_C06589g KLLA0_C02849g KLLA0_C02849g KLLA0_B14432g KLLA0_B14432g LOS1 LOS1 SHE2 SHE2 SPT6 SPT6 IWS1 IWS1 KLLA0_B10472g KLLA0_B10472g SUS1 SUS1 KLLA0_B07117g KLLA0_B07117g KLLA0_B06138g KLLA0_B06138g KLLA0_B02629g KLLA0_B02629g KLLA0_B02442g KLLA0_B02442g KLLA0_B01760g KLLA0_B01760g DYN2 DYN2 KLLA0_A11594g KLLA0_A11594g KLLA0_A05797g KLLA0_A05797g KLLA0_A05247g KLLA0_A05247g KLLA0_A02321g KLLA0_A02321g KLLA0_A00869g KLLA0_A00869g RPS28 RPS28 KLLA0_F26697g KLLA0_F26697g KLLA0_F25036g KLLA0_F25036g KLLA0_F23694g KLLA0_F23694g KLLA0_F22363g KLLA0_F22363g KLLA0_F21648g KLLA0_F21648g KLLA0_F17523g KLLA0_F17523g DBP5 DBP5 KLLA0_F09845g KLLA0_F09845g KLLA0_F09812g KLLA0_F09812g KLLA0_F07843g KLLA0_F07843g KLLA0_F07227g KLLA0_F07227g KLLA0_F06754g KLLA0_F06754g KLLA0_F06622g KLLA0_F06622g KLLA0_F06600g KLLA0_F06600g KLLA0_F03333g KLLA0_F03333g KLLA0_F01661g KLLA0_F01661g NPL4 NPL4 KLLA0_E22463g KLLA0_E22463g SUB2 SUB2 KLLA0_E21231g KLLA0_E21231g KLLA0_E20703g KLLA0_E20703g KLLA0_E18965g KLLA0_E18965g KLLA0_E16061g KLLA0_E16061g
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLLA0_E17227gKLLA0E17227p. (203 aa)
LOC160S ribosomal subunit assembly/export protein LOC1; Required for efficient assembly and nuclear export of the 60S ribosomal subunit. (207 aa)
KLLA0_E14191gNuclear pore protein. (860 aa)
KLLA0_E13575gE3 ubiquitin-protein ligase. (819 aa)
KLLA0_E13025gKLLA0E13025p. (858 aa)
HEK2Heterogeneous nuclear rnp K-like protein 2; RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity). (383 aa)
KLLA0_E11067gKLLA0E11067p. (1606 aa)
KLLA0_E09087gNuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (722 aa)
CSN12COP9 signalosome complex subunit 12; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response. (424 aa)
KLLA0_E04665gKLLA0E04665p. (647 aa)
KLLA0_E02751gKLLA0E02751p. (222 aa)
KLLA0_D16775gKLLA0D16775p. (1303 aa)
KLLA0_D14806gU3 small nucleolar RNA-associated protein 22. (1212 aa)
KLLA0_D13420gKLLA0D13420p. (166 aa)
KLLA0_D10659gKLLA0D10659p; Belongs to the universal ribosomal protein uS7 family. (227 aa)
KLLA0_D09526gKLLA0D09526p. (217 aa)
SHE3SWI5-dependent HO expression protein 3; RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity); Belongs to the SHE3 family. (345 aa)
KLLA0_D08305gKLLA0D08305p; Belongs to the universal ribosomal protein uS3 family. (237 aa)
KLLA0_D04818gKLLA0D04818p. (354 aa)
KLLA0_D03674gKLLA0D03674p. (453 aa)
PAB1Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (592 aa)
SEC13Protein transport protein SEC13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...] (302 aa)
DHH1ATP-dependent RNA helicase DHH1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (514 aa)
KLLA0_C16115gKLLA0C16115p. (1183 aa)
KLLA0_C15587gKLLA0C15587p. (184 aa)
KLLA0_C15235gKLLA0C15235p. (544 aa)
KLLA0_C14157gKLLA0C14157p. (1090 aa)
KLLA0_C12771gKLLA0C12771p. (1009 aa)
KLLA0_C09801gKLLA0C09801p. (588 aa)
KLLA0_C08415g6-phosphogluconolactonase-like protein; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (321 aa)
KLLA0_C06589gKLLA0C06589p. (949 aa)
KLLA0_C02849gKLLA0C02849p. (440 aa)
KLLA0_B14432gKLLA0B14432p. (216 aa)
LOS1Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity); Belongs to the exportin family. (1063 aa)
SHE2SWI5-dependent HO expression protein 2; RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell (By similarity). (241 aa)
SPT6Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1460 aa)
IWS1Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. (362 aa)
KLLA0_B10472gNuclear cap-binding protein subunit 2. (198 aa)
SUS1Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (96 aa)
KLLA0_B07117gKLLA0B07117p; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (348 aa)
KLLA0_B06138gKLLA0B06138p. (661 aa)
KLLA0_B02629gKLLA0B02629p. (178 aa)
KLLA0_B02442gKLLA0B02442p. (491 aa)
KLLA0_B01760gKLLA0B01760p. (606 aa)
DYN2Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). (87 aa)
KLLA0_A11594gKLLA0A11594p. (1530 aa)
KLLA0_A05797gKLLA0A05797p. (200 aa)
KLLA0_A05247gKLLA0A05247p. (259 aa)
KLLA0_A02321gKLLA0A02321p. (961 aa)
KLLA0_A00869gKLLA0A00869p. (960 aa)
RPS2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (67 aa)
KLLA0_F26697gKLLA0F26697p. (1130 aa)
KLLA0_F25036gKLLA0F25036p. (389 aa)
KLLA0_F23694gKLLA0F23694p. (721 aa)
KLLA0_F22363gKLLA0F22363p. (405 aa)
KLLA0_F21648gKLLA0F21648p. (1221 aa)
KLLA0_F17523gKLLA0F17523p. (855 aa)
DBP5ATP-dependent RNA helicase DBP5; ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity). (469 aa)
KLLA0_F09845gKLLA0F09845p. (522 aa)
KLLA0_F09812gKLLA0F09812p; Belongs to the universal ribosomal protein uS5 family. (259 aa)
KLLA0_F07843gKLLA0F07843p; Belongs to the universal ribosomal protein uS19 family. (142 aa)
KLLA0_F07227gKLLA0F07227p. (414 aa)
KLLA0_F06754gKLLA0F06754p; Belongs to the WD repeat SEC13 family. (344 aa)
KLLA0_F06622gKLLA0F06622p. (478 aa)
KLLA0_F06600gKLLA0F06600p. (480 aa)
KLLA0_F03333gKLLA0F03333p. (409 aa)
KLLA0_F01661gKLLA0F01661p. (687 aa)
NPL4Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family. (596 aa)
KLLA0_E22463gNuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (724 aa)
SUB2ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (437 aa)
KLLA0_E21231gKLLA0E21231p. (64 aa)
KLLA0_E20703gKLLA0E20703p. (371 aa)
KLLA0_E18965gKLLA0E18965p. (1319 aa)
KLLA0_E16061gKLLA0E16061p. (1086 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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