STRINGSTRING
KLLA0_F14861g KLLA0_F14861g KLLA0_E14785g KLLA0_E14785g KLLA0_C03091g KLLA0_C03091g RPL25 RPL25 ubi3 ubi3 KLLA0_F27357g KLLA0_F27357g KLLA0_F25168g KLLA0_F25168g DBP10 DBP10 KLLA0_F24662g KLLA0_F24662g KLLA0_F24178g KLLA0_F24178g DBP2 DBP2 KLLA0_F23265g KLLA0_F23265g KLLA0_F22473g KLLA0_F22473g KLLA0_F19888g KLLA0_F19888g KLLA0_F19294g KLLA0_F19294g KLLA0_F18194g KLLA0_F18194g CLF1 CLF1 ISY1 ISY1 RPL3 RPL3 DRS1 DRS1 IPI1 IPI1 KLLA0_F14344g KLLA0_F14344g RSA3 RSA3 KLLA0_F11506g KLLA0_F11506g PRP5 PRP5 KLLA0_F10395g KLLA0_F10395g TIF34 TIF34 KLLA0_F07249g KLLA0_F07249g KLLA0_F06666g KLLA0_F06666g KLLA0_F06204g KLLA0_F06204g KLLA0_F03949g KLLA0_F03949g KLLA0_F03663g KLLA0_F03663g KLLA0_F03399g KLLA0_F03399g NIP1 NIP1 KLLA0_F01122g KLLA0_F01122g NOG1 NOG1 KLLA0_E21187g KLLA0_E21187g KLLA0_E20505g KLLA0_E20505g HCR1 HCR1 REX4 REX4 KLLA0_E17799g KLLA0_E17799g RPS0 RPS0 SPB4 SPB4 KLLA0_E14125g KLLA0_E14125g KLLA0_E12519g KLLA0_E12519g EXO84 EXO84 KLLA0_E11287g KLLA0_E11287g KLLA0_E11045g KLLA0_E11045g RLP24 RLP24 KLLA0_E09285g KLLA0_E09285g KLLA0_E06095g KLLA0_E06095g KLLA0_E04929g KLLA0_E04929g KLLA0_E04819g KLLA0_E04819g RVB1 RVB1 KLLA0_D17160g KLLA0_D17160g KLLA0_D15873g KLLA0_D15873g MRD1 MRD1 KLLA0_D14883g KLLA0_D14883g KLLA0_D13420g KLLA0_D13420g KLLA0_D10978g KLLA0_D10978g KLLA0_D10571g KLLA0_D10571g KLLA0_D09735g KLLA0_D09735g KLLA0_D08932g KLLA0_D08932g IPI3 IPI3 KLLA0_D07678g KLLA0_D07678g KLLA0_D06941g KLLA0_D06941g KLLA0_D05643g KLLA0_D05643g KLLA0_D03795g KLLA0_D03795g KLLA0_D03036g KLLA0_D03036g KLLA0_D02728g KLLA0_D02728g TIF6 TIF6 KLLA0_D00792g KLLA0_D00792g ESF2 ESF2 CWC24 CWC24 KLLA0_C17798g KLLA0_C17798g RVB2 RVB2 KLLA0_C15675g KLLA0_C15675g PRP28 PRP28 CWC2 CWC2 KLLA0_C15345g KLLA0_C15345g KLLA0_C14564g KLLA0_C14564g TIF32 TIF32 KLLA0_C10318g KLLA0_C10318g KLLA0_C08910g KLLA0_C08910g KLLA0_C08547g KLLA0_C08547g YTM1 YTM1 CEF1 CEF1 KLLA0_C07216g KLLA0_C07216g KLLA0_C05192g KLLA0_C05192g KLLA0_C01408g KLLA0_C01408g KLLA0_B13563g KLLA0_B13563g KLLA0_B10560g KLLA0_B10560g KLLA0_B08525g KLLA0_B08525g KLLA0_B08239g KLLA0_B08239g KLLA0_B06369g KLLA0_B06369g RIX1 RIX1 MRH4 MRH4 SPT5 SPT5 TIF35 TIF35 KLLA0_B00561g KLLA0_B00561g KLLA0_A11814g KLLA0_A11814g KLLA0_A09537g KLLA0_A09537g RSE1 RSE1 KLLA0_A08019g KLLA0_A08019g KLLA0_A07931g KLLA0_A07931g KLLA0_A07733g KLLA0_A07733g KLLA0_A06688g KLLA0_A06688g KLLA0_A05797g KLLA0_A05797g KLLA0_A05280g KLLA0_A05280g KLLA0_A04565g KLLA0_A04565g PRT1 PRT1 KLLA0_A02299g KLLA0_A02299g KLLA0_A00737g KLLA0_A00737g
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLLA0_F14861gKLLA0F14861p. (589 aa)
KLLA0_E14785gKLLA0E14785p. (310 aa)
KLLA0_C03091gKLLA0C03091p. (108 aa)
RPL2560S ribosomal protein L25; Belongs to the universal ribosomal protein uL23 family. (142 aa)
ubi3Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (150 aa)
KLLA0_F27357gKLLA0F27357p. (870 aa)
KLLA0_F25168gKLLA0F25168p. (742 aa)
DBP10ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (973 aa)
KLLA0_F24662gKLLA0F24662p. (530 aa)
KLLA0_F24178gKLLA0F24178p. (485 aa)
DBP2ATP-dependent RNA helicase DBP2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (554 aa)
KLLA0_F23265gKLLA0F23265p. (967 aa)
KLLA0_F22473gKLLA0F22473p. (253 aa)
KLLA0_F19888gMidasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4915 aa)
KLLA0_F19294gKLLA0F19294p. (570 aa)
KLLA0_F18194gKLLA0F18194p. (899 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (684 aa)
ISY1Pre-mRNA-splicing factor ISY1; Involved in pre-mRNA splicing. (237 aa)
RPL360S ribosomal protein L3. (387 aa)
DRS1ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly. (748 aa)
IPI1Pre-rRNA-processing protein IPI1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (381 aa)
KLLA0_F14344gKLLA0F14344p. (284 aa)
RSA3Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (203 aa)
KLLA0_F11506gRibosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (444 aa)
PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (812 aa)
KLLA0_F10395gKLLA0F10395p. (372 aa)
TIF34Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (347 aa)
KLLA0_F07249gKLLA0F07249p. (256 aa)
KLLA0_F06666gKLLA0F06666p. (648 aa)
KLLA0_F06204gKLLA0F06204p. (877 aa)
KLLA0_F03949gKLLA0F03949p. (475 aa)
KLLA0_F03663gKLLA0F03663p. (368 aa)
KLLA0_F03399gKLLA0F03399p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (619 aa)
NIP1Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (819 aa)
KLLA0_F01122gKLLA0F01122p. (712 aa)
NOG1Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (643 aa)
KLLA0_E21187gKLLA0E21187p. (429 aa)
KLLA0_E20505gKLLA0E20505p. (357 aa)
HCR1Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (277 aa)
REX4RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (294 aa)
KLLA0_E17799gKLLA0E17799p. (298 aa)
RPS040S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (254 aa)
SPB4ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (596 aa)
KLLA0_E14125gKLLA0E14125p. (477 aa)
KLLA0_E12519gKLLA0E12519p. (1006 aa)
EXO84Exocyst complex component EXO84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity). (720 aa)
KLLA0_E11287gKLLA0E11287p; Belongs to the eIF-1A family. (155 aa)
KLLA0_E11045gKLLA0E11045p. (432 aa)
RLP24Ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles. (198 aa)
KLLA0_E09285gKLLA0E09285p. (424 aa)
KLLA0_E06095gKLLA0E06095p. (398 aa)
KLLA0_E04929gKLLA0E04929p. (112 aa)
KLLA0_E04819gKLLA0E04819p. (459 aa)
RVB1RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (457 aa)
KLLA0_D17160gSmall nuclear ribonucleoprotein Sm D3. (100 aa)
KLLA0_D15873gKLLA0D15873p. (431 aa)
MRD1Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family. (878 aa)
KLLA0_D14883gKLLA0D14883p. (467 aa)
KLLA0_D13420gKLLA0D13420p. (166 aa)
KLLA0_D10978gKLLA0D10978p. (270 aa)
KLLA0_D10571gKLLA0D10571p. (520 aa)
KLLA0_D09735gNucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (662 aa)
KLLA0_D08932gKLLA0D08932p. (278 aa)
IPI3Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (508 aa)
KLLA0_D07678gSmall nuclear ribonucleoprotein G. (73 aa)
KLLA0_D06941gKLLA0D06941p. (297 aa)
KLLA0_D05643gKLLA0D05643p. (220 aa)
KLLA0_D03795gKLLA0D03795p. (234 aa)
KLLA0_D03036gKLLA0D03036p. (368 aa)
KLLA0_D02728gKLLA0D02728p. (667 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
KLLA0_D00792gKLLA0D00792p. (1020 aa)
ESF2Pre-rRNA-processing protein ESF2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (293 aa)
CWC24Pre-mRNA-splicing factor CWC24; Involved in pre-mRNA splicing. (229 aa)
KLLA0_C17798gKLLA0C17798p. (2149 aa)
RVB2RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (467 aa)
KLLA0_C15675gKLLA0C15675p. (111 aa)
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (539 aa)
CWC2Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (337 aa)
KLLA0_C15345gRibonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (149 aa)
KLLA0_C14564gKLLA0C14564p. (165 aa)
TIF32Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (925 aa)
KLLA0_C10318gKLLA0C10318p. (333 aa)
KLLA0_C08910gKLLA0C08910p. (115 aa)
KLLA0_C08547gKLLA0C08547p. (515 aa)
YTM1Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (444 aa)
CEF1Pre-mRNA-splicing factor CEF1; Involved in pre-mRNA splicing and cell cycle control. (543 aa)
KLLA0_C07216gKLLA0C07216p. (683 aa)
KLLA0_C05192gKLLA0C05192p. (189 aa)
KLLA0_C01408gKLLA0C01408p. (326 aa)
KLLA0_B13563gRibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (238 aa)
KLLA0_B10560gKLLA0B10560p. (460 aa)
KLLA0_B08525gKLLA0B08525p. (326 aa)
KLLA0_B08239gKLLA0B08239p. (1729 aa)
KLLA0_B06369gKLLA0B06369p. (271 aa)
RIX1Pre-rRNA-processing protein RIX1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1. (776 aa)
MRH4ATP-dependent RNA helicase MRH4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily. (584 aa)
SPT5Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (1036 aa)
TIF35Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (269 aa)
KLLA0_B00561gKLLA0B00561p. (767 aa)
KLLA0_A11814gKLLA0A11814p. (302 aa)
KLLA0_A09537gKLLA0A09537p. (954 aa)
RSE1Pre-mRNA-splicing factor RSE1; Involved in pre-mRNA splicing and cell cycle control. (1269 aa)
KLLA0_A08019gKLLA0A08019p. (615 aa)
KLLA0_A07931gKLLA0A07931p. (344 aa)
KLLA0_A07733gKLLA0A07733p. (1064 aa)
KLLA0_A06688gKLLA0A06688p. (933 aa)
KLLA0_A05797gKLLA0A05797p. (200 aa)
KLLA0_A05280gKLLA0A05280p. (2411 aa)
KLLA0_A04565gKLLA0A04565p. (189 aa)
PRT1Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (732 aa)
KLLA0_A02299gSmall nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (93 aa)
KLLA0_A00737gKLLA0A00737p. (582 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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