STRINGSTRING
KLLA0_E00837g KLLA0_E00837g KLLA0_E17535g KLLA0_E17535g KLLA0_E23783g KLLA0_E23783g KLLA0_B06622g KLLA0_B06622g CBF5 CBF5 RLP7 RLP7 KLLA0_F27269g KLLA0_F27269g KLLA0_F26224g KLLA0_F26224g KLLA0_F26070g KLLA0_F26070g KLLA0_F25278g KLLA0_F25278g KLLA0_F24816g KLLA0_F24816g DBP10 DBP10 NAT10 NAT10 KLLA0_F23760g KLLA0_F23760g KLLA0_F23650g KLLA0_F23650g KLLA0_F23243g KLLA0_F23243g KLLA0_F21846g KLLA0_F21846g KLLA0_F21670g KLLA0_F21670g GAR1 GAR1 UTP10 UTP10 RPB5 RPB5 KLLA0_F20119g KLLA0_F20119g KLLA0_F19140g KLLA0_F19140g KLLA0_F17435g KLLA0_F17435g KLLA0_F17237g KLLA0_F17237g KLLA0_F15598g KLLA0_F15598g KLLA0_F15180g KLLA0_F15180g DBP7 DBP7 KLLA0_F13772g KLLA0_F13772g KLLA0_F13508g KLLA0_F13508g RSA3 RSA3 KLLA0_F13244g KLLA0_F13244g KLLA0_F12540g KLLA0_F12540g ARX1 ARX1 KLLA0_F11000g KLLA0_F11000g NSA1 NSA1 NOP58 NOP58 KLLA0_F08206g KLLA0_F08206g NOP12 NOP12 DBP6 DBP6 KLLA0_F05962g KLLA0_F05962g KLLA0_F04675g KLLA0_F04675g RRT14 RRT14 KLLA0_F03399g KLLA0_F03399g KLLA0_F02453g KLLA0_F02453g KLLA0_F02321g KLLA0_F02321g KLLA0_F02013g KLLA0_F02013g KLLA0_F01364g KLLA0_F01364g KLLA0_F00484g KLLA0_F00484g KLLA0_E24663g KLLA0_E24663g NOG1 NOG1 SNU13 SNU13 KLLA0_E22485g KLLA0_E22485g KLLA0_E21869g KLLA0_E21869g KLLA0_E21165g KLLA0_E21165g KLLA0_E19515g KLLA0_E19515g KLLA0_E18151g KLLA0_E18151g KLLA0_E17799g KLLA0_E17799g KLLA0_E17425g KLLA0_E17425g KLLA0_E15995g KLLA0_E15995g KLLA0_E15753g KLLA0_E15753g SPB4 SPB4 LOC1 LOC1 KLLA0_E13641g KLLA0_E13641g KLLA0_E13047g KLLA0_E13047g KLLA0_E12519g KLLA0_E12519g KLLA0_E12431g KLLA0_E12431g KLLA0_E11155g KLLA0_E11155g KLLA0_E11133g KLLA0_E11133g CGR1 CGR1 KLLA0_E10671g KLLA0_E10671g KLLA0_E10495g KLLA0_E10495g RLP24 RLP24 KLLA0_E08515g KLLA0_E08515g KLLA0_E08361g KLLA0_E08361g UTP25 UTP25 KLLA0_E07833g KLLA0_E07833g KLLA0_E07393g KLLA0_E07393g KLLA0_E04665g KLLA0_E04665g KLLA0_E01937g KLLA0_E01937g GRC3 GRC3 KLLA0_D19602g KLLA0_D19602g SQS1 SQS1 KLLA0_D19448g KLLA0_D19448g KLLA0_D18755g KLLA0_D18755g KLLA0_D18029g KLLA0_D18029g KLLA0_D16940g KLLA0_D16940g KLLA0_D16709g KLLA0_D16709g KLLA0_D16390g KLLA0_D16390g KLLA0_D16137g KLLA0_D16137g KLLA0_D14861g KLLA0_D14861g KLLA0_D14806g KLLA0_D14806g NOP16 NOP16 KLLA0_D13618g KLLA0_D13618g KLLA0_D13222g KLLA0_D13222g KLLA0_D12254g KLLA0_D12254g KLLA0_D11792g KLLA0_D11792g KLLA0_D11220g KLLA0_D11220g KLLA0_D10351g KLLA0_D10351g KLLA0_D09757g KLLA0_D09757g KLLA0_D09735g KLLA0_D09735g DBP4 DBP4 KLLA0_D08459g KLLA0_D08459g KLLA0_D08393g KLLA0_D08393g KLLA0_D08206g KLLA0_D08206g KLLA0_D08008g KLLA0_D08008g KLLA0_D07139g KLLA0_D07139g KLLA0_D06941g KLLA0_D06941g KLLA0_D06699g KLLA0_D06699g KLLA0_D06677g KLLA0_D06677g KLLA0_D05995g KLLA0_D05995g KLLA0_D03718g KLLA0_D03718g TIF6 TIF6 KLLA0_D01980g KLLA0_D01980g KLLA0_D01947g KLLA0_D01947g KLLA0_D01023g KLLA0_D01023g KLLA0_D00792g KLLA0_D00792g ESF2 ESF2 NOG2 NOG2 KLLA0_C17578g KLLA0_C17578g KLLA0_C17512g KLLA0_C17512g ROK1 ROK1 NOP10 NOP10 KLLA0_C16401g KLLA0_C16401g NOP14 NOP14 DBP3 DBP3 KLLA0_C15345g KLLA0_C15345g KLLA0_C14718g KLLA0_C14718g KLLA0_C14586g KLLA0_C14586g PXR1 PXR1 KLLA0_C12331g KLLA0_C12331g KLLA0_C12199g KLLA0_C12199g KLLA0_C11979g KLLA0_C11979g KLLA0_C11847g KLLA0_C11847g KLLA0_C11495g KLLA0_C11495g BMT2 BMT2 MAK5 MAK5 BFR2 BFR2 KLLA0_C09262g KLLA0_C09262g KLLA0_C08976g KLLA0_C08976g KLLA0_C08547g KLLA0_C08547g KLLA0_C07359g KLLA0_C07359g RRP36 RRP36 KLLA0_C06633g KLLA0_C06633g PNO1 PNO1 KLLA0_C06116g KLLA0_C06116g KLLA0_C05984g KLLA0_C05984g KLLA0_C05852g KLLA0_C05852g KLLA0_C05368g KLLA0_C05368g DBP9 DBP9 KLLA0_C04389g KLLA0_C04389g KLLA0_C02959g KLLA0_C02959g KLLA0_C01914g KLLA0_C01914g KLLA0_C01408g KLLA0_C01408g SPB1 SPB1 KLLA0_C00506g KLLA0_C00506g KLLA0_B13860g KLLA0_B13860g KLLA0_B13563g KLLA0_B13563g KLLA0_B13541g KLLA0_B13541g KLLA0_B13409g KLLA0_B13409g KLLA0_B13046g KLLA0_B13046g KLLA0_B13024g KLLA0_B13024g KLLA0_B12738g KLLA0_B12738g KLLA0_B11792g KLLA0_B11792g KLLA0_B11077g KLLA0_B11077g KLLA0_B10934g KLLA0_B10934g KLLA0_B08239g KLLA0_B08239g KLLA0_B06303g KLLA0_B06303g KLLA0_B06116g KLLA0_B06116g KLLA0_B05973g KLLA0_B05973g FPR3 FPR3 KLLA0_B04180g KLLA0_B04180g KLLA0_B03476g KLLA0_B03476g KLLA0_B02827g KLLA0_B02827g KLLA0_B02266g KLLA0_B02266g KLLA0_B02068g KLLA0_B02068g KLLA0_B01804g KLLA0_B01804g KLLA0_B01518g KLLA0_B01518g KLLA0_B01221g KLLA0_B01221g KLLA0_A11066g KLLA0_A11066g HAS1 HAS1 KLLA0_A07931g KLLA0_A07931g KLLA0_A07150g KLLA0_A07150g KLLA0_A07018g KLLA0_A07018g KLLA0_A05973g KLLA0_A05973g KLLA0_A05753g KLLA0_A05753g DBP8 DBP8 KLLA0_A05181g KLLA0_A05181g KLLA0_A04818g KLLA0_A04818g KLLA0_A04653g KLLA0_A04653g KLLA0_A04037g KLLA0_A04037g KLLA0_A02079g KLLA0_A02079g ACS2 ACS2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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co-expression
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KLLA0_E00837gKLLA0E00837p. (814 aa)
KLLA0_E17535gRepressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (329 aa)
KLLA0_E23783gKLLA0E23783p. (553 aa)
KLLA0_B06622gKLLA0B06622p. (508 aa)
CBF5H/ACA ribonucleoprotein complex subunit CBF5; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridy [...] (474 aa)
RLP7Ribosome biogenesis protein RLP7; Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (318 aa)
KLLA0_F27269gKLLA0F27269p. (1216 aa)
KLLA0_F26224gKLLA0F26224p. (732 aa)
KLLA0_F26070gKLLA0F26070p. (447 aa)
KLLA0_F25278gKLLA0F25278p. (224 aa)
KLLA0_F24816gKLLA0F24816p. (478 aa)
DBP10ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (973 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1055 aa)
KLLA0_F23760gKLLA0F23760p. (127 aa)
KLLA0_F23650gKLLA0F23650p. (312 aa)
KLLA0_F23243gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1653 aa)
KLLA0_F21846gKLLA0F21846p. (376 aa)
KLLA0_F21670gKLLA0F21670p. (292 aa)
GAR1H/ACA ribonucleoprotein complex subunit GAR1; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA. (219 aa)
UTP10U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). (1774 aa)
RPB5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (215 aa)
KLLA0_F20119gCondensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1085 aa)
KLLA0_F19140gKLLA0F19140p. (527 aa)
KLLA0_F17435gKLLA0F17435p. (1271 aa)
KLLA0_F17237gKLLA0F17237p. (523 aa)
KLLA0_F15598gKLLA0F15598p. (478 aa)
KLLA0_F15180gKLLA0F15180p. (524 aa)
DBP7ATP-dependent RNA helicase DBP7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (740 aa)
KLLA0_F13772gKLLA0F13772p. (520 aa)
KLLA0_F13508gU3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (249 aa)
RSA3Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (203 aa)
KLLA0_F13244gKLLA0F13244p. (814 aa)
KLLA0_F12540gKLLA0F12540p. (125 aa)
ARX1Probable metalloprotease ARX1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). (571 aa)
KLLA0_F11000gKLLA0F11000p. (555 aa)
NSA1Ribosome biogenesis protein NSA1; Involved in the biogenesis of the 60S ribosomal subunit. (436 aa)
NOP58Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (511 aa)
KLLA0_F08206gKLLA0F08206p. (838 aa)
NOP12Nucleolar protein 12; Involved in pre-25S rRNA processing; Belongs to the RRM RBM34 family. (462 aa)
DBP6ATP-dependent RNA helicase DBP6; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (630 aa)
KLLA0_F05962gKLLA0F05962p. (267 aa)
KLLA0_F04675gKLLA0F04675p; Belongs to the universal ribosomal protein uL13 family. (199 aa)
RRT14Regulator of rDNA transcription 14; Involved in ribosome biogenesis, probably through modulation of rDNA transcription; Belongs to the RRT14 family. (201 aa)
KLLA0_F03399gKLLA0F03399p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (619 aa)
KLLA0_F02453gKLLA0F02453p. (214 aa)
KLLA0_F02321gKLLA0F02321p. (287 aa)
KLLA0_F02013gKLLA0F02013p. (566 aa)
KLLA0_F01364gKLLA0F01364p. (1073 aa)
KLLA0_F00484gKLLA0F00484p. (198 aa)
KLLA0_E24663gKLLA0E24663p. (136 aa)
NOG1Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (643 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
KLLA0_E22485gKLLA0E22485p. (1144 aa)
KLLA0_E21869gCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (260 aa)
KLLA0_E21165gKLLA0E21165p. (627 aa)
KLLA0_E19515gKLLA0E19515p. (572 aa)
KLLA0_E18151gKLLA0E18151p. (1696 aa)
KLLA0_E17799gKLLA0E17799p. (298 aa)
KLLA0_E17425gKLLA0E17425p. (2493 aa)
KLLA0_E15995gKLLA0E15995p. (183 aa)
KLLA0_E15753gKLLA0E15753p. (85 aa)
SPB4ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (596 aa)
LOC160S ribosomal subunit assembly/export protein LOC1; Required for efficient assembly and nuclear export of the 60S ribosomal subunit. (207 aa)
KLLA0_E13641gKLLA0E13641p. (395 aa)
KLLA0_E13047gKLLA0E13047p. (368 aa)
KLLA0_E12519gKLLA0E12519p. (1006 aa)
KLLA0_E12431gKLLA0E12431p. (116 aa)
KLLA0_E11155gKLLA0E11155p. (434 aa)
KLLA0_E11133gKLLA0E11133p. (460 aa)
CGR1rRNA-processing protein CGR1; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Belongs to the CGR1 family. (121 aa)
KLLA0_E10671gKLLA0E10671p. (862 aa)
KLLA0_E10495gKLLA0E10495p. (138 aa)
RLP24Ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles. (198 aa)
KLLA0_E08515gKLLA0E08515p. (323 aa)
KLLA0_E08361gKLLA0E08361p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (491 aa)
UTP25U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (704 aa)
KLLA0_E07833gKLLA0E07833p. (283 aa)
KLLA0_E07393gKLLA0E07393p. (588 aa)
KLLA0_E04665gKLLA0E04665p. (647 aa)
KLLA0_E01937gKLLA0E01937p. (484 aa)
GRC3Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily. (631 aa)
KLLA0_D19602gKLLA0D19602p. (620 aa)
SQS1Protein SQS1; May be involved in splicing; Belongs to the SQS1 family. (740 aa)
KLLA0_D19448gKLLA0D19448p. (817 aa)
KLLA0_D18755gKLLA0D18755p. (461 aa)
KLLA0_D18029gKLLA0D18029p. (244 aa)
KLLA0_D16940gKLLA0D16940p. (540 aa)
KLLA0_D16709gKLLA0D16709p. (159 aa)
KLLA0_D16390gKLLA0D16390p. (936 aa)
KLLA0_D16137gKLLA0D16137p. (341 aa)
KLLA0_D14861gKLLA0D14861p. (334 aa)
KLLA0_D14806gU3 small nucleolar RNA-associated protein 22. (1212 aa)
NOP16Nucleolar protein 16; Involved in the biogenesis of the 60S ribosomal subunit. (239 aa)
KLLA0_D13618gKLLA0D13618p. (530 aa)
KLLA0_D13222gKLLA0D13222p. (736 aa)
KLLA0_D12254gKLLA0D12254p. (513 aa)
KLLA0_D11792gKLLA0D11792p. (685 aa)
KLLA0_D11220gKLLA0D11220p. (477 aa)
KLLA0_D10351gKLLA0D10351p. (859 aa)
KLLA0_D09757gU3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (608 aa)
KLLA0_D09735gNucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (662 aa)
DBP4ATP-dependent RNA helicase DBP4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (770 aa)
KLLA0_D08459gKLLA0D08459p; Belongs to the peptidase C19 family. (750 aa)
KLLA0_D08393gKLLA0D08393p. (220 aa)
KLLA0_D08206gKLLA0D08206p. (391 aa)
KLLA0_D08008gKLLA0D08008p. (70 aa)
KLLA0_D07139gDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
KLLA0_D06941gKLLA0D06941p. (297 aa)
KLLA0_D06699gKLLA0D06699p. (70 aa)
KLLA0_D06677gKLLA0D06677p. (851 aa)
KLLA0_D05995gKLLA0D05995p. (303 aa)
KLLA0_D03718gKLLA0D03718p. (410 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
KLLA0_D01980gKLLA0D01980p. (182 aa)
KLLA0_D01947gKLLA0D01947p. (412 aa)
KLLA0_D01023gKLLA0D01023p. (268 aa)
KLLA0_D00792gKLLA0D00792p. (1020 aa)
ESF2Pre-rRNA-processing protein ESF2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (293 aa)
NOG2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (513 aa)
KLLA0_C17578gKLLA0C17578p. (1525 aa)
KLLA0_C17512gDNA helicase; Belongs to the MCM family. (892 aa)
ROK1ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (579 aa)
NOP10H/ACA ribonucleoprotein complex subunit NOP10; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA. (57 aa)
KLLA0_C16401gKLLA0C16401p. (612 aa)
NOP14Probable nucleolar complex protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (837 aa)
DBP3ATP-dependent RNA helicase DBP3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (504 aa)
KLLA0_C15345gRibonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (149 aa)
KLLA0_C14718gKLLA0C14718p. (285 aa)
KLLA0_C14586gKLLA0C14586p. (474 aa)
PXR1Protein PXR1; Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase; Belongs to the PINX1 family. (271 aa)
KLLA0_C12331gKLLA0C12331p. (662 aa)
KLLA0_C12199gKLLA0C12199p. (198 aa)
KLLA0_C11979gKLLA0C11979p. (261 aa)
KLLA0_C11847gRibosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family. (377 aa)
KLLA0_C11495gKLLA0C11495p. (445 aa)
BMT225S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family. (354 aa)
MAK5ATP-dependent RNA helicase MAK5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (796 aa)
BFR2Protein BFR2. (526 aa)
KLLA0_C09262gKLLA0C09262p. (558 aa)
KLLA0_C08976gKLLA0C08976p. (911 aa)
KLLA0_C08547gKLLA0C08547p. (515 aa)
KLLA0_C07359gtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (431 aa)
RRP36rRNA biogenesis protein RRP36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity). (332 aa)
KLLA0_C06633gKLLA0C06633p. (631 aa)
PNO1Pre-rRNA-processing protein PNO1; Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity). (274 aa)
KLLA0_C06116gDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (785 aa)
KLLA0_C05984gKLLA0C05984p. (364 aa)
KLLA0_C05852gKLLA0C05852p. (482 aa)
KLLA0_C05368gKLLA0C05368p. (1605 aa)
DBP9ATP-dependent RNA helicase DBP9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (594 aa)
KLLA0_C04389gKLLA0C04389p. (335 aa)
KLLA0_C02959gKLLA0C02959p. (412 aa)
KLLA0_C01914gKLLA0C01914p. (252 aa)
KLLA0_C01408gKLLA0C01408p. (326 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
KLLA0_C00506gKRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (330 aa)
KLLA0_B13860gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (160 aa)
KLLA0_B13563gRibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (238 aa)
KLLA0_B13541gKLLA0B13541p. (171 aa)
KLLA0_B13409gKLLA0B13409p. (138 aa)
KLLA0_B13046gRibosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (204 aa)
KLLA0_B13024gKLLA0B13024p. (124 aa)
KLLA0_B12738gKLLA0B12738p. (658 aa)
KLLA0_B11792gKLLA0B11792p. (187 aa)
KLLA0_B11077gKLLA0B11077p. (567 aa)
KLLA0_B10934gKLLA0B10934p. (253 aa)
KLLA0_B08239gKLLA0B08239p. (1729 aa)
KLLA0_B06303gDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1203 aa)
KLLA0_B06116gKLLA0B06116p. (1051 aa)
KLLA0_B05973gKLLA0B05973p. (153 aa)
FPR3FK506-binding protein 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily. (418 aa)
KLLA0_B04180gKLLA0B04180p. (539 aa)
KLLA0_B03476gKLLA0B03476p. (158 aa)
KLLA0_B02827gKLLA0B02827p. (942 aa)
KLLA0_B02266g60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (181 aa)
KLLA0_B02068gKLLA0B02068p. (1167 aa)
KLLA0_B01804gKLLA0B01804p. (3242 aa)
KLLA0_B01518gKLLA0B01518p. (454 aa)
KLLA0_B01221gKLLA0B01221p. (223 aa)
KLLA0_A11066gKLLA0A11066p. (282 aa)
HAS1ATP-dependent RNA helicase HAS1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (497 aa)
KLLA0_A07931gKLLA0A07931p. (344 aa)
KLLA0_A07150gKLLA0A07150p. (190 aa)
KLLA0_A07018gKLLA0A07018p. (189 aa)
KLLA0_A05973gKLLA0A05973p. (194 aa)
KLLA0_A05753gKLLA0A05753p. (270 aa)
DBP8ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (435 aa)
KLLA0_A05181gKLLA0A05181p. (197 aa)
KLLA0_A04818gCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (277 aa)
KLLA0_A04653gKLLA0A04653p. (700 aa)
KLLA0_A04037gProtein MAK16; Belongs to the MAK16 family. (302 aa)
KLLA0_A02079gKLLA0A02079p. (243 aa)
ACS2Acetyl-coenzyme A synthetase 2. (684 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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