STRINGSTRING
KLLA0_E17799g KLLA0_E17799g SPB4 SPB4 LOC1 LOC1 NSA2 NSA2 KLLA0_E12519g KLLA0_E12519g KLLA0_F01727g KLLA0_F01727g KLLA0_F03399g KLLA0_F03399g KLLA0_F05247g KLLA0_F05247g DBP6 DBP6 NSA1 NSA1 ARX1 ARX1 RSA3 RSA3 DRS1 DRS1 KLLA0_F21670g KLLA0_F21670g KLLA0_F23650g KLLA0_F23650g DBP10 DBP10 RPL25 RPL25 RLP7 RLP7 KLLA0_E12431g KLLA0_E12431g KLLA0_F00484g KLLA0_F00484g KLLA0_F01122g KLLA0_F01122g CGR1 CGR1 NOG1 NOG1 RLP24 RLP24 KLLA0_E00837g KLLA0_E00837g SQS1 SQS1 NOP16 NOP16 KLLA0_D13618g KLLA0_D13618g KLLA0_D09735g KLLA0_D09735g KLLA0_D05621g KLLA0_D05621g TIF6 TIF6 NOG2 NOG2 DBP3 DBP3 KLLA0_C12331g KLLA0_C12331g KLLA0_C11979g KLLA0_C11979g KLLA0_C01870g KLLA0_C01870g SPB1 SPB1 KLLA0_B13563g KLLA0_B13563g KLLA0_B13046g KLLA0_B13046g KLLA0_B10934g KLLA0_B10934g KLLA0_B03234g KLLA0_B03234g KLLA0_B02266g KLLA0_B02266g HAS1 HAS1 KLLA0_A07931g KLLA0_A07931g KLLA0_A06336g KLLA0_A06336g KLLA0_A04037g KLLA0_A04037g
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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KLLA0_E17799gKLLA0E17799p. (298 aa)
SPB4ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (596 aa)
LOC160S ribosomal subunit assembly/export protein LOC1; Required for efficient assembly and nuclear export of the 60S ribosomal subunit. (207 aa)
NSA2Ribosome biogenesis protein NSA2; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (261 aa)
KLLA0_E12519gKLLA0E12519p. (1006 aa)
KLLA0_F01727gKLLA0F01727p. (404 aa)
KLLA0_F03399gKLLA0F03399p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (619 aa)
KLLA0_F05247gKLLA0F05247p. (120 aa)
DBP6ATP-dependent RNA helicase DBP6; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (630 aa)
NSA1Ribosome biogenesis protein NSA1; Involved in the biogenesis of the 60S ribosomal subunit. (436 aa)
ARX1Probable metalloprotease ARX1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). (571 aa)
RSA3Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (203 aa)
DRS1ATP-dependent RNA helicase DRS1; ATP-binding RNA helicase involved in ribosome assembly. (748 aa)
KLLA0_F21670gKLLA0F21670p. (292 aa)
KLLA0_F23650gKLLA0F23650p. (312 aa)
DBP10ATP-dependent RNA helicase DBP10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (973 aa)
RPL2560S ribosomal protein L25; Belongs to the universal ribosomal protein uL23 family. (142 aa)
RLP7Ribosome biogenesis protein RLP7; Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family. (318 aa)
KLLA0_E12431gKLLA0E12431p. (116 aa)
KLLA0_F00484gKLLA0F00484p. (198 aa)
KLLA0_F01122gKLLA0F01122p. (712 aa)
CGR1rRNA-processing protein CGR1; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Belongs to the CGR1 family. (121 aa)
NOG1Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (643 aa)
RLP24Ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles. (198 aa)
KLLA0_E00837gKLLA0E00837p. (814 aa)
SQS1Protein SQS1; May be involved in splicing; Belongs to the SQS1 family. (740 aa)
NOP16Nucleolar protein 16; Involved in the biogenesis of the 60S ribosomal subunit. (239 aa)
KLLA0_D13618gKLLA0D13618p. (530 aa)
KLLA0_D09735gNucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (662 aa)
KLLA0_D05621gKLLA0D05621p. (167 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
NOG2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (513 aa)
DBP3ATP-dependent RNA helicase DBP3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. (504 aa)
KLLA0_C12331gKLLA0C12331p. (662 aa)
KLLA0_C11979gKLLA0C11979p. (261 aa)
KLLA0_C01870gRibosomal protein L37; Binds to the 23S rRNA. (88 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
KLLA0_B13563gRibosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (238 aa)
KLLA0_B13046gRibosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (204 aa)
KLLA0_B10934gKLLA0B10934p. (253 aa)
KLLA0_B03234gKLLA0B03234p. (804 aa)
KLLA0_B02266g60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (181 aa)
HAS1ATP-dependent RNA helicase HAS1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (497 aa)
KLLA0_A07931gKLLA0A07931p. (344 aa)
KLLA0_A06336gKLLA0A06336p; Belongs to the universal ribosomal protein uL22 family. (184 aa)
KLLA0_A04037gProtein MAK16; Belongs to the MAK16 family. (302 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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