STRINGSTRING
PRP46 PRP46 CWC26 CWC26 LSM4 LSM4 SLT11 SLT11 CLF1 CLF1 ISY1 ISY1 SLU7 SLU7 SPP381 SPP381 PRP5 PRP5 KLLA0_F09207g KLLA0_F09207g PRP45 PRP45 SNU13 SNU13 SUB2 SUB2 CCM1 CCM1 SYF2 SYF2 LSM6 LSM6 SQS1 SQS1 MSS116 MSS116 SYF1 SYF1 KLLA0_A02299g KLLA0_A02299g RSE1 RSE1 KLLA0_B08910g KLLA0_B08910g CWC21 CWC21 KLLA0_B10472g KLLA0_B10472g CWC23 CWC23 CWC25 CWC25 SPP2 SPP2 CEF1 CEF1 CWC2 CWC2 PRP28 PRP28 SNU71 SNU71 CWC24 CWC24 KLLA0_D07678g KLLA0_D07678g SWT21 SWT21 KLLA0_D09284g KLLA0_D09284g CWC15 CWC15 KLLA0_D17160g KLLA0_D17160g
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRP46Pre-mRNA-splicing factor PRP46; Involved in pre-mRNA splicing and required for cell cycle progression at G2/M. (434 aa)
CWC26Pre-mRNA-splicing factor CWC26; Involved in pre-mRNA splicing. (268 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (183 aa)
SLT11Pre-mRNA-splicing factor SLT11; Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). (302 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (684 aa)
ISY1Pre-mRNA-splicing factor ISY1; Involved in pre-mRNA splicing. (237 aa)
SLU7Pre-mRNA-splicing factor SLU7; Involved in pre-mRNA splicing. (341 aa)
SPP381Pre-mRNA-splicing factor SPP381; Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA (By similarity). (262 aa)
PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (812 aa)
KLLA0_F09207gU6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
PRP45Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing. (430 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
SUB2ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (437 aa)
CCM1Mitochondrial group I intron splicing factor CCM1; RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity); Belongs to the CCM1 family. (853 aa)
SYF2Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing. (221 aa)
LSM6U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (80 aa)
SQS1Protein SQS1; May be involved in splicing; Belongs to the SQS1 family. (740 aa)
MSS116ATP-dependent RNA helicase MSS116, mitochondrial; ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity); Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. (685 aa)
SYF1Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing and cell cycle progression. (798 aa)
KLLA0_A02299gSmall nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (93 aa)
RSE1Pre-mRNA-splicing factor RSE1; Involved in pre-mRNA splicing and cell cycle control. (1269 aa)
KLLA0_B08910gSpliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (143 aa)
CWC21Pre-mRNA-splicing factor CWC21; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). (113 aa)
KLLA0_B10472gNuclear cap-binding protein subunit 2. (198 aa)
CWC23Pre-mRNA-splicing factor CWC23; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). (270 aa)
CWC25Pre-mRNA-splicing factor CWC25; Involved in pre-mRNA splicing. (206 aa)
SPP2Pre-mRNA-splicing factor SPP2; Involved in spliceosome maturation and the first step of pre- mRNA splicing. (189 aa)
CEF1Pre-mRNA-splicing factor CEF1; Involved in pre-mRNA splicing and cell cycle control. (543 aa)
CWC2Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (337 aa)
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (539 aa)
SNU71U1 small nuclear ribonucleoprotein component SNU71; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity). (568 aa)
CWC24Pre-mRNA-splicing factor CWC24; Involved in pre-mRNA splicing. (229 aa)
KLLA0_D07678gSmall nuclear ribonucleoprotein G. (73 aa)
SWT21Protein SWT21; Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction (By similarity). (411 aa)
KLLA0_D09284gSmall nuclear ribonucleoprotein Sm D2. (110 aa)
CWC15Pre-mRNA-splicing factor CWC15; Involved in pre-mRNA splicing. (187 aa)
KLLA0_D17160gSmall nuclear ribonucleoprotein Sm D3. (100 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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