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HIR1 HIR1 EGD1 EGD1 SSN3 SSN3 MATA1 MATA1 MIG1 MIG1 SIR2 SIR2 KLLA0_E17535g KLLA0_E17535g HMLALPHA2 HMLALPHA2 SSN2 SSN2 SET2 SET2 OAF3 OAF3 TUP1 TUP1 GAL80 GAL80 RGT1 RGT1 SRB8 SRB8 NRM1 NRM1 HIR2 HIR2 KLLA0_E08383g KLLA0_E08383g SSN8 SSN8 RIM101 RIM101
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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HIR1Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (861 aa)
EGD1Nascent polypeptide-associated complex subunit beta; Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the [...] (158 aa)
SSN3Serine/threonine-protein kinase SSN3; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity). (593 aa)
MATA1Mating-type protein A1; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with ALPHA2 to repress transcription of haploid-specific genes (By similarity). Belongs to the MATA1 family. (228 aa)
MIG1Regulatory protein MIG1; Involved in glucose repression of glucose metabolism genes; Belongs to the creA/MIG C2H2-type zinc-finger protein family. (474 aa)
SIR2NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase, which asts as a key regulator of gene expression believed to help form modified chromatin structures on the genes it regulates. It is involved in telomeric silencing and in hm mating type loci silencing (By similarity); Belongs to the sirtuin family. Class I subfamily. (670 aa)
KLLA0_E17535gRepressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. (329 aa)
HMLALPHA2Mating-type protein ALPHA2; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional corepressor that acts in conjunction with A1 to repress transcription of haploid-specific genes (By similarity); Belongs to the TALE/M-ATYP homeobox family. (223 aa)
SSN2Mediator of RNA polymerase II transcription subunit 13; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). (1387 aa)
SET2Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (702 aa)
OAF3Oleate activated transcription factor 3; Transcriptional inhibitor with a significantly increased number of target genes in response to oleate; Belongs to the OAF3 family. (657 aa)
TUP1General transcriptional corepressor TUP1; Represses transcription by RNA polymerase II. (682 aa)
GAL80Galactose/lactose metabolism regulatory protein GAL80; This protein is a negative regulator for the gene expression of the lactose/galactose metabolic genes. It seems to block activation by the transcriptional activator LAC9 in the absence of an inducing sugar. (457 aa)
RGT1Glucose transport transcription regulator RGT1; Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription (By similarity); Belongs to the EDS1/RGT1 family. (1007 aa)
SRB8Mediator of RNA polymerase II transcription subunit 12; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). (1322 aa)
NRM1Transcription factor NRM1; Negative regulatory component of the MBF complex involved in cell-cycle-dependent transcription. (221 aa)
HIR2Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (847 aa)
KLLA0_E08383gHistone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (704 aa)
SSN8RNA polymerase II holoenzyme cyclin-like subunit; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By s [...] (304 aa)
RIM101pH-response transcription factor pacC/RIM101; Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including RIM101 itself) and represses transcription of acid- expressed genes (By similarity); Belongs to the pacC/RIM101 family. (517 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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