STRINGSTRING
KLLA0_C06633g KLLA0_C06633g KLLA0_B11231g KLLA0_B11231g RPS14 RPS14 RPS28 RPS28 KLLA0_F27665g KLLA0_F27665g ERB1 ERB1 KLLA0_F25542g KLLA0_F25542g UTP10 UTP10 KLLA0_F18304g KLLA0_F18304g KLLA0_F18040g KLLA0_F18040g KLLA0_F17435g KLLA0_F17435g KLLA0_F16280g KLLA0_F16280g KLLA0_F15598g KLLA0_F15598g IPI1 IPI1 KLLA0_F13772g KLLA0_F13772g KLLA0_F13508g KLLA0_F13508g KLLA0_F13244g KLLA0_F13244g KLLA0_F11000g KLLA0_F11000g KLLA0_F09812g KLLA0_F09812g NOP58 NOP58 KLLA0_F07843g KLLA0_F07843g RAT1 RAT1 KLLA0_F06622g KLLA0_F06622g KLLA0_F05962g KLLA0_F05962g KLLA0_F02013g KLLA0_F02013g KLLA0_F01364g KLLA0_F01364g KLLA0_F00352g KLLA0_F00352g RPS6 RPS6 KLLA0_E23673g KLLA0_E23673g SNU13 SNU13 KLLA0_E21121g KLLA0_E21121g KLLA0_E20461g KLLA0_E20461g REX4 REX4 KLLA0_E17425g KLLA0_E17425g KLLA0_E17007g KLLA0_E17007g RPS0 RPS0 KLLA0_E15995g KLLA0_E15995g KLLA0_E13729g KLLA0_E13729g KLLA0_E13641g KLLA0_E13641g KLLA0_E12739g KLLA0_E12739g KLLA0_E11661g KLLA0_E11661g KLLA0_E10495g KLLA0_E10495g KLLA0_E09219g KLLA0_E09219g UTP25 UTP25 KLLA0_E07833g KLLA0_E07833g KLLA0_E05941g KLLA0_E05941g KLLA0_E05149g KLLA0_E05149g RPS29 RPS29 KLLA0_E02091g KLLA0_E02091g KLLA0_E01453g KLLA0_E01453g GRC3 GRC3 KLLA0_D19701g KLLA0_D19701g KLLA0_D19008g KLLA0_D19008g KLLA0_D16390g KLLA0_D16390g STS1 STS1 NOP7 NOP7 KLLA0_D14993g KLLA0_D14993g KLLA0_D14806g KLLA0_D14806g KLLA0_D13618g KLLA0_D13618g KLLA0_D13222g KLLA0_D13222g KLLA0_D12254g KLLA0_D12254g KLLA0_D11792g KLLA0_D11792g KLLA0_D10659g KLLA0_D10659g KLLA0_D10351g KLLA0_D10351g KLLA0_D09757g KLLA0_D09757g KLLA0_D09625g KLLA0_D09625g IPI3 IPI3 KLLA0_D08305g KLLA0_D08305g KLLA0_D06677g KLLA0_D06677g KLLA0_D05115g KLLA0_D05115g KLLA0_D03168g KLLA0_D03168g KLLA0_D01309g KLLA0_D01309g ROK1 ROK1 KLLA0_C16401g KLLA0_C16401g NOP14 NOP14 KLLA0_C14718g KLLA0_C14718g RRP3 RRP3 KLLA0_C13519g KLLA0_C13519g KLLA0_C11979g KLLA0_C11979g KLLA0_C11297g KLLA0_C11297g KLLA0_C11099g KLLA0_C11099g KLLA0_C09262g KLLA0_C09262g KLLA0_C08976g KLLA0_C08976g KLLA0_C08371g KLLA0_C08371g KLLA0_C07755g KLLA0_C07755g YTM1 YTM1 RRP36 RRP36 PNO1 PNO1 KLLA0_C05984g KLLA0_C05984g KLLA0_C04389g KLLA0_C04389g KLLA0_C03520g KLLA0_C03520g KLLA0_C01914g KLLA0_C01914g KLLA0_C01408g KLLA0_C01408g SPB1 SPB1 KLLA0_C00506g KLLA0_C00506g KLLA0_B11792g KLLA0_B11792g KLLA0_B11077g KLLA0_B11077g KLLA0_B10890g KLLA0_B10890g KLLA0_B08239g KLLA0_B08239g KLLA0_B08173g KLLA0_B08173g KLLA0_B07931g KLLA0_B07931g RPS22 RPS22 KLLA0_B06182g KLLA0_B06182g RPS1 RPS1 KLLA0_B04180g KLLA0_B04180g RIX1 RIX1 KLLA0_B03652g KLLA0_B03652g KLLA0_B02827g KLLA0_B02827g KLLA0_B02266g KLLA0_B02266g KLLA0_B02068g KLLA0_B02068g KLLA0_B01562g KLLA0_B01562g KLLA0_B01518g KLLA0_B01518g KLLA0_B01474g KLLA0_B01474g KLLA0_A11660g KLLA0_A11660g KLLA0_A10483g KLLA0_A10483g KLLA0_A07194g KLLA0_A07194g KLLA0_A07150g KLLA0_A07150g KLLA0_A07018g KLLA0_A07018g KLLA0_A06710g KLLA0_A06710g KLLA0_A06017g KLLA0_A06017g DBP8 DBP8 KLLA0_A02079g KLLA0_A02079g RPS16 RPS16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLLA0_C06633gKLLA0C06633p. (631 aa)
KLLA0_B11231gKLLA0B11231p; Belongs to the universal ribosomal protein uS12 family. (145 aa)
RPS1440S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (137 aa)
RPS2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (67 aa)
KLLA0_F27665gKLLA0F27665p. (1044 aa)
ERB1Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (791 aa)
KLLA0_F25542gKLLA0F25542p. (117 aa)
UTP10U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). (1774 aa)
KLLA0_F18304gKLLA0F18304p. (236 aa)
KLLA0_F18040gKLLA0F18040p; Belongs to the universal ribosomal protein uS15 family. (151 aa)
KLLA0_F17435gKLLA0F17435p. (1271 aa)
KLLA0_F16280g20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (472 aa)
KLLA0_F15598gKLLA0F15598p. (478 aa)
IPI1Pre-rRNA-processing protein IPI1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (381 aa)
KLLA0_F13772gKLLA0F13772p. (520 aa)
KLLA0_F13508gU3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (249 aa)
KLLA0_F13244gKLLA0F13244p. (814 aa)
KLLA0_F11000gKLLA0F11000p. (555 aa)
KLLA0_F09812gKLLA0F09812p; Belongs to the universal ribosomal protein uS5 family. (259 aa)
NOP58Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (511 aa)
KLLA0_F07843gKLLA0F07843p; Belongs to the universal ribosomal protein uS19 family. (142 aa)
RAT15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (992 aa)
KLLA0_F06622gKLLA0F06622p. (478 aa)
KLLA0_F05962gKLLA0F05962p. (267 aa)
KLLA0_F02013gKLLA0F02013p. (566 aa)
KLLA0_F01364gKLLA0F01364p. (1073 aa)
KLLA0_F00352g40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (134 aa)
RPS640S ribosomal protein S6. (236 aa)
KLLA0_E23673gKLLA0E23673p; Belongs to the universal ribosomal protein uS4 family. (188 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
KLLA0_E21121gSerine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (526 aa)
KLLA0_E20461g40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (201 aa)
REX4RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (294 aa)
KLLA0_E17425gKLLA0E17425p. (2493 aa)
KLLA0_E17007gKLLA0E17007p. (177 aa)
RPS040S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (254 aa)
KLLA0_E15995gKLLA0E15995p. (183 aa)
KLLA0_E13729gKLLA0E13729p. (483 aa)
KLLA0_E13641gKLLA0E13641p. (395 aa)
KLLA0_E12739gKLLA0E12739p. (437 aa)
KLLA0_E11661g40S ribosomal protein S27. (82 aa)
KLLA0_E10495gKLLA0E10495p. (138 aa)
KLLA0_E09219gKLLA0E09219p. (264 aa)
UTP25U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (704 aa)
KLLA0_E07833gKLLA0E07833p. (283 aa)
KLLA0_E05941gKLLA0E05941p. (92 aa)
KLLA0_E05149gKLLA0E05149p. (787 aa)
RPS2940S ribosomal protein S29; Belongs to the universal ribosomal protein uS14 family. (56 aa)
KLLA0_E02091gKLLA0E02091p. (240 aa)
KLLA0_E01453gKLLA0E01453p. (155 aa)
GRC3Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily. (631 aa)
KLLA0_D19701gKLLA0D19701p. (297 aa)
KLLA0_D19008gKLLA0D19008p. (422 aa)
KLLA0_D16390gKLLA0D16390p. (936 aa)
STS1Tethering factor for nuclear proteasome STS1; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity). (333 aa)
NOP7Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (605 aa)
KLLA0_D14993gKLLA0D14993p. (225 aa)
KLLA0_D14806gU3 small nucleolar RNA-associated protein 22. (1212 aa)
KLLA0_D13618gKLLA0D13618p. (530 aa)
KLLA0_D13222gKLLA0D13222p. (736 aa)
KLLA0_D12254gKLLA0D12254p. (513 aa)
KLLA0_D11792gKLLA0D11792p. (685 aa)
KLLA0_D10659gKLLA0D10659p; Belongs to the universal ribosomal protein uS7 family. (227 aa)
KLLA0_D10351gKLLA0D10351p. (859 aa)
KLLA0_D09757gU3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (608 aa)
KLLA0_D09625gKLLA0D09625p. (245 aa)
IPI3Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (508 aa)
KLLA0_D08305gKLLA0D08305p; Belongs to the universal ribosomal protein uS3 family. (237 aa)
KLLA0_D06677gKLLA0D06677p. (851 aa)
KLLA0_D05115g40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (119 aa)
KLLA0_D03168gKLLA0D03168p. (505 aa)
KLLA0_D01309gKLLA0D01309p. (744 aa)
ROK1ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (579 aa)
KLLA0_C16401gKLLA0C16401p. (612 aa)
NOP14Probable nucleolar complex protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (837 aa)
KLLA0_C14718gKLLA0C14718p. (285 aa)
RRP3ATP-dependent rRNA helicase RRP3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. (487 aa)
KLLA0_C13519g40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (190 aa)
KLLA0_C11979gKLLA0C11979p. (261 aa)
KLLA0_C11297gKLLA0C11297p; Belongs to the universal ribosomal protein uS13 family. (137 aa)
KLLA0_C11099gKLLA0C11099p. (305 aa)
KLLA0_C09262gKLLA0C09262p. (558 aa)
KLLA0_C08976gKLLA0C08976p. (911 aa)
KLLA0_C08371gKLLA0C08371p. (125 aa)
KLLA0_C07755g40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (135 aa)
YTM1Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (444 aa)
RRP36rRNA biogenesis protein RRP36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity). (332 aa)
PNO1Pre-rRNA-processing protein PNO1; Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity). (274 aa)
KLLA0_C05984gKLLA0C05984p. (364 aa)
KLLA0_C04389gKLLA0C04389p. (335 aa)
KLLA0_C03520gKLLA0C03520p. (379 aa)
KLLA0_C01914gKLLA0C01914p. (252 aa)
KLLA0_C01408gKLLA0C01408p. (326 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
KLLA0_C00506gKRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (330 aa)
KLLA0_B11792gKLLA0B11792p. (187 aa)
KLLA0_B11077gKLLA0B11077p. (567 aa)
KLLA0_B10890gKLLA0B10890p. (521 aa)
KLLA0_B08239gKLLA0B08239p. (1729 aa)
KLLA0_B08173gKLLA0B08173p. (106 aa)
KLLA0_B07931gKLLA0B07931p; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RPS2240S ribosomal protein S22; Belongs to the universal ribosomal protein uS8 family. (130 aa)
KLLA0_B06182g40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (108 aa)
RPS140S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family. (255 aa)
KLLA0_B04180gKLLA0B04180p. (539 aa)
RIX1Pre-rRNA-processing protein RIX1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1. (776 aa)
KLLA0_B03652g40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (261 aa)
KLLA0_B02827gKLLA0B02827p. (942 aa)
KLLA0_B02266g60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (181 aa)
KLLA0_B02068gKLLA0B02068p. (1167 aa)
KLLA0_B01562gKLLA0B01562p; Belongs to the universal ribosomal protein uS13 family. (146 aa)
KLLA0_B01518gKLLA0B01518p. (454 aa)
KLLA0_B01474gKLLA0B01474p. (136 aa)
KLLA0_A11660gKLLA0A11660p. (482 aa)
KLLA0_A10483gKLLA0A10483p; Belongs to the universal ribosomal protein uS17 family. (156 aa)
KLLA0_A07194gKLLA0A07194p. (144 aa)
KLLA0_A07150gKLLA0A07150p. (190 aa)
KLLA0_A07018gKLLA0A07018p. (189 aa)
KLLA0_A06710gKLLA0A06710p. (423 aa)
KLLA0_A06017gKLLA0A06017p. (456 aa)
DBP8ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (435 aa)
KLLA0_A02079gKLLA0A02079p. (243 aa)
RPS1640S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (143 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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