STRINGSTRING
FIP1 FIP1 KLLA0_E04929g KLLA0_E04929g SPP2 SPP2 KLLA0_C06787g KLLA0_C06787g KLLA0_C07194g KLLA0_C07194g CEF1 CEF1 KLLA0_C07953g KLLA0_C07953g KLLA0_C08019g KLLA0_C08019g KLLA0_C08195g KLLA0_C08195g HUB1 HUB1 KLLA0_C08800g KLLA0_C08800g KLLA0_C09801g KLLA0_C09801g CLP1 CLP1 KLLA0_C13475g KLLA0_C13475g KLLA0_C14025g KLLA0_C14025g KLLA0_C14388g KLLA0_C14388g KLLA0_C15235g KLLA0_C15235g PRP28 PRP28 KLLA0_C15675g KLLA0_C15675g KLLA0_C17798g KLLA0_C17798g SNU71 SNU71 KLLA0_C18172g KLLA0_C18172g KLLA0_C18194g KLLA0_C18194g CWC24 CWC24 KLLA0_D02728g KLLA0_D02728g KLLA0_D03234g KLLA0_D03234g KLLA0_D03773g KLLA0_D03773g KLLA0_D06699g KLLA0_D06699g KLLA0_D07139g KLLA0_D07139g KLLA0_D07678g KLLA0_D07678g KLLA0_D08008g KLLA0_D08008g KLLA0_D09284g KLLA0_D09284g KLLA0_D09526g KLLA0_D09526g KLLA0_D13420g KLLA0_D13420g KLLA0_D13772g KLLA0_D13772g KLLA0_D14883g KLLA0_D14883g RRT5 RRT5 KLLA0_D16170g KLLA0_D16170g CWC15 CWC15 KLLA0_D17160g KLLA0_D17160g KLLA0_E01409g KLLA0_E01409g KLLA0_E02751g KLLA0_E02751g SYF2 SYF2 KLLA0_E04819g KLLA0_E04819g KLLA0_A00594g KLLA0_A00594g KLLA0_A02299g KLLA0_A02299g KLLA0_A04565g KLLA0_A04565g KLLA0_A05280g KLLA0_A05280g KLLA0_A05346g KLLA0_A05346g KLLA0_A05797g KLLA0_A05797g KLLA0_A06688g KLLA0_A06688g KLLA0_A07733g KLLA0_A07733g KLLA0_A07909g KLLA0_A07909g RSE1 RSE1 KLLA0_A09097g KLLA0_A09097g KLLA0_A09537g KLLA0_A09537g KLLA0_A11594g KLLA0_A11594g KLLA0_B00561g KLLA0_B00561g KLLA0_B00627g KLLA0_B00627g KLLA0_B00979g KLLA0_B00979g KLLA0_B01760g KLLA0_B01760g KLLA0_B02156g KLLA0_B02156g KLLA0_B03476g KLLA0_B03476g KLLA0_B05577g KLLA0_B05577g KLLA0_B06138g KLLA0_B06138g KLLA0_B06369g KLLA0_B06369g KLLA0_B08910g KLLA0_B08910g CWC21 CWC21 KLLA0_B10472g KLLA0_B10472g JIP5 JIP5 KLLA0_B11143g KLLA0_B11143g KLLA0_B11594g KLLA0_B11594g KLLA0_B11638g KLLA0_B11638g KLLA0_B13255g KLLA0_B13255g KLLA0_C00693g KLLA0_C00693g CWC25 CWC25 KLLA0_C03322g KLLA0_C03322g KLLA0_C05192g KLLA0_C05192g KLLA0_C06160g KLLA0_C06160g KLLA0_A11605g KLLA0_A11605g KLLA0_F26697g KLLA0_F26697g KLLA0_F26433g KLLA0_F26433g RNA14 RNA14 KLLA0_F26224g KLLA0_F26224g KLLA0_F24662g KLLA0_F24662g KLLA0_F22473g KLLA0_F22473g CWC26 CWC26 KLLA0_F22363g KLLA0_F22363g RPB5 RPB5 KLLA0_F20526g KLLA0_F20526g SLT11 SLT11 KLLA0_F18018g KLLA0_F18018g CLF1 CLF1 KLLA0_F17523g KLLA0_F17523g KLLA0_F15411g KLLA0_F15411g SLU7 SLU7 KLLA0_F13442g KLLA0_F13442g KLLA0_F12034g KLLA0_F12034g PRP46 PRP46 KLLA0_F10703g KLLA0_F10703g PRP5 PRP5 KLLA0_F09383g KLLA0_F09383g KLLA0_F09097g KLLA0_F09097g KLLA0_F08591g KLLA0_F08591g KLLA0_F08481g KLLA0_F08481g KLLA0_F07249g KLLA0_F07249g KLLA0_F06754g KLLA0_F06754g KLLA0_F06204g KLLA0_F06204g KLLA0_F05071g KLLA0_F05071g KLLA0_F04191g KLLA0_F04191g KLLA0_F03531g KLLA0_F03531g PRP45 PRP45 KLLA0_F01661g KLLA0_F01661g KLLA0_E22463g KLLA0_E22463g KLLA0_E21187g KLLA0_E21187g KLLA0_E20703g KLLA0_E20703g KLLA0_E20615g KLLA0_E20615g KLLA0_E19845g KLLA0_E19845g KLLA0_E18965g KLLA0_E18965g KLLA0_E17227g KLLA0_E17227g KLLA0_E16457g KLLA0_E16457g KLLA0_E14191g KLLA0_E14191g KLLA0_E14125g KLLA0_E14125g KLLA0_E13597g KLLA0_E13597g HEK2 HEK2 KLLA0_E11793g KLLA0_E11793g KLLA0_E11771g KLLA0_E11771g KLLA0_E11067g KLLA0_E11067g KLLA0_E11045g KLLA0_E11045g KLLA0_E09329g KLLA0_E09329g KLLA0_E09285g KLLA0_E09285g KLLA0_E09087g KLLA0_E09087g
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FIP1Pre-mRNA polyadenylation factor FIP1; Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase; Belongs to the FIP1 family. (295 aa)
KLLA0_E04929gKLLA0E04929p. (112 aa)
SPP2Pre-mRNA-splicing factor SPP2; Involved in spliceosome maturation and the first step of pre- mRNA splicing. (189 aa)
KLLA0_C06787gKLLA0C06787p. (171 aa)
KLLA0_C07194gKLLA0C07194p. (297 aa)
CEF1Pre-mRNA-splicing factor CEF1; Involved in pre-mRNA splicing and cell cycle control. (543 aa)
KLLA0_C07953gKLLA0C07953p. (346 aa)
KLLA0_C08019gKLLA0C08019p. (301 aa)
KLLA0_C08195gKLLA0C08195p. (243 aa)
HUB1Ubiquitin-like modifier HUB1. (74 aa)
KLLA0_C08800gKLLA0C08800p. (157 aa)
KLLA0_C09801gKLLA0C09801p. (588 aa)
CLP1mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (437 aa)
KLLA0_C13475gKLLA0C13475p. (907 aa)
KLLA0_C14025gKLLA0C14025p. (529 aa)
KLLA0_C14388gKLLA0C14388p. (203 aa)
KLLA0_C15235gKLLA0C15235p. (544 aa)
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (539 aa)
KLLA0_C15675gKLLA0C15675p. (111 aa)
KLLA0_C17798gKLLA0C17798p. (2149 aa)
SNU71U1 small nuclear ribonucleoprotein component SNU71; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity). (568 aa)
KLLA0_C18172gKLLA0C18172p. (152 aa)
KLLA0_C18194gKLLA0C18194p. (388 aa)
CWC24Pre-mRNA-splicing factor CWC24; Involved in pre-mRNA splicing. (229 aa)
KLLA0_D02728gKLLA0D02728p. (667 aa)
KLLA0_D03234gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (122 aa)
KLLA0_D03773gKLLA0D03773p. (141 aa)
KLLA0_D06699gKLLA0D06699p. (70 aa)
KLLA0_D07139gDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
KLLA0_D07678gSmall nuclear ribonucleoprotein G. (73 aa)
KLLA0_D08008gKLLA0D08008p. (70 aa)
KLLA0_D09284gSmall nuclear ribonucleoprotein Sm D2. (110 aa)
KLLA0_D09526gKLLA0D09526p. (217 aa)
KLLA0_D13420gKLLA0D13420p. (166 aa)
KLLA0_D13772gKLLA0D13772p. (345 aa)
KLLA0_D14883gKLLA0D14883p. (467 aa)
RRT5Regulator of rDNA transcription protein 5; May be involved in the modulation of rDNA transcription. (425 aa)
KLLA0_D16170gKLLA0D16170p. (307 aa)
CWC15Pre-mRNA-splicing factor CWC15; Involved in pre-mRNA splicing. (187 aa)
KLLA0_D17160gSmall nuclear ribonucleoprotein Sm D3. (100 aa)
KLLA0_E01409gKLLA0E01409p. (186 aa)
KLLA0_E02751gKLLA0E02751p. (222 aa)
SYF2Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing. (221 aa)
KLLA0_E04819gKLLA0E04819p. (459 aa)
KLLA0_A00594gKLLA0A00594p. (1748 aa)
KLLA0_A02299gSmall nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (93 aa)
KLLA0_A04565gKLLA0A04565p. (189 aa)
KLLA0_A05280gKLLA0A05280p. (2411 aa)
KLLA0_A05346gKLLA0A05346p. (874 aa)
KLLA0_A05797gKLLA0A05797p. (200 aa)
KLLA0_A06688gKLLA0A06688p. (933 aa)
KLLA0_A07733gKLLA0A07733p. (1064 aa)
KLLA0_A07909gKLLA0A07909p. (1106 aa)
RSE1Pre-mRNA-splicing factor RSE1; Involved in pre-mRNA splicing and cell cycle control. (1269 aa)
KLLA0_A09097gKLLA0A09097p. (805 aa)
KLLA0_A09537gKLLA0A09537p. (954 aa)
KLLA0_A11594gKLLA0A11594p. (1530 aa)
KLLA0_B00561gKLLA0B00561p. (767 aa)
KLLA0_B00627gKLLA0B00627p. (191 aa)
KLLA0_B00979gKLLA0B00979p. (342 aa)
KLLA0_B01760gKLLA0B01760p. (606 aa)
KLLA0_B02156gKLLA0B02156p. (242 aa)
KLLA0_B03476gKLLA0B03476p. (158 aa)
KLLA0_B05577gDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1221 aa)
KLLA0_B06138gKLLA0B06138p. (661 aa)
KLLA0_B06369gKLLA0B06369p. (271 aa)
KLLA0_B08910gSpliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (143 aa)
CWC21Pre-mRNA-splicing factor CWC21; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). (113 aa)
KLLA0_B10472gNuclear cap-binding protein subunit 2. (198 aa)
JIP5WD repeat-containing protein JIP5. (525 aa)
KLLA0_B11143gKLLA0B11143p. (571 aa)
KLLA0_B11594gKLLA0B11594p. (114 aa)
KLLA0_B11638gKLLA0B11638p. (1111 aa)
KLLA0_B13255gPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (598 aa)
KLLA0_C00693gKLLA0C00693p; Belongs to the MT-A70-like family. (323 aa)
CWC25Pre-mRNA-splicing factor CWC25; Involved in pre-mRNA splicing. (206 aa)
KLLA0_C03322gKLLA0C03322p. (385 aa)
KLLA0_C05192gKLLA0C05192p. (189 aa)
KLLA0_C06160gKLLA0C06160p. (121 aa)
KLLA0_A11605gKLLA0A11605p. (87 aa)
KLLA0_F26697gKLLA0F26697p. (1130 aa)
KLLA0_F26433gKLLA0F26433p. (589 aa)
RNA14mRNA 3'-end-processing protein RNA14; Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (661 aa)
KLLA0_F26224gKLLA0F26224p. (732 aa)
KLLA0_F24662gKLLA0F24662p. (530 aa)
KLLA0_F22473gKLLA0F22473p. (253 aa)
CWC26Pre-mRNA-splicing factor CWC26; Involved in pre-mRNA splicing. (268 aa)
KLLA0_F22363gKLLA0F22363p. (405 aa)
RPB5DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower [...] (215 aa)
KLLA0_F20526gKLLA0F20526p. (414 aa)
SLT11Pre-mRNA-splicing factor SLT11; Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). (302 aa)
KLLA0_F18018gKLLA0F18018p. (459 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (684 aa)
KLLA0_F17523gKLLA0F17523p. (855 aa)
KLLA0_F15411gTranscription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (686 aa)
SLU7Pre-mRNA-splicing factor SLU7; Involved in pre-mRNA splicing. (341 aa)
KLLA0_F13442gKLLA0F13442p. (587 aa)
KLLA0_F12034gKLLA0F12034p. (1089 aa)
PRP46Pre-mRNA-splicing factor PRP46; Involved in pre-mRNA splicing and required for cell cycle progression at G2/M. (434 aa)
KLLA0_F10703gKLLA0F10703p. (417 aa)
PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (812 aa)
KLLA0_F09383gKLLA0F09383p. (258 aa)
KLLA0_F09097gKLLA0F09097p; Belongs to the MT-A70-like family. (524 aa)
KLLA0_F08591gKLLA0F08591p. (557 aa)
KLLA0_F08481gKLLA0F08481p. (483 aa)
KLLA0_F07249gKLLA0F07249p. (256 aa)
KLLA0_F06754gKLLA0F06754p; Belongs to the WD repeat SEC13 family. (344 aa)
KLLA0_F06204gKLLA0F06204p. (877 aa)
KLLA0_F05071gDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1720 aa)
KLLA0_F04191gKLLA0F04191p. (885 aa)
KLLA0_F03531gKLLA0F03531p. (1465 aa)
PRP45Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing. (430 aa)
KLLA0_F01661gKLLA0F01661p. (687 aa)
KLLA0_E22463gNuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (724 aa)
KLLA0_E21187gKLLA0E21187p. (429 aa)
KLLA0_E20703gKLLA0E20703p. (371 aa)
KLLA0_E20615gKLLA0E20615p. (1452 aa)
KLLA0_E19845gKLLA0E19845p. (592 aa)
KLLA0_E18965gKLLA0E18965p. (1319 aa)
KLLA0_E17227gKLLA0E17227p. (203 aa)
KLLA0_E16457gKLLA0E16457p. (96 aa)
KLLA0_E14191gNuclear pore protein. (860 aa)
KLLA0_E14125gKLLA0E14125p. (477 aa)
KLLA0_E13597gKLLA0E13597p. (822 aa)
HEK2Heterogeneous nuclear rnp K-like protein 2; RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity). (383 aa)
KLLA0_E11793gKLLA0E11793p. (780 aa)
KLLA0_E11771gKLLA0E11771p. (1648 aa)
KLLA0_E11067gKLLA0E11067p. (1606 aa)
KLLA0_E11045gKLLA0E11045p. (432 aa)
KLLA0_E09329gKLLA0E09329p. (75 aa)
KLLA0_E09285gKLLA0E09285p. (424 aa)
KLLA0_E09087gNuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (722 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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