(47 nodes) Translation initiation complex formation network (Kluyveromyces lactis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	KLLA0_E23673g	KLLA0E23673p; Belongs to the universal ribosomal protein uS4 family. (188 aa)
	KLLA0_E21011g	KLLA0E21011p; Belongs to the eukaryotic initiation factor 4E family. (210 aa)
	KLLA0_E20461g	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (201 aa)
	HCR1	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (277 aa)
	RPS0	40S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (254 aa)
	KLLA0_E11661g	40S ribosomal protein S27. (82 aa)
	KLLA0_B07931g	KLLA0B07931p; Belongs to the universal ribosomal protein uS8 family. (130 aa)
	KLLA0_B08173g	KLLA0B08173p. (106 aa)
	KLLA0_B10560g	KLLA0B10560p. (460 aa)
	KLLA0_C07755g	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (135 aa)
	KLLA0_B01562g	KLLA0B01562p; Belongs to the universal ribosomal protein uS13 family. (146 aa)
	KLLA0_B03652g	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (261 aa)
	RPS1	40S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family. (255 aa)
	KLLA0_B06182g	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (108 aa)
	RPS22	40S ribosomal protein S22; Belongs to the universal ribosomal protein uS8 family. (130 aa)
	KLLA0_C13519g	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (190 aa)
	TIF32	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (925 aa)
	PAB1	Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (592 aa)
	KLLA0_D05115g	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (119 aa)
	KLLA0_D08206g	KLLA0D08206p. (391 aa)
	KLLA0_D08305g	KLLA0D08305p; Belongs to the universal ribosomal protein uS3 family. (237 aa)
	KLLA0_D08932g	KLLA0D08932p. (278 aa)
	KLLA0_D10571g	KLLA0D10571p. (520 aa)
	KLLA0_D10659g	KLLA0D10659p; Belongs to the universal ribosomal protein uS7 family. (227 aa)
	CSN9	COP9 signalosome complex subunit 9; Component of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The complex is involved in the regulation of the mating pheromone response (By similarity). (158 aa)
	RPS29	40S ribosomal protein S29; Belongs to the universal ribosomal protein uS14 family. (56 aa)
	KLLA0_E11287g	KLLA0E11287p; Belongs to the eIF-1A family. (155 aa)
	TIF1	ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (396 aa)
	KLLA0_A04730g	KLLA0A04730p. (1021 aa)
	PRT1	Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (732 aa)
	RPS16	40S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (143 aa)
	KLLA0_B01474g	KLLA0B01474p. (136 aa)
	TIF35	Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (269 aa)
	KLLA0_A11814g	KLLA0A11814p. (302 aa)
	KLLA0_A10483g	KLLA0A10483p; Belongs to the universal ribosomal protein uS17 family. (156 aa)
	KLLA0_A08338g	KLLA0A08338p. (766 aa)
	KLLA0_A07194g	KLLA0A07194p. (144 aa)
	KLLA0_B11231g	KLLA0B11231p; Belongs to the universal ribosomal protein uS12 family. (145 aa)
	RPS14	40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (137 aa)
	KLLA0_F25542g	KLLA0F25542p. (117 aa)
	KLLA0_F18040g	KLLA0F18040p; Belongs to the universal ribosomal protein uS15 family. (151 aa)
	KLLA0_F09812g	KLLA0F09812p; Belongs to the universal ribosomal protein uS5 family. (259 aa)
	KLLA0_F07843g	KLLA0F07843p; Belongs to the universal ribosomal protein uS19 family. (142 aa)
	TIF34	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (347 aa)
	NIP1	Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (819 aa)
	KLLA0_F00352g	40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (134 aa)
	RPS6	40S ribosomal protein S6. (236 aa)

Your Current Organism:

Kluyveromyces lactis

NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCR1	KLLA0_A04730g	Q6CMJ8	Q6CXY2	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0A04730p.	0.894
HCR1	KLLA0_A07194g	Q6CMJ8	Q6CXM0	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0A07194p.	0.890
HCR1	KLLA0_A10483g	Q6CMJ8	Q6CX80	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0A10483p; Belongs to the universal ribosomal protein uS17 family.	0.906
HCR1	KLLA0_A11814g	Q6CMJ8	Q6CX25	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0A11814p.	0.990
HCR1	KLLA0_B01474g	Q6CMJ8	Q6CWU3	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0B01474p.	0.837
HCR1	KLLA0_B01562g	Q6CMJ8	Q6CWT9	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0B01562p; Belongs to the universal ribosomal protein uS13 family.	0.899
HCR1	KLLA0_B03652g	Q6CMJ8	Q6CWJ2	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family.	0.905
HCR1	KLLA0_B06182g	Q6CMJ8	Q6CW78	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.911
HCR1	KLLA0_B07931g	Q6CMJ8	Q6CW06	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0B07931p; Belongs to the universal ribosomal protein uS8 family.	0.861
HCR1	KLLA0_B08173g	Q6CMJ8	Q6CVZ5	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0B08173p.	0.920
HCR1	KLLA0_B10560g	Q6CMJ8	Q6CVP0	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0B10560p.	0.492
HCR1	KLLA0_B11231g	Q6CMJ8	F2Z602	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0B11231p; Belongs to the universal ribosomal protein uS12 family.	0.966
HCR1	KLLA0_C07755g	Q6CMJ8	Q6CU44	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family.	0.908
HCR1	KLLA0_C13519g	Q6CMJ8	Q6CTD6	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family.	0.908
HCR1	KLLA0_D05115g	Q6CMJ8	Q6CS01	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family.	0.881
HCR1	KLLA0_D08305g	Q6CMJ8	Q6CRK7	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0D08305p; Belongs to the universal ribosomal protein uS3 family.	0.979
HCR1	KLLA0_D08932g	Q6CMJ8	Q6CRH9	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0D08932p.	0.995
HCR1	KLLA0_D10571g	Q6CMJ8	Q6CRA7	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0D10571p.	0.986
HCR1	KLLA0_D10659g	Q6CMJ8	Q6CRA3	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0D10659p; Belongs to the universal ribosomal protein uS7 family.	0.903
HCR1	KLLA0_E11287g	Q6CMJ8	Q6CNN1	Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.	KLLA0E11287p; Belongs to the eIF-1A family.	0.990