STRINGSTRING
KLLA0_C07755g KLLA0_C07755g YTM1 YTM1 RRP36 RRP36 KLLA0_C06633g KLLA0_C06633g PNO1 PNO1 KLLA0_C05984g KLLA0_C05984g KLLA0_C04389g KLLA0_C04389g KLLA0_C03520g KLLA0_C03520g KLLA0_C01914g KLLA0_C01914g KLLA0_C01408g KLLA0_C01408g SPB1 SPB1 KLLA0_C00506g KLLA0_C00506g KLLA0_B11792g KLLA0_B11792g KLLA0_B11077g KLLA0_B11077g KLLA0_B10890g KLLA0_B10890g KLLA0_B08239g KLLA0_B08239g KLLA0_B08173g KLLA0_B08173g KLLA0_B07931g KLLA0_B07931g RPS22 RPS22 KLLA0_B06182g KLLA0_B06182g RPS1 RPS1 KLLA0_B04180g KLLA0_B04180g RIX1 RIX1 KLLA0_B03652g KLLA0_B03652g KLLA0_B02827g KLLA0_B02827g KLLA0_B02266g KLLA0_B02266g KLLA0_B02068g KLLA0_B02068g KLLA0_B01562g KLLA0_B01562g KLLA0_B01518g KLLA0_B01518g KLLA0_B01474g KLLA0_B01474g KLLA0_A11660g KLLA0_A11660g KLLA0_A10483g KLLA0_A10483g KLLA0_A07194g KLLA0_A07194g KLLA0_A07150g KLLA0_A07150g KLLA0_A07018g KLLA0_A07018g KLLA0_A06710g KLLA0_A06710g KLLA0_A06017g KLLA0_A06017g DBP8 DBP8 KLLA0_A02079g KLLA0_A02079g KLLA0_A01045g KLLA0_A01045g RPS16 RPS16 RPS28 RPS28 DIM1 DIM1 KLLA0_F27665g KLLA0_F27665g ERB1 ERB1 KLLA0_F25542g KLLA0_F25542g NAT10 NAT10 KLLA0_B11231g KLLA0_B11231g RPS14 RPS14 UTP10 UTP10 KLLA0_F18304g KLLA0_F18304g KLLA0_F18040g KLLA0_F18040g KLLA0_F17435g KLLA0_F17435g KLLA0_F16280g KLLA0_F16280g KLLA0_F15598g KLLA0_F15598g IPI1 IPI1 KLLA0_F13772g KLLA0_F13772g KLLA0_F13508g KLLA0_F13508g KLLA0_F13244g KLLA0_F13244g KLLA0_F11000g KLLA0_F11000g KLLA0_F09812g KLLA0_F09812g NOP58 NOP58 KLLA0_F07843g KLLA0_F07843g RAT1 RAT1 KLLA0_F06622g KLLA0_F06622g KLLA0_F05962g KLLA0_F05962g KLLA0_F02013g KLLA0_F02013g KLLA0_F01364g KLLA0_F01364g KLLA0_F00352g KLLA0_F00352g RPS6 RPS6 KLLA0_E23673g KLLA0_E23673g SNU13 SNU13 KLLA0_E21121g KLLA0_E21121g KLLA0_E20461g KLLA0_E20461g REX4 REX4 KLLA0_E17425g KLLA0_E17425g KLLA0_E17007g KLLA0_E17007g RPS0 RPS0 KLLA0_E15995g KLLA0_E15995g KLLA0_E13729g KLLA0_E13729g KLLA0_E13641g KLLA0_E13641g KLLA0_E12739g KLLA0_E12739g KLLA0_E11661g KLLA0_E11661g KLLA0_E10495g KLLA0_E10495g KLLA0_E09219g KLLA0_E09219g UTP25 UTP25 KLLA0_E07833g KLLA0_E07833g KLLA0_E05941g KLLA0_E05941g KLLA0_E05149g KLLA0_E05149g RPS29 RPS29 KLLA0_E02091g KLLA0_E02091g KLLA0_E01453g KLLA0_E01453g GRC3 GRC3 KLLA0_D19701g KLLA0_D19701g KLLA0_D19008g KLLA0_D19008g KLLA0_D16390g KLLA0_D16390g STS1 STS1 NOP7 NOP7 KLLA0_D14993g KLLA0_D14993g KLLA0_D14806g KLLA0_D14806g KLLA0_D13618g KLLA0_D13618g KLLA0_D13222g KLLA0_D13222g KLLA0_D12254g KLLA0_D12254g KLLA0_D11792g KLLA0_D11792g KLLA0_D10659g KLLA0_D10659g KLLA0_D10351g KLLA0_D10351g KLLA0_D09757g KLLA0_D09757g KLLA0_D09625g KLLA0_D09625g IPI3 IPI3 KLLA0_D08305g KLLA0_D08305g KLLA0_D06677g KLLA0_D06677g KLLA0_D05115g KLLA0_D05115g KLLA0_D03168g KLLA0_D03168g KLLA0_D01309g KLLA0_D01309g TSR3 TSR3 ROK1 ROK1 KLLA0_C16401g KLLA0_C16401g NOP14 NOP14 KLLA0_C14718g KLLA0_C14718g RRP3 RRP3 KLLA0_C13519g KLLA0_C13519g KLLA0_C11979g KLLA0_C11979g KLLA0_C11297g KLLA0_C11297g KLLA0_C11099g KLLA0_C11099g KLLA0_C09262g KLLA0_C09262g KLLA0_C08976g KLLA0_C08976g KLLA0_C08371g KLLA0_C08371g
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLLA0_C07755g40S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (135 aa)
YTM1Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (444 aa)
RRP36rRNA biogenesis protein RRP36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity). (332 aa)
KLLA0_C06633gKLLA0C06633p. (631 aa)
PNO1Pre-rRNA-processing protein PNO1; Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity). (274 aa)
KLLA0_C05984gKLLA0C05984p. (364 aa)
KLLA0_C04389gKLLA0C04389p. (335 aa)
KLLA0_C03520gKLLA0C03520p. (379 aa)
KLLA0_C01914gKLLA0C01914p. (252 aa)
KLLA0_C01408gKLLA0C01408p. (326 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (833 aa)
KLLA0_C00506gKRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (330 aa)
KLLA0_B11792gKLLA0B11792p. (187 aa)
KLLA0_B11077gKLLA0B11077p. (567 aa)
KLLA0_B10890gKLLA0B10890p. (521 aa)
KLLA0_B08239gKLLA0B08239p. (1729 aa)
KLLA0_B08173gKLLA0B08173p. (106 aa)
KLLA0_B07931gKLLA0B07931p; Belongs to the universal ribosomal protein uS8 family. (130 aa)
RPS2240S ribosomal protein S22; Belongs to the universal ribosomal protein uS8 family. (130 aa)
KLLA0_B06182g40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. (108 aa)
RPS140S ribosomal protein S1; Belongs to the eukaryotic ribosomal protein eS1 family. (255 aa)
KLLA0_B04180gKLLA0B04180p. (539 aa)
RIX1Pre-rRNA-processing protein RIX1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1. (776 aa)
KLLA0_B03652g40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (261 aa)
KLLA0_B02827gKLLA0B02827p. (942 aa)
KLLA0_B02266g60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (181 aa)
KLLA0_B02068gKLLA0B02068p. (1167 aa)
KLLA0_B01562gKLLA0B01562p; Belongs to the universal ribosomal protein uS13 family. (146 aa)
KLLA0_B01518gKLLA0B01518p. (454 aa)
KLLA0_B01474gKLLA0B01474p. (136 aa)
KLLA0_A11660gKLLA0A11660p. (482 aa)
KLLA0_A10483gKLLA0A10483p; Belongs to the universal ribosomal protein uS17 family. (156 aa)
KLLA0_A07194gKLLA0A07194p. (144 aa)
KLLA0_A07150gKLLA0A07150p. (190 aa)
KLLA0_A07018gKLLA0A07018p. (189 aa)
KLLA0_A06710gKLLA0A06710p. (423 aa)
KLLA0_A06017gKLLA0A06017p. (456 aa)
DBP8ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (435 aa)
KLLA0_A02079gKLLA0A02079p. (243 aa)
KLLA0_A01045gKLLA0A01045p. (309 aa)
RPS1640S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (143 aa)
RPS2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (67 aa)
DIM1Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (320 aa)
KLLA0_F27665gKLLA0F27665p. (1044 aa)
ERB1Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (791 aa)
KLLA0_F25542gKLLA0F25542p. (117 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1055 aa)
KLLA0_B11231gKLLA0B11231p; Belongs to the universal ribosomal protein uS12 family. (145 aa)
RPS1440S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family. (137 aa)
UTP10U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). (1774 aa)
KLLA0_F18304gKLLA0F18304p. (236 aa)
KLLA0_F18040gKLLA0F18040p; Belongs to the universal ribosomal protein uS15 family. (151 aa)
KLLA0_F17435gKLLA0F17435p. (1271 aa)
KLLA0_F16280g20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (472 aa)
KLLA0_F15598gKLLA0F15598p. (478 aa)
IPI1Pre-rRNA-processing protein IPI1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (381 aa)
KLLA0_F13772gKLLA0F13772p. (520 aa)
KLLA0_F13508gU3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (249 aa)
KLLA0_F13244gKLLA0F13244p. (814 aa)
KLLA0_F11000gKLLA0F11000p. (555 aa)
KLLA0_F09812gKLLA0F09812p; Belongs to the universal ribosomal protein uS5 family. (259 aa)
NOP58Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (511 aa)
KLLA0_F07843gKLLA0F07843p; Belongs to the universal ribosomal protein uS19 family. (142 aa)
RAT15'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity); Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. (992 aa)
KLLA0_F06622gKLLA0F06622p. (478 aa)
KLLA0_F05962gKLLA0F05962p. (267 aa)
KLLA0_F02013gKLLA0F02013p. (566 aa)
KLLA0_F01364gKLLA0F01364p. (1073 aa)
KLLA0_F00352g40S ribosomal protein S12; Belongs to the eukaryotic ribosomal protein eS12 family. (134 aa)
RPS640S ribosomal protein S6. (236 aa)
KLLA0_E23673gKLLA0E23673p; Belongs to the universal ribosomal protein uS4 family. (188 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
KLLA0_E21121gSerine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (526 aa)
KLLA0_E20461g40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (201 aa)
REX4RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (294 aa)
KLLA0_E17425gKLLA0E17425p. (2493 aa)
KLLA0_E17007gKLLA0E17007p. (177 aa)
RPS040S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (254 aa)
KLLA0_E15995gKLLA0E15995p. (183 aa)
KLLA0_E13729gKLLA0E13729p. (483 aa)
KLLA0_E13641gKLLA0E13641p. (395 aa)
KLLA0_E12739gKLLA0E12739p. (437 aa)
KLLA0_E11661g40S ribosomal protein S27. (82 aa)
KLLA0_E10495gKLLA0E10495p. (138 aa)
KLLA0_E09219gKLLA0E09219p. (264 aa)
UTP25U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (704 aa)
KLLA0_E07833gKLLA0E07833p. (283 aa)
KLLA0_E05941gKLLA0E05941p. (92 aa)
KLLA0_E05149gKLLA0E05149p. (787 aa)
RPS2940S ribosomal protein S29; Belongs to the universal ribosomal protein uS14 family. (56 aa)
KLLA0_E02091gKLLA0E02091p. (240 aa)
KLLA0_E01453gKLLA0E01453p. (155 aa)
GRC3Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily. (631 aa)
KLLA0_D19701gKLLA0D19701p. (297 aa)
KLLA0_D19008gKLLA0D19008p. (422 aa)
KLLA0_D16390gKLLA0D16390p. (936 aa)
STS1Tethering factor for nuclear proteasome STS1; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity). (333 aa)
NOP7Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (605 aa)
KLLA0_D14993gKLLA0D14993p. (225 aa)
KLLA0_D14806gU3 small nucleolar RNA-associated protein 22. (1212 aa)
KLLA0_D13618gKLLA0D13618p. (530 aa)
KLLA0_D13222gKLLA0D13222p. (736 aa)
KLLA0_D12254gKLLA0D12254p. (513 aa)
KLLA0_D11792gKLLA0D11792p. (685 aa)
KLLA0_D10659gKLLA0D10659p; Belongs to the universal ribosomal protein uS7 family. (227 aa)
KLLA0_D10351gKLLA0D10351p. (859 aa)
KLLA0_D09757gU3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (608 aa)
KLLA0_D09625gKLLA0D09625p. (245 aa)
IPI3Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (508 aa)
KLLA0_D08305gKLLA0D08305p; Belongs to the universal ribosomal protein uS3 family. (237 aa)
KLLA0_D06677gKLLA0D06677p. (851 aa)
KLLA0_D05115g40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (119 aa)
KLLA0_D03168gKLLA0D03168p. (505 aa)
KLLA0_D01309gKLLA0D01309p. (744 aa)
TSR3Ribosome biogenesis protein TSR3; Ribosome biogenesis protein required for processing 35S pre- rRNA at site D; Belongs to the TSR3 family. (314 aa)
ROK1ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (579 aa)
KLLA0_C16401gKLLA0C16401p. (612 aa)
NOP14Probable nucleolar complex protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). (837 aa)
KLLA0_C14718gKLLA0C14718p. (285 aa)
RRP3ATP-dependent rRNA helicase RRP3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. (487 aa)
KLLA0_C13519g40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (190 aa)
KLLA0_C11979gKLLA0C11979p. (261 aa)
KLLA0_C11297gKLLA0C11297p; Belongs to the universal ribosomal protein uS13 family. (137 aa)
KLLA0_C11099gKLLA0C11099p. (305 aa)
KLLA0_C09262gKLLA0C09262p. (558 aa)
KLLA0_C08976gKLLA0C08976p. (911 aa)
KLLA0_C08371gKLLA0C08371p. (125 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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