4 items (Kluyveromyces lactis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ICL1	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family. (542 aa)
	FET3	Iron transport multicopper oxidase FET3; Iron transport multicopper ferroxidase required for Fe(2+) high affinity uptake. Required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport (By similarity). (631 aa)
	PAB1	Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (592 aa)
	AKR1	Palmitoyltransferase AKR1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. (752 aa)

Your Current Organism:

Kluyveromyces lactis

NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1	FET3	Q875M2	Q6CII3	Palmitoyltransferase AKR1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.	Iron transport multicopper oxidase FET3; Iron transport multicopper ferroxidase required for Fe(2+) high affinity uptake. Required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport (By similarity).	0.564
FET3	AKR1	Q6CII3	Q875M2	Iron transport multicopper oxidase FET3; Iron transport multicopper ferroxidase required for Fe(2+) high affinity uptake. Required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport (By similarity).	Palmitoyltransferase AKR1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.	0.564