STRINGSTRING
KLLA0_A11605g KLLA0_A11605g LSM4 LSM4 KLLA0_F26433g KLLA0_F26433g KLLA0_F24662g KLLA0_F24662g DBP2 DBP2 KLLA0_F22473g KLLA0_F22473g SLT11 SLT11 CLF1 CLF1 KLLA0_F17523g KLLA0_F17523g ISY1 ISY1 SLU7 SLU7 PRP46 PRP46 PRP5 PRP5 KLLA0_F09207g KLLA0_F09207g KLLA0_F08591g KLLA0_F08591g KLLA0_F08481g KLLA0_F08481g KLLA0_F06204g KLLA0_F06204g KLLA0_F04191g KLLA0_F04191g PRP45 PRP45 KLLA0_E22881g KLLA0_E22881g SNU13 SNU13 SUB2 SUB2 KLLA0_E21187g KLLA0_E21187g KLLA0_E20527g KLLA0_E20527g KLLA0_E18239g KLLA0_E18239g KLLA0_E16457g KLLA0_E16457g KLLA0_E14125g KLLA0_E14125g KLLA0_E10209g KLLA0_E10209g KLLA0_E09285g KLLA0_E09285g KLLA0_E04929g KLLA0_E04929g KLLA0_E04819g KLLA0_E04819g SYF2 SYF2 KLLA0_E02751g KLLA0_E02751g LSM6 LSM6 KLLA0_E01409g KLLA0_E01409g SSB1 SSB1 KLLA0_D17160g KLLA0_D17160g CWC15 CWC15 KLLA0_D14883g KLLA0_D14883g KLLA0_D09284g KLLA0_D09284g KLLA0_D07678g KLLA0_D07678g KLLA0_D04224g KLLA0_D04224g KLLA0_D03883g KLLA0_D03883g KLLA0_D03795g KLLA0_D03795g KLLA0_D03773g KLLA0_D03773g KLLA0_C18172g KLLA0_C18172g KLLA0_C17798g KLLA0_C17798g KLLA0_C15675g KLLA0_C15675g PRP28 PRP28 KLLA0_C14388g KLLA0_C14388g KLLA0_C08800g KLLA0_C08800g KLLA0_C08019g KLLA0_C08019g CEF1 CEF1 KLLA0_C05192g KLLA0_C05192g KLLA0_C03322g KLLA0_C03322g KLLA0_C02849g KLLA0_C02849g KLLA0_B11638g KLLA0_B11638g KLLA0_B10472g KLLA0_B10472g KLLA0_B08910g KLLA0_B08910g KLLA0_B05203g KLLA0_B05203g KLLA0_B02156g KLLA0_B02156g KLLA0_B00627g KLLA0_B00627g KLLA0_B00561g KLLA0_B00561g KLLA0_A11594g KLLA0_A11594g FAL1 FAL1 KLLA0_A09537g KLLA0_A09537g RSE1 RSE1 KLLA0_A07733g KLLA0_A07733g KLLA0_A06688g KLLA0_A06688g KLLA0_A05280g KLLA0_A05280g KLLA0_A04565g KLLA0_A04565g KLLA0_A02299g KLLA0_A02299g SYF1 SYF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLLA0_A11605gKLLA0A11605p. (87 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (183 aa)
KLLA0_F26433gKLLA0F26433p. (589 aa)
KLLA0_F24662gKLLA0F24662p. (530 aa)
DBP2ATP-dependent RNA helicase DBP2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing. (554 aa)
KLLA0_F22473gKLLA0F22473p. (253 aa)
SLT11Pre-mRNA-splicing factor SLT11; Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). (302 aa)
CLF1Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity). (684 aa)
KLLA0_F17523gKLLA0F17523p. (855 aa)
ISY1Pre-mRNA-splicing factor ISY1; Involved in pre-mRNA splicing. (237 aa)
SLU7Pre-mRNA-splicing factor SLU7; Involved in pre-mRNA splicing. (341 aa)
PRP46Pre-mRNA-splicing factor PRP46; Involved in pre-mRNA splicing and required for cell cycle progression at G2/M. (434 aa)
PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (812 aa)
KLLA0_F09207gU6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
KLLA0_F08591gKLLA0F08591p. (557 aa)
KLLA0_F08481gKLLA0F08481p. (483 aa)
KLLA0_F06204gKLLA0F06204p. (877 aa)
KLLA0_F04191gKLLA0F04191p. (885 aa)
PRP45Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing. (430 aa)
KLLA0_E22881gKLLA0E22881p. (110 aa)
SNU1313 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity). (126 aa)
SUB2ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (437 aa)
KLLA0_E21187gKLLA0E21187p. (429 aa)
KLLA0_E20527gKLLA0E20527p; Belongs to the heat shock protein 70 family. (650 aa)
KLLA0_E18239gKLLA0E18239p. (571 aa)
KLLA0_E16457gKLLA0E16457p. (96 aa)
KLLA0_E14125gKLLA0E14125p. (477 aa)
KLLA0_E10209gKLLA0E10209p. (84 aa)
KLLA0_E09285gKLLA0E09285p. (424 aa)
KLLA0_E04929gKLLA0E04929p. (112 aa)
KLLA0_E04819gKLLA0E04819p. (459 aa)
SYF2Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing. (221 aa)
KLLA0_E02751gKLLA0E02751p. (222 aa)
LSM6U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (80 aa)
KLLA0_E01409gKLLA0E01409p. (186 aa)
SSB1Ribosome-associated molecular chaperone SSB1; Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation- prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP- [...] (613 aa)
KLLA0_D17160gSmall nuclear ribonucleoprotein Sm D3. (100 aa)
CWC15Pre-mRNA-splicing factor CWC15; Involved in pre-mRNA splicing. (187 aa)
KLLA0_D14883gKLLA0D14883p. (467 aa)
KLLA0_D09284gSmall nuclear ribonucleoprotein Sm D2. (110 aa)
KLLA0_D07678gSmall nuclear ribonucleoprotein G. (73 aa)
KLLA0_D04224gKLLA0D04224p; Belongs to the heat shock protein 70 family. (640 aa)
KLLA0_D03883gKLLA0D03883p. (491 aa)
KLLA0_D03795gKLLA0D03795p. (234 aa)
KLLA0_D03773gKLLA0D03773p. (141 aa)
KLLA0_C18172gKLLA0C18172p. (152 aa)
KLLA0_C17798gKLLA0C17798p. (2149 aa)
KLLA0_C15675gKLLA0C15675p. (111 aa)
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (539 aa)
KLLA0_C14388gKLLA0C14388p. (203 aa)
KLLA0_C08800gKLLA0C08800p. (157 aa)
KLLA0_C08019gKLLA0C08019p. (301 aa)
CEF1Pre-mRNA-splicing factor CEF1; Involved in pre-mRNA splicing and cell cycle control. (543 aa)
KLLA0_C05192gKLLA0C05192p. (189 aa)
KLLA0_C03322gKLLA0C03322p. (385 aa)
KLLA0_C02849gKLLA0C02849p. (440 aa)
KLLA0_B11638gKLLA0B11638p. (1111 aa)
KLLA0_B10472gNuclear cap-binding protein subunit 2. (198 aa)
KLLA0_B08910gSpliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (143 aa)
KLLA0_B05203gKLLA0B05203p. (83 aa)
KLLA0_B02156gKLLA0B02156p. (242 aa)
KLLA0_B00627gKLLA0B00627p. (191 aa)
KLLA0_B00561gKLLA0B00561p. (767 aa)
KLLA0_A11594gKLLA0A11594p. (1530 aa)
FAL1ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (398 aa)
KLLA0_A09537gKLLA0A09537p. (954 aa)
RSE1Pre-mRNA-splicing factor RSE1; Involved in pre-mRNA splicing and cell cycle control. (1269 aa)
KLLA0_A07733gKLLA0A07733p. (1064 aa)
KLLA0_A06688gKLLA0A06688p. (933 aa)
KLLA0_A05280gKLLA0A05280p. (2411 aa)
KLLA0_A04565gKLLA0A04565p. (189 aa)
KLLA0_A02299gSmall nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (93 aa)
SYF1Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing and cell cycle progression. (798 aa)
Your Current Organism:
Kluyveromyces lactis
NCBI taxonomy Id: 284590
Other names: K. lactis NRRL Y-1140, Kluyveromyces lactis NRRL Y-1140
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