STRINGSTRING
VPS27 VPS27 YALI0_A20350g YALI0_A20350g YALI0_A18722g YALI0_A18722g YALI0_E02640g YALI0_E02640g YALI0_F32131g YALI0_F32131g BOS1 BOS1 YALI0_F31251g YALI0_F31251g SEC13 SEC13 YALI0_F28655g YALI0_F28655g ATG18 ATG18 VRG4 VRG4 YALI0_F21769g YALI0_F21769g YALI0_F21307g YALI0_F21307g YALI0_F19976g YALI0_F19976g YALI0_F19602g YALI0_F19602g YALI0_F19074g YALI0_F19074g YALI0_F13255g YALI0_F13255g ATG9 ATG9 YALI0_F06791g YALI0_F06791g HSE1 HSE1 ATG15 ATG15 SNX3 SNX3 SEC24 SEC24 YALI0_F03861g YALI0_F03861g YALI0_F03454g YALI0_F03454g YALI0_F02387g YALI0_F02387g YALI0_F02277g YALI0_F02277g END3 END3 YALI0_E33253g YALI0_E33253g YALI0_E33165g YALI0_E33165g YALI0_E32542g YALI0_E32542g SEC31 SEC31 YALI0_E29733g YALI0_E29733g YALI0_E29161g YALI0_E29161g YALI0_E24145g YALI0_E24145g YALI0_E22198g YALI0_E22198g YALI0_E21824g YALI0_E21824g AKR1 AKR1 YALI0_E19767g YALI0_E19767g YALI0_E18117g YALI0_E18117g YALI0_E18007g YALI0_E18007g SEC23 SEC23 YALI0_E15994g YALI0_E15994g YALI0_E15598g YALI0_E15598g YALI0_E14036g YALI0_E14036g YALI0_E13904g YALI0_E13904g YALI0_E13530g YALI0_E13530g YALI0_E11803g YALI0_E11803g YALI0_E08448g YALI0_E08448g YALI0_E00396g YALI0_E00396g YALI0_E00286g YALI0_E00286g YALI0_D27038g YALI0_D27038g YALI0_D23705g YALI0_D23705g SEC22 SEC22 YALI0_D20944g YALI0_D20944g PAN1 PAN1 YALI0_D13442g YALI0_D13442g YALI0_D11198g YALI0_D11198g YALI0_D10307g YALI0_D10307g YALI0_D09064g YALI0_D09064g SNX41 SNX41 PSD2 PSD2 YALI0_D01177g YALI0_D01177g YALI0_D00693g YALI0_D00693g SAR1 SAR1 YALI0_C21802g YALI0_C21802g YALI0_C18623g YALI0_C18623g SNF7 SNF7 ATG27 ATG27 YALI0_C12617g YALI0_C12617g YALI0_C12474g YALI0_C12474g MON1 MON1 VMA21 VMA21 YALI0_B21912g YALI0_B21912g YALI0_B21340g YALI0_B21340g YALI0_B18040g YALI0_B18040g YALI0_B16786g YALI0_B16786g YALI0_B16368g YALI0_B16368g YALI0_B15334g YALI0_B15334g HSV2 HSV2 SEC16 SEC16 YALI0_B11682g YALI0_B11682g YALI0_B04246g YALI0_B04246g YALI0_B02244g YALI0_B02244g YALI0_A17578g YALI0_A17578g YALI0_A17127g YALI0_A17127g YALI0_A10098g YALI0_A10098g SLA1 SLA1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VPS27Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (565 aa)
YALI0_A20350gYALI0A20350p. (334 aa)
YALI0_A18722gVacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (246 aa)
YALI0_E02640gYALI0E02640p. (370 aa)
YALI0_F32131gYALI0F32131p. (363 aa)
BOS1Protein transport protein BOS1; SNARE required for protein transport between the ER and the Golgi complex; Belongs to the BOS1 family. (226 aa)
YALI0_F31251gYALI0F31251p. (800 aa)
SEC13Protein transport protein SEC13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...] (298 aa)
YALI0_F28655gYALI0F28655p; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1726 aa)
ATG18Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct ATG9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (400 aa)
VRG4GDP-mannose transporter; Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. (326 aa)
YALI0_F21769gAP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (782 aa)
YALI0_F21307gYALI0F21307p. (211 aa)
YALI0_F19976gYALI0F19976p; Belongs to the adaptor complexes medium subunit family. (514 aa)
YALI0_F19602gYALI0F19602p. (205 aa)
YALI0_F19074gCoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (952 aa)
YALI0_F13255gCoatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (189 aa)
ATG9Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (788 aa)
YALI0_F06791gVacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family. (3212 aa)
HSE1Class E vacuolar protein-sorting machinery protein HSE1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (685 aa)
ATG15Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (549 aa)
SNX3Sorting nexin-3; Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity). (152 aa)
SEC24Protein transport protein SEC24; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (934 aa)
YALI0_F03861gYALI0F03861p. (682 aa)
YALI0_F03454gCoatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (923 aa)
YALI0_F02387gYALI0F02387p. (1906 aa)
YALI0_F02277gYALI0F02277p. (130 aa)
END3Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (400 aa)
YALI0_E33253gClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (217 aa)
YALI0_E33165gYALI0E33165p; Belongs to the syntaxin family. (370 aa)
YALI0_E32542gCoatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (519 aa)
SEC31Protein transport protein SEC31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1184 aa)
YALI0_E29733gAP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (189 aa)
YALI0_E29161gYALI0E29161p. (2031 aa)
YALI0_E24145gYALI0E24145p. (346 aa)
YALI0_E22198gYALI0E22198p. (1698 aa)
YALI0_E21824gYALI0E21824p. (524 aa)
AKR1Palmitoyltransferase AKR1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. (702 aa)
YALI0_E19767gCoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1244 aa)
YALI0_E18117gE3 ubiquitin-protein ligase. (854 aa)
YALI0_E18007gYALI0E18007p. (254 aa)
SEC23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (758 aa)
YALI0_E15994gYALI0E15994p. (175 aa)
YALI0_E15598gAP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (717 aa)
YALI0_E14036gYALI0E14036p. (906 aa)
YALI0_E13904gYALI0E13904p. (436 aa)
YALI0_E13530gYALI0E13530p. (303 aa)
YALI0_E11803gYALI0E11803p; Belongs to the small GTPase superfamily. Arf family. (182 aa)
YALI0_E08448gYALI0E08448p. (491 aa)
YALI0_E00396gYALI0E00396p. (213 aa)
YALI0_E00286gYALI0E00286p. (317 aa)
YALI0_D27038gYALI0D27038p. (933 aa)
YALI0_D23705gProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (750 aa)
SEC22Protein transport protein SEC22; Required for transport from the ER to the Golgi complex. Belongs to the synaptobrevin family. (213 aa)
YALI0_D20944gYALI0D20944p. (183 aa)
PAN1Actin cytoskeleton-regulatory complex protein PAN1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1634 aa)
YALI0_D13442gYALI0D13442p. (499 aa)
YALI0_D11198gYALI0D11198p. (735 aa)
YALI0_D10307gYALI0D10307p. (325 aa)
YALI0_D09064gYALI0D09064p. (429 aa)
SNX41Sorting nexin-41; May be required for cytoplasm to vacuole transport (Cvt) and pexophagy. (570 aa)
PSD2Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily. (1190 aa)
YALI0_D01177gYALI0D01177p. (485 aa)
YALI0_D00693gYALI0D00693p. (469 aa)
SAR1Small COPII coat GTPase SAR1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated trans [...] (190 aa)
YALI0_C21802gCoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (879 aa)
YALI0_C18623gAP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (929 aa)
SNF7Vacuolar-sorting protein SNF7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity). (215 aa)
ATG27Autophagy-related protein 27; Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre- autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity); Belongs to the ATG27 family. (276 aa)
YALI0_C12617gYALI0C12617p. (383 aa)
YALI0_C12474gYALI0C12474p; Belongs to the adaptor complexes medium subunit family. (460 aa)
MON1Vacuolar fusion protein MON1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family. (543 aa)
VMA21Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (72 aa)
YALI0_B21912gYALI0B21912p. (194 aa)
YALI0_B21340gAP-1 complex subunit gamma. (806 aa)
YALI0_B18040gYALI0B18040p. (230 aa)
YALI0_B16786gYALI0B16786p. (169 aa)
YALI0_B16368gYALI0B16368p; Belongs to the AAA ATPase family. (428 aa)
YALI0_B15334gVacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (253 aa)
HSV2SVP1-like protein 2; Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways. (359 aa)
SEC16COPII coat assembly protein SEC16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity); Belongs to the SEC16 family. (2183 aa)
YALI0_B11682gYALI0B11682p; Belongs to the adaptor complexes medium subunit family. (450 aa)
YALI0_B04246gAP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
YALI0_B02244gYALI0B02244p. (219 aa)
YALI0_A17578gYALI0A17578p. (1233 aa)
YALI0_A17127gClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1571 aa)
YALI0_A10098gYALI0A10098p. (318 aa)
SLA1Actin cytoskeleton-regulatory complex protein SLA1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1136 aa)
Your Current Organism:
Yarrowia lipolytica
NCBI taxonomy Id: 284591
Other names: Y. lipolytica CLIB122, Yarrowia lipolytica CLIB122
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