node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG1 | ATG5 | Q6C7U0 | Q6C4Q6 | Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] | Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...] | 0.992 |
ATG1 | PAY32 | Q6C7U0 | Q99144 | Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] | Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.414 |
ATG1 | PEX3 | Q6C7U0 | Q874C0 | Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | 0.477 |
ATG5 | ATG1 | Q6C4Q6 | Q6C7U0 | Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...] | Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] | 0.992 |
ATG5 | GPD | Q6C4Q6 | Q6CCU7 | Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...] | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.493 |
GPD | ATG5 | Q6CCU7 | Q6C4Q6 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...] | 0.493 |
GPD | PEX3 | Q6CCU7 | Q874C0 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | 0.406 |
GPD | SEC61 | Q6CCU7 | P78979 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | 0.410 |
PAT1 | PAY32 | Q6L8K7 | Q99144 | Acetyl-CoA acetyltransferase; Essential for n-decane utilization. | Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.874 |
PAT1 | PEX6 | Q6L8K7 | P36966 | Acetyl-CoA acetyltransferase; Essential for n-decane utilization. | Peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis; Belongs to the AAA ATPase family. | 0.762 |
PAY32 | ATG1 | Q99144 | Q6C7U0 | Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] | 0.414 |
PAY32 | PAT1 | Q99144 | Q6L8K7 | Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | Acetyl-CoA acetyltransferase; Essential for n-decane utilization. | 0.874 |
PAY32 | PEX3 | Q99144 | Q874C0 | Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | 0.895 |
PAY32 | PEX6 | Q99144 | P36966 | Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | Peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis; Belongs to the AAA ATPase family. | 0.983 |
PEX3 | ATG1 | Q874C0 | Q6C7U0 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] | 0.477 |
PEX3 | GPD | Q874C0 | Q6CCU7 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. | 0.406 |
PEX3 | PAY32 | Q874C0 | Q99144 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.895 |
PEX3 | PEX6 | Q874C0 | P36966 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | Peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis; Belongs to the AAA ATPase family. | 0.915 |
PEX3 | SEC13 | Q874C0 | Q6BZX5 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | Protein transport protein SEC13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...] | 0.428 |
PEX3 | SEC61 | Q874C0 | P78979 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. | Protein transport protein SEC61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity). | 0.720 |