18 items (Yarrowia lipolytica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACEB_YARLI	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family. (565 aa)
	URA3	Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (286 aa)
	PEX16	Peroxisomal membrane protein PEX16. (391 aa)
	ICL1	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family. (540 aa)
	PAY32	Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. (598 aa)
	YALI0_D19140g	Malate synthase; Belongs to the malate synthase family. (531 aa)
	PEX2	Peroxisomal biogenesis factor 2; Required for the import of several proteins into peroxisomes. Belongs to the pex2/pex10/pex12 family. (381 aa)
	YALI0_E27654g	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (701 aa)
	YALI0_C23859g	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (699 aa)
	POX1	Acyl-coenzyme A oxidase 1. (689 aa)
	POX2	Acyl-coenzyme A oxidase 2; Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group. (700 aa)
	POX3	Acyl-coenzyme A oxidase 3; Oxidizes aliphatic acyl-CoA substrates of different chain lengths such as hexanoyl-CoA, decanoyl-CoA and myristoyl-CoA as well as aromatic/heterocyclic ring-substituted chromogenic substrates, such as furylpropionyl-CoA. Of the above substrates, the efficiency of the enzyme, exhibits the following order: decanoyl-CoA > myristoyl-CoA > hexanoyl-CoA > furyl-propionyl-CoA. (700 aa)
	LEU2	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa)
	YALI0_D05071g	Endonuclease. (315 aa)
	PAT1	Acetyl-CoA acetyltransferase; Essential for n-decane utilization. (397 aa)
	PEX3	Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis. Seems to directly or indirectly sequesters components of the peroxisome biogenesis machinery; Belongs to the peroxin-3 family. (431 aa)
	YALI0_E15708g	Malate synthase; Belongs to the malate synthase family. (547 aa)
	YALI0_E06567g	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (689 aa)

Your Current Organism:

Yarrowia lipolytica

NCBI taxonomy Id: 284591
Other names: Y. lipolytica CLIB122, Yarrowia lipolytica CLIB122

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACEB_YARLI	ICL1	Q6BZP5	P41555	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	0.904
ACEB_YARLI	PAT1	Q6BZP5	Q6L8K7	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acetyl-CoA acetyltransferase; Essential for n-decane utilization.	0.631
ACEB_YARLI	PAY32	Q6BZP5	Q99144	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.	0.495
ACEB_YARLI	POX1	Q6BZP5	O74934	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase 1.	0.696
ACEB_YARLI	POX2	Q6BZP5	O74935	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase 2; Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.	0.726
ACEB_YARLI	POX3	Q6BZP5	O74936	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase 3; Oxidizes aliphatic acyl-CoA substrates of different chain lengths such as hexanoyl-CoA, decanoyl-CoA and myristoyl-CoA as well as aromatic/heterocyclic ring-substituted chromogenic substrates, such as furylpropionyl-CoA. Of the above substrates, the efficiency of the enzyme, exhibits the following order: decanoyl-CoA > myristoyl-CoA > hexanoyl-CoA > furyl-propionyl-CoA.	0.613
ACEB_YARLI	YALI0_C23859g	Q6BZP5	F2Z630	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.620
ACEB_YARLI	YALI0_D19140g	Q6BZP5	Q6C8J4	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Malate synthase; Belongs to the malate synthase family.	0.990
ACEB_YARLI	YALI0_E06567g	Q6BZP5	Q6C6T0	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.634
ACEB_YARLI	YALI0_E15708g	Q6BZP5	Q6C5R9	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Malate synthase; Belongs to the malate synthase family.	0.990
ACEB_YARLI	YALI0_E27654g	Q6BZP5	F2Z627	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.623
ICL1	ACEB_YARLI	P41555	Q6BZP5	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	2-methylisocitrate lyase, mitochondrial; Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	0.904
ICL1	PAT1	P41555	Q6L8K7	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acetyl-CoA acetyltransferase; Essential for n-decane utilization.	0.638
ICL1	PAY32	P41555	Q99144	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.	0.614
ICL1	POX1	P41555	O74934	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase 1.	0.800
ICL1	POX2	P41555	O74935	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase 2; Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.	0.693
ICL1	POX3	P41555	O74936	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase 3; Oxidizes aliphatic acyl-CoA substrates of different chain lengths such as hexanoyl-CoA, decanoyl-CoA and myristoyl-CoA as well as aromatic/heterocyclic ring-substituted chromogenic substrates, such as furylpropionyl-CoA. Of the above substrates, the efficiency of the enzyme, exhibits the following order: decanoyl-CoA > myristoyl-CoA > hexanoyl-CoA > furyl-propionyl-CoA.	0.470
ICL1	YALI0_C23859g	P41555	F2Z630	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.518
ICL1	YALI0_D19140g	P41555	Q6C8J4	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Malate synthase; Belongs to the malate synthase family.	0.994
ICL1	YALI0_E06567g	P41555	Q6C6T0	Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate; Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.518