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B5RTV4_DEBHA B5RTV4_DEBHA B5RTZ9_DEBHA B5RTZ9_DEBHA B5RU12_DEBHA B5RU12_DEBHA B5RU87_DEBHA B5RU87_DEBHA B5RUG9_DEBHA B5RUG9_DEBHA B5RUR2_DEBHA B5RUR2_DEBHA B5RV16_DEBHA B5RV16_DEBHA B5RV56_DEBHA B5RV56_DEBHA Q6BGR2_DEBHA Q6BGR2_DEBHA PSD2 PSD2 SNX41 SNX41 Q6BHR0_DEBHA Q6BHR0_DEBHA Q6BI18_DEBHA Q6BI18_DEBHA Q6BIF8_DEBHA Q6BIF8_DEBHA ATG18 ATG18 Q6BIN5_DEBHA Q6BIN5_DEBHA Q6BIP8_DEBHA Q6BIP8_DEBHA SEC13 SEC13 YPT35 YPT35 Q6BIS6_DEBHA Q6BIS6_DEBHA Q6BJ65_DEBHA Q6BJ65_DEBHA Q6BK19_DEBHA Q6BK19_DEBHA Q6BK53_DEBHA Q6BK53_DEBHA Q6BKP8_DEBHA Q6BKP8_DEBHA Q6BKT9_DEBHA Q6BKT9_DEBHA Q6BKZ5_DEBHA Q6BKZ5_DEBHA Q6BL33_DEBHA Q6BL33_DEBHA Q6BLC2_DEBHA Q6BLC2_DEBHA Q6BLD4_DEBHA Q6BLD4_DEBHA ATG15 ATG15 Q6BLW2_DEBHA Q6BLW2_DEBHA ATG27 ATG27 Q6BM84_DEBHA Q6BM84_DEBHA Q6BNJ6_DEBHA Q6BNJ6_DEBHA PAN1 PAN1 Q6BNL4_DEBHA Q6BNL4_DEBHA Q6BNM8_DEBHA Q6BNM8_DEBHA HSE1 HSE1 AKR1 AKR1 Q6BPK8_DEBHA Q6BPK8_DEBHA Q6BPY2_DEBHA Q6BPY2_DEBHA Q6BQ62_DEBHA Q6BQ62_DEBHA Q6BQI1_DEBHA Q6BQI1_DEBHA SEC23 SEC23 Q6BR73_DEBHA Q6BR73_DEBHA SEC31 SEC31 Q6BRT0_DEBHA Q6BRT0_DEBHA Q6BRY7_DEBHA Q6BRY7_DEBHA Q6BS46_DEBHA Q6BS46_DEBHA VPS27 VPS27 SNF7 SNF7 Q6BSM5_DEBHA Q6BSM5_DEBHA Q6BSN3_DEBHA Q6BSN3_DEBHA Q6BSQ4_DEBHA Q6BSQ4_DEBHA SSH4 SSH4 Q6BT41_DEBHA Q6BT41_DEBHA SEC24 SEC24 Q6BT90_DEBHA Q6BT90_DEBHA Q6BTZ5_DEBHA Q6BTZ5_DEBHA Q6BUK1_DEBHA Q6BUK1_DEBHA Q6BUQ9_DEBHA Q6BUQ9_DEBHA HSV2 HSV2 SAR1 SAR1 Q6BVB1_DEBHA Q6BVB1_DEBHA ATG9 ATG9 Q6BWH7_DEBHA Q6BWH7_DEBHA Q6BWM3_DEBHA Q6BWM3_DEBHA Q6BWP7_DEBHA Q6BWP7_DEBHA Q6BWS9_DEBHA Q6BWS9_DEBHA Q6BWY2_DEBHA Q6BWY2_DEBHA Q6BXA6_DEBHA Q6BXA6_DEBHA Q6BXG3_DEBHA Q6BXG3_DEBHA VMA21 VMA21 Q6BXQ4_DEBHA Q6BXQ4_DEBHA Q6BXZ5_DEBHA Q6BXZ5_DEBHA Q6BY14_DEBHA Q6BY14_DEBHA Q6BY45_DEBHA Q6BY45_DEBHA END3 END3 Q6BY82_DEBHA Q6BY82_DEBHA Q6BZ11_DEBHA Q6BZ11_DEBHA Q6BZ81_DEBHA Q6BZ81_DEBHA ATG20 ATG20 SNX4 SNX4 Q6BZF2_DEBHA Q6BZF2_DEBHA W0TYU3_DEBHA W0TYU3_DEBHA B5RT69_DEBHA B5RT69_DEBHA B5RT82_DEBHA B5RT82_DEBHA B5RTI8_DEBHA B5RTI8_DEBHA B5RTL4_DEBHA B5RTL4_DEBHA B5RTM1_DEBHA B5RTM1_DEBHA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B5RTV4_DEBHAClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1669 aa)
B5RTZ9_DEBHADEHA2E12518p. (765 aa)
B5RU12_DEBHADEHA2E13772p. (433 aa)
B5RU87_DEBHADEHA2F03894p. (155 aa)
B5RUG9_DEBHADEHA2F14652p. (696 aa)
B5RUR2_DEBHADEHA2G11726p. (496 aa)
B5RV16_DEBHAAP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1116 aa)
B5RV56_DEBHADEHA2G08910p. (2494 aa)
Q6BGR2_DEBHADEHA2G24552p. (196 aa)
PSD2Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily. (1157 aa)
SNX41Sorting nexin-41; May be required for cytoplasm to vacuole transport (Cvt) and pexophagy. (670 aa)
Q6BHR0_DEBHADEHA2G16566p. (150 aa)
Q6BI18_DEBHAAP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (175 aa)
Q6BIF8_DEBHADEHA2G10824p. (322 aa)
ATG18Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct ATG9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (562 aa)
Q6BIN5_DEBHADEHA2G08954p; Belongs to the syntaxin family. (376 aa)
Q6BIP8_DEBHADEHA2G08646p; Belongs to the adaptor complexes medium subunit family. (688 aa)
SEC13Protein transport protein SEC13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...] (297 aa)
YPT35PX domain-containing protein YPT35; Belongs to the YPT35 family. (157 aa)
Q6BIS6_DEBHADEHA2G07986p. (1185 aa)
Q6BJ65_DEBHADEHA2G04840p. (200 aa)
Q6BK19_DEBHAAP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (1048 aa)
Q6BK53_DEBHAAP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (698 aa)
Q6BKP8_DEBHACoatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (190 aa)
Q6BKT9_DEBHACoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (948 aa)
Q6BKZ5_DEBHAAP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (740 aa)
Q6BL33_DEBHAAP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (153 aa)
Q6BLC2_DEBHADEHA2F14674p; Belongs to the synaptobrevin family. (214 aa)
Q6BLD4_DEBHACoatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (551 aa)
ATG15Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (615 aa)
Q6BLW2_DEBHAAP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (145 aa)
ATG27Autophagy-related protein 27; Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre- autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity); Belongs to the ATG27 family. (282 aa)
Q6BM84_DEBHADEHA2F07568p. (207 aa)
Q6BNJ6_DEBHADEHA2E21164p. (350 aa)
PAN1Actin cytoskeleton-regulatory complex protein PAN1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1449 aa)
Q6BNL4_DEBHADEHA2E20790p. (987 aa)
Q6BNM8_DEBHADEHA2E20482p. (671 aa)
HSE1Class E vacuolar protein-sorting machinery protein HSE1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB). (512 aa)
AKR1Palmitoyltransferase AKR1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. (821 aa)
Q6BPK8_DEBHADEHA2E12782p. (230 aa)
Q6BPY2_DEBHADEHA2E09922p; Belongs to the AAA ATPase family. (429 aa)
Q6BQ62_DEBHADEHA2E08030p. (392 aa)
Q6BQI1_DEBHADEHA2E05038p. (177 aa)
SEC23Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (746 aa)
Q6BR73_DEBHADEHA2D18678p. (227 aa)
SEC31Protein transport protein SEC31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1265 aa)
Q6BRT0_DEBHADEHA2D14080p; Belongs to the adaptor complexes medium subunit family. (435 aa)
Q6BRY7_DEBHADEHA2D12870p. (315 aa)
Q6BS46_DEBHADEHA2D11660p. (220 aa)
VPS27Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane. (732 aa)
SNF7Vacuolar-sorting protein SNF7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity). (226 aa)
Q6BSM5_DEBHAVacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (241 aa)
Q6BSN3_DEBHADEHA2D07502p. (185 aa)
Q6BSQ4_DEBHADEHA2D06996p. (665 aa)
SSH4Protein SSH4; Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity); Belongs to the SSH4 family. (529 aa)
Q6BT41_DEBHAE3 ubiquitin-protein ligase. (781 aa)
SEC24Protein transport protein SEC24; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (924 aa)
Q6BT90_DEBHADEHA2D02574p. (334 aa)
Q6BTZ5_DEBHADEHA2C14740p. (462 aa)
Q6BUK1_DEBHADEHA2C09988p; Belongs to the adaptor complexes medium subunit family. (466 aa)
Q6BUQ9_DEBHADEHA2C08778p. (2042 aa)
HSV2SVP1-like protein 2; Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways. (432 aa)
SAR1Small COPII coat GTPase SAR1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated trans [...] (190 aa)
Q6BVB1_DEBHACoatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (922 aa)
ATG9Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (905 aa)
Q6BWH7_DEBHAAP-1 complex subunit gamma. (829 aa)
Q6BWM3_DEBHACoatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family. (312 aa)
Q6BWP7_DEBHAVacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (280 aa)
Q6BWS9_DEBHADEHA2B08844p. (713 aa)
Q6BWY2_DEBHADEHA2B07546p. (449 aa)
Q6BXA6_DEBHADEHA2B04620p. (1228 aa)
Q6BXG3_DEBHAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (222 aa)
VMA21Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family. (78 aa)
Q6BXQ4_DEBHADEHA2B01144p. (224 aa)
Q6BXZ5_DEBHADEHA2A13684p. (455 aa)
Q6BY14_DEBHADEHA2A13244p. (785 aa)
Q6BY45_DEBHADEHA2A12518p. (140 aa)
END3Actin cytoskeleton-regulatory complex protein END3; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (393 aa)
Q6BY82_DEBHADEHA2A11594p. (1032 aa)
Q6BZ11_DEBHAProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (808 aa)
Q6BZ81_DEBHACoatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (941 aa)
ATG20Autophagy-related protein 20; Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway (By similarity). (625 aa)
SNX4Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). (582 aa)
Q6BZF2_DEBHADEHA2A01804p. (505 aa)
W0TYU3_DEBHADEHA2F26532p. (357 aa)
B5RT69_DEBHADEHA2C03190p. (175 aa)
B5RT82_DEBHADEHA2C05940p. (461 aa)
B5RTI8_DEBHACoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1209 aa)
B5RTL4_DEBHADEHA2D18194p. (340 aa)
B5RTM1_DEBHADEHA2D18392p. (115 aa)
Your Current Organism:
Debaryomyces hansenii
NCBI taxonomy Id: 284592
Other names: D. hansenii CBS767, Debaryomyces hansenii CBS767
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