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ADE2 ADE2 URA3 URA3 Q6FIK4_CANGA Q6FIK4_CANGA HER2 HER2 Q6FIL1_CANGA Q6FIL1_CANGA Q6FIM3_CANGA Q6FIM3_CANGA Q6FIS2_CANGA Q6FIS2_CANGA Q6FJG0_CANGA Q6FJG0_CANGA Q6FJR4_CANGA Q6FJR4_CANGA Q6FK26_CANGA Q6FK26_CANGA Q6FK78_CANGA Q6FK78_CANGA ADK2 ADK2 RTC5 RTC5 URA6 URA6 DUT1 DUT1 Q6FKW6_CANGA Q6FKW6_CANGA Q6FLF4_CANGA Q6FLF4_CANGA Q6FLL0_CANGA Q6FLL0_CANGA AIM32 AIM32 CBR1 CBR1 Q6FLV2_CANGA Q6FLV2_CANGA ADK1 ADK1 Q6FM59_CANGA Q6FM59_CANGA Q6FM77_CANGA Q6FM77_CANGA Q6FMP8_CANGA Q6FMP8_CANGA CDC21 CDC21 PURA_CANGA PURA_CANGA Q6FMX3_CANGA Q6FMX3_CANGA FOL3 FOL3 Q6FND0_CANGA Q6FND0_CANGA Q6FNM6_CANGA Q6FNM6_CANGA MET12 MET12 Q6FNV3_CANGA Q6FNV3_CANGA Q6FNZ2_CANGA Q6FNZ2_CANGA Q6FP46_CANGA Q6FP46_CANGA URA5 URA5 AAH1 AAH1 Q6FPD8_CANGA Q6FPD8_CANGA Q6FPH0_CANGA Q6FPH0_CANGA MET7 MET7 Q6FPK3_CANGA Q6FPK3_CANGA FCY2 FCY2 Q6FPT8_CANGA Q6FPT8_CANGA SHM1 SHM1 Q6FQJ9_CANGA Q6FQJ9_CANGA Q6FQQ2_CANGA Q6FQQ2_CANGA Q6FQV0_CANGA Q6FQV0_CANGA Q6FR47_CANGA Q6FR47_CANGA Q6FRC2_CANGA Q6FRC2_CANGA FUR1 FUR1 Q6FRK3_CANGA Q6FRK3_CANGA Q6FRL0_CANGA Q6FRL0_CANGA Q6FS74_CANGA Q6FS74_CANGA Q6FSB3_CANGA Q6FSB3_CANGA Q6FSL0_CANGA Q6FSL0_CANGA Q6FSS3_CANGA Q6FSS3_CANGA GTF1 GTF1 Q6FSW0_CANGA Q6FSW0_CANGA APT1 APT1 Q6FT22_CANGA Q6FT22_CANGA Q6FT28_CANGA Q6FT28_CANGA Q6FT98_CANGA Q6FT98_CANGA MTD1 MTD1 Q6FTS7_CANGA Q6FTS7_CANGA Q6FTV6_CANGA Q6FTV6_CANGA MET13 MET13 Q6FU94_CANGA Q6FU94_CANGA URA7 URA7 GUA1 GUA1 Q6FUH4_CANGA Q6FUH4_CANGA Q6FUK4_CANGA Q6FUK4_CANGA Q6FUL2_CANGA Q6FUL2_CANGA HPT1 HPT1 SHM2 SHM2 HAM1 HAM1 MCR1 MCR1 Q6FVZ0_CANGA Q6FVZ0_CANGA Q6FW29_CANGA Q6FW29_CANGA FCY1 FCY1 Q6FWH8_CANGA Q6FWH8_CANGA ADO1 ADO1 Q6FXE7_CANGA Q6FXE7_CANGA Q6FXH8_CANGA Q6FXH8_CANGA PET112 PET112 Q6FXX5_CANGA Q6FXX5_CANGA Q6FY79_CANGA Q6FY79_CANGA URA9 URA9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ADE2Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (570 aa)
URA3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (265 aa)
Q6FIK4_CANGAAmidophosphoribosyltransferase. (513 aa)
HER2Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (467 aa)
Q6FIL1_CANGAUncharacterized protein. (138 aa)
Q6FIM3_CANGANucleoside diphosphate kinase. (152 aa)
Q6FIS2_CANGAGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (172 aa)
Q6FJG0_CANGAPRK domain-containing protein. (225 aa)
Q6FJR4_CANGAGlutamine amidotransferase type-1 domain-containing protein. (255 aa)
Q6FK26_CANGAUncharacterized protein. (944 aa)
Q6FK78_CANGAPribosyltran domain-containing protein. (208 aa)
ADK2GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (251 aa)
RTC5Restriction of telomere capping protein 5; May be involved in a process influencing telomere capping. Belongs to the RTC5 family. (555 aa)
URA6Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (260 aa)
DUT1Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (144 aa)
Q6FKW6_CANGAUncharacterized protein. (564 aa)
Q6FLF4_CANGACytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (121 aa)
Q6FLL0_CANGAMetallophos domain-containing protein. (585 aa)
AIM32Altered inheritance of mitochondria protein 32; Belongs to the AIM32 family. (313 aa)
CBR1NADH-cytochrome b5 reductase 1; Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity). (285 aa)
Q6FLV2_CANGAGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1032 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (222 aa)
Q6FM59_CANGAInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (527 aa)
Q6FM77_CANGASGNH_hydro domain-containing protein. (248 aa)
Q6FMP8_CANGAGuanylate kinase-like domain-containing protein. (185 aa)
CDC21Thymidylat_synt domain-containing protein. (256 aa)
PURA_CANGAAdenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (432 aa)
Q6FMX3_CANGAGlutamine amidotransferase type-1 domain-containing protein. (1346 aa)
FOL3Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. (446 aa)
Q6FND0_CANGAUncharacterized protein. (946 aa)
Q6FNM6_CANGAPribosyltran domain-containing protein. (196 aa)
MET12Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (645 aa)
Q6FNV3_CANGAPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (315 aa)
Q6FNZ2_CANGAFolic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family. In the central section; belongs to the HPPK family. (807 aa)
Q6FP46_CANGAUncharacterized protein. (989 aa)
URA5Pribosyltran domain-containing protein. (223 aa)
AAH1Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. (347 aa)
Q6FPD8_CANGAUncharacterized protein. (358 aa)
Q6FPH0_CANGADHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (217 aa)
MET7Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (494 aa)
Q6FPK3_CANGARibonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (894 aa)
FCY2Uncharacterized protein; Belongs to the purine-cytosine permease (2.A.39) family. (515 aa)
Q6FPT8_CANGACMP/dCMP-type deaminase domain-containing protein. (259 aa)
SHM1Serine hydroxymethyltransferase, mitochondrial; Interconversion of serine and glycine. (485 aa)
Q6FQJ9_CANGAUridine kinase; Belongs to the uridine kinase family. (476 aa)
Q6FQQ2_CANGASAICAR_synt domain-containing protein. (306 aa)
Q6FQV0_CANGAAdenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (212 aa)
Q6FR47_CANGAUncharacterized protein. (343 aa)
Q6FRC2_CANGAUncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (634 aa)
FUR1Uncharacterized protein. (216 aa)
Q6FRK3_CANGAATP-grasp domain-containing protein. (791 aa)
Q6FRL0_CANGAA to I editase domain-containing protein. (385 aa)
Q6FS74_CANGAUncharacterized protein. (867 aa)
Q6FSB3_CANGAThymidylate_kin domain-containing protein. (218 aa)
Q6FSL0_CANGAZn(2)-C6 fungal-type domain-containing protein. (1423 aa)
Q6FSS3_CANGACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (147 aa)
GTF1Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion; Belongs to the GatF family. (173 aa)
Q6FSW0_CANGAA_deaminase domain-containing protein; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (758 aa)
APT1Pribosyltran domain-containing protein. (190 aa)
Q6FT22_CANGAUncharacterized protein. (419 aa)
Q6FT28_CANGACMP/dCMP-type deaminase domain-containing protein. (307 aa)
Q6FT98_CANGAUncharacterized protein. (335 aa)
MTD1Uncharacterized protein. (323 aa)
Q6FTS7_CANGAUncharacterized protein. (229 aa)
Q6FTV6_CANGAGTP_cyclohydroI domain-containing protein. (245 aa)
MET13Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (600 aa)
Q6FU94_CANGAUncharacterized protein. (303 aa)
URA7CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (578 aa)
GUA1GMP synthase [glutamine-hydrolyzing]. (525 aa)
Q6FUH4_CANGAUncharacterized protein. (932 aa)
Q6FUK4_CANGAFormyl_trans_N domain-containing protein. (210 aa)
Q6FUL2_CANGAIU_nuc_hydro domain-containing protein. (337 aa)
HPT1Pribosyltran domain-containing protein. (215 aa)
SHM2Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine; Belongs to the SHMT family. (469 aa)
HAM1Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa)
MCR1NADH-cytochrome b5 reductase 2; May mediate the reduction of outer membrane cytochrome b5. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (298 aa)
Q6FVZ0_CANGAAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (391 aa)
Q6FW29_CANGAUncharacterized protein. (400 aa)
FCY1CMP/dCMP-type deaminase domain-containing protein. (155 aa)
Q6FWH8_CANGAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (483 aa)
ADO1PfkB domain-containing protein. (338 aa)
Q6FXE7_CANGANADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (312 aa)
Q6FXH8_CANGAAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa)
PET112Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (542 aa)
Q6FXX5_CANGACMP/dCMP-type deaminase domain-containing protein. (329 aa)
Q6FY79_CANGAMGS domain-containing protein. (590 aa)
URA9Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. (439 aa)
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
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