STRINGSTRING
OCT1 OCT1 Q6FW95_CANGA Q6FW95_CANGA MDM10 MDM10 Q6FWZ1_CANGA Q6FWZ1_CANGA Q6FYA4_CANGA Q6FYA4_CANGA TIM50 TIM50 MAS1 MAS1 MIC60 MIC60 MMM1 MMM1 MIA40 MIA40 Q6FW68_CANGA Q6FW68_CANGA Q6FRU6_CANGA Q6FRU6_CANGA B4UMZ0_CANGA B4UMZ0_CANGA B4UMZ9_CANGA B4UMZ9_CANGA B4UN53_CANGA B4UN53_CANGA Q6FJE9_CANGA Q6FJE9_CANGA PAM17 PAM17 TIM8 TIM8 Q6FKB3_CANGA Q6FKB3_CANGA Q6FKE2_CANGA Q6FKE2_CANGA Q6FLE4_CANGA Q6FLE4_CANGA Q6FMA7_CANGA Q6FMA7_CANGA MCX1 MCX1 HSP60 HSP60 Q6FMU6_CANGA Q6FMU6_CANGA TIM21 TIM21 Q6FMZ6_CANGA Q6FMZ6_CANGA Q6FNC3_CANGA Q6FNC3_CANGA Q6FNP1_CANGA Q6FNP1_CANGA YDJ1 YDJ1 TIM22 TIM22 PAM16 PAM16 Q6FTP2_CANGA Q6FTP2_CANGA Q6FU46_CANGA Q6FU46_CANGA Q6FU64_CANGA Q6FU64_CANGA Q6FUR7_CANGA Q6FUR7_CANGA TIM54 TIM54 mge1 mge1 Q6FPN3_CANGA Q6FPN3_CANGA Q6FPQ5_CANGA Q6FPQ5_CANGA PAM18 PAM18 Q6FPV3_CANGA Q6FPV3_CANGA Q6FQG0_CANGA Q6FQG0_CANGA Q6FQI7_CANGA Q6FQI7_CANGA MDM12 MDM12 Q6FQJ6_CANGA Q6FQJ6_CANGA Q6FQK3_CANGA Q6FQK3_CANGA Q6FR61_CANGA Q6FR61_CANGA Q6FRD6_CANGA Q6FRD6_CANGA TIM13 TIM13 Q6FRH4_CANGA Q6FRH4_CANGA HSP10 HSP10 Q6FRI9_CANGA Q6FRI9_CANGA TIM9 TIM9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OCT1Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity). (761 aa)
Q6FW95_CANGAUncharacterized protein. (181 aa)
MDM10Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...] (460 aa)
Q6FWZ1_CANGAUncharacterized protein. (111 aa)
Q6FYA4_CANGASuccinate dehydrogenase [ubiquinone] cytochrome b small subunit. (181 aa)
TIM50Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity). (485 aa)
MAS1Uncharacterized protein; Belongs to the peptidase M16 family. (465 aa)
MIC60MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity). (520 aa)
MMM1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (431 aa)
MIA40Mitochondrial intermembrane space import and assembly protein 40; Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond [...] (404 aa)
Q6FW68_CANGAJ domain-containing protein. (143 aa)
Q6FRU6_CANGAUncharacterized protein. (113 aa)
B4UMZ0_CANGAUncharacterized protein. (49 aa)
B4UMZ9_CANGAzf-Tim10_DDP domain-containing protein. (93 aa)
B4UN53_CANGAUncharacterized protein. (61 aa)
Q6FJE9_CANGABac_surface_Ag domain-containing protein. (466 aa)
PAM17Presequence translocated-associated motor subunit PAM17, mitochondrial; Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. (186 aa)
TIM8Mitochondrial import inner membrane translocase subunit TIM8; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates [...] (87 aa)
Q6FKB3_CANGAUncharacterized protein. (600 aa)
Q6FKE2_CANGAUncharacterized protein. (452 aa)
Q6FLE4_CANGAUncharacterized protein. (587 aa)
Q6FMA7_CANGAUncharacterized protein. (145 aa)
MCX1Uncharacterized protein. (549 aa)
HSP60Uncharacterized protein; Belongs to the chaperonin (HSP60) family. (568 aa)
Q6FMU6_CANGAAAA domain-containing protein. (745 aa)
TIM21Mitochondrial import inner membrane translocase subunit TIM21; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity). (215 aa)
Q6FMZ6_CANGAAAA domain-containing protein; Belongs to the AAA ATPase family. (359 aa)
Q6FNC3_CANGAUncharacterized protein. (184 aa)
Q6FNP1_CANGAUncharacterized protein. (60 aa)
YDJ1Uncharacterized protein. (407 aa)
TIM22Mitochondrial import inner membrane translocase subunit TIM22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). (193 aa)
PAM16Mitochondrial import inner membrane translocase subunit TIM16; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity); Belongs to the TIM16/PAM16 family. (146 aa)
Q6FTP2_CANGASulfhydryl oxidase. (174 aa)
Q6FU46_CANGAUncharacterized protein. (300 aa)
Q6FU64_CANGAPeptidase_S24 domain-containing protein. (171 aa)
Q6FUR7_CANGAUncharacterized protein. (125 aa)
TIM54Mitochondrial import inner membrane translocase subunit TIM54; Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as external driving force (By similarity). (452 aa)
mge1GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins (By similarity). (231 aa)
Q6FPN3_CANGAMitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family. (412 aa)
Q6FPQ5_CANGAJ domain-containing protein. (425 aa)
PAM18Mitochondrial import inner membrane translocase subunit TIM14; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity); Belongs to the TIM14 family. (153 aa)
Q6FPV3_CANGAUncharacterized protein; Belongs to the peptidase M16 family. (481 aa)
Q6FQG0_CANGAUncharacterized protein. (386 aa)
Q6FQI7_CANGAMitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (161 aa)
MDM12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...] (257 aa)
Q6FQJ6_CANGAUncharacterized protein. (382 aa)
Q6FQK3_CANGAMitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (212 aa)
Q6FR61_CANGAMitochondrial inner membrane protease subunit. (189 aa)
Q6FRD6_CANGAAAA domain-containing protein. (750 aa)
TIM13Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates [...] (95 aa)
Q6FRH4_CANGAzf-Tim10_DDP domain-containing protein. (101 aa)
HSP10Uncharacterized protein; Belongs to the GroES chaperonin family. (106 aa)
Q6FRI9_CANGAUncharacterized protein. (583 aa)
TIM9Mitochondrial import inner membrane translocase subunit TIM9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family. (87 aa)
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.