STRINGSTRING
CDC34 CDC34 HSC82 HSC82 Q6FP48_CANGA Q6FP48_CANGA GLC7 GLC7 YKU80 YKU80 B4UMZ4_CANGA B4UMZ4_CANGA CBF3D CBF3D Q6FVE3_CANGA Q6FVE3_CANGA SIN3 SIN3 Q6FVE9_CANGA Q6FVE9_CANGA Q6FVZ1_CANGA Q6FVZ1_CANGA Q6FW20_CANGA Q6FW20_CANGA Q6FW44_CANGA Q6FW44_CANGA Q6FW51_CANGA Q6FW51_CANGA Q6FWA4_CANGA Q6FWA4_CANGA Q6FWB7_CANGA Q6FWB7_CANGA BRE1 BRE1 HTA1 HTA1 Q6FWT1_CANGA Q6FWT1_CANGA SPT16 SPT16 Q6FX29_CANGA Q6FX29_CANGA RPD3 RPD3 Q6FXE6_CANGA Q6FXE6_CANGA HAT2 HAT2 Q6FXJ9_CANGA Q6FXJ9_CANGA Q6FXK6_CANGA Q6FXK6_CANGA YAF9 YAF9 Q6FPT2_CANGA Q6FPT2_CANGA Q6FPV8_CANGA Q6FPV8_CANGA Q6FQ29_CANGA Q6FQ29_CANGA Q6FQ82_CANGA Q6FQ82_CANGA MSH2 MSH2 Q6FLR1_CANGA Q6FLR1_CANGA Q6FLK4_CANGA Q6FLK4_CANGA Q6FLK1_CANGA Q6FLK1_CANGA RPB2 RPB2 ASF1 ASF1 Q6FL75_CANGA Q6FL75_CANGA Q6FQL0_CANGA Q6FQL0_CANGA YKU70 YKU70 UBC2 UBC2 Q6FR90_CANGA Q6FR90_CANGA Q6FRA2_CANGA Q6FRA2_CANGA Q6FY20_CANGA Q6FY20_CANGA Q6FY84_CANGA Q6FY84_CANGA Q6FNI8_CANGA Q6FNI8_CANGA POB3 POB3 Q6FKI6_CANGA Q6FKI6_CANGA Q6FKK1_CANGA Q6FKK1_CANGA HAT1 HAT1 HST2 HST2 Q6FN05_CANGA Q6FN05_CANGA SPT4 SPT4 Q6FKB2_CANGA Q6FKB2_CANGA Q6FPR6_CANGA Q6FPR6_CANGA SET1 SET1 Q6FJY5_CANGA Q6FJY5_CANGA Q6FJV7_CANGA Q6FJV7_CANGA Q6FJN1_CANGA Q6FJN1_CANGA MCM7 MCM7 Q6FJH8_CANGA Q6FJH8_CANGA Q6FJF5_CANGA Q6FJF5_CANGA MEC3 MEC3 ESA1 ESA1 HDA1 HDA1 SUB2 SUB2 Q6FUA8_CANGA Q6FUA8_CANGA Q6FU79_CANGA Q6FU79_CANGA Q6FU29_CANGA Q6FU29_CANGA Q6FTQ1_CANGA Q6FTQ1_CANGA Q6FTP4_CANGA Q6FTP4_CANGA Q6FTI6_CANGA Q6FTI6_CANGA RAP1 RAP1 F2Z6H6_CANGA F2Z6H6_CANGA DOT1 DOT1 YDJ1 YDJ1 CDC53 CDC53 Q6FNY8_CANGA Q6FNY8_CANGA Q6FMS5_CANGA Q6FMS5_CANGA ADA2 ADA2 Q6FMN7_CANGA Q6FMN7_CANGA Q6FM15_CANGA Q6FM15_CANGA MAF1 MAF1 EFM7 EFM7 Q6FUN9_CANGA Q6FUN9_CANGA Q6FUH6_CANGA Q6FUH6_CANGA INO80 INO80 Q6FKG8_CANGA Q6FKG8_CANGA RBX1 RBX1 Q6FRF3_CANGA Q6FRF3_CANGA Q6FRH6_CANGA Q6FRH6_CANGA Q6FRI7_CANGA Q6FRI7_CANGA RTT106 RTT106 Q6FRR2_CANGA Q6FRR2_CANGA Q6FRT0_CANGA Q6FRT0_CANGA Q6FS79_CANGA Q6FS79_CANGA Q6FS84_CANGA Q6FS84_CANGA Q6FSH3_CANGA Q6FSH3_CANGA Q6FSQ1_CANGA Q6FSQ1_CANGA Q6FSY5_CANGA Q6FSY5_CANGA Q6FTC1_CANGA Q6FTC1_CANGA Q6FTD5_CANGA Q6FTD5_CANGA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDC34UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (295 aa)
HSC82HATPase_c domain-containing protein. (705 aa)
Q6FP48_CANGAZds_C domain-containing protein. (828 aa)
GLC7Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (312 aa)
YKU80Ku domain-containing protein. (615 aa)
B4UMZ4_CANGAHistone H2A; Belongs to the histone H2A family. (133 aa)
CBF3DUncharacterized protein; Belongs to the SKP1 family. (179 aa)
Q6FVE3_CANGAHRDC domain-containing protein. (737 aa)
SIN3HDAC_interact domain-containing protein. (1493 aa)
Q6FVE9_CANGADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (717 aa)
Q6FVZ1_CANGAHelicase ATP-binding domain-containing protein. (964 aa)
Q6FW20_CANGAUncharacterized protein. (689 aa)
Q6FW44_CANGAORC_WH_C domain-containing protein. (628 aa)
Q6FW51_CANGASPRY domain-containing protein. (481 aa)
Q6FWA4_CANGAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (258 aa)
Q6FWB7_CANGAHist_deacetyl domain-containing protein. (445 aa)
BRE1E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (693 aa)
HTA1Histone H2A.1; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa)
Q6FWT1_CANGACondensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1157 aa)
SPT16FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1027 aa)
Q6FX29_CANGAUncharacterized protein. (785 aa)
RPD3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (433 aa)
Q6FXE6_CANGARFX-type winged-helix domain-containing protein. (588 aa)
HAT2Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates Lys-12 of histone H4 which is required for telomeric silencing. (419 aa)
Q6FXJ9_CANGAUncharacterized protein. (438 aa)
Q6FXK6_CANGACytokin_check_N domain-containing protein. (927 aa)
YAF9Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (221 aa)
Q6FPT2_CANGAUncharacterized protein. (479 aa)
Q6FPV8_CANGAUncharacterized protein. (293 aa)
Q6FQ29_CANGAUncharacterized protein. (1039 aa)
Q6FQ82_CANGAOrigin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (539 aa)
MSH2DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (957 aa)
Q6FLR1_CANGADNA helicase; Belongs to the MCM family. (945 aa)
Q6FLK4_CANGAUncharacterized protein. (229 aa)
Q6FLK1_CANGANicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (431 aa)
RPB2DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1223 aa)
ASF1Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (305 aa)
Q6FL75_CANGAN-acetyltransferase domain-containing protein. (531 aa)
Q6FQL0_CANGAUncharacterized protein. (1026 aa)
YKU70Ku domain-containing protein. (606 aa)
UBC2Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
Q6FR90_CANGANuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (724 aa)
Q6FRA2_CANGAUncharacterized protein. (514 aa)
Q6FY20_CANGAIsochorismatase domain-containing protein. (211 aa)
Q6FY84_CANGAHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (719 aa)
Q6FNI8_CANGAUSP domain-containing protein; Belongs to the peptidase C19 family. (771 aa)
POB3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (543 aa)
Q6FKI6_CANGAOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (1017 aa)
Q6FKK1_CANGAtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (427 aa)
HAT1Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (388 aa)
HST2NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (364 aa)
Q6FN05_CANGAHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (353 aa)
SPT4Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (102 aa)
Q6FKB2_CANGAUncharacterized protein. (437 aa)
Q6FPR6_CANGAPHD-type domain-containing protein. (671 aa)
SET1Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. (1111 aa)
Q6FJY5_CANGAPHD-type domain-containing protein. (360 aa)
Q6FJV7_CANGAUncharacterized protein. (1209 aa)
Q6FJN1_CANGAUncharacterized protein. (402 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa)
Q6FJH8_CANGAWD_REPEATS_REGION domain-containing protein. (316 aa)
Q6FJF5_CANGAUncharacterized protein. (362 aa)
MEC3Uncharacterized protein. (430 aa)
ESA1Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...] (446 aa)
HDA1Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (693 aa)
SUB2ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (439 aa)
Q6FUA8_CANGADNA helicase; Belongs to the MCM family. (772 aa)
Q6FU79_CANGADeacetylase sirtuin-type domain-containing protein. (364 aa)
Q6FU29_CANGAANK_REP_REGION domain-containing protein. (1092 aa)
Q6FTQ1_CANGAWD_REPEATS_REGION domain-containing protein. (440 aa)
Q6FTP4_CANGARanBD1 domain-containing protein. (722 aa)
Q6FTI6_CANGAUncharacterized protein. (1154 aa)
RAP1Uncharacterized protein. (687 aa)
F2Z6H6_CANGAPeptidase S59 domain-containing protein. (1283 aa)
DOT1Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (652 aa)
YDJ1Uncharacterized protein. (407 aa)
CDC53CULLIN_2 domain-containing protein; Belongs to the cullin family. (822 aa)
Q6FNY8_CANGAAAA_16 domain-containing protein. (472 aa)
Q6FMS5_CANGAUncharacterized protein. (710 aa)
ADA2Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (445 aa)
Q6FMN7_CANGAUncharacterized protein. (112 aa)
Q6FM15_CANGADUF1752 domain-containing protein. (1008 aa)
MAF1Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By similarity); Belongs to the MAF1 family. (391 aa)
EFM7Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family. (256 aa)
Q6FUN9_CANGAUncharacterized protein. (280 aa)
Q6FUH6_CANGAZds_C domain-containing protein. (817 aa)
INO80Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1484 aa)
Q6FKG8_CANGAUncharacterized protein. (336 aa)
RBX1RING-type domain-containing protein. (102 aa)
Q6FRF3_CANGAUncharacterized protein. (1258 aa)
Q6FRH6_CANGARXT2_N domain-containing protein. (421 aa)
Q6FRI7_CANGADeacetylase sirtuin-type domain-containing protein. (434 aa)
RTT106Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). (453 aa)
Q6FRR2_CANGAZf-primase domain-containing protein. (583 aa)
Q6FRT0_CANGAUncharacterized protein. (1126 aa)
Q6FS79_CANGACytokin_check_N domain-containing protein. (1785 aa)
Q6FS84_CANGARING-type domain-containing protein. (1544 aa)
Q6FSH3_CANGAUncharacterized protein. (740 aa)
Q6FSQ1_CANGAUncharacterized protein. (1354 aa)
Q6FSY5_CANGASUN domain-containing protein. (659 aa)
Q6FTC1_CANGAMSP domain-containing protein. (258 aa)
Q6FTD5_CANGAUncharacterized protein. (1452 aa)
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.