STRINGSTRING
TPO3 TPO3 MSN2 MSN2 PHM8 PHM8 GPX2 GPX2 PDR1 PDR1 CYC1 CYC1 URA3 URA3 LEU2 LEU2 ADE2 ADE2 MSN4 MSN4 AQR1 AQR1 MCM1 MCM1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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Your Input:
TPO3Multidrug transporter TPO3; Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Involved in the resistance to the imidazole antifungal drugs tioconazole, miconazole, clotrimazole and ketoconazole; to the triazole fluconazole; but not to the antifungals flucytosine or amphotericin B. Plays a role in spermine homeostasis, but spermine accumulation in response to clotrimazole is independent of TPO3. Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily. (630 aa)
MSN2Uncharacterized protein. (597 aa)
PHM8Uncharacterized protein. (314 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (164 aa)
PDR1Transcription factor PDR1; Master transcriptional regulator of a pleiotropic drug resistance network that contributes to the azole resistance of clinical isolates and petite mutants. Regulates the efflux of rhodamine 6G. Regulates both constitutive and drug-induced expression of the pleiotropic ABC efflux transporter CDR1. Commonly regulated genes include also those encoding ABC transporters PDH1, SNQ2, and YOR1, a phospholipid biosynthetic enzyme (PDR16), seven-transmembrane (TM) domain-containing proteins (RTA1 and RSB1), an oxidoreductase (YMR102c-like), a sphingolipid biosynthetic [...] (1107 aa)
CYC1Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
URA3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (265 aa)
LEU23-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (365 aa)
ADE2Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (570 aa)
MSN4Uncharacterized protein. (541 aa)
AQR1Multidrug transporter AQR1; Multidrug transporter acts as a determinant of resistance to acetic acid, flucytosine and clotrimazole, these 3 compounds acting synergistically against the pathogen. Reduces the intracellular accumulation of the antifungal agents flucytosine and, to a moderate extent, of clotrimazole. Its role in acetic acid resistance may be indirect, presumably through the transport of a still unidentified physiological substrate. (592 aa)
MCM1MADS-box domain-containing protein. (252 aa)
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
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