node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADE2 | LEU2 | O74197 | O14429 | Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.875 |
ADE2 | URA3 | O74197 | P33283 | Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | 0.928 |
CYC1 | URA3 | P25400 | P33283 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | 0.486 |
LEU2 | ADE2 | O14429 | O74197 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. | 0.875 |
LEU2 | URA3 | O14429 | P33283 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | 0.911 |
MCM1 | MSN2 | Q6FPY6 | Q6FU62 | MADS-box domain-containing protein. | Uncharacterized protein. | 0.933 |
MCM1 | MSN4 | Q6FPY6 | Q6FIM7 | MADS-box domain-containing protein. | Uncharacterized protein. | 0.925 |
MSN2 | MCM1 | Q6FU62 | Q6FPY6 | Uncharacterized protein. | MADS-box domain-containing protein. | 0.933 |
MSN2 | MSN4 | Q6FU62 | Q6FIM7 | Uncharacterized protein. | Uncharacterized protein. | 0.930 |
MSN2 | PHM8 | Q6FU62 | Q6FWW7 | Uncharacterized protein. | Uncharacterized protein. | 0.455 |
MSN4 | MCM1 | Q6FIM7 | Q6FPY6 | Uncharacterized protein. | MADS-box domain-containing protein. | 0.925 |
MSN4 | MSN2 | Q6FIM7 | Q6FU62 | Uncharacterized protein. | Uncharacterized protein. | 0.930 |
PDR1 | TPO3 | Q6FXU7 | Q6FQ03 | Transcription factor PDR1; Master transcriptional regulator of a pleiotropic drug resistance network that contributes to the azole resistance of clinical isolates and petite mutants. Regulates the efflux of rhodamine 6G. Regulates both constitutive and drug-induced expression of the pleiotropic ABC efflux transporter CDR1. Commonly regulated genes include also those encoding ABC transporters PDH1, SNQ2, and YOR1, a phospholipid biosynthetic enzyme (PDR16), seven-transmembrane (TM) domain-containing proteins (RTA1 and RSB1), an oxidoreductase (YMR102c-like), a sphingolipid biosynthetic [...] | Multidrug transporter TPO3; Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Involved in the resistance to the imidazole antifungal drugs tioconazole, miconazole, clotrimazole and ketoconazole; to the triazole fluconazole; but not to the antifungals flucytosine or amphotericin B. Plays a role in spermine homeostasis, but spermine accumulation in response to clotrimazole is independent of TPO3. Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily. | 0.449 |
PDR1 | URA3 | Q6FXU7 | P33283 | Transcription factor PDR1; Master transcriptional regulator of a pleiotropic drug resistance network that contributes to the azole resistance of clinical isolates and petite mutants. Regulates the efflux of rhodamine 6G. Regulates both constitutive and drug-induced expression of the pleiotropic ABC efflux transporter CDR1. Commonly regulated genes include also those encoding ABC transporters PDH1, SNQ2, and YOR1, a phospholipid biosynthetic enzyme (PDR16), seven-transmembrane (TM) domain-containing proteins (RTA1 and RSB1), an oxidoreductase (YMR102c-like), a sphingolipid biosynthetic [...] | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | 0.571 |
PHM8 | MSN2 | Q6FWW7 | Q6FU62 | Uncharacterized protein. | Uncharacterized protein. | 0.455 |
TPO3 | PDR1 | Q6FQ03 | Q6FXU7 | Multidrug transporter TPO3; Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm. Involved in the resistance to the imidazole antifungal drugs tioconazole, miconazole, clotrimazole and ketoconazole; to the triazole fluconazole; but not to the antifungals flucytosine or amphotericin B. Plays a role in spermine homeostasis, but spermine accumulation in response to clotrimazole is independent of TPO3. Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily. | Transcription factor PDR1; Master transcriptional regulator of a pleiotropic drug resistance network that contributes to the azole resistance of clinical isolates and petite mutants. Regulates the efflux of rhodamine 6G. Regulates both constitutive and drug-induced expression of the pleiotropic ABC efflux transporter CDR1. Commonly regulated genes include also those encoding ABC transporters PDH1, SNQ2, and YOR1, a phospholipid biosynthetic enzyme (PDR16), seven-transmembrane (TM) domain-containing proteins (RTA1 and RSB1), an oxidoreductase (YMR102c-like), a sphingolipid biosynthetic [...] | 0.449 |
URA3 | ADE2 | P33283 | O74197 | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. | 0.928 |
URA3 | CYC1 | P33283 | P25400 | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. | 0.486 |
URA3 | LEU2 | P33283 | O14429 | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.911 |
URA3 | PDR1 | P33283 | Q6FXU7 | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. | Transcription factor PDR1; Master transcriptional regulator of a pleiotropic drug resistance network that contributes to the azole resistance of clinical isolates and petite mutants. Regulates the efflux of rhodamine 6G. Regulates both constitutive and drug-induced expression of the pleiotropic ABC efflux transporter CDR1. Commonly regulated genes include also those encoding ABC transporters PDH1, SNQ2, and YOR1, a phospholipid biosynthetic enzyme (PDR16), seven-transmembrane (TM) domain-containing proteins (RTA1 and RSB1), an oxidoreductase (YMR102c-like), a sphingolipid biosynthetic [...] | 0.571 |