STRINGSTRING
AQR1 AQR1 CAP1 CAP1 CDR1 CDR1 HIS3 HIS3 ACT1 ACT1 QDR2 QDR2 URA3 URA3 CYC1 CYC1 YOR1 YOR1 PDR1 PDR1 MET3 MET3 GPD1-2 GPD1-2 FLR1 FLR1 GPD2 GPD2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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AQR1Multidrug transporter AQR1; Multidrug transporter acts as a determinant of resistance to acetic acid, flucytosine and clotrimazole, these 3 compounds acting synergistically against the pathogen. Reduces the intracellular accumulation of the antifungal agents flucytosine and, to a moderate extent, of clotrimazole. Its role in acetic acid resistance may be indirect, presumably through the transport of a still unidentified physiological substrate. (592 aa)
CAP1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (262 aa)
CDR1Pleiotropic ABC efflux transporter of multiple drugs CDR1; Pleiotropic ABC efflux transporter that transports and confers resistance to structurally and functionally unrelated compounds including rhodamine 6G, Nile red, caspofungin, cycloheximide, or azoles such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, and isavuconazole. Chlorbromuron, itraconazole, yohimbine, ketoconazole, miconazole, clotrimazole, DE-11, tamoxifen, quinidine, verapamil can compete for rhodamine 6G's binding site(s) while compounds such as propanil, chloramphenicol, benomyl, voriconazole [...] (1499 aa)
HIS3Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (210 aa)
ACT1Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
QDR2Multidrug transporter QDR2; Multidrug resistance transporter involved in resistance to the antifungal drugs miconazole, tioconazole, clotrimazole, and ketoconazole; as well as to quinidine. Decreases the intracellular accumulation of clotrimazole in and plays a role in the extrusion of this antifungal from preloaded cells. Belongs to the major facilitator superfamily. CAR1 family. (583 aa)
URA3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (265 aa)
CYC1Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
YOR1Uncharacterized protein. (1477 aa)
PDR1Transcription factor PDR1; Master transcriptional regulator of a pleiotropic drug resistance network that contributes to the azole resistance of clinical isolates and petite mutants. Regulates the efflux of rhodamine 6G. Regulates both constitutive and drug-induced expression of the pleiotropic ABC efflux transporter CDR1. Commonly regulated genes include also those encoding ABC transporters PDH1, SNQ2, and YOR1, a phospholipid biosynthetic enzyme (PDR16), seven-transmembrane (TM) domain-containing proteins (RTA1 and RSB1), an oxidoreductase (YMR102c-like), a sphingolipid biosynthetic [...] (1107 aa)
MET3Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. Belongs to the sulfate adenylyltransferase family. (507 aa)
GPD1-2Glyceraldehyde-3-phosphate dehydrogenase 1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
FLR1Multidrug transporter FLR1; Multidrug transporter that confers resistance to 5- flucytosine (5-FC) and clotrimazole. Confers also resistance to benomyl, but not 4-nitroquinoline-N-oxide, cycloheximide, or fluconazole. Plays direct roles in extrusion of 5- flucytosine and clotrimazole. Belongs to the major facilitator superfamily. (557 aa)
GPD2Glyceraldehyde-3-phosphate dehydrogenase 2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
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