STRINGSTRING
CDR1 CDR1 FKS3 FKS3 PDR1 PDR1 ERG9 ERG9 NMT1 NMT1 LEU2 LEU2 SNQ2 SNQ2 FCY2 FCY2 FKS2 FKS2 ERG11 ERG11 FCY1 FCY1 UGP1 UGP1 FKS1 FKS1 URA3 URA3 TRP1 TRP1 MSH2 MSH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDR1Pleiotropic ABC efflux transporter of multiple drugs CDR1; Pleiotropic ABC efflux transporter that transports and confers resistance to structurally and functionally unrelated compounds including rhodamine 6G, Nile red, caspofungin, cycloheximide, or azoles such as fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole, and isavuconazole. Chlorbromuron, itraconazole, yohimbine, ketoconazole, miconazole, clotrimazole, DE-11, tamoxifen, quinidine, verapamil can compete for rhodamine 6G's binding site(s) while compounds such as propanil, chloramphenicol, benomyl, voriconazole [...] (1499 aa)
FKS3FKS1_dom1 domain-containing protein. (1840 aa)
PDR1Transcription factor PDR1; Master transcriptional regulator of a pleiotropic drug resistance network that contributes to the azole resistance of clinical isolates and petite mutants. Regulates the efflux of rhodamine 6G. Regulates both constitutive and drug-induced expression of the pleiotropic ABC efflux transporter CDR1. Commonly regulated genes include also those encoding ABC transporters PDH1, SNQ2, and YOR1, a phospholipid biosynthetic enzyme (PDR16), seven-transmembrane (TM) domain-containing proteins (RTA1 and RSB1), an oxidoreductase (YMR102c-like), a sphingolipid biosynthetic [...] (1107 aa)
ERG9Squalene synthase; Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol; Belongs to the phytoene/squalene synthase family. (443 aa)
NMT1Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (451 aa)
LEU23-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (365 aa)
SNQ2ABC multidrug transporter SNQ2; ABC multidrug transporter involved in the response to azoles such as fluconazole, itraconazole, ketoconazole and voriconazole and contributes to the development of PDR1-dependent azole resistance. Plays a role in biofilm tolerance to fluconazole. Confers also resistance to 4- nitroquinoline-N-oxide (4-NQO). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1507 aa)
FCY2Uncharacterized protein; Belongs to the purine-cytosine permease (2.A.39) family. (515 aa)
FKS2FKS1_dom1 domain-containing protein. (1897 aa)
ERG11Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). (533 aa)
FCY1CMP/dCMP-type deaminase domain-containing protein. (155 aa)
UGP1UTP--glucose-1-phosphate uridylyltransferase. (502 aa)
FKS1FKS1_dom1 domain-containing protein. (1863 aa)
URA3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (265 aa)
TRP1N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (217 aa)
MSH2DNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (957 aa)
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
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