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ERG27 ERG27 ERG11 ERG11 URA3 URA3 ADE2 ADE2 PGK1 PGK1 Q6FKH6_CANGA Q6FKH6_CANGA ERG6 ERG6 CYS3 CYS3 DOA4 DOA4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERG273-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols. (348 aa)
ERG11Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). (533 aa)
URA3Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. (265 aa)
ADE2Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (570 aa)
PGK1Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (416 aa)
Q6FKH6_CANGA3-hydroxy-3-methylglutaryl coenzyme A reductase. (1056 aa)
ERG6Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (372 aa)
CYS3Uncharacterized protein. (391 aa)
DOA4Ubiquitin carboxyl-terminal hydrolase 4; Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Removes also ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Required for promoting coordination of DNA replication and avoids DNA overreplication (By similarity); Belongs to the peptidase C19 family. (887 aa)
Your Current Organism:
Candida glabrata
NCBI taxonomy Id: 284593
Other names: Candida glabrata ATCC 2001, Candida glabrata ATCC2001, Candida glabrata CBS 138, Candida glabrata CBS138, [. glabrata CBS 138, [Candida] glabrata CBS 138
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