STRINGSTRING
AGOS_AGR137W AGOS_AGR137W AGOS_AGR101C AGOS_AGR101C AGOS_AGL101C AGOS_AGL101C AGOS_AGL212W AGOS_AGL212W TEL1 TEL1 AGOS_AFR637W AGOS_AFR637W AGOS_AFR553C AGOS_AFR553C AGOS_AFR458C AGOS_AFR458C AGOS_AFR456C AGOS_AFR456C AGOS_AFR443C AGOS_AFR443C RAD5 RAD5 MUS81 MUS81 AGOS_AFR093W AGOS_AFR093W AGOS_AFL008W AGOS_AFL008W AGOS_AFL159W AGOS_AFL159W AGOS_AER387C AGOS_AER387C RAD52 RAD52 RAD59 RAD59 AGOS_AER008W AGOS_AER008W AGOS_AEL020W AGOS_AEL020W AGOS_AEL039W AGOS_AEL039W AGOS_AEL133C AGOS_AEL133C AGOS_AEL218W AGOS_AEL218W AGOS_AEL297W AGOS_AEL297W AGOS_ADR250C AGOS_ADR250C AGOS_ADR025W AGOS_ADR025W MPH1 MPH1 AGOS_ADL176W AGOS_ADL176W AGOS_ADL351W AGOS_ADL351W AGOS_ACR226W AGOS_ACR226W LIG4 LIG4 AGOS_ABR073C AGOS_ABR073C AGOS_ABL030W AGOS_ABL030W AGOS_ABL117C AGOS_ABL117C RAD18 RAD18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGOS_AGR137WAGR137Wp. (503 aa)
AGOS_AGR101CAGR101Cp; Belongs to the RecA family. (333 aa)
AGOS_AGL101CDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (631 aa)
AGOS_AGL212WAGL212Wp. (903 aa)
TEL1Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2768 aa)
AGOS_AFR637WAFR637Wp. (1296 aa)
AGOS_AFR553CDouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (674 aa)
AGOS_AFR458CAFR458Cp. (215 aa)
AGOS_AFR456CAFR456Cp. (1015 aa)
AGOS_AFR443CAFR443Cp. (576 aa)
RAD5DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1085 aa)
MUS81Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (604 aa)
AGOS_AFR093WAFR093Wp. (1131 aa)
AGOS_AFL008WReplication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (694 aa)
AGOS_AFL159WAFL159Wp. (1323 aa)
AGOS_AER387CAER387Cp. (655 aa)
RAD52DNA repair and recombination protein RAD52; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (435 aa)
RAD59DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA (By similarity). (204 aa)
AGOS_AER008WAER008Wp. (510 aa)
AGOS_AEL020WAEL020Wp. (551 aa)
AGOS_AEL039WDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (508 aa)
AGOS_AEL133CAEL133Cp. (116 aa)
AGOS_AEL218WAEL218Wp. (1471 aa)
AGOS_AEL297WAEL297Wp. (895 aa)
AGOS_ADR250CADR250Cp. (473 aa)
AGOS_ADR025WADR025Wp. (364 aa)
MPH1ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1077 aa)
AGOS_ADL176WADL176Wp. (275 aa)
AGOS_ADL351WADL351Wp. (199 aa)
AGOS_ACR226WDNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (381 aa)
LIG4DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (981 aa)
AGOS_ABR073CABR073Cp. (1026 aa)
AGOS_ABL030WABL030Wp. (602 aa)
AGOS_ABL117CABL117Cp. (602 aa)
RAD18Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (443 aa)
Your Current Organism:
Eremothecium gossypii
NCBI taxonomy Id: 284811
Other names: Ashbya gossypii ATCC 10895, E. gossypii ATCC 10895, Eremothecium gossypii ATCC 10895
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