STRINGSTRING
GEM1 GEM1 AGOS_ADR136C AGOS_ADR136C FMP52 FMP52 FIS1 FIS1 AGOS_ADL061W AGOS_ADL061W CBR1 CBR1 AGOS_ADL247C AGOS_ADL247C AGOS_ACR114C AGOS_ACR114C AGOS_ACR080C AGOS_ACR080C MCR1 MCR1 MDM12 MDM12 NCP1 NCP1 AGOS_AAL152W AGOS_AAL152W AGOS_AAL174C AGOS_AAL174C MMM1 MMM1 AGOS_ACL064C AGOS_ACL064C AGOS_ABR195C AGOS_ABR195C AGOS_ABR131W AGOS_ABR131W BNA4 BNA4 AGOS_AGL211C AGOS_AGL211C SEN2 SEN2 SEN54 SEN54 AGOS_AGR254C AGOS_AGR254C AGOS_AGR345C AGOS_AGR345C AGOS_AGR348W AGOS_AGR348W AGOS_AGR392C AGOS_AGR392C MIM1_ASHGO MIM1_ASHGO AGOS_ABR036W AGOS_ABR036W AGOS_AAR176C AGOS_AAR176C AGOS_AAR106C AGOS_AAR106C AGOS_AGL305W AGOS_AGL305W AGOS_AFR680W AGOS_AFR680W AGOS_AFR373W AGOS_AFR373W NCA2 NCA2 AGOS_AFR295W AGOS_AFR295W ATG32 ATG32 AGOS_AFL183C AGOS_AFL183C AGOS_AER448W AGOS_AER448W MDM34 MDM34 AGOS_AER403C AGOS_AER403C AGOS_AER365W AGOS_AER365W MDV1 MDV1 AGOS_AEL318W AGOS_AEL318W AGOS_AEL332W AGOS_AEL332W MDM10 MDM10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GEM1Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. (661 aa)
AGOS_ADR136CADR136Cp. (284 aa)
FMP52Protein FMP52, mitochondrial. (224 aa)
FIS1Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity). (155 aa)
AGOS_ADL061WActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
CBR1NADH-cytochrome b5 reductase 1; Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity). (287 aa)
AGOS_ADL247CADL247Cp. (391 aa)
AGOS_ACR114CACR114Cp. (234 aa)
AGOS_ACR080CACR080Cp. (58 aa)
MCR1NADH-cytochrome b5 reductase 2; May mediate the reduction of outer membrane cytochrome b5. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (306 aa)
MDM12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...] (264 aa)
NCP1NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (688 aa)
AGOS_AAL152WAAL152Wp. (787 aa)
AGOS_AAL174CAAL174Cp; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (756 aa)
MMM1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (444 aa)
AGOS_ACL064CVacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family. (3116 aa)
AGOS_ABR195CABR195Cp; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (808 aa)
AGOS_ABR131WABR131Wp. (594 aa)
BNA4Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (466 aa)
AGOS_AGL211CAGL211Cp. (612 aa)
SEN2tRNA-splicing endonuclease subunit SEN2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (356 aa)
SEN54tRNA-splicing endonuclease subunit SEN54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] (455 aa)
AGOS_AGR254CTafazzin family protein; Belongs to the taffazin family. (395 aa)
AGOS_AGR345CAGR345Cp. (150 aa)
AGOS_AGR348WAGR348Wp. (551 aa)
AGOS_AGR392CAGR392Cp. (495 aa)
MIM1_ASHGOMitochondrial import protein 1; Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins; Belongs to the MIM1 family. (155 aa)
AGOS_ABR036WABR036Wp; Belongs to the AAA ATPase family. (360 aa)
AGOS_AAR176CAAR176Cp. (153 aa)
AGOS_AAR106CAAR106Cp. (50 aa)
AGOS_AGL305WAGL305Wp. (1057 aa)
AGOS_AFR680WAFR680Wp. (461 aa)
AGOS_AFR373WAFR373Wp. (467 aa)
NCA2Nuclear control of ATPase protein 2; Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase. (569 aa)
AGOS_AFR295WGlycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (631 aa)
ATG32Autophagy-related protein 32; Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Promotes also autophagy- dependent peroxisome degradation (By similarity); Belongs to the ATG32 family. (452 aa)
AGOS_AFL183CAFL183Cp. (386 aa)
AGOS_AER448WAER448Wp. (714 aa)
MDM34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (590 aa)
AGOS_AER403CAER403Cp. (480 aa)
AGOS_AER365WAER365Wp. (60 aa)
MDV1Mitochondrial division protein 1; Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity); Belongs to the WD repeat MDV1/CAF4 family. (715 aa)
AGOS_AEL318WAEL318Wp. (181 aa)
AGOS_AEL332WAEL332Wp. (205 aa)
MDM10Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...] (465 aa)
Your Current Organism:
Eremothecium gossypii
NCBI taxonomy Id: 284811
Other names: Ashbya gossypii ATCC 10895, E. gossypii ATCC 10895, Eremothecium gossypii ATCC 10895
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