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| | TFB2 | General transcription and DNA repair factor IIH subunit TFB2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (514 aa) |
| | AGOS_ADL176W | ADL176Wp. (275 aa) |
| | AGOS_ADL168C | ADL168Cp; Belongs to the protein kinase superfamily. (362 aa) |
| | AGOS_ADL145C | ADL145Cp. (875 aa) |
| | AGOS_ADL097W | ADL097Wp. (574 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (310 aa) |
| | AGOS_ADL026W | DNA helicase; Belongs to the MCM family. (888 aa) |
| | MPH1 | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1077 aa) |
| | AGOS_ADR025W | ADR025Wp. (364 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (813 aa) |
| | EXO5 | Exonuclease V, mitochondrial; Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity). (527 aa) |
| | AGOS_ADR058C | ADR058Cp; Belongs to the protein kinase superfamily. (295 aa) |
| | RPB1 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1745 aa) |
| | AGOS_ADR111W | ADR111Wp. (321 aa) |
| | AGOS_ADR113W | ADR113Wp. (708 aa) |
| | PSF2 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (211 aa) |
| | MSH3 | DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1032 aa) |
| | AGOS_ADR186C | ADR186Cp. (174 aa) |
| | AGOS_ADR216W | ADR216Wp. (1115 aa) |
| | AGOS_ADR250C | ADR250Cp. (473 aa) |
| | SUB2 | ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (438 aa) |
| | AGOS_ADR293CA | ADR293C-Ap. (91 aa) |
| | SWR1 | Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1486 aa) |
| | AGOS_ADR338C | General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (469 aa) |
| | AGOS_ADR344W | ADR344Wp. (281 aa) |
| | AGOS_ADR352C | ADR352Cp. (254 aa) |
| | AGOS_ADR369C | ADR369Cp. (827 aa) |
| | AGOS_ADR380W | ADR380Wp. (322 aa) |
| | RAD17 | DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. (389 aa) |
| | DPB2 | DNA polymerase epsilon subunit B; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family. (677 aa) |
| | AGOS_AEL337C | AEL337Cp. (1097 aa) |
| | AGOS_AEL333W | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (630 aa) |
| | AGOS_AEL297W | AEL297Wp. (895 aa) |
| | AGOS_AEL292W | AEL292Wp. (629 aa) |
| | AGOS_AEL229W | AEL229Wp. (505 aa) |
| | AGOS_AEL218W | AEL218Wp. (1471 aa) |
| | AGOS_AEL196W | AEL196Wp. (333 aa) |
| | HSM3 | DNA mismatch repair protein HSM3; Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC) (By similarity); Belongs to the proteasome subunit S5B/HSM3 family. (475 aa) |
| | AGOS_AEL133C | AEL133Cp. (116 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (285 aa) |
| | AGOS_AEL065C | AEL065Cp. (1025 aa) |
| | AGOS_AEL053C | AEL053Cp. (211 aa) |
| | EAF5 | Chromatin modification-related protein EAF5; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (221 aa) |
| | AGOS_AEL039W | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (508 aa) |
| | ECO1 | N-acetyltransferase ECO1; Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity). (266 aa) |
| | HHT1 | Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (136 aa) |
| | AGOS_AEL007W | AEL007Wp. (597 aa) |
| | AGOS_AEL005C | AEL005Cp. (225 aa) |
| | HTA2 | Histone H2A.2; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa) |
| | AGOS_AER008W | AER008Wp. (510 aa) |
| | AGOS_AER034C | AER034Cp. (110 aa) |
| | AGOS_AER035W | AER035Wp. (1006 aa) |
| | AGOS_AER044W | AER044Wp. (1103 aa) |
| | RAD59 | DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA (By similarity). (204 aa) |
| | AGOS_AER068C | AER068Cp. (635 aa) |
| | BRE1 | E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (643 aa) |
| | AGOS_AER115W | AER115Wp. (2027 aa) |
| | AGOS_AER127C | AER127Cp. (391 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (802 aa) |
| | POB3 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (542 aa) |
| | AGOS_AER202C | Serine/threonine-protein phosphatase. (309 aa) |
| | AGOS_AER203C | AER203Cp. (458 aa) |
| | AGOS_AER216C | AER216Cp. (502 aa) |
| | RRM3 | ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (691 aa) |
| | EAF1 | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (957 aa) |
| | AGOS_AER324C | AER324Cp. (529 aa) |
| | RAD52 | DNA repair and recombination protein RAD52; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (435 aa) |
| | AGOS_AER318C | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (435 aa) |
| | DOT1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (575 aa) |
| | UNG1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (285 aa) |
| | SPT16 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1031 aa) |
| | AGOS_AER363W | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (304 aa) |
| | CSM2 | Chromosome segregation in meiosis protein 2; Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs) (By similarity); Belongs to the CSM2 family. (211 aa) |
| | AGOS_AER375C | AER375Cp. (1288 aa) |
| | AGOS_AER377C | AER377Cp. (1012 aa) |
| | AGOS_AER381C | DNA polymerase. (1435 aa) |
| | AGOS_AER387C | AER387Cp. (655 aa) |
| | AGOS_AER393C | AER393Cp; Belongs to the PI3/PI4-kinase family. (3697 aa) |
| | AGOS_AER402C | AER402Cp. (869 aa) |
| | AGOS_AER420C | AER420Cp. (239 aa) |
| | AGOS_AER421W | AER421Wp. (903 aa) |
| | AGOS_AER448W | AER448Wp. (714 aa) |
| | YAF9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (208 aa) |
| | AGOS_AFL215C | AFL215Cp. (579 aa) |
| | AGOS_AFL199C | AFL199Cp. (771 aa) |
| | AGOS_AFL198W | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (384 aa) |
| | AGOS_AFL189W | DNA polymerase. (1092 aa) |
| | AGOS_AFL177W | AFL177Wp. (373 aa) |
| | AGOS_AFL159W | AFL159Wp. (1323 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa) |
| | AGOS_AFL091W | AFL091Wp; Belongs to the protein kinase superfamily. (478 aa) |
| | RPB9 | DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription [...] (122 aa) |
| | DDC1 | DNA damage checkpoint protein 1; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. (543 aa) |
| | AGOS_AFL064W | AFL064Wp. (138 aa) |
| | AGOS_AFL059C | AFL059Cp. (1318 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1162 aa) |
| | AGOS_AFL019C | AFL019Cp. (671 aa) |
| | AGOS_AFL008W | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (694 aa) |
| | AGOS_AFR011W | AFR011Wp. (285 aa) |
| | AGOS_AFR016W | AFR016Wp. (558 aa) |
| | AGOS_AFR058C | AFR058Cp. (1593 aa) |
| | AGOS_AFR093W | AFR093Wp. (1131 aa) |
| | ARP4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (479 aa) |
| | AGOS_AFR133C | AFR133Cp. (970 aa) |
| | AGOS_AFR135W | Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (791 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (604 aa) |
| | AGOS_AFR149C | AFR149Cp. (220 aa) |
| | AGOS_AFR178W | DNA helicase; Belongs to the MCM family. (885 aa) |
| | RAD5 | DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1085 aa) |
| | AGOS_AFR226C | AFR226Cp. (704 aa) |
| | AGOS_AFR266W | AFR266Wp. (562 aa) |
| | AGOS_AFR280W | AFR280Wp. (830 aa) |
| | AGOS_AFR287W | AFR287Wp. (611 aa) |
| | RRD1 | Serine/threonine-protein phosphatase 2A activator 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A- phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity). (365 aa) |
| | SLD5 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). (266 aa) |
| | AGOS_AFR353W | AFR353Wp. (548 aa) |
| | AGOS_AFR355C | AFR355Cp; Belongs to the MCM family. (943 aa) |
| | AGOS_AFR358W | AFR358Wp. (413 aa) |
| | AGOS_AFR422W | AFR422Wp. (349 aa) |
| | AGOS_AFR443C | AFR443Cp. (576 aa) |
| | AGOS_AFR456C | AFR456Cp. (1015 aa) |
| | AGOS_AFR458C | AFR458Cp. (215 aa) |
| | AGOS_AFR496W | AFR496Wp. (1311 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (488 aa) |
| | EPL1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (742 aa) |
| | AGOS_AFR546W | DNA helicase; Belongs to the MCM family. (1005 aa) |
| | AGOS_AFR553C | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (674 aa) |
| | AGOS_AFR562C | AFR562Cp. (1445 aa) |
| | AGOS_AFR603C | AFR603Cp; Component of the post-replicative DNA mismatch repair system (MMR). (956 aa) |
| | AGOS_AFR637W | AFR637Wp. (1296 aa) |
| | POL2 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication. (2180 aa) |
| | TOF1 | Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1265 aa) |
| | LCD1 | DNA damage checkpoint protein LCD1; Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity). (694 aa) |
| | AGOS_AFR741W | AFR741Wp. (407 aa) |
| | TEL1 | Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2768 aa) |
| | AGOS_AGL273C | AGL273Cp. (399 aa) |
| | AGOS_AGL212W | AGL212Wp. (903 aa) |
| | AGOS_AGL101C | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (631 aa) |
| | AGOS_AGL173W | AGL173Wp. (1374 aa) |
| | AGOS_AGL150C | AGL150Cp. (327 aa) |
| | SCC2 | Sister chromatid cohesion protein 2; Plays a structural role in chromatin. Probably involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity); Belongs to the SCC2/Nipped-B family. (1479 aa) |
| | AGOS_AGL131W | AGL131Wp. (487 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (459 aa) |
| | AGOS_AGL118W | AGL118Wp. (414 aa) |
| | AGOS_AGL076W | AGL076Wp. (1268 aa) |
| | AGOS_AGL062C | AGL062Cp. (1110 aa) |
| | AGOS_AGL022W | AGL022Wp. (2145 aa) |
| | AGOS_AGL043C | AGL043Cp; Belongs to the AAA ATPase family. (405 aa) |
| | AGOS_AGL023W | Structural maintenance of chromosomes protein. (1222 aa) |
| | CHL1 | ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (801 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (391 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity). (498 aa) |
| | DPB4 | DNA polymerase epsilon subunit D; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. (204 aa) |
| | AGOS_AGR071C | AGR071Cp. (612 aa) |
| | AGOS_AGR083W | AGR083Wp. (295 aa) |
| | AGOS_AGR101C | AGR101Cp; Belongs to the RecA family. (333 aa) |
| | AGOS_AGR112C | AGR112Cp. (623 aa) |
| | AGOS_AGR114C | AGR114Cp. (774 aa) |
| | AGOS_AGR116W | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1167 aa) |
| | AGOS_AGR121C | AGR121Cp; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | AGOS_AGR133C | AGR133Cp. (653 aa) |
| | PPH3 | Serine/threonine-protein phosphatase 4 catalytic subunit; Involved in the dephosphorylation and activation of the transcription factor GLN3 in response to nutrient availability. Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double- stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity). Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. (310 aa) |
| | AGOS_AGR137W | AGR137Wp. (503 aa) |
| | SHU2 | Suppressor of hydroxyurea sensitivity protein 2; Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation (By similarity). Belongs to the SHU2 family. (201 aa) |
| | TFB5 | General transcription and DNA repair factor IIH subunit TFB5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (72 aa) |
| | AGOS_AGR162C | AGR162Cp. (763 aa) |
| | HTA1 | Histone H2A.1; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa) |
| | AGOS_AGR276W | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MEC3 | DNA damage checkpoint control protein MEC3; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. (386 aa) |
| | AGOS_AGR365C | AGR365Cp. (522 aa) |
| | INO80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1414 aa) |
| | PSF3 | DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication. (185 aa) |
| | SEM1 | Probable 26S proteasome complex subunit SEM1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis; Belongs to the DSS1/SEM1 family. (69 aa) |
| | AGOS_AFR591CA | AFR591C-Ap. (245 aa) |
| | HTB2 | Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa) |
| | AGOS_AAL182W | Structural maintenance of chromosomes protein; Belongs to the SMC family. (1231 aa) |
| | AGOS_AAL173C | Histone acetyltransferase. (420 aa) |
| | AGOS_AAL120C | AAL120Cp. (297 aa) |
| | AGOS_AAL113W | AAL113Wp; Belongs to the AAA ATPase family. (432 aa) |
| | AGOS_AAL112C | AAL112Cp. (304 aa) |
| | AGOS_AAL099C | DNA polymerase. (1464 aa) |
| | AGOS_AAL093C | AAL093Cp. (734 aa) |
| | AGOS_AAL080W | AAL080Wp. (1060 aa) |
| | AGOS_AAL042W | AAL042Wp. (609 aa) |
| | RAD18 | Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (443 aa) |
| | AGOS_AAR103C | AAR103Cp. (878 aa) |
| | AGOS_AAR111C | AAR111Cp. (542 aa) |
| | AGOS_AAR136W | AAR136Wp. (617 aa) |
| | AGOS_AAR147W | AAR147Wp. (1580 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | SOH1 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (127 aa) |
| | AGOS_AAR169C | AAR169Cp. (540 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (301 aa) |
| | PSF1 | DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication. (203 aa) |
| | AGOS_ABL183W | ABL183Wp. (547 aa) |
| | AGOS_ABL117C | ABL117Cp. (602 aa) |
| | AGOS_ABL096W | ABL096Wp. (446 aa) |
| | MGM101 | Mitochondrial genome maintenance protein MGM101; Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity); Belongs to the MGM101 family. (254 aa) |
| | AGOS_ABL054C | ABL054Cp. (359 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (378 aa) |
| | AGOS_ABL051W | ABL051Wp. (404 aa) |
| | SLD2 | DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family. (379 aa) |
| | AGOS_ABL030W | ABL030Wp. (602 aa) |
| | AGOS_ABR019C | ABR019Cp. (730 aa) |
| | AGOS_ABR056C | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (489 aa) |
| | AGOS_ABR073C | ABR073Cp. (1026 aa) |
| | DEF1 | RNA polymerase II degradation factor 1; RNA polymerase II degradation factor recruits the ubiquitination machinery to the RNA polymerase II for polyubiquitination, removal and degradation, when RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation (By similarity); Belongs to the DEF1 family. (705 aa) |
| | AGOS_ABR093C | ABR093Cp. (214 aa) |
| | CSM3 | Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (240 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2324 aa) |
| | AGOS_ABR137W | ABR137Wp. (955 aa) |
| | TFB3 | RNA polymerase II transcription factor B subunit 3; Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity). (318 aa) |
| | AGOS_ACL194C | ACL194Cp. (221 aa) |
| | AGOS_ACL158W | ACL158Wp. (95 aa) |
| | AGOS_ACL155W | DNA ligase. (697 aa) |
| | AGOS_ACL088C | ACL088Cp. (548 aa) |
| | AGOS_ACL060C | ACL060Cp. (504 aa) |
| | AGOS_ACL004W | ACL004Wp. (1377 aa) |
| | AGOS_ACR142W | Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (847 aa) |
| | AGOS_ACR013C | ACR013Cp. (488 aa) |
| | LIG4 | DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (981 aa) |
| | AGOS_ACR102W | Replication factor C subunit 1. (840 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. [...] (435 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (612 aa) |
| | EAF6 | Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (98 aa) |
| | AGOS_ACR226W | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (381 aa) |
| | NTG1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (367 aa) |
| | AGOS_ACR286C | ACR286Cp. (1019 aa) |
| | AGOS_ADL283W | ADL283Wp; Belongs to the protein kinase superfamily. (306 aa) |
| | AGOS_ADL351W | ADL351Wp. (199 aa) |
| | AGOS_ADL345C | ADL345Cp. (746 aa) |
| | TFB4 | General transcription and DNA repair factor IIH subunit TFB4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (341 aa) |
| | EME1 | Crossover junction endonuclease EME1; Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the EME1/MMS4 family. (714 aa) |
| | NHP6 | Non-histone chromosomal protein 6; DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity). (94 aa) |
| | AGOS_ADL309W | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) |
| | AGOS_ADL303C | ADL303Cp. (355 aa) |
| | AGOS_ADL289C | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (726 aa) |
| | AGOS_ADL276W | ADL276Wp. (235 aa) |
