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| | AGOS_AGL022W | AGL022Wp. (2145 aa) |
| | AGOS_AGL062C | AGL062Cp. (1110 aa) |
| | AGOS_AGL075C | AGL075Cp. (594 aa) |
| | AGOS_AGL076W | AGL076Wp. (1268 aa) |
| | AGOS_AGL088C | AGL088Cp. (229 aa) |
| | AGOS_AGL118W | AGL118Wp. (414 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (459 aa) |
| | AGOS_AGL132C | AGL132Cp. (416 aa) |
| | SCC2 | Sister chromatid cohesion protein 2; Plays a structural role in chromatin. Probably involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity); Belongs to the SCC2/Nipped-B family. (1479 aa) |
| | AGOS_AGL141W | AGL141Wp. (252 aa) |
| | AGOS_AGL155W | Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (198 aa) |
| | AGOS_AGL195C | AGL195Cp. (554 aa) |
| | AGOS_AGL203C | AGL203Cp; Belongs to the ubiquitin-conjugating enzyme family. (270 aa) |
| | AGOS_AGL078W | AGL078Wp. (1037 aa) |
| | AGOS_AGL212W | AGL212Wp. (903 aa) |
| | AGOS_AGL234W | AGL234Wp. (629 aa) |
| | AGOS_AGL235C | AGL235Cp. (185 aa) |
| | SGF11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (105 aa) |
| | AGOS_AGL282W | AGL282Wp. (214 aa) |
| | TEL1 | Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2768 aa) |
| | AGOS_AGL331C | AGL331Cp. (136 aa) |
| | LCD1 | DNA damage checkpoint protein LCD1; Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity). (694 aa) |
| | AGOS_AFR656C | AFR656Cp. (487 aa) |
| | AGOS_AFR641W | AFR641Wp; Belongs to the nucleosome assembly protein (NAP) family. (201 aa) |
| | AGOS_AFR603C | AFR603Cp; Component of the post-replicative DNA mismatch repair system (MMR). (956 aa) |
| | SPT4 | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). (102 aa) |
| | AGOS_AFR562C | AFR562Cp. (1445 aa) |
| | AGOS_AFR538C | AFR538Cp. (485 aa) |
| | AGOS_AFR537W | AFR537Wp. (1025 aa) |
| | AGOS_AFR527W | AFR527Wp. (137 aa) |
| | AGOS_AFR525C | AFR525Cp. (397 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (488 aa) |
| | AGOS_AFR466C | AFR466Cp. (219 aa) |
| | AGOS_AFR446W | AFR446Wp. (299 aa) |
| | AGOS_AFR394W | AFR394Wp; Belongs to the AAA ATPase family. (467 aa) |
| | AGOS_AFR388W | AFR388Wp. (329 aa) |
| | AGOS_AFR365C | AFR365Cp. (150 aa) |
| | AGOS_AFR355C | AFR355Cp; Belongs to the MCM family. (943 aa) |
| | AGOS_AFR287W | AFR287Wp. (611 aa) |
| | AGOS_AFR272W | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (249 aa) |
| | RPB2 | DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is [...] (1222 aa) |
| | AGOS_AFR397C | AFR397Cp. (149 aa) |
| | AGOS_AFR223W | AFR223Wp. (534 aa) |
| | AGOS_AFR221C | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (314 aa) |
| | RAD5 | DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1085 aa) |
| | AGOS_AFR172C | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (449 aa) |
| | AGOS_AFR166C | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (314 aa) |
| | AGOS_AFR153W | AFR153Wp. (576 aa) |
| | AGOS_AFR135W | Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (791 aa) |
| | AGOS_AFR112W | AFR112Wp. (251 aa) |
| | ARP4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (479 aa) |
| | FPR1 | FK506-binding protein 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP1 subfamily. (114 aa) |
| | SFH1 | Chromatin structure-remodeling complex subunit SFH1; Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome [...] (383 aa) |
| | AGOS_AFL006C | AFL006Cp. (433 aa) |
| | SWC5 | SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (286 aa) |
| | AGOS_AFL020W | AFL020Wp. (504 aa) |
| | AGOS_AFL040W | AFL040Wp. (1086 aa) |
| | AGOS_AFL059C | AFL059Cp. (1318 aa) |
| | AGOS_AFL097C | AFL097Cp. (526 aa) |
| | AGOS_AFL112W | AFL112Wp. (1194 aa) |
| | AGOS_AFL127C | AFL127Cp. (1521 aa) |
| | AGOS_AFL132C | AFL132Cp. (658 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa) |
| | AGOS_AFL171W | AFL171Wp. (432 aa) |
| | AGOS_AFL202C | AFL202Cp. (481 aa) |
| | AGOS_AFL215C | AFL215Cp. (579 aa) |
| | YAF9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (208 aa) |
| | AGOS_AER458C | AER458Cp; Belongs to the nucleosome assembly protein (NAP) family. (230 aa) |
| | CHZ1 | Histone H2A.Z-specific chaperone CHZ1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin. (140 aa) |
| | AGOS_AER410W | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1427 aa) |
| | AGOS_AER397C | AER397Cp. (1428 aa) |
| | AGOS_AER375C | AER375Cp. (1288 aa) |
| | SPT16 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1031 aa) |
| | AGOS_AER341W | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (442 aa) |
| | DOT1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (575 aa) |
| | AGOS_AER318C | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (435 aa) |
| | GCN5 | Histone acetyltransferase GCN5; Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). (452 aa) |
| | AGOS_AER280C | AER280Cp. (510 aa) |
| | EAF1 | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (957 aa) |
| | AGOS_AER237W | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (152 aa) |
| | AGOS_AER231W | AER231Wp. (451 aa) |
| | HEK2 | Heterogeneous nuclear rnp K-like protein 2; RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity). (316 aa) |
| | AGOS_AER172C | AER172Cp. (1268 aa) |
| | POB3 | FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (542 aa) |
| | BRE1 | E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (643 aa) |
| | AGOS_AER068C | AER068Cp. (635 aa) |
| | SWC7 | SWR1-complex protein 7; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. (127 aa) |
| | HHF1 | Histone H4.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). (103 aa) |
| | MAF1 | Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By similarity); Belongs to the MAF1 family. (397 aa) |
| | AGOS_ACR286C | ACR286Cp. (1019 aa) |
| | AGOS_ABL051W | ABL051Wp. (404 aa) |
| | AGOS_ABL042W | ABL042Wp. (477 aa) |
| | AGOS_ABL030W | ABL030Wp. (602 aa) |
| | AGOS_ABL015C | ABL015Cp. (204 aa) |
| | AGOS_ABL005C | ABL005Cp. (849 aa) |
| | AGOS_ABR034W | ABR034Wp. (613 aa) |
| | AGOS_ABR059W | ABR059Wp; Belongs to the ubiquitin-conjugating enzyme family. (165 aa) |
| | AGOS_ABR073C | ABR073Cp. (1026 aa) |
| | AGOS_ABR084W | ABR084Wp; Belongs to the actin family. (464 aa) |
| | AGOS_AGR276W | DNA helicase; Belongs to the MCM family. (734 aa) |
| | AGOS_AGR273C | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1158 aa) |
| | AGOS_AGR236W | Structural maintenance of chromosomes protein. (1170 aa) |
| | HTB1 | Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (132 aa) |
| | AGOS_AGR179W | AGR179Wp. (976 aa) |
| | AGOS_AGR172W | AGR172Wp. (1108 aa) |
| | HIR1 | Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (825 aa) |
| | AGOS_AGR161C | AGR161Cp. (337 aa) |
| | AGOS_AGR133C | AGR133Cp. (653 aa) |
| | AGOS_AGR131W | AGR131Wp. (134 aa) |
| | AGOS_AGR128C | AGR128Cp. (195 aa) |
| | AGOS_AGR123C | AGR123Cp. (1422 aa) |
| | AGOS_AGR117C | AGR117Cp. (799 aa) |
| | ARP6 | Actin-like protein ARP6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (410 aa) |
| | AGOS_AGR089C | Structural maintenance of chromosomes protein. (1370 aa) |
| | AGOS_AEL246C | AEL246Cp. (815 aa) |
| | AGOS_AEL250C | AEL250Cp. (417 aa) |
| | AGOS_AEL256C | AEL256Cp. (1866 aa) |
| | AGOS_AEL291C | AEL291Cp. (551 aa) |
| | AGOS_AEL297W | AEL297Wp. (895 aa) |
| | SWC3 | SWR1-complex protein 3; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity). (688 aa) |
| | AGOS_AEL245W | AEL245Wp. (712 aa) |
| | AGOS_AGR057C | AGR057Cp. (727 aa) |
| | DPB4 | DNA polymerase epsilon subunit D; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. (204 aa) |
| | HHOA | Histone H1; Could act as an H1-type linker histone; Belongs to the histone H1/H5 family. (225 aa) |
| | AGOS_ACR098C | ACR098Cp. (220 aa) |
| | AGOS_ACR099C | ACR099Cp. (247 aa) |
| | AGOS_ACR115W | ACR115Wp. (348 aa) |
| | AGOS_ACR116W | ACR116Wp. (453 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. [...] (435 aa) |
| | AGOS_ACR160C | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (430 aa) |
| | AGOS_ACR165W | ACR165Wp. (1139 aa) |
| | AGOS_ACR184C | ACR184Cp; Belongs to the actin family. (401 aa) |
| | EAF6 | Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (98 aa) |
| | AGOS_ACR236W | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (737 aa) |
| | HSP82 | Heat shock protein HSP82; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (704 aa) |
| | HTB2 | Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa) |
| | AGOS_ADL358W | ADL358Wp. (585 aa) |
| | ASA1 | ASTRA-associated protein 1; Component of the ASTRA complex involved in chromatin remodeling. (395 aa) |
| | AGOS_ADL396W | ADL396Wp; Belongs to the nucleosome assembly protein (NAP) family. (194 aa) |
| | AGOS_ADL313W | ADL313Wp. (366 aa) |
| | AGOS_ABR178C | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (561 aa) |
| | AGOS_ABR167C | ABR167Cp. (776 aa) |
| | AGOS_ABR139W | ABR139Wp. (1326 aa) |
| | SET1 | Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. (975 aa) |
| | AGOS_ABR135C | ABR135Cp. (414 aa) |
| | MEC1 | Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...] (2324 aa) |
| | AGOS_ABR097C | ABR097Cp. (469 aa) |
| | AGOS_AAL182W | Structural maintenance of chromosomes protein; Belongs to the SMC family. (1231 aa) |
| | AGOS_AAL181C | AAL181Cp. (1221 aa) |
| | AGOS_AAL177W | AAL177Wp. (1198 aa) |
| | AGOS_AAL173C | Histone acetyltransferase. (420 aa) |
| | AGOS_AAL169C | AAL169Cp. (643 aa) |
| | HDA2 | HDA1 complex subunit 2; Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). (665 aa) |
| | AGOS_AAL057C | AAL057Cp. (809 aa) |
| | AGOS_AAL030C | AAL030Cp. (1539 aa) |
| | SPT6 | Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family. (1432 aa) |
| | AGOS_AAR123C | AAR123Cp. (258 aa) |
| | AGOS_AAR147W | AAR147Wp. (1580 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | AGOS_AAR158W | AAR158Wp. (571 aa) |
| | AGOS_ABL180W | ABL180Wp. (681 aa) |
| | AGOS_ABL178W | ABL178Wp. (291 aa) |
| | RTT106 | Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity). (421 aa) |
| | AGOS_ABL145W | ABL145Wp; Belongs to the peptidase C19 family. (749 aa) |
| | AGOS_ABL095W | ABL095Wp. (1021 aa) |
| | AGOS_ABL092W | ABL092Wp. (598 aa) |
| | HIR3 | Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family. (1643 aa) |
| | AGOS_ABL058C | ABL058Cp. (1548 aa) |
| | AGOS_ABR022C | ABR022Cp. (999 aa) |
| | HDA3 | HDA1 complex subunit 3; Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). (637 aa) |
| | AGOS_ADR366W | ADR366Wp. (324 aa) |
| | ASF1 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (276 aa) |
| | SWR1 | Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1486 aa) |
| | AGOS_ADR292W | ADR292Wp. (989 aa) |
| | AGOS_ADR295C | ADR295Cp; Belongs to the SKP1 family. (179 aa) |
| | SUB2 | ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (438 aa) |
| | AGOS_ADR216W | ADR216Wp. (1115 aa) |
| | AGOS_ADR207C | ADR207Cp. (172 aa) |
| | AGOS_ADR114C | ADR114Cp. (694 aa) |
| | LGE1 | Transcriptional regulatory protein LGE1; Involved in transcriptional activation. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear (By similarity). (244 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (813 aa) |
| | AGOS_ADL028W | ADL028Wp. (599 aa) |
| | AGOS_ADR106W | ADR106Wp; Belongs to the cullin family. (798 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (310 aa) |
| | HTA2 | Histone H2A.2; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa) |
| | JHD1 | JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. (486 aa) |
| | AGOS_ABR213W | ABR213Wp. (112 aa) |
| | AGOS_ABR244C | ABR244Cp. (504 aa) |
| | AGOS_ACL167C | ACL167Cp. (438 aa) |
| | AGOS_ACL004W | ACL004Wp. (1377 aa) |
| | HTZ1 | Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...] (133 aa) |
| | AGOS_ACL008C | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (732 aa) |
| | AGOS_ADL097W | ADL097Wp. (574 aa) |
| | AGOS_ADL098C | ADL098Cp. (804 aa) |
| | AGOS_ADL181W | ADL181Wp. (109 aa) |
| | AGOS_ADL200C | ADL200Cp. (327 aa) |
| | HAT2 | Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. (423 aa) |
| | HIR2 | Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (850 aa) |
| | AGOS_ADL216C | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (702 aa) |
| | AGOS_ADL253C | ADL253Cp; Belongs to the actin family. (751 aa) |
| | AGOS_AEL005C | AEL005Cp. (225 aa) |
| | ECO1 | N-acetyltransferase ECO1; Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity). (266 aa) |
| | EAF5 | Chromatin modification-related protein EAF5; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (221 aa) |
| | AGOS_AEL065C | AEL065Cp. (1025 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (285 aa) |
| | AGOS_ADL257C | ADL257Cp. (410 aa) |
| | AGOS_ADL263W | Chromatin modification-related protein. (293 aa) |
| | AGOS_ADL289C | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (726 aa) |
| | AGOS_ADL309W | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa) |
| | AGOS_AEL109W | AEL109Wp; Belongs to the nucleosome assembly protein (NAP) family. (429 aa) |
| | AGOS_AEL135C | AEL135Cp. (687 aa) |
| | AGOS_AEL229W | AEL229Wp. (505 aa) |
| | AGOS_AGR401W | AGR401Wp. (568 aa) |
| | AGOS_AGR395W | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (433 aa) |
| | INO80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1414 aa) |
| | AGOS_AGR312W | AGR312Wp. (616 aa) |
| | AGOS_ADL339W | ADL339Wp. (436 aa) |
| | SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (99 aa) |
| | AGOS_ADL344W | ADL344Wp. (910 aa) |
| | AGOS_ADL345C | ADL345Cp. (746 aa) |
| | MEC3 | DNA damage checkpoint control protein MEC3; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. (386 aa) |
| | AGOS_AGR028C | AGR028Cp. (579 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (391 aa) |
| | AGOS_AGL018C | NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (340 aa) |
| | AGOS_AGL028C | AGL028Cp. (592 aa) |
| | AGOS_AGL043C | AGL043Cp; Belongs to the AAA ATPase family. (405 aa) |
