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| | AGOS_ACR098C | ACR098Cp. (220 aa) |
| | AGOS_ACR099C | ACR099Cp. (247 aa) |
| | AGOS_ACR115W | ACR115Wp. (348 aa) |
| | AGOS_ACR116W | ACR116Wp. (453 aa) |
| | AGOS_ACR184C | ACR184Cp; Belongs to the actin family. (401 aa) |
| | EAF6 | Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (98 aa) |
| | AGOS_ACR193C | ACR193Cp. (729 aa) |
| | AGOS_ACR236W | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (737 aa) |
| | AGOS_ADL313W | ADL313Wp. (366 aa) |
| | SET5 | Potential protein lysine methyltransferase SET5; Putative protein lysine methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily. (488 aa) |
| | ESA1 | Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, histone H2A to form H2AK4ac and H2AK7ac, and histone variant H2A.Z to form H2A.ZK14ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. [...] (435 aa) |
| | SEM1 | Probable 26S proteasome complex subunit SEM1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis; Belongs to the DSS1/SEM1 family. (69 aa) |
| | AGOS_AGR401W | AGR401Wp. (568 aa) |
| | AGOS_AGR398W | AGR398Wp. (1057 aa) |
| | AGOS_AGR395W | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (433 aa) |
| | NUT1 | Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (1098 aa) |
| | AGOS_AGR201C | Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (600 aa) |
| | AGOS_AGR123C | AGR123Cp. (1422 aa) |
| | AGOS_AGR207C | AGR207Cp. (320 aa) |
| | AGOS_AGR028C | AGR028Cp. (579 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (391 aa) |
| | AGOS_AGL018C | NAD-dependent protein deacetylase; Belongs to the sirtuin family. Class I subfamily. (340 aa) |
| | AGOS_AGL075C | AGL075Cp. (594 aa) |
| | AGOS_AGL118W | AGL118Wp. (414 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (459 aa) |
| | AGOS_AGL132C | AGL132Cp. (416 aa) |
| | ACS2 | Acetyl-coenzyme A synthetase 2. (687 aa) |
| | AGOS_AGL155W | Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (198 aa) |
| | AGOS_AGL177C | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (162 aa) |
| | AGOS_AGL195C | AGL195Cp. (554 aa) |
| | AGOS_AGL228C | AGL228Cp. (127 aa) |
| | SGF11 | SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (105 aa) |
| | TEL1 | Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity). (2768 aa) |
| | AGOS_AGL330W | AGL330Wp. (1011 aa) |
| | AGOS_AFR611C | AFR611Cp. (127 aa) |
| | AGOS_AFR551W | Ubiquitin carboxyl-terminal hydrolase. (469 aa) |
| | AGOS_AFR527W | AFR527Wp. (137 aa) |
| | EPL1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (742 aa) |
| | SWC4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (488 aa) |
| | AGOS_AFR492W | AFR492Wp. (691 aa) |
| | AGOS_AFR409W | AFR409Wp. (222 aa) |
| | AGOS_AFR388W | AFR388Wp. (329 aa) |
| | AGOS_AFR374C | AFR374Cp. (101 aa) |
| | AGOS_AFR221C | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (314 aa) |
| | AGOS_AFR172C | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (449 aa) |
| | AGOS_AFR153W | AFR153Wp. (576 aa) |
| | ARP4 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (479 aa) |
| | AGOS_AFR104W | RBR-type E3 ubiquitin transferase. (543 aa) |
| | AGOS_AFR077W | AFR077Wp. (792 aa) |
| | AGOS_AFR063W | AFR063Wp. (233 aa) |
| | AGOS_AFL006C | AFL006Cp. (433 aa) |
| | AGOS_AFL020W | AFL020Wp. (504 aa) |
| | AGOS_AFL097C | AFL097Cp. (526 aa) |
| | IPL1 | Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...] (367 aa) |
| | AGOS_AFL108C | AFL108Cp. (1453 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa) |
| | AGOS_AFL171W | AFL171Wp. (432 aa) |
| | AGOS_AFL215C | AFL215Cp. (579 aa) |
| | YAF9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (208 aa) |
| | AGOS_AER439W | AER439Wp. (414 aa) |
| | AGOS_AER393C | AER393Cp; Belongs to the PI3/PI4-kinase family. (3697 aa) |
| | AGOS_AER391C | AER391Cp. (632 aa) |
| | DOT1 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone. (575 aa) |
| | AGOS_AER318C | Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. (435 aa) |
| | BRE1 | E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family. (643 aa) |
| | GCN5 | Histone acetyltransferase GCN5; Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). (452 aa) |
| | AGOS_AER281C | AER281Cp. (463 aa) |
| | EAF1 | Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (957 aa) |
| | AGOS_AER231W | AER231Wp. (451 aa) |
| | NOP1 | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gl [...] (326 aa) |
| | AGOS_AER172C | AER172Cp. (1268 aa) |
| | AGOS_AER095W | AER095Wp. (355 aa) |
| | AGOS_AER077W | AER077Wp. (281 aa) |
| | SUS1 | Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of [...] (99 aa) |
| | AGOS_ADL322C | ADL322Cp. (501 aa) |
| | AGOS_ADL265W | ADL265Wp. (682 aa) |
| | AGOS_ADL263W | Chromatin modification-related protein. (293 aa) |
| | AGOS_ADL244W | ADL244Wp. (1096 aa) |
| | AGOS_ADL216C | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (702 aa) |
| | AGOS_ADL200C | ADL200Cp. (327 aa) |
| | EAF3 | Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (310 aa) |
| | AGOS_ADR207C | ADR207Cp. (172 aa) |
| | AGOS_ADR276W | ADR276Wp. (420 aa) |
| | ASF1 | Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. (276 aa) |
| | ACS1 | Acetyl-coenzyme A synthetase 1; Belongs to the ATP-dependent AMP-binding enzyme family. (694 aa) |
| | HDA3 | HDA1 complex subunit 3; Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). (637 aa) |
| | AGOS_AEL344W | AEL344Wp. (540 aa) |
| | AGOS_AEL250C | AEL250Cp. (417 aa) |
| | AGOS_AEL246C | AEL246Cp. (815 aa) |
| | AGOS_AEL229W | AEL229Wp. (505 aa) |
| | AGOS_AEL157W | AEL157Wp. (411 aa) |
| | SET2 | Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (684 aa) |
| | YNG2 | Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family. (285 aa) |
| | AGOS_AAL173C | Histone acetyltransferase. (420 aa) |
| | AGOS_AAL102C | AAL102Cp. (159 aa) |
| | AGOS_AAL097C | AAL097Cp. (368 aa) |
| | HDA2 | HDA1 complex subunit 2; Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N- terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). (665 aa) |
| | AGOS_AAL019W | AAL019Wp. (236 aa) |
| | AGOS_AAR003W | AAR003Wp. (580 aa) |
| | AGOS_AAR111C | AAR111Cp. (542 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | AGOS_ABL145W | ABL145Wp; Belongs to the peptidase C19 family. (749 aa) |
| | AGOS_ABL012C | E3 ubiquitin-protein ligase PEP5. (1021 aa) |
| | STE20 | Serine/threonine-protein kinase STE20; MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (970 aa) |
| | AGOS_ABR110W | Protein arginine N-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. (787 aa) |
| | SET1 | Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily. (975 aa) |
| | AGOS_ACL167C | ACL167Cp. (438 aa) |
| | AGOS_ACL164C | ACL164Cp; Belongs to the peptidase C19 family. (1389 aa) |
| | AGOS_ACL099W | ACL099Wp. (327 aa) |
| | AGOS_ACL004W | ACL004Wp. (1377 aa) |
| | HAT2 | Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. (423 aa) |
