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| | AGOS_ADR369C | ADR369Cp. (827 aa) |
| | AGOS_ADR357C | ADR357Cp. (1131 aa) |
| | SWR1 | Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1486 aa) |
| | AGOS_ADR302W | ADR302Wp. (691 aa) |
| | AGOS_ADR250C | ADR250Cp. (473 aa) |
| | MSH3 | DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (1032 aa) |
| | AGOS_ADR157W | ADR157Wp. (424 aa) |
| | AGOS_ADR144C | Endonuclease. (295 aa) |
| | AGOS_ADR113W | ADR113Wp. (708 aa) |
| | AGOS_ADR111W | ADR111Wp. (321 aa) |
| | EXO5 | Exonuclease V, mitochondrial; Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity). (527 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (813 aa) |
| | AGOS_ADR025W | ADR025Wp. (364 aa) |
| | MPH1 | ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (1077 aa) |
| | EST3 | Telomere replication protein EST3; Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity). (202 aa) |
| | AGOS_ADL026W | DNA helicase; Belongs to the MCM family. (888 aa) |
| | AGOS_ADL098C | ADL098Cp. (804 aa) |
| | AGOS_ADL299C | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (645 aa) |
| | AGOS_ADL303C | ADL303Cp. (355 aa) |
| | AGOS_ADL345C | ADL345Cp. (746 aa) |
| | AGOS_ADL351W | ADL351Wp. (199 aa) |
| | AGOS_ACR286C | ACR286Cp. (1019 aa) |
| | NTG1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (367 aa) |
| | AGOS_ACR256C | ACR256Cp; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (592 aa) |
| | AGOS_ACR238W | ACR238Wp. (356 aa) |
| | AGOS_ACR226W | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (381 aa) |
| | AGOS_ACR102W | Replication factor C subunit 1. (840 aa) |
| | LIG4 | DNA ligase 4; Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining; Belongs to the ATP-dependent DNA ligase family. (981 aa) |
| | AGOS_ACL008C | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (732 aa) |
| | AGOS_ACL088C | ACL088Cp. (548 aa) |
| | AGOS_ACL098C | ACL098Cp. (657 aa) |
| | AGOS_ACL155W | DNA ligase. (697 aa) |
| | AGOS_ABR139W | ABR139Wp. (1326 aa) |
| | AGOS_ABR137W | ABR137Wp. (955 aa) |
| | AGOS_ABR019C | ABR019Cp. (730 aa) |
| | AGOS_ABL030W | ABL030Wp. (602 aa) |
| | AGOS_ABR022C | ABR022Cp. (999 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (378 aa) |
| | UNG1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (285 aa) |
| | AGOS_ABL054C | ABL054Cp. (359 aa) |
| | AGOS_ABL117C | ABL117Cp. (602 aa) |
| | AGOS_ABL138W | ABL138Wp; Belongs to the universal ribosomal protein uS3 family. (244 aa) |
| | AGOS_ABL183W | ABL183Wp. (547 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (301 aa) |
| | AGOS_AAR169C | AAR169Cp. (540 aa) |
| | UBC2 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation; Belongs to the ubiquitin-conjugating enzyme family. (170 aa) |
| | AGOS_AAR147W | AAR147Wp. (1580 aa) |
| | AGOS_AAR136W | AAR136Wp. (617 aa) |
| | RAD18 | Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA. (443 aa) |
| | AGOS_AAL030C | AAL030Cp. (1539 aa) |
| | MHR1 | Mitochondrial homologous recombination protein 1; Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (By similarity); Belongs to the mitochondrion-specific ribosomal protein mL67 family. (213 aa) |
| | AGOS_AAL080W | AAL080Wp. (1060 aa) |
| | AGOS_AAL093C | AAL093Cp. (734 aa) |
| | AGOS_AAL099C | DNA polymerase. (1464 aa) |
| | AGOS_AAL112C | AAL112Cp. (304 aa) |
| | AGOS_AAL132C | AAL132Cp. (415 aa) |
| | AGOS_AAL182W | Structural maintenance of chromosomes protein; Belongs to the SMC family. (1231 aa) |
| | RAD52 | DNA repair and recombination protein RAD52; Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (435 aa) |
| | RRM3 | ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (691 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (802 aa) |
| | AGOS_AER127C | AER127Cp. (391 aa) |
| | AGOS_AER115W | AER115Wp. (2027 aa) |
| | AGOS_AER008W | AER008Wp. (510 aa) |
| | AGOS_AEL039W | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (508 aa) |
| | AGOS_AEL065C | AEL065Cp. (1025 aa) |
| | AGOS_AEL196W | AEL196Wp. (333 aa) |
| | AGOS_AEL218W | AEL218Wp. (1471 aa) |
| | AGOS_AEL256C | AEL256Cp. (1866 aa) |
| | AGOS_AER375C | AER375Cp. (1288 aa) |
| | AGOS_AER381C | DNA polymerase. (1435 aa) |
| | AGOS_AER387C | AER387Cp. (655 aa) |
| | AGOS_AER410W | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1427 aa) |
| | AGOS_AER414W | AER414Wp. (769 aa) |
| | AGOS_AER420C | AER420Cp. (239 aa) |
| | AGOS_AER421W | AER421Wp. (903 aa) |
| | AGOS_AFL199C | AFL199Cp. (771 aa) |
| | AGOS_AFL189W | DNA polymerase. (1092 aa) |
| | AGOS_AFL159W | AFL159Wp. (1323 aa) |
| | RVB2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (469 aa) |
| | AGOS_AFL040W | AFL040Wp. (1086 aa) |
| | AGOS_AFR011W | AFR011Wp. (285 aa) |
| | AGOS_AFR016W | AFR016Wp. (558 aa) |
| | AGOS_AFR093W | AFR093Wp. (1131 aa) |
| | AGOS_AFR133C | AFR133Cp. (970 aa) |
| | MUS81 | Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family. (604 aa) |
| | AGOS_AFR178W | DNA helicase; Belongs to the MCM family. (885 aa) |
| | RAD5 | DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). (1085 aa) |
| | AGOS_AFR226C | AFR226Cp. (704 aa) |
| | AGOS_AFR238W | AFR238Wp. (698 aa) |
| | AGOS_AFR280W | AFR280Wp. (830 aa) |
| | AGOS_AFR355C | AFR355Cp; Belongs to the MCM family. (943 aa) |
| | AGOS_AFR422W | AFR422Wp. (349 aa) |
| | AGOS_AFR443C | AFR443Cp. (576 aa) |
| | AGOS_AFR456C | AFR456Cp. (1015 aa) |
| | AGOS_AFR494W | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (853 aa) |
| | AGOS_AFR537W | AFR537Wp. (1025 aa) |
| | AGOS_AFR546W | DNA helicase; Belongs to the MCM family. (1005 aa) |
| | AGOS_AFR553C | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (674 aa) |
| | AGOS_AFR562C | AFR562Cp. (1445 aa) |
| | AGOS_AFR603C | AFR603Cp; Component of the post-replicative DNA mismatch repair system (MMR). (956 aa) |
| | AGOS_AFR637W | AFR637Wp. (1296 aa) |
| | POL2 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication. (2180 aa) |
| | AGOS_AGL212W | AGL212Wp. (903 aa) |
| | AGOS_AGL101C | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (631 aa) |
| | RVB1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (459 aa) |
| | CHL1 | ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (801 aa) |
| | DPB4 | DNA polymerase epsilon subunit D; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. (204 aa) |
| | AGOS_AGR101C | AGR101Cp; Belongs to the RecA family. (333 aa) |
| | AGOS_AGR112C | AGR112Cp. (623 aa) |
| | AGOS_AGR114C | AGR114Cp. (774 aa) |
| | AGOS_AGR116W | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1167 aa) |
| | AGOS_AGR123C | AGR123Cp. (1422 aa) |
| | AGOS_AGR137W | AGR137Wp. (503 aa) |
| | AGOS_AGR276W | DNA helicase; Belongs to the MCM family. (734 aa) |
| | DBP9 | ATP-dependent RNA helicase DBP9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (595 aa) |
| | INO80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1414 aa) |
| | AGOS_AEL297W | AEL297Wp. (895 aa) |
| | DPB2 | DNA polymerase epsilon subunit B; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family. (677 aa) |
