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| | LEU2 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (372 aa) |
| | GLY1 | Low-specificity L-threonine aldolase. (382 aa) |
| | ICL1 | Isocitrate lyase; Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2- methylisocitrate. (560 aa) |
| | THR4 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (512 aa) |
| | AGOS_AGR396W | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (172 aa) |
| | AGOS_AGR371C | AGR371Cp. (318 aa) |
| | AGOS_AGR357W | AGR357Wp; Belongs to the asparaginase 1 family. (388 aa) |
| | AGOS_AGR351W | Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (729 aa) |
| | AGOS_AGR301C | AGR301Cp. (687 aa) |
| | AGOS_AGR298C | AGR298Cp; Belongs to the precorrin methyltransferase family. (586 aa) |
| | AGOS_AGR288W | AGR288Wp. (391 aa) |
| | AGOS_AGR272W | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (385 aa) |
| | AGOS_AGR271C | AGR271Cp; Belongs to the membrane-bound acyltransferase family. (607 aa) |
| | AGOS_AGR255W | AGR255Wp. (284 aa) |
| | MET3 | Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. Belongs to the sulfate adenylyltransferase family. (500 aa) |
| | AGOS_AGR241W | AGR241Wp. (235 aa) |
| | AGOS_AGR219W | Prephenate dehydrogenase [NADP(+)]; Belongs to the prephenate/arogenate dehydrogenase family. (442 aa) |
| | AGOS_AGR200W | AGR200Wp. (379 aa) |
| | ADK1 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (277 aa) |
| | LEU1 | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (776 aa) |
| | AGOS_AGR167W | AGR167Wp. (512 aa) |
| | AGOS_AGR132W | AGR132Wp. (857 aa) |
| | ADK2 | GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (251 aa) |
| | AGOS_AGR103W | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (408 aa) |
| | CAR1 | Arginase; Belongs to the arginase family. (399 aa) |
| | AGOS_AGR227W | AGR227Wp. (385 aa) |
| | ERG27 | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols. (348 aa) |
| | ARO1 | 3-phosphoshikimate 1-carboxyvinyltransferase; The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. In the 3rd section; belongs to the shikimate kinase family. In the C-terminal section; belongs to the shikimate dehydrogenase family. (1577 aa) |
| | AGOS_AGR030C | AGR030Cp. (324 aa) |
| | AGOS_AGR021C | AGR021Cp. (387 aa) |
| | HEM2 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). (340 aa) |
| | AGOS_AGR012C | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (492 aa) |
| | AGOS_AGR002W | Citrate synthase; Belongs to the citrate synthase family. (482 aa) |
| | AGOS_AGL057W | Isocitrate lyase. (557 aa) |
| | AGOS_AGL073W | Amine oxidase. (677 aa) |
| | AGOS_AGL087C | AGL087Cp. (462 aa) |
| | SDH4 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (171 aa) |
| | ACS2 | Acetyl-coenzyme A synthetase 2. (687 aa) |
| | AGOS_AGL165W | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (463 aa) |
| | AGOS_AGL175W | AGL175Wp. (404 aa) |
| | TPI1 | Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (248 aa) |
| | AGOS_AGL210C | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (367 aa) |
| | AGOS_AGL082W | UTP--glucose-1-phosphate uridylyltransferase. (499 aa) |
| | AGOS_AGL080C | AGL080Cp. (320 aa) |
| | AGOS_AGL200W | AGL200Wp. (436 aa) |
| | COQ2 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (356 aa) |
| | MVD1 | Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (397 aa) |
| | AGOS_AGL256W | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (507 aa) |
| | AGOS_AGL271W | AGL271Wp. (1180 aa) |
| | AGOS_AGL334W | Amidophosphoribosyltransferase. (510 aa) |
| | AGOS_AFR747W | AFR747Wp. (426 aa) |
| | AGOS_AFR716C | Phosphotransferase. (493 aa) |
| | AGOS_AFR703W | Histidine biosynthesis trifunctional protein. (806 aa) |
| | AGOS_AFR693C | AFR693Cp. (252 aa) |
| | AGOS_AFR692C | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (382 aa) |
| | AGOS_AFR682C | AFR682Cp. (478 aa) |
| | AGOS_AFR675W | AFR675Wp; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (353 aa) |
| | COQ6 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (471 aa) |
| | AGOS_AFR629W | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (785 aa) |
| | AGOS_AFR624W | Elongation of fatty acids protein. (351 aa) |
| | MPG1 | Mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity); Belongs to the transferase hexapeptide repeat family. (361 aa) |
| | AGOS_AFR592W | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (279 aa) |
| | AGOS_AFR586W | Elongation of fatty acids protein. (342 aa) |
| | AGOS_AFR573C | AFR573Cp. (1346 aa) |
| | AGOS_AFR572W | AFR572Wp; Belongs to the sterol desaturase family. (311 aa) |
| | AGOS_AFR548C | AFR548Cp. (497 aa) |
| | AGOS_AFR547W | Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (900 aa) |
| | AGOS_AFR529W | AFR529Wp; Belongs to the glycosyl hydrolase 32 family. (572 aa) |
| | AGOS_AFR512W | Dihydrolipoyl dehydrogenase. (496 aa) |
| | AGOS_AFR489W | AFR489Wp. (727 aa) |
| | AGOS_AFR485C | Tryptophan synthase. (707 aa) |
| | ERG9 | Squalene synthase; Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity); Belongs to the phytoene/squalene synthase family. (441 aa) |
| | AGOS_AFR431C | Phosphatidyl-N-methylethanolamine N-methyltransferase; Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC). (211 aa) |
| | AGOS_AFR593C | AFR593Cp; Belongs to the FBPase class 1 family. (342 aa) |
| | AGOS_AFR410W | AFR410Wp. (326 aa) |
| | AGOS_AFR346W | AFR346Wp. (438 aa) |
| | DGK1 | CTP-dependent diacylglycerol kinase 1; CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus. Involved in pre-tRNA splicing (By similarity). Belongs to the DGK1 family. (317 aa) |
| | AGOS_AFR303W | AFR303Wp. (571 aa) |
| | AGOS_AFR302W | AFR302Wp; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa) |
| | AGOS_AFR295W | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (631 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase (ATP); Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (541 aa) |
| | AGOS_AFR282W | AFR282Wp. (307 aa) |
| | AGOS_AFR279C | Phosphotransferase. (488 aa) |
| | AGOS_AFR264W | AFR264Wp; Belongs to the class-I aminoacyl-tRNA synthetase family. (707 aa) |
| | AGOS_AFR254C | AFR254Cp. (793 aa) |
| | AGOS_AFR213C | AFR213Cp. (590 aa) |
| | AGOS_AFR211C | Aspartate aminotransferase. (419 aa) |
| | AGOS_AFR207C | AFR207Cp. (166 aa) |
| | ERG3 | Delta(7)-sterol 5(6)-desaturase; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis. (351 aa) |
| | AGOS_AFR137C | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (367 aa) |
| | AGOS_AFR134C | Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (319 aa) |
| | AGOS_AFR129W | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (498 aa) |
| | CHO2 | Phosphatidylethanolamine N-methyltransferase; Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME); Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family. (843 aa) |
| | AGOS_AFR098W | AFR098Wp; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (349 aa) |
| | AGOS_AFR071W | Phospholipase. (1577 aa) |
| | AGOS_AFR053C | AFR053Cp. (115 aa) |
| | PSD1 | Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily. (514 aa) |
| | AGOS_AFR012C | AFR012Cp. (483 aa) |
| | AGOS_AFR001W | AFR001Wp. (350 aa) |
| | AGOS_AFL046W | Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (549 aa) |
| | AGOS_AFL047W | Phospho-2-dehydro-3-deoxyheptonate aldolase. (364 aa) |
| | AGOS_AFR090W | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (217 aa) |
| | AGOS_AFL195W | AFL195Wp. (692 aa) |
| | AGOS_AFL201W | AFL201Wp; Belongs to the aldehyde dehydrogenase family. (497 aa) |
| | RPE1 | Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family. (239 aa) |
| | AGOS_AFL213W | AFL213Wp. (462 aa) |
| | AGOS_AFL229W | AFL229Wp. (605 aa) |
| | AGOS_AFL181C | AFL181Cp. (222 aa) |
| | AGOS_AFL185W | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (958 aa) |
| | AGOS_AER446W | AER446Wp. (479 aa) |
| | AGOS_AER374C | AER374Cp. (1004 aa) |
| | AGOS_AER364W | Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (453 aa) |
| | POX1 | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (733 aa) |
| | AGOS_AER357C | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (276 aa) |
| | AGOS_AER354W | Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (446 aa) |
| | AGOS_AER351W | AER351Wp. (262 aa) |
| | AGOS_AER341W | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (442 aa) |
| | AGOS_AER335W | Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (428 aa) |
| | ENO | Enolase. (437 aa) |
| | AGOS_AER276C | AER276Cp. (1110 aa) |
| | AGOS_AER239W | AER239Wp. (367 aa) |
| | AGOS_AER230C | AER230Cp. (414 aa) |
| | AGOS_AER228C | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (300 aa) |
| | AGOS_AER221W | AER221Wp. (302 aa) |
| | AGOS_AER215W | AER215Wp. (303 aa) |
| | AGOS_AER198W | AER198Wp. (316 aa) |
| | AGOS_AER152W | 3-hydroxy-3-methylglutaryl coenzyme A reductase. (1028 aa) |
| | AGOS_AER143W | Phosphotransferase. (425 aa) |
| | AGOS_AER164C | AER164Cp. (645 aa) |
| | AGOS_AER268W | AER268Wp. (329 aa) |
| | AGOS_AER123W | Ornithine aminotransferase. (434 aa) |
| | AGOS_AER117W | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (522 aa) |
| | AGOS_AER087C | AER087Cp; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (450 aa) |
| | AGOS_AER083C | AER083Cp. (425 aa) |
| | AGOS_AER061C | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (425 aa) |
| | AGOS_AER032W | AER032Wp. (351 aa) |
| | GPD | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa) |
| | TRP1 | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (210 aa) |
| | AGOS_AER004W | AER004Wp; Belongs to the FPP/GGPP synthase family. (475 aa) |
| | AGOS_AER003C | Alkyl transferase; Belongs to the UPP synthase family. (274 aa) |
| | NTH2 | Probable trehalase. (738 aa) |
| | AGOS_AEL019W | AEL019Wp. (469 aa) |
| | AGOS_AEL022W | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (344 aa) |
| | PGK1 | Phosphoglycerate kinase. (416 aa) |
| | GLC3 | 1,4-alpha-glucan-branching enzyme; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (703 aa) |
| | AGOS_AEL084W | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (433 aa) |
| | AGOS_AEL122W | AEL122Wp; Belongs to the FPP/GGPP synthase family. (351 aa) |
| | AGOS_AEL161W | AEL161Wp. (356 aa) |
| | SHM1 | Serine hydroxymethyltransferase, mitochondrial; Interconversion of serine and glycine. (497 aa) |
| | AGOS_AEL208W | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (987 aa) |
| | AGOS_AEL211W | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (417 aa) |
| | AGOS_AEL215C | AEL215Cp. (348 aa) |
| | BTS1 | Geranylgeranyl pyrophosphate synthase; Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. May be involved in vesicle trafficking and protein sorting (By similarity). (320 aa) |
| | PGI1 | Glucose-6-phosphate isomerase. (555 aa) |
| | AGOS_AEL276C | AEL276Cp. (1518 aa) |
| | AGOS_AEL305C | Acetolactate synthase. (668 aa) |
| | AGOS_AEL338C | AEL338Cp; Belongs to the class-I aminoacyl-tRNA synthetase family. (533 aa) |
| | AGOS_AEL341W | AEL341Wp. (393 aa) |
| | AGOS_ADR417W | ADR417Wp; Belongs to the aldehyde dehydrogenase family. (507 aa) |
| | ACS1 | Acetyl-coenzyme A synthetase 1; Belongs to the ATP-dependent AMP-binding enzyme family. (694 aa) |
| | AGOS_ADR396W | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (169 aa) |
| | PYK1 | Pyruvate kinase. (501 aa) |
| | AGOS_ADR351C | ADR351Cp. (452 aa) |
| | AGOS_ADR314C | ADR314Cp. (457 aa) |
| | GPD-2 | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (424 aa) |
| | AGOS_ADR290W | ADR290Wp. (2195 aa) |
| | AGOS_ADR275W | Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (418 aa) |
| | AGOS_ADR254W | ADR254Wp. (581 aa) |
| | AGOS_ADR252W | Malate dehydrogenase. (339 aa) |
| | AGOS_ADR231C | Patatin-like phospholipase domain-containing protein; Lipid hydrolase; Belongs to the PLPL family. (816 aa) |
| | ERG6 | Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (373 aa) |
| | AGOS_ADR165C | ADR165Cp; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa) |
| | AGOS_ADR164C | Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (199 aa) |
| | ERG11 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). (529 aa) |
| | AGOS_ADR152C | Malate dehydrogenase. (332 aa) |
| | ARGJ_ASHGO | Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate. (443 aa) |
| | ARG2 | Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family. (542 aa) |
| | COQ3 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (313 aa) |
| | AGOS_ADR118C | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (212 aa) |
| | AGOS_ADR107W | ADR107Wp; Belongs to the alpha-IPM synthase/homocitrate synthase family. (442 aa) |
| | AGOS_ADR092W | ADR092Wp. (355 aa) |
| | MKAR_ASHGO | Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (351 aa) |
| | PMI1 | Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (429 aa) |
| | AGOS_ADL015C | ADL015Cp. (578 aa) |
| | AGOS_ADL031W | ADL031Wp. (467 aa) |
| | AGOS_ADL032W | Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (776 aa) |
| | AGOS_ADL062W | ADL062Wp; In the N-terminal section; belongs to the acetylglutamate kinase family. (855 aa) |
| | HIS1 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity). (297 aa) |
| | AGOS_ADL086C | Aspartokinase. (552 aa) |
| | HIS6 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (263 aa) |
| | AGOS_ADL164C | ADL164Cp; Belongs to the LDH/MDH superfamily. (381 aa) |
| | AGOS_ADL180C | ADL180Cp. (320 aa) |
| | ARG8 | Acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (423 aa) |
| | AGOS_ADL214C | ADL214Cp. (367 aa) |
| | AGOS_ADL223W | Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (362 aa) |
| | AGOS_ADL249W | ADL249Wp. (387 aa) |
| | AGOS_ADL268C | ADL268Cp. (294 aa) |
| | HIS3 | Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (220 aa) |
| | AGOS_ADL287C | Chorismate synthase. (376 aa) |
| | AGOS_ADL296C | ADL296Cp. (301 aa) |
| | LYS2 | L-2-aminoadipate reductase large subunit; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate. (1385 aa) |
| | AGOS_ADL356C | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (464 aa) |
| | AGOS_ADL366W | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (680 aa) |
| | AGOS_ADL378W | Trehalose-6-phosphate synthase. (494 aa) |
| | AGOS_ADL384W | Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (376 aa) |
| | AGOS_ADL326W | Chorismate mutase. (259 aa) |
| | AGOS_ACR268C | Malate synthase; Belongs to the malate synthase family. (552 aa) |
| | AGOS_ACR254C | ACR254Cp. (597 aa) |
| | AGOS_ACR232C | Threonine dehydratase. (560 aa) |
| | SHM2 | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. Belongs to the SHMT family. (469 aa) |
| | AGOS_ACR210C | Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (565 aa) |
| | AGOS_ACR198W | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (308 aa) |
| | LYS1 | Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis. (372 aa) |
| | AGOS_ACR094C | ACR094Cp. (309 aa) |
| | AGOS_ACR070W | ACR070Wp. (358 aa) |
| | AGOS_ACR056W | Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (247 aa) |
| | AGOS_ACR052W | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (633 aa) |
| | AGOS_ACR013C | ACR013Cp. (488 aa) |
| | AGOS_ACR108C | ACR108Cp. (296 aa) |
| | AGOS_ACL032C | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (470 aa) |
| | AGOS_ACL044W | ACL044Wp; Belongs to the aldehyde dehydrogenase family. (513 aa) |
| | AGOS_ACL059C | ACL059Cp. (453 aa) |
| | SDH2 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (261 aa) |
| | RKI1 | Ribose-5-phosphate isomerase. (255 aa) |
| | AGOS_ACL117W | ACL117Wp. (581 aa) |
| | AGOS_ACL122W | ACL122Wp. (324 aa) |
| | AGOS_ACL123C | ACL123Cp. (277 aa) |
| | AGOS_ACL130C | ACL130Cp. (316 aa) |
| | AGOS_ACL134C | ACL134Cp. (586 aa) |
| | AGOS_ACL148C | S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (381 aa) |
| | AGOS_ACL150W | Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (219 aa) |
| | COQ7 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (226 aa) |
| | AGOS_ACL196W | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (334 aa) |
| | AGOS_ACL198W | Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (394 aa) |
| | AGOS_ABR236W | Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (253 aa) |
| | AGOS_ABR212C | ABR212Cp. (768 aa) |
| | AGOS_ABR209W | ABR209Wp. (501 aa) |
| | AGOS_ABR204C | ABR204Cp; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (771 aa) |
| | AGOS_ABR186W | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate. (308 aa) |
| | AGOS_ABR168W | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (283 aa) |
| | AGOS_ABR163W | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa) |
| | AGOS_ABR116C | ABR116Cp. (445 aa) |
| | NDK1 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity); Belongs to the NDK family. (151 aa) |
| | AGOS_ABR076C | ABR076Cp; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (271 aa) |
| | AGOS_ABR068C | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (360 aa) |
| | AGOS_ABR053C | ABR053Cp; Belongs to the cytochrome P450 family. (515 aa) |
| | AGOS_ABL006C | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (482 aa) |
| | AGOS_ABL022W | ABL022Wp. (401 aa) |
| | AGOS_ABL029W | ABL029Wp; Belongs to the phosphohexose mutase family. (568 aa) |
| | AGOS_ABL033C | ABL033Cp. (373 aa) |
| | AGOS_ABL038W | Aspartate aminotransferase. (443 aa) |
| | AGOS_ABL056C | Glucose-6-phosphate 1-epimerase; Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P). (296 aa) |
| | AGOS_ABL080W | Homoserine dehydrogenase. (356 aa) |
| | AGOS_ABL102C | Phospho-2-dehydro-3-deoxyheptonate aldolase. (373 aa) |
| | HEM1 | 5-aminolevulinate synthase, mitochondrial; Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (556 aa) |
| | LYS4 | Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (686 aa) |
| | HEM3 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (326 aa) |
| | FMN1 | Riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme; Belongs to the flavokinase family. (186 aa) |
| | AGOS_ABL125W | ABL125Wp. (336 aa) |
| | AGOS_ABL126W | ABL126Wp. (624 aa) |
| | COQ5 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (322 aa) |
| | AGOS_ABL206C | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (512 aa) |
| | AGOS_AAR167C | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa) |
| | AGOS_AAR152W | AAR152Wp. (262 aa) |
| | AGOS_AAR122C | Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (250 aa) |
| | AGOS_AAR120C | AAR120Cp. (215 aa) |
| | AGOS_AAR084W | AAR084Wp. (351 aa) |
| | AGOS_AAR071W | AAR071Wp. (2231 aa) |
| | AGOS_AAR021W | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (523 aa) |
| | AGOS_AAR008W | Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa) |
| | AGOS_AAR004C | Citrate synthase; Belongs to the citrate synthase family. (477 aa) |
| | AGOS_AAL021W | AAL021Wp. (300 aa) |
| | AGOS_AAL022W | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (415 aa) |
| | AGOS_AAL044C | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (349 aa) |
| | AGOS_AAL061C | AAL061Cp. (420 aa) |
| | AGOS_AAL073W | AAL073Wp. (563 aa) |
| | AGOS_AAL084W | AAL084Wp. (338 aa) |
| | COX10 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the UbiA prenyltransferase family. (435 aa) |
| | PSD2 | Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily. (1014 aa) |
| | ERG1 | Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. (497 aa) |
| | AGOS_AAL186W | AAL186Wp. (319 aa) |
