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| | AGOS_AGR407C | AGR407Cp; Belongs to the peptidase A1 family. (393 aa) |
| | AGOS_AGR320W | AGR320Wp. (302 aa) |
| | AGOS_AGR149W | Vacuolar protein sorting-associated protein 41; Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family. (885 aa) |
| | AGOS_AGR127C | AGR127Cp. (562 aa) |
| | AGOS_AGL099C | AGL099Cp. (747 aa) |
| | AGOS_AGL113C | Phosphatidylinositol 3-kinase VPS34. (870 aa) |
| | AGOS_AGL144C | Kinase; Belongs to the inositol phosphokinase (IPK) family. (339 aa) |
| | AGOS_AGL156W | AGL156Wp. (910 aa) |
| | PHO85 | Negative regulator of the PHO system; When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (301 aa) |
| | AGOS_AGL252W | Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. (795 aa) |
| | ATG22 | Autophagy-related protein 22; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity); Belongs to the ATG22 family. (507 aa) |
| | AGOS_AFR420W | Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2462 aa) |
| | AGOS_AFR419C | AFR419Cp; Belongs to the actin family. (455 aa) |
| | AGOS_AFR341C | AFR341Cp. (928 aa) |
| | AGOS_AFR002C | AFR002Cp. (1230 aa) |
| | AGOS_AFL053W | AFL053Wp; Belongs to the STXBP/unc-18/SEC1 family. (581 aa) |
| | AGOS_AFL090W | AFL090Wp; Belongs to the protein kinase superfamily. (346 aa) |
| | AGOS_AFL168W | AFL168Wp. (215 aa) |
| | ATG3 | Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of [...] (282 aa) |
| | ATG16 | Autophagy protein 16; Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). (124 aa) |
| | AGOS_AFL232W | AFL232Wp; Belongs to the syntaxin family. (274 aa) |
| | AGOS_AER438C | AER438Cp. (348 aa) |
| | CIS1 | Autophagy-related protein 31; Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy (By similarity). (142 aa) |
| | ATG8 | Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (120 aa) |
| | AGOS_AER380C | AER380Cp. (716 aa) |
| | ATG7 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (625 aa) |
| | AGOS_AER232C | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (569 aa) |
| | AGOS_AER169C | AER169Cp. (762 aa) |
| | ATG23 | Autophagy-related protein 23; Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Plays also a role in regulation of filamentous growth (By similarity); Belongs to the ATG23 family. (407 aa) |
| | YKT6 | Synaptobrevin homolog YKT6. (200 aa) |
| | ATG17 | Autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity); Belongs to the ATG17 family. (413 aa) |
| | AGOS_AER080W | AER080Wp. (1032 aa) |
| | AGOS_AER064C | AER064Cp; Belongs to the STXBP/unc-18/SEC1 family. (648 aa) |
| | ATG27 | Autophagy-related protein 27; Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre- autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity); Belongs to the ATG27 family. (251 aa) |
| | AGOS_AEL115C | AEL115Cp; Belongs to the protein kinase superfamily. (386 aa) |
| | AGOS_AEL230W | Non-specific serine/threonine protein kinase. (608 aa) |
| | ATG13 | Autophagy-related protein 13; Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity). (659 aa) |
| | AGOS_ADR331C | ADR331Cp. (1561 aa) |
| | AGOS_ADR316W | ADR316Wp; Belongs to the actin family. (391 aa) |
| | AGOS_ADR099C | Serine/threonine-protein phosphatase. (362 aa) |
| | AGOS_ADR074C | ADR074Cp. (159 aa) |
| | ATG9 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] (897 aa) |
| | AGOS_ADL012C | ADL012Cp. (325 aa) |
| | AGOS_ADL262W | ADL262Wp. (270 aa) |
| | ATG11 | Autophagy-related protein 11; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). (1072 aa) |
| | AGOS_ADL316C | ADL316Cp. (1411 aa) |
| | ATG14 | Autophagy-related protein 14; Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity). (308 aa) |
| | AGOS_ADL389W | Non-specific serine/threonine protein kinase. (711 aa) |
| | AGOS_ACR218W | ACR218Wp. (1568 aa) |
| | AGOS_ACR174C | ACR174Cp. (381 aa) |
| | AGOS_ACR154W | ACR154Wp. (451 aa) |
| | AGOS_ACR144W | ACR144Wp; Belongs to the peptidase A1 family. (408 aa) |
| | AGOS_ACR143W | ACR143Wp; Belongs to the peptidase A1 family. (393 aa) |
| | ATG5 | Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...] (293 aa) |
| | AGOS_ACR051C | ACR051Cp. (550 aa) |
| | AGOS_ACR012C | ACR012Cp; Belongs to the peptidase S8 family. (541 aa) |
| | AGOS_ACR003C | ACR003Cp. (208 aa) |
| | AGOS_ACL053C | ACL053Cp. (1181 aa) |
| | ATG1 | Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (972 aa) |
| | ATG10 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity). (170 aa) |
| | ATG21 | Autophagy-related protein 21; Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity); Belongs to the WD repeat SVP1 family. (409 aa) |
| | SEC17 | Vesicular-fusion protein SEC17; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus; Belongs to the SNAP family. (291 aa) |
| | AGOS_ABR152C | ABR152Cp. (629 aa) |
| | AGOS_ABR145C | ABR145Cp. (557 aa) |
| | AGOS_ABR089C | ABR089Cp. (571 aa) |
| | AGOS_ABR088C | ABR088Cp. (532 aa) |
| | AGOS_ABR072W | ABR072Wp. (347 aa) |
| | AGOS_ABL012C | E3 ubiquitin-protein ligase PEP5. (1021 aa) |
| | ATG4 | Probable cysteine protease ATG4; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C- terminus for its conjugation t [...] (521 aa) |
| | ATG2 | Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and in peroxisome degradation. Belongs to the ATG2 family. (1525 aa) |
| | AGOS_AAR184W | Kinase; Belongs to the inositol phosphokinase (IPK) family. (836 aa) |
| | MON1 | Vacuolar fusion protein MON1; In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking. Belongs to the MON1/SAND family. (581 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). (189 aa) |
| | ATG15 | Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (544 aa) |
| | CCZ1 | Vacuolar fusion protein CCZ1; In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking. (663 aa) |
| | AGOS_AAL009C | AAL009Cp. (303 aa) |
| | AGOS_AAL032W | AAL032Wp. (244 aa) |
| | AGOS_AAL083W | AAL083Wp. (1698 aa) |
| | ATG29 | Autophagy-related protein 29; Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Plays also a role in mitophagy and regulation of filamentous growth (By similarity); Belongs to the ATG29 family. (172 aa) |
| | ATG18 | Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct ATG9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). (537 aa) |
