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| | prp5 | Pre-mRNA-splicing factor prp5; Required for both cell cycle progression at G2/M and pre-mRNA splicing. Interacts genetically with the PRP4 kinase. Belongs to the WD repeat PRL1/PRL2 family. (473 aa) |
| | ntr2 | Uncharacterized protein C17A2.08c. (361 aa) |
| | dri1 | Uncharacterized RNA-binding protein C17H9.04c. (604 aa) |
| | irc6 | Uncharacterized protein C19A8.11c. (246 aa) |
| | usp101 | U1 small nuclear ribonucleoprotein 70 kDa homolog; Involved in nuclear mRNA splicing (By similarity). Essential for growth. (261 aa) |
| | sap114 | Pre-mRNA-splicing factor sap114; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). (481 aa) |
| | mpn1 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family. (265 aa) |
| | prp19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair. Belongs to the WD repeat PRP19 family. (488 aa) |
| | smd2 | Small nuclear ribonucleoprotein Sm D2; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (115 aa) |
| | saf2 | WW domain-containing protein C2F3.14c. (331 aa) |
| | sap49 | Spliceosome-associated protein 49. (335 aa) |
| | sde2 | Telomere maintenance protein SDE2; Plays a role in the regulation of telomeric and centromeric silencing. Contributes to the prevention of abnormal telomere elongation. Required for chromosome segregation to daughter cells in mitosis and meiosis. May participate in the recruitment of the histone deacetylase silencing complex SHREC, which prevents transcription at telomeres; Belongs to the SDE2 family. (263 aa) |
| | cwf21 | Pre-mRNA-splicing factor cwf21; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). (293 aa) |
| | usp104 | Pre-mRNA-processing protein prp40; Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity). (695 aa) |
| | spp42 | Pre-mRNA-splicing factor spp42; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2363 aa) |
| | lsm4 | Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (121 aa) |
| | rbd1 | Uncharacterized protein C13E7.11. (298 aa) |
| | prp22 | Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22; Acts late in the splicing of pre-mRNA. Required for the splicing of introns with a branch nucleotide to 3'-splice site distance greater or equal to 15. Mediates the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. (1168 aa) |
| | smd1 | Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (117 aa) |
| | prp31 | Pre-mRNA-processing factor 31; Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes. Belongs to the PRP31 family. (518 aa) |
| | cip1 | RNA-binding post-transcriptional regulator cip1; Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress. (490 aa) |
| | cyp7 | Peptidylprolyl isomerase cyp7; PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing; Belongs to the cyclophilin-type PPIase family. CWC27 subfamily. (463 aa) |
| | prp43 | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. (735 aa) |
| | SPBC16H5.12c | Uncharacterized protein C16H5.12c. (737 aa) |
| | pdc2 | DNA topoisomerase 2-associated protein pat1; Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. Stabilizes the 3' terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity); Belongs to the PAT1 family. (754 aa) |
| | nrl1 | Protein NRDE2 homolog; Belongs to the NRDE2 family. (972 aa) |
| | lsm5 | U6 snRNA-associated Sm-like protein LSm5; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. LSm5 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). (80 aa) |
| | cwf28 | Pre-mRNA-splicing factor cwf28; Involved in spliceosome maturation and the first step of pre- mRNA splicing. (381 aa) |
| | prp17 | Pre-mRNA-processing factor 17; Functions in the second step of pre-mRNA splicing. Involved in splicing intron which are longer than 200 nucleotides. (558 aa) |
| | uap2 | Splicing factor U2AF-associated protein 2; Has a role in pre-mRNA splicing. Belongs to the HTATSF1 family. (367 aa) |
| | sap14 | Splicing factor 3B subunit 6-like protein; Necessary for the splicing of pre-mRNA. (115 aa) |
| | sap61 | Pre-mRNA-splicing factor sap61; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (492 aa) |
| | syf2 | Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing. (229 aa) |
| | smf1 | Small nuclear ribonucleoprotein F; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (78 aa) |
| | bis1 | Stress response protein bis1; Has a role in maintaining cell viability during stationary phase induced by stress response. May be involved in pre-mRNA splicing; Belongs to the ESS2 family. (384 aa) |
| | cwf5 | Pre-mRNA-splicing factor cwf5; Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). Involved in pre-mRNA splicing; Belongs to the RRM SLT11 family. (354 aa) |
| | wbp4 | Uncharacterized protein C18H10.07. (224 aa) |
| | saf4 | Protein saf4; May be involved in mRNA splicing; Belongs to the CWC16 family. (299 aa) |
| | cxr1 | Uncharacterized RNA-binding protein C23E6.01c. (473 aa) |
| | sqs1 | G-patch and R3H domain-containing protein C30B4.02c. (695 aa) |
| | cwf12 | Pre-mRNA-splicing factor cwf12; Involved in mRNA splicing and cell cycle control; Belongs to the ISY1 family. (217 aa) |
| | snp27 | U4/U6.U5 tri-snRNP-associated protein 3-like protein C162.01c; May play a role in mRNA splicing. (244 aa) |
| | scw1 | Cell wall integrity protein scw1; Acts as a negative regulator of cell wall and septum deposition. (561 aa) |
| | lsm8 | U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family. (94 aa) |
| | lsm7 | U6 snRNA-associated Sm-like protein LSm7; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Probable component of the spliceosome; Belongs to the snRNP Sm proteins family. (113 aa) |
| | saf1 | Protein saf1. (278 aa) |
| | bpb1 | Branchpoint-bridging protein; Necessary for the splicing of pre-mRNA. The BPB1(SF1)-u2af59- u2af23 complex has a role in the recognition of the branch site (5'- UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns. (587 aa) |
| | cyp3 | Peptidyl-prolyl cis-trans isomerase cyp3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). (173 aa) |
| | cwf14 | Pre-mRNA-splicing factor cwf14; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (146 aa) |
| | ess1 | UPF0587 protein C2D10.03c; Belongs to the UPF0587 family. (157 aa) |
| | rbd2 | Rhomboid protein 2; Probable serine protease; Belongs to the peptidase S54 family. (251 aa) |
| | cyp9 | Peptidyl-prolyl cis-trans isomerase 9; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). (610 aa) |
| | smg1 | Small nuclear ribonucleoprotein G; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (77 aa) |
| | usp102 | U1 small nuclear ribonucleoprotein usp102; Involved in nuclear mRNA splicing. (249 aa) |
| | usp105 | Pre-mRNA-processing factor 39; Function prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRNP/5'-splice site interaction. Has a direct role in the assembly or function of a catalytically active spliceosome (By similarity); Belongs to the PRP39 family. (612 aa) |
| | cwf29 | U2 snRNP component ist3; Required for pre-mRNA splicing and spliceosome assembly. (217 aa) |
| | cwf10 | Pre-mRNA-splicing factor cwf10; Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (984 aa) |
| | prp18 | Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing. Belongs to the PRP18 family. (343 aa) |
| | lsm2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa) |
| | cwf26 | Pre-mRNA-splicing factor cwf26; Involved in mRNA splicing. (306 aa) |
| | rsm1 | mRNA export factor rsm1; Involved in the export of mRNA from the nucleus to the cytoplasm. (296 aa) |
| | cwf11 | Pre-mRNA-splicing factor cwf11; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome; Belongs to the CWF11 family. (1284 aa) |
| | snu66 | U4/U6.U5 tri-snRNP-associated protein snu66; Required for efficient splicing of pre-mRNA. Belongs to the SNU66/SART1 family. (649 aa) |
| | spf38 | Pre-mRNA-splicing factor cwf17; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (340 aa) |
| | usp109 | U1 snRNP-associated protein usp109. (365 aa) |
| | hub1 | Ubiquitin-like modifier hub1; Forms a conjugate with snu66 and facilitates its localization to the nucleus. Involved in morphogenesis. Required for efficient splicing of pre-mRNA. (73 aa) |
| | lin1 | LIN1-like protein; Belongs to the LIN1 family. (408 aa) |
| | dsk1 | Protein kinase dsk1; May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle. (544 aa) |
| | prp2 | Splicing factor U2AF 59 kDa subunit; Necessary for the splicing of pre-mRNA. The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC- 3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns; Belongs to the splicing factor SR family. (517 aa) |
| | cdc5 | Pre-mRNA-splicing factor cdc5; Involved in mRNA splicing and cell cycle control. Belongs to the CEF1 family. (757 aa) |
| | cwf15 | Pre-mRNA-splicing factor cwf15; Involved in pre-mRNA splicing. (265 aa) |
| | srp2 | Pre-mRNA-splicing factor srp2; Has a role in pre-mRNA splicing where it is involved in spliceosome assembly. (365 aa) |
| | cyp1 | Peptidyl-prolyl cis-trans isomerase ppi1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. (155 aa) |
| | cwf2 | Pre-mRNA-splicing factor cwf2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (388 aa) |
| | lsm1 | U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends. (140 aa) |
| | dim1 | Mitosis protein dim1; Plays a fundamental role as a protein essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis. May play a role in mitotic spindle formation and/or function. May have a role in the maintenance or establishment of the steady-state level of the APC complex. (142 aa) |
| | cwf4 | Pre-mRNA-splicing factor cwf4; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity); Belongs to the crooked-neck family. (674 aa) |
| | prp4 | Serine/threonine-protein kinase prp4; Has a role in pre-mRNA splicing and is essential for growth. Phosphorylates srp1. (477 aa) |
| | uaf2 | Splicing factor U2AF 23 kDa subunit; Necessary for the splicing of pre-mRNA. The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC- 3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns. (216 aa) |
| | dre4 | Pre-mRNA-splicing factor dre4; Component of the spliceosome involved in mRNA processing. (411 aa) |
| | gep3 | Uncharacterized protein C2F7.09c. (491 aa) |
| | snu23 | U4/U6.U5 small nuclear ribonucleoprotein component snu23. (173 aa) |
| | usp108 | U1 snRNP-associated protein usp108; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. (337 aa) |
| | prp3 | U4/U5/U6 small nuclear ribonucleoprotein prp3; Participates in pre-mRNA splicing and in nuclear mRNA export. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex. (542 aa) |
| | cip2 | RNA-binding post-transcriptional regulator cip2; Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress. (576 aa) |
| | prp45 | Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing; Belongs to the SNW family. (557 aa) |
| | cwf19 | Pre-mRNA-splicing factor cwf19; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome; Belongs to the CWF19 family. (639 aa) |
| | SPAC30D11.14c | Uncharacterized protein C30D11.14c. (534 aa) |
| | cyp8 | Peptidyl-prolyl cis-trans isomerase cyp8; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins; Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. (516 aa) |
| | fal1 | ATP-dependent RNA helicase fal1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. (394 aa) |
| | smb1 | Small nuclear ribonucleoprotein-associated protein B; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (147 aa) |
| | prp10 | U2 snRNP component prp10; Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly; Belongs to the SF3B1 family. (1205 aa) |
| | srp1 | Pre-mRNA-splicing factor srp1; Has a role in pre-mRNA splicing where it is involved in spliceosome assembly. (275 aa) |
| | SPBC11C11.01 | Uncharacterized protein C11C11.01. (466 aa) |
| | mug161 | CWF19-like protein mug161; Has a role in meiosis; Belongs to the CWF19 family. (561 aa) |
| | SPAC25G10.01 | Uncharacterized RNA-binding protein C25G10.01. (297 aa) |
| | pnn1 | Pinin homolog 1; Transcriptional activator that may participate in the regulation of mRNA splicing; Belongs to the pinin family. (197 aa) |
| | cdc28 | Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28; Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing (By similarity). Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily. (1055 aa) |
| | prp1 | Pre-mRNA-splicing factor prp1; Involved in pre-mRNA splicing. Interacts with prp6 and prp13. May also be involved in the regulation of the G0-G1/G2 transition. Required for pre-spliceosome formation, which is the first step of pre- mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site- 3' splice 3'-exon region. (906 aa) |
| | aar2 | A1 cistron-splicing factor aar2; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth (By similarity); Belongs to the AAR2 family. (346 aa) |
| | msl1 | Probable U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA (By similarity). (111 aa) |
| | usp107 | U1 snRNP-associated protein usp107; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. (695 aa) |
| | SPAC31G5.21 | Uncharacterized protein C31G5.21. (118 aa) |
| | wdr83 | Uncharacterized WD repeat-containing protein C713.05. (297 aa) |
| | SPAC20H4.09 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. (647 aa) |
| | gpl1 | Uncharacterized protein C20H4.06c. (534 aa) |
| | tcg1 | Single-stranded TG1-3 DNA-binding protein; Binds single-stranded telomeric sequences of the type (TG[1- 3])n in vitro. Has a role in meiosis. (349 aa) |
| | SPAC683.02c | Uncharacterized protein C683.02c. (218 aa) |
| | cwf24 | Pre-mRNA-splicing factor cwf24; Involved in mRNA splicing. (533 aa) |
| | cwf22 | Pre-mRNA-splicing factor cwf22; May be involved in pre-mRNA splicing. (887 aa) |
| | prp16 | Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing. (1173 aa) |
| | usp103 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. usp103/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (182 aa) |
| | ctr1 | Uncharacterized protein C140.04. (295 aa) |
| | cwf16 | Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. (270 aa) |
| | prp11 | Pre-mRNA-processing ATP-dependent RNA helicase prp11; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1014 aa) |
| | saf3 | Uncharacterized protein C1782.03. (355 aa) |
| | sap62 | Pre-mRNA-splicing factor sap62; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (217 aa) |
| | sap10 | Uncharacterized protein C211.05; Belongs to the SF3B5 family. (85 aa) |
| | cwf3 | Pre-mRNA-splicing factor cwf3; Involved in pre-mRNA splicing and cell cycle progression. Belongs to the crooked-neck family. (790 aa) |
| | syo2 | Uncharacterized ARM-like repeat-containing protein C1703.03c. (664 aa) |
| | frg1 | Protein frg1; May have a role in processing of pre-rRNA or in the assembly of rRNA into ribosomal subunits. May be involved in pre-mRNA splicing (By similarity). (245 aa) |
| | pkr1 | V-type ATPase assembly factor pkr1; Functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V(0); Belongs to the PKR1 family. (132 aa) |
| | pwi1 | PWI domain-containing protein C825.05c. (301 aa) |
| | luc7 | U1 snRNP-associated protein usp106; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. (264 aa) |
| | ubp10 | Probable mRNA-splicing protein ubp10; May play a role in mRNA splicing. It is unsure if the protein really exhibits hydrolase activity. Could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity); Belongs to the peptidase C19 family. (502 aa) |
| | cwf7 | Pre-mRNA-splicing factor cwf7; Involved in mRNA splicing; Belongs to the SPF27 family. (187 aa) |
| | lea1 | U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing. This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA (By similarity). (239 aa) |
| | prp24 | Uncharacterized RNA-binding protein C1861.04c. (1014 aa) |
| | sme1 | Small nuclear ribonucleoprotein E; Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification (By similarity). (84 aa) |
| | brr2 | Pre-mRNA-splicing factor brr2; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2176 aa) |
| | ini1 | Pre-mRNA-splicing factor ini1; Required for pre-mRNA splicing. Belongs to the PHF5 family. (117 aa) |
| | rna4 | Uncharacterized WD repeat-containing protein C227.12. (462 aa) |
| | ntr1 | G-patch domain-containing protein C1486.03. (797 aa) |
| | prp12 | Pre-mRNA-splicing factor prp12; Involved in mRNA splicing and G2/M transition. (1206 aa) |
| | cwf18 | Pre-mRNA-splicing factor cwf18; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (142 aa) |
| | smd3 | Small nuclear ribonucleoprotein Sm D3; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (97 aa) |
| | prp38 | Pre-mRNA-splicing factor 38; Required for pre-mRNA splicing and maintenance of stable U6 small nuclear RNA levels. Implicated in the formation of stable and biologically active snRNP structures. As part of the U4/U6.U5 tri-snRNP particle, dispensible for spliceosome assembly, but required for conformational changes, which result in U4 snRNA release and the subsequent catalytic activation of the spliceosome (By similarity). (210 aa) |
| | rct1 | Peptidyl-prolyl cis-trans isomerase cyp6; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily. (432 aa) |
| | lsm6 | U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (75 aa) |
| | sap145 | Pre-mRNA-splicing factor sap145; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). (601 aa) |
| | SPAC1952.06c | Beta-catenin-like protein 1 homolog; Probable spliceosomal component involved in the activation of pre-mRNA splicing. (564 aa) |
| | lsm3 | Probable U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (93 aa) |
| | prp28 | Pre-mRNA-splicing ATP-dependent RNA helicase prp28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (662 aa) |
| | slu7 | Pre-mRNA-splicing factor slu7; Involved in pre-mRNA splicing. (379 aa) |
| | SPBC1539.02 | Meiotic chromosome segregation protein C1539.02; Required for meiotic chromosome segregation. (386 aa) |
| | cwf25 | Pre-mRNA-splicing factor cwf25; Involved in mRNA splicing. (376 aa) |
