STRINGSTRING
prp5 prp5 prp19 prp19 spp42 spp42 prp43 prp43 prp17 prp17 syf2 syf2 smf1 smf1 cwf5 cwf5 cwf12 cwf12 cwf14 cwf14 cwf10 cwf10 cwf11 cwf11 cwf15 cwf15 cyp1 cyp1 cwf4 cwf4 prp45 prp45 cwf19 cwf19 cwf3 cwf3 cwf7 cwf7 lea1 lea1 brr2 brr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prp5Pre-mRNA-splicing factor prp5; Required for both cell cycle progression at G2/M and pre-mRNA splicing. Interacts genetically with the PRP4 kinase. Belongs to the WD repeat PRL1/PRL2 family. (473 aa)
prp19Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair. Belongs to the WD repeat PRP19 family. (488 aa)
spp42Pre-mRNA-splicing factor spp42; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2363 aa)
prp43Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. (735 aa)
prp17Pre-mRNA-processing factor 17; Functions in the second step of pre-mRNA splicing. Involved in splicing intron which are longer than 200 nucleotides. (558 aa)
syf2Pre-mRNA-splicing factor syf2; Involved in pre-mRNA splicing. (229 aa)
smf1Small nuclear ribonucleoprotein F; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (78 aa)
cwf5Pre-mRNA-splicing factor cwf5; Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). Involved in pre-mRNA splicing; Belongs to the RRM SLT11 family. (354 aa)
cwf12Pre-mRNA-splicing factor cwf12; Involved in mRNA splicing and cell cycle control; Belongs to the ISY1 family. (217 aa)
cwf14Pre-mRNA-splicing factor cwf14; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (146 aa)
cwf10Pre-mRNA-splicing factor cwf10; Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (984 aa)
cwf11Pre-mRNA-splicing factor cwf11; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome; Belongs to the CWF11 family. (1284 aa)
cwf15Pre-mRNA-splicing factor cwf15; Involved in pre-mRNA splicing. (265 aa)
cyp1Peptidyl-prolyl cis-trans isomerase ppi1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily. (155 aa)
cwf4Pre-mRNA-splicing factor cwf4; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity); Belongs to the crooked-neck family. (674 aa)
prp45Pre-mRNA-processing protein 45; Involved in pre-mRNA splicing; Belongs to the SNW family. (557 aa)
cwf19Pre-mRNA-splicing factor cwf19; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome; Belongs to the CWF19 family. (639 aa)
cwf3Pre-mRNA-splicing factor cwf3; Involved in pre-mRNA splicing and cell cycle progression. Belongs to the crooked-neck family. (790 aa)
cwf7Pre-mRNA-splicing factor cwf7; Involved in mRNA splicing; Belongs to the SPF27 family. (187 aa)
lea1U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing. This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA (By similarity). (239 aa)
brr2Pre-mRNA-splicing factor brr2; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2176 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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