(13 nodes) Nucleocytoplasmic carrier activity, and Nuclear matrix network (Schizosaccharomyces pombe)

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Your Input:
	kap104	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...] (910 aa)
	msn5	Uncharacterized protein C328.01c. (1234 aa)
	nmd5	Probable importin c550.11; Active in protein import into the nucleus. (1029 aa)
	kap123	Probable importin subunit beta-4; Required for nuclear protein import, its predominant substrate seems to be ribosomal proteins. Binds to nucleoporins and the GTP-bound form of gsp1 (Ran) (By similarity); Belongs to the importin beta family. (1067 aa)
	sal3	Importin subunit beta-3; Involved in the nuclear import of cdc25 and mcs1. Belongs to the importin beta family. Importin beta-3 subfamily. (1095 aa)
	los1	Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity). (978 aa)
	crm1	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family. (1078 aa)
	spi1	GTP-binding nuclear protein spi1; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. (216 aa)
	rna1	Ran GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state. (386 aa)
	sbp1	Ran-specific GTPase-activating protein 1; Stimulates the GTPase activity in the presence of RNA1. May potentiate the action of RanGAP1 (RNA1), thus playing the role of a negative regulator; Belongs to the RANBP1 family. (215 aa)
	kap111	Importin beta-like protein kap111; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope; Belongs to the importin beta family. (990 aa)
	kap114	Importin subunit beta-5; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA- binding protein (TBP) and of histones H2A and H2B (By similarity). (993 aa)
	mtr10	Uncharacterized protein C11G11.07. (955 aa)

Your Current Organism:

Schizosaccharomyces pombe

NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
crm1	kap104	P14068	O14089	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	0.944
crm1	kap114	P14068	Q10297	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Importin subunit beta-5; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA- binding protein (TBP) and of histones H2A and H2B (By similarity).	0.527
crm1	kap123	P14068	O60100	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Probable importin subunit beta-4; Required for nuclear protein import, its predominant substrate seems to be ribosomal proteins. Binds to nucleoporins and the GTP-bound form of gsp1 (Ran) (By similarity); Belongs to the importin beta family.	0.744
crm1	los1	P14068	O94258	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).	0.954
crm1	msn5	P14068	O14116	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Uncharacterized protein C328.01c.	0.943
crm1	mtr10	P14068	Q9USZ2	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Uncharacterized protein C11G11.07.	0.891
crm1	nmd5	P14068	O59809	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Probable importin c550.11; Active in protein import into the nucleus.	0.814
crm1	rna1	P14068	P41391	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Ran GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state.	0.955
crm1	sal3	P14068	O74476	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Importin subunit beta-3; Involved in the nuclear import of cdc25 and mcs1. Belongs to the importin beta family. Importin beta-3 subfamily.	0.692
crm1	sbp1	P14068	Q09717	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	Ran-specific GTPase-activating protein 1; Stimulates the GTPase activity in the presence of RNA1. May potentiate the action of RanGAP1 (RNA1), thus playing the role of a negative regulator; Belongs to the RANBP1 family.	0.996
crm1	spi1	P14068	P28748	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	GTP-binding nuclear protein spi1; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export.	0.998
kap104	crm1	O14089	P14068	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.	0.944
kap104	kap111	O14089	Q09796	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Importin beta-like protein kap111; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope; Belongs to the importin beta family.	0.642
kap104	kap114	O14089	Q10297	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Importin subunit beta-5; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA- binding protein (TBP) and of histones H2A and H2B (By similarity).	0.924
kap104	kap123	O14089	O60100	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Probable importin subunit beta-4; Required for nuclear protein import, its predominant substrate seems to be ribosomal proteins. Binds to nucleoporins and the GTP-bound form of gsp1 (Ran) (By similarity); Belongs to the importin beta family.	0.953
kap104	los1	O14089	O94258	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).	0.878
kap104	msn5	O14089	O14116	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Uncharacterized protein C328.01c.	0.733
kap104	mtr10	O14089	Q9USZ2	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Uncharacterized protein C11G11.07.	0.905
kap104	nmd5	O14089	O59809	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Probable importin c550.11; Active in protein import into the nucleus.	0.794
kap104	rna1	O14089	P41391	Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...]	Ran GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state.	0.454