STRINGSTRING
SPAC1B3.01c SPAC1B3.01c gud1 gud1 SPACUNK4.15 SPACUNK4.15 gua1 gua1 isn1 isn1 cts1 cts1 apt1 apt1 dcd1 dcd1 ura6 ura6 SPCC965.14c SPCC965.14c SPBC3H7.05c SPBC3H7.05c urk1 urk1 iah1 iah1 adk1 adk1 tmp1 tmp1 cdc22 cdc22 suc22 suc22 ndk1 ndk1 ada1 ada1 rds1 rds1 ado1 ado1 hdd1 hdd1 azr1 azr1 cdd1 cdd1 SPAC13C5.04 SPAC13C5.04 SPAC11D3.06 SPAC11D3.06 toe3 toe3 uck2 uck2 toe1 toe1 guk1 guk1 dea2 dea2 urh1 urh1 SPBC1683.05 SPBC1683.05 SPBC1683.02 SPBC1683.02 dut1 dut1 gua2 gua2 urg1 urg1 urg3 urg3 urg2 urg2 mam301 mam301 ynd1 ynd1 yfh7 yfh7 SPAC1805.16c SPAC1805.16c toe2 toe2 fap7 fap7 ham1 ham1 set7 set7
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SPAC1B3.01cUracil phosphoribosyltransferase 1; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (219 aa)
gud1Probable guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (527 aa)
SPACUNK4.15Uncharacterized protein UNK4,15. (208 aa)
gua1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (524 aa)
isn1IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation; Belongs to the ISN1 family. (405 aa)
cts1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (600 aa)
apt1Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. (188 aa)
dcd1Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. Belongs to the cytidine and deoxycytidylate deaminase family. (322 aa)
ura6Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa)
SPCC965.14cProbable cytosine deaminase; Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4; Belongs to the cytidine and deoxycytidylate deaminase family. (162 aa)
SPBC3H7.05cUncharacterized membrane protein C3H7.05c. (357 aa)
urk1Uridine kinase; Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway. (454 aa)
iah1Isoamyl acetate-hydrolyzing esterase. (246 aa)
adk1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (220 aa)
tmp1Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. (210 aa)
cdc22Ribonucleoside-diphosphate reductase large chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (811 aa)
suc22Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (391 aa)
ndk1Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (151 aa)
ada1AMP deaminase; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (831 aa)
rds1Protein rds1; May have a function in stress-related responses of the cell. (402 aa)
ado1Adenosine kinase. (340 aa)
hdd1HD domain-containing protein C4G3.17. (198 aa)
azr15-azacytidine resistance protein azr1; Confers azacytidine resistance in high copy. (299 aa)
cdd1Putative cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa)
SPAC13C5.04Putative glutamine amidotransferase-like protein C13C5.04. (248 aa)
SPAC11D3.06Uncharacterized transporter C11D3.06. (455 aa)
toe3Uncharacterized transcriptional regulatory protein PB24D3.01. (594 aa)
uck2Uracil phosphoribosyltransferase 2; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (220 aa)
toe1Uncharacterized transcriptional regulatory protein C1399.05c. (529 aa)
guk1Guanylate kinase; Essential for recycling GMP and indirectly, cGMP; Belongs to the guanylate kinase family. (202 aa)
dea2Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. Also exhibits a low activity towards N(6)- substituted adenines that are commonly known as the plant hormones cytokinins. (367 aa)
urh1Uncharacterized protein C1683.06c. (310 aa)
SPBC1683.05Uncharacterized permease C1683.05. (559 aa)
SPBC1683.02Uncharacterized deaminase C1683.02; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. (339 aa)
dut1Probable deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (140 aa)
gua2GMP synthase [glutamine-hydrolyzing]. (539 aa)
urg1Uracil-regulated protein 1; Belongs to the GTP cyclohydrolase II family. (439 aa)
urg3Protein urg3; Belongs to the URC4/urg3 family. (399 aa)
urg2Putative uracil phosphoribosyltransferase urg2; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate; Belongs to the UPRTase family. (204 aa)
mam301Uncharacterized protein C4B3.03c. (679 aa)
ynd1Golgi apyrase; Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Required for Golgi glycosylation and cell wall integrity. Involved in N-mannosylation of proteins in Golgi. (572 aa)
yfh7Putative uridine kinase C227.14. (235 aa)
SPAC1805.16cPutative purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity). (315 aa)
toe2Uncharacterized transcriptional regulatory protein C139.03. (625 aa)
fap7Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (175 aa)
ham1Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (188 aa)
set7SET domain-containing protein 7; Belongs to the class V-like SAM-binding methyltransferase superfamily. (147 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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