16 items (Schizosaccharomyces pombe) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	cyt2	Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein. (216 aa)
	hem1	5-aminolevulinate synthase, mitochondrial; Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis. (558 aa)
	met8	Siroheme biosynthesis protein met8; Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity); Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. MET8 subfamily. (264 aa)
	hem15	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (423 aa)
	met1	Probable uroporphyrinogen-III C-methyltransferase; Siroheme synthase involved in methionine biosynthesis. Belongs to the precorrin methyltransferase family. (496 aa)
	cyc3	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (377 aa)
	SPCC417.11c	Uncharacterized aminotransferase C417.11c; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (438 aa)
	hem2	Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). (329 aa)
	hem4	Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (251 aa)
	hem3	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (336 aa)
	hem14	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (490 aa)
	ymc1	Uncharacterized mitochondrial carrier C4G9.20c. (298 aa)
	hem12	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa)
	hem13	Probable oxygen-dependent coproporphyrinogen-III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity). (312 aa)
	cox10	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. (387 aa)
	shy1	Cytochrome oxidase assembly protein shy1; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane; Belongs to the SURF1 family. (290 aa)

Your Current Organism:

Schizosaccharomyces pombe

NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPCC417.11c	hem1	O94492	O14092	Uncharacterized aminotransferase C417.11c; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	5-aminolevulinate synthase, mitochondrial; Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.	0.918
SPCC417.11c	hem2	O94492	P78974	Uncharacterized aminotransferase C417.11c; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).	0.953
cox10	cyc3	Q9Y7Y4	O74794	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	0.977
cox10	cyt2	Q9Y7Y4	O13962	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein.	0.977
cox10	hem12	Q9Y7Y4	Q9USJ5	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	0.651
cox10	hem13	Q9Y7Y4	Q9UTE2	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Probable oxygen-dependent coproporphyrinogen-III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity).	0.746
cox10	hem15	Q9Y7Y4	O59786	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.987
cox10	hem2	Q9Y7Y4	P78974	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).	0.581
cox10	hem3	Q9Y7Y4	Q09899	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.	0.594
cox10	hem4	Q9Y7Y4	P87214	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.829
cox10	shy1	Q9Y7Y4	Q9Y810	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Cytochrome oxidase assembly protein shy1; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane; Belongs to the SURF1 family.	0.991
cox10	ymc1	Q9Y7Y4	Q10248	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	Uncharacterized mitochondrial carrier C4G9.20c.	0.497
cyc3	cox10	O74794	Q9Y7Y4	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	0.977
cyc3	cyt2	O74794	O13962	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein.	0.934
cyc3	hem12	O74794	Q9USJ5	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.	0.759
cyc3	hem15	O74794	O59786	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.	0.917
cyc3	shy1	O74794	Q9Y810	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	Cytochrome oxidase assembly protein shy1; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane; Belongs to the SURF1 family.	0.645
cyc3	ymc1	O74794	Q10248	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	Uncharacterized mitochondrial carrier C4G9.20c.	0.477
cyt2	cox10	O13962	Q9Y7Y4	Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein.	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O.	0.977
cyt2	cyc3	O13962	O74794	Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein.	Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	0.934