node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SPCC417.11c | hem1 | O94492 | O14092 | Uncharacterized aminotransferase C417.11c; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 5-aminolevulinate synthase, mitochondrial; Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis. | 0.918 |
SPCC417.11c | hem2 | O94492 | P78974 | Uncharacterized aminotransferase C417.11c; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.953 |
cox10 | cyc3 | Q9Y7Y4 | O74794 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | 0.977 |
cox10 | cyt2 | Q9Y7Y4 | O13962 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein. | 0.977 |
cox10 | hem12 | Q9Y7Y4 | Q9USJ5 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.651 |
cox10 | hem13 | Q9Y7Y4 | Q9UTE2 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Probable oxygen-dependent coproporphyrinogen-III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity). | 0.746 |
cox10 | hem15 | Q9Y7Y4 | O59786 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.987 |
cox10 | hem2 | Q9Y7Y4 | P78974 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). | 0.581 |
cox10 | hem3 | Q9Y7Y4 | Q09899 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.594 |
cox10 | hem4 | Q9Y7Y4 | P87214 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.829 |
cox10 | shy1 | Q9Y7Y4 | Q9Y810 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Cytochrome oxidase assembly protein shy1; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane; Belongs to the SURF1 family. | 0.991 |
cox10 | ymc1 | Q9Y7Y4 | Q10248 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | Uncharacterized mitochondrial carrier C4G9.20c. | 0.497 |
cyc3 | cox10 | O74794 | Q9Y7Y4 | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | 0.977 |
cyc3 | cyt2 | O74794 | O13962 | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein. | 0.934 |
cyc3 | hem12 | O74794 | Q9USJ5 | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.759 |
cyc3 | hem15 | O74794 | O59786 | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.917 |
cyc3 | shy1 | O74794 | Q9Y810 | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Cytochrome oxidase assembly protein shy1; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane; Belongs to the SURF1 family. | 0.645 |
cyc3 | ymc1 | O74794 | Q10248 | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | Uncharacterized mitochondrial carrier C4G9.20c. | 0.477 |
cyt2 | cox10 | O13962 | Q9Y7Y4 | Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein. | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. | 0.977 |
cyt2 | cyc3 | O13962 | O74794 | Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein. | Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. | 0.934 |