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| | orb6 | Serine/threonine-protein kinase orb6; Interacts with pak1/shk1 and coordinates cell morphogenesis with the cell cycle. It is essential for maintenance of cell polarity and is involved in mitotic control. (469 aa) |
| | mei4 | Meiosis-specific transcription factor mei4; Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene. (517 aa) |
| | csx1 | RNA-binding post-transcriptional regulator csx1; Regulates global gene expression after oxidative stress. Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover. (632 aa) |
| | hrk1 | Serine/threonine-protein kinase haspin homolog hrk1; Serine/threonine haspin-like protein kinase involved in cell cycle regulation. Acts in chromosomal passenger complex (CPC) targeting to centromeres by phosphorylating histone H3 at 'Thr3' (H3T3ph). (488 aa) |
| | ppk9 | Protein kinase domain-containing protein ppk9. (532 aa) |
| | mak2 | Peroxide stress-activated histidine kinase mak2; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity. (2310 aa) |
| | ppk11 | Serine/threonine-protein kinase ppk11. (312 aa) |
| | prr1 | Transcription factor prr1; Involved in oxidative stress. Transcription factor that acts upon trr1 and ctt1; In the N-terminal section; belongs to the HSF family. (539 aa) |
| | wis4 | MAP kinase kinase kinase wis4; Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1401 aa) |
| | ksp1 | Serine/threonine-protein kinase ksp1. (474 aa) |
| | SPBC16E9.15 | Uncharacterized protein C16E9.15; Belongs to the HSBP1 family. (75 aa) |
| | scr1 | DNA-binding protein scr1; Involved in carbon catabolite repression. Represses the transcription of various genes including the inv1 gene. Belongs to the creA/MIG C2H2-type zinc-finger protein family. (565 aa) |
| | ppk30 | Serine/threonine-protein kinase ppk30. (953 aa) |
| | ppk25 | Serine/threonine-protein kinase ppk25. (423 aa) |
| | git7 | Glucose-insensitive transcription protein 7; Involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes. (379 aa) |
| | SPBC530.11c | Uncharacterized transcriptional regulatory protein C530.11c. (819 aa) |
| | oca2 | Serine/threonine-protein kinase oca2; Overexpression causes cell cycle arrest. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (650 aa) |
| | ssn6 | General transcriptional corepressor ssn6; Acts as component of the ssn6-tup corepressor complexes, which are involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone dea [...] (1102 aa) |
| | cki3 | Casein kinase I homolog 3; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (439 aa) |
| | win1 | MAP kinase kinase kinase win1; Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation. (1436 aa) |
| | nnk1 | Probable serine/threonine-protein kinase C70.05c. (781 aa) |
| | ssp2 | SNF1-like protein kinase ssp2; Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation. Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes. The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation th [...] (576 aa) |
| | mak3 | Peroxide stress-activated histidine kinase mak3; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity. (2344 aa) |
| | mob2 | Maintenance of ploidy protein mob2; Required for coordinating polarized cell growth during interphase with the onset of mitosis; Belongs to the MOB1/phocein family. (244 aa) |
| | dca7 | Uncharacterized WD repeat-containing protein C17D11.08. (435 aa) |
| | ppk27 | Serine/threonine-protein kinase ppk27. (413 aa) |
| | nak1 | Serine/threonine-protein kinase nak1; Has a role in the regulation of cell polarity, growth and division. (652 aa) |
| | SPBP8B7.26 | Uncharacterized protein P8B7.26. (262 aa) |
| | sog2 | Leucine-rich repeat-containing protein sog2. (886 aa) |
| | git11 | Guanine nucleotide-binding protein subunit gamma; Belongs to the G protein gamma family. (72 aa) |
| | mpr1 | Multistep phosphorelay regulator 1; Binds to the msc4 response regulator which is part of a multistep phosphorelay system that transmits oxidative stress signals to the spc1 MAPK cascade. (295 aa) |
| | ppk31 | Serine/threonine-protein kinase ppk31; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1032 aa) |
| | pet802 | Uncharacterized mitochondrial carrier C1271.11. (258 aa) |
| | SPAC2H10.01 | Uncharacterized transcriptional regulatory protein C2H10.01. (480 aa) |
| | srk1 | Serine/threonine-protein kinase srk1; Has a role in the regulation of meiosis via the sty1 stress- activated MAPK pathway. Inhibits nitrogen-limitation induced arrest at G1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (580 aa) |
| | SPCC1322.09 | Maintenance of telomere capping protein 1; Involved in telomere capping; Belongs to the MTC1 family. (455 aa) |
| | fil1 | GATA zinc finger domain-containing protein C1393.08. (557 aa) |
| | git3 | Glucose receptor protein git3; Activates gpa2 when triggered by glucose and then activates adenylate cyclase; Belongs to the G-protein coupled receptor GPR1/git3 family. (466 aa) |
| | mei3 | 21 kDa protein inducing meiosis and sporulation; This protein, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. It down regulates the ran1/pat1 gene product. (148 aa) |
| | pat1 | Negative regulator of sexual conjugation and meiosis; This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place. (470 aa) |
| | mei2 | Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. (750 aa) |
| | mat1-Mi | Mating-type M-specific polypeptide Mi; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Required for meiosis, but plays no role in conjugation. (42 aa) |
| | mat1-Mc | Mating-type M-specific polypeptide Mc; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Positive regulator of MFM genes. The HMG box recognizes the DNA sequence 5'- AACAAAG-3'. Required for conjugation and efficient meiosis. (181 aa) |
| | byr1 | Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation. (340 aa) |
| | cyr1 | Adenylate cyclase; Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP. (1692 aa) |
| | kin1 | Protein kinase kin1; Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (891 aa) |
| | pyp1 | Tyrosine-protein phosphatase 1; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (550 aa) |
| | gpa1 | Guanine nucleotide-binding protein alpha-1 subunit; Implicated in the mating and sporulation pathway. Probably coupled to mating-factor receptors. May act in concert with Ras1; Belongs to the G-alpha family. G(q) subfamily. (407 aa) |
| | spk1 | Mitogen-activated protein kinase spk1; Involved in mating signal transduction pathway. (372 aa) |
| | byr2 | Protein kinase byr2; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase. (659 aa) |
| | pyp2 | Tyrosine-protein phosphatase 2; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (711 aa) |
| | sxa2 | Carboxypeptidase sxa2; Involved in degradation or processing of the mating pheromones. Its loss causes a persistent response to the pheromones. It may be required for stabilization of enzymes that are essential for zygote formation. May degrade the mating pheromone P-factor. (507 aa) |
| | sxa1 | Aspartic proteinase sxa1; Involved in degradation or processing of the mating pheromones. Its loss may cause a persistent response to the pheromones. It may cleave the mating pheromone M-factor. May be involved in processing of zymogens that are required for zygote formation. (533 aa) |
| | wis1 | Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa) |
| | mfm1 | M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor. (42 aa) |
| | mfm2 | M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor. (44 aa) |
| | cgs2 | 3',5'-cyclic-nucleotide phosphodiesterase. (346 aa) |
| | cgs1 | cAMP-dependent protein kinase regulatory subunit. (412 aa) |
| | pmd1 | Leptomycin B resistance protein pmd1; May be a transmembrane transporter of the mating factor, namely P-factor or M-factor. Confers resistance to leptomycin B and to several other antifungal drugs; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1362 aa) |
| | ste4 | Sexual differentiation protein ste4; Essential for mating and meiosis. (264 aa) |
| | ste11 | Transcription factor ste11; Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'- TTCTTTGTTY-3'. (468 aa) |
| | cki1 | Casein kinase I homolog 1; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. (446 aa) |
| | cki2 | Casein kinase I homolog 2; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology. (435 aa) |
| | hhp1 | Casein kinase I homolog hhp1; Involved in DNA repair. Has a probable role in repairing alkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (365 aa) |
| | hhp2 | Casein kinase I homolog hhp2; Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (400 aa) |
| | ptc1 | Protein phosphatase 2C homolog 1; It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability. (347 aa) |
| | pka1 | cAMP-dependent protein kinase catalytic subunit. (512 aa) |
| | rep1 | Transcriptional activator protein rec16; Transcriptional activator that controls the onset of premeiotic DNA synthesis by regulating res2 and some other factor(s) in a mei2 independent cascade. (472 aa) |
| | mfm3 | M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor. (41 aa) |
| | rad24 | DNA damage checkpoint protein rad24; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. Acts as a negative regulator of meiosis by antagonizing the function of mei2. It inhibits the association of meiRNA (a non-coding RNA molecule required for the nuclear mei2 dot formation) to the phosphorylated but not to the unphosphorylated form of mei2 in vitro. (270 aa) |
| | rad25 | DNA damage checkpoint protein rad25; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. (270 aa) |
| | sak1 | Protein sak1; Positively regulates cyclic AMP-dependent protein kinase- mediated exit from the mitotic cell cycle; Belongs to the RFX family. (766 aa) |
| | ssp1 | Serine/threonine-protein kinase ssp1; Involved in actin localization and thus in polarized cell growth; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (652 aa) |
| | atf1 | Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa) |
| | amk2 | 5'-AMP-activated protein kinase subunit beta; Beta subunit of AMP-activated protein kinase (AMPK), which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source- regulated subcellular location and substrate specificity of the AMPK kinase complex. (298 aa) |
| | ght5 | High-affinity glucose transporter ght5; High-affinity glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (546 aa) |
| | rst2 | Zinc finger protein rst2; Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter. (567 aa) |
| | atf21 | Transcription factor atf21. (355 aa) |
| | mam1 | Mating factor M secretion protein mam1; Required in S.pombe M (minus) cells for production of M- factor pheromone. Involved in the transport of the farnesyl-derivation of the M-factor pheromone; Belongs to the ABC transporter superfamily. Alpha-factor sex pheromone exporter (TC 3.A.1.206) family. (1336 aa) |
| | mcs4 | Response regulator mcs4; Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle. (522 aa) |
| | mam2 | Pheromone P-factor receptor; Receptor for the peptide pheromone P-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; P-factor signaling alone may be sufficient; Belongs to the G-protein coupled receptor 4 family. (348 aa) |
| | gpa2 | Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This protein may be involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of adenylyl cyclase; Belongs to the G-alpha family. (354 aa) |
| | ptc3 | Protein phosphatase 2C homolog 3; Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase. (414 aa) |
| | map2 | P-factor-like 1; In h- cells under nutritional starvation, P-factor induces alteration of cell morphology toward mating, arrest of the cell cycle at the G1 phase prior to the initiation of DNA synthesis and indirect transcriptional activation of the sxa2 gene which down-regulates the signaling pathway. (201 aa) |
| | tup11 | Transcriptional repressor tup11; Transcriptional repressor. (614 aa) |
| | atf31 | Transcription factor atf31. (209 aa) |
| | rgs1 | Regulator of G-protein signaling 1; Negatively regulates pheromone signaling during mating. Acts in a negative feedback loop that is essential for the mating process. This loop acts to down-regulate cellular sensitivity to pheromone. Activated by ste11. (481 aa) |
| | ppk8 | Serine/threonine-protein kinase ppk8. (513 aa) |
| | sds23 | Protein sds23/moc1; Required for normal DNA replication and for proper mitosis. Induces sexual development and ascus formation. Belongs to the SDS23 family. (408 aa) |
| | ppk14 | Serine/threonine-protein kinase ppk14; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily. (566 aa) |
| | pof11 | F-box/WD repeat-containing protein pof11; Has a role in meiosis. (506 aa) |
| | sty1 | Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa) |
| | pcr1 | Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa) |
| | ste7 | Protein ste7; Has a role in promoting meiosis whereby it is involved in establishing the mating pheromone signaling pathway. It also has a role in suppressing meiosis until the conjugation process is complete; Belongs to the arrestin family. (569 aa) |
| | lkh1 | Dual specificity protein kinase lkh1; Protein kinase that may act as a negative regulator of filamentous growth and flocculation. Appears to have a role in normal cell wall and septum formation and in cell separation. May have antagonistic function in the regulation of beta-glucan distribution between the sites for cell wall and septum assembly. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (690 aa) |
| | SPAC3F10.12c | Uncharacterized bHLH domain-containing protein C3F10.12c. (201 aa) |
| | git5 | Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Required for adenylate cyclase activation. (305 aa) |
| | cbs2 | 5'-AMP-activated protein kinase subunit gamma; Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer- term effects via phosphorylation of transcription regulators [...] (334 aa) |
| | gsk3 | Protein kinase gsk3; Interacts with cdc14 which is thought to play a role in the initiation and completion of mitosis. Involved in the positive regulation of mis12. (387 aa) |
| | spo5 | Sporulation-specific protein 5; RNA-binding protein which plays a role in sporulation. Regulates the progression of meiosis I and may function in the vicinity of the Mei2 dot. (567 aa) |
| | ctf8 | Chromosome transmission fidelity protein 8; Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Replication factor C (RFC) complex has an essential but redundant activity in sister chromatid cohesion establishment. An RFC-like complex (ctf18-RFC) is formed where ctf18 replaces rfc1 in the RFC complex along with the association of dcc1 and ctf8. This complex is required for efficient establishment of chromosome cohesion during S-phase. Acts as a PCNA loader, loading PCNA onto primed templates. (109 aa) |
| | SPBC409.08 | Uncharacterized MFS-type transporter SPBC409.08. (552 aa) |
| | mor2 | Cell polarity protein mor2; Required for the maintenance of cell polarity. Has a role in localizing F-actin at the cell tips; To yeast TAO3/PAG1. (2196 aa) |
| | ppk15 | Serine/threonine-protein kinase ppk15. (534 aa) |
| | rsv1 | Zinc finger protein rsv1; Involved in maintaining cell viability under glucose starvation conditions. May have a role in regulating genes involved in gluconeogenesis. (428 aa) |
| | git1 | Adenylate cyclase activation protein git1; Involved in the glucose/cAMP-signaling pathway. Required for maintaining basal cAMP levels and for producing a glucose-triggered cAMP response. (1098 aa) |
| | mak1 | Peroxide stress-activated histidine kinase mak1; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Also has a role in G2/M regulation. (1639 aa) |
| | pmo25 | Mo25-like protein; Belongs to the Mo25 family. (329 aa) |
| | ubc8 | Ubiquitin-conjugating enzyme E2 8; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (184 aa) |
| | gsk31 | Protein kinase gsk31; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. (381 aa) |
| | ppk16 | Serine/threonine-protein kinase ppk16; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (672 aa) |
| | sgt1 | Protein ecdysoneless homolog; Involved in the regulation of carbohydrate metabolism. May act as a transcription factor; Belongs to the ECD family. (590 aa) |
| | skb5 | Shk1 kinase-binding protein 5; Stimulates catalytic function of the p21-activated kinase homolog shk1. (140 aa) |
| | ppk22 | Serine/threonine-protein kinase ppk22. (526 aa) |
| | ppk6 | Serine/threonine-protein kinase ppk6. (775 aa) |
| | ckk2 | Serine/threonine-protein kinase ppk34. (354 aa) |
| | tup12 | Transcriptional repressor tup12; Transcriptional repressor. (598 aa) |
| | SPCC191.10 | Uncharacterized protein C191.10. (149 aa) |
| | rsv2 | Zinc finger protein rsv2. (637 aa) |
