STRINGSTRING
mei4 mei4 csx1 csx1 ssn6 ssn6 mei3 mei3 pat1 pat1 mei2 mei2 ste11 ste11 atf1 atf1 rst2 rst2 atf21 atf21 tup11 tup11 atf31 atf31 sty1 sty1 pcr1 pcr1 lkh1 lkh1 spo5 spo5 rsv1 rsv1 tup12 tup12 SPCC191.10 SPCC191.10 rsv2 rsv2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mei4Meiosis-specific transcription factor mei4; Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene. (517 aa)
csx1RNA-binding post-transcriptional regulator csx1; Regulates global gene expression after oxidative stress. Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover. (632 aa)
ssn6General transcriptional corepressor ssn6; Acts as component of the ssn6-tup corepressor complexes, which are involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone dea [...] (1102 aa)
mei321 kDa protein inducing meiosis and sporulation; This protein, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. It down regulates the ran1/pat1 gene product. (148 aa)
pat1Negative regulator of sexual conjugation and meiosis; This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place. (470 aa)
mei2Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator. (750 aa)
ste11Transcription factor ste11; Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'- TTCTTTGTTY-3'. (468 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
rst2Zinc finger protein rst2; Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter. (567 aa)
atf21Transcription factor atf21. (355 aa)
tup11Transcriptional repressor tup11; Transcriptional repressor. (614 aa)
atf31Transcription factor atf31. (209 aa)
sty1Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
lkh1Dual specificity protein kinase lkh1; Protein kinase that may act as a negative regulator of filamentous growth and flocculation. Appears to have a role in normal cell wall and septum formation and in cell separation. May have antagonistic function in the regulation of beta-glucan distribution between the sites for cell wall and septum assembly. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (690 aa)
spo5Sporulation-specific protein 5; RNA-binding protein which plays a role in sporulation. Regulates the progression of meiosis I and may function in the vicinity of the Mei2 dot. (567 aa)
rsv1Zinc finger protein rsv1; Involved in maintaining cell viability under glucose starvation conditions. May have a role in regulating genes involved in gluconeogenesis. (428 aa)
tup12Transcriptional repressor tup12; Transcriptional repressor. (598 aa)
SPCC191.10Uncharacterized protein C191.10. (149 aa)
rsv2Zinc finger protein rsv2. (637 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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