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| | alp14 | Spindle pole body component alp14; Required for bipolar spindle formation and proper chromosome segregation. Has a role in connecting the kinetochores and the plus end of pole to chromosome microtubules. Also required for the activation of the spindle checkpoint pathway; Belongs to the TOG/XMAP215 family. (809 aa) |
| | csm1 | Monopolin complex subunit pcs1; The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. In contrast to its S.cerevisiae ortholog CSM1, is not required ofr mono-orientation during meiosis I. (261 aa) |
| | smc5 | Structural maintenance of chromosomes protein 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (1076 aa) |
| | sgo2 | Shugoshin-2; Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis. (647 aa) |
| | fin1 | G2-specific protein kinase fin1; Promotes chromosome condensation and nuclear envelope dynamics during mitosis. Activity appears at metaphase-anaphase transition; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. (722 aa) |
| | kap95 | Importin subunit beta-1; Importin beta subunit that functions in nuclear protein import through association with the importin alpha subunit, which binds to the clasical nuclear localization signal (cNLS) in cargo substrates. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by importin beta through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binds to importin beta and the three components separate, lea [...] (863 aa) |
| | sec2 | Rab guanine nucleotide exchange factor sec2; Guanyl-nucleotide exchange factor for ypt2. Catalyzing the dissociation of GDP from ypt2 and promotes the binding of GTP (By similarity). (527 aa) |
| | utp21 | U3 small nucleolar RNA-associated protein 21 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (902 aa) |
| | bir1 | Protein bir1; Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3. (997 aa) |
| | irs4 | Increased rDNA silencing protein 4 homolog; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity). (1379 aa) |
| | mdb1 | DNA damage response protein Mdb1; Involved in DNA damage response (DDR) mediated through its interaction with phosphorylated H2A proteins hta1 and hta2 which mark the discrete foci of DNA damage. (624 aa) |
| | kap104 | Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of [...] (910 aa) |
| | nog2 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (537 aa) |
| | cbc1 | Nuclear cap-binding protein subunit 1; Component of the CBC complex, which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. (780 aa) |
| | spc34 | DASH complex subunit spc34; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. (164 aa) |
| | php4 | CCAAT-binding factor complex subunit php4; Component of the transcription regulatory CCAAT-binding complex. Required for the reprogramming of the cell for iron use. Downregulates pcl1, sdh4, and isa1 underlow-iron conditions. (295 aa) |
| | klp5 | Kinesin-like protein 5; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (883 aa) |
| | mad2 | Mitotic spindle checkpoint component mad2; Feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. It interacts with the anaphase promoting complex/cyclosome (APC/C) thereby inhibiting APC/C-dependent proteolysis, a step required for exit from mitosis. Belongs to the MAD2 family. (203 aa) |
| | cbh1 | CENP-B homolog protein 1; Binds to centromeric K-type repeat DNA and ARS3002 DNA. The CBH-binding consensus sequence is Py-Pu-A-T-A-T-Py-Pu-T-A. (514 aa) |
| | ssm4 | Microtubule-associated protein ssm4; Binds to nuclear microtubules with the effect of either modifying their structure or function. This then promotes meiotic nuclear division. (670 aa) |
| | peg1 | Protein peg1; Microtubule binding protein that regulates the stability of dynamic microtubules. Required for mitotic spindle formation. Belongs to the CLASP family. (1462 aa) |
| | las1 | Pre-rRNA-processing protein las1; Required for both pre-rRNA processing and heterochromatic gene silencing. (470 aa) |
| | SPBC19G7.04 | HMG box-containing protein C19G7.04. (362 aa) |
| | iws1 | Transcription factor iws1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family. (428 aa) |
| | cwf28 | Pre-mRNA-splicing factor cwf28; Involved in spliceosome maturation and the first step of pre- mRNA splicing. (381 aa) |
| | mde4 | Monopolin complex subunit mde4; The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. (421 aa) |
| | klp6 | Kinesin-like protein 6; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (784 aa) |
| | ark1 | Serine/threonine-protein kinase ark1; Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis. (355 aa) |
| | bis1 | Stress response protein bis1; Has a role in maintaining cell viability during stationary phase induced by stress response. May be involved in pre-mRNA splicing; Belongs to the ESS2 family. (384 aa) |
| | utp4 | U3 small nucleolar RNA-associated protein 4; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t- UTPs) (By similarity). (710 aa) |
| | sid4 | Septation initiation protein sid4; Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach. (660 aa) |
| | sof1 | Protein sof1; Required for ribosomal RNA processing. (436 aa) |
| | dnt1 | Nucleolar protein dnt1; Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1. May also have a role in silencing rDNA transcription. Required for maintaining the exclusive nucleolus localization of nuc1. (599 aa) |
| | duo1 | DASH complex subunit duo1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (282 aa) |
| | rpn8 | 26S proteasome regulatory subunit rpn8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. (324 aa) |
| | sec8 | Exocyst complex component sec8; Component of the exocyst complex involved in the delivery of secretory vesicles to the plasma membrane. Also required for polarized cell growth and division septum assembly. The exocyst complex plays an important role in the targeting of rho3, as well as the two main hydrolases required for cell separation, eng1 and agn1, to the cell wall surrounding the septum before cell separation begins. (1073 aa) |
| | mmb1 | Microtubule-associated protein mug164; Involved in the cell polarity process and in regulation of microtubule growth. Has a role in meiosis. (517 aa) |
| | sec6 | Exocyst complex component sec6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (752 aa) |
| | nbl1 | Meiotically up-regulated gene 118 protein; Has a role in meiosis. (141 aa) |
| | rrn11 | RNA polymerase I-specific transcription initiation factor rrn11; Subunit of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I. Binding to the DNA template is dependent on the initial binding of other factors. (200 aa) |
| | utp15 | U3 small nucleolar RNA-associated protein 15; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t- UTPs) (By similarity). (494 aa) |
| | imp1 | Importin subunit alpha-2; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in nuclear protein import. Required for efficient nuclera import of both an SV [...] (539 aa) |
| | snf22 | SWI/SNF chromatin-remodeling complex subunit snf22; Helicase. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. (1680 aa) |
| | mcp1 | Meiotic coiled-coil protein 1. (661 aa) |
| | sfi1 | Protein sfi1; Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication; Belongs to the SFI1 family. (840 aa) |
| | pxd1 | Uncharacterized protein C1322.02. (351 aa) |
| | sqs2 | Meiotically up-regulated protein C1442.13c; Has a role in meiosis and sporulation. Required for meiotic chromosome segregation. (187 aa) |
| | rev1 | DNA repair protein rev1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis (By similarity). (935 aa) |
| | bms1 | Ribosome biogenesis protein bms1; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily. (1121 aa) |
| | nog1 | Probable nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (642 aa) |
| | apm3 | AP-3 complex subunit mu; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity); Belongs to the adaptor complexes medium subunit family. (425 aa) |
| | dbl7 | Uncharacterized protein C651.12c. (273 aa) |
| | spt2 | Protein spt2; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Global regulatory protein that plays positive as well as negative regulatory roles in transcription. Belongs to the SPT2 family. (406 aa) |
| | SPBC1604.16c | Uncharacterized protein C1604.16c. (199 aa) |
| | cdc2 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint. (297 aa) |
| | nda2 | Tubulin alpha-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (455 aa) |
| | atb2 | Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa) |
| | nda3 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa) |
| | mzt1 | Mitotic-spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC). (64 aa) |
| | cdc13 | G2/mitotic-specific cyclin cdc13; Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1. (482 aa) |
| | dhc1 | Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for nuclear movement during meiotic prophase. (4196 aa) |
| | pim1 | Protein pim1; Promotes the exchange of Ran(spi1)-bound GDP by GTP. Involved in the control of mitosis. Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport. (539 aa) |
| | rsv1 | Zinc finger protein rsv1; Involved in maintaining cell viability under glucose starvation conditions. May have a role in regulating genes involved in gluconeogenesis. (428 aa) |
| | sgo1 | Shugoshin-1; Plays a central role in chromosome cohesion during meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting centromeric rec8 from separase degradation during anaphase I. (319 aa) |
| | swc2 | SWR complex protein 2; Participates in the catalytic exchange of histone H2A for the H2A variant pht1, an euchromatin-specific factor, leading to chromatin remodeling and changes in transcription of targeted genes. (316 aa) |
| | ask1 | DASH complex subunit ask1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Plays a role in meiosis. (307 aa) |
| | msd1 | Meiotically up-regulated gene 172 protein; Has a role in meiosis; Belongs to the ADIP family. (331 aa) |
| | cdc48 | Cell division cycle protein 48; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. By recruiting and promoting the degradation of ubiquitinated proteins, plays a role in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum- associated degradation (ERAD) pathway which mediates the cytoplasmic elimination of misfolded proteins exported from the ER. Involved in spindle disassembly. Component of the [...] (815 aa) |
| | cbc2 | Nuclear cap-binding protein subunit 2; Component of the CBC complex, which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. (182 aa) |
| | dam1 | DASH complex subunit dam1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. (155 aa) |
| | ase1 | Anaphase spindle elongation protein 1; Required for anaphase spindle elongation and microtubule bundling in both interphase and mitosis. Has a role in spatial and temporal regulation of septation and cytokinesis and ensures equal partition of segregating sister chromatids. Ensures correct midzone positioning of protein kinase ark1. Acts as a regulatory component at cytokinesis checkpoint where it inhibits nuclear division when actomyosin ring formation is impaired. (731 aa) |
| | wdr8 | Uncharacterized WD repeat-containing protein C32H8.09. (483 aa) |
| | pkl1 | Kinesin-like protein 1; Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (832 aa) |
| | syb1 | Synaptobrevin homolog 1; Involved in membrane trafficking during cytokinesis and cell elongation; Belongs to the synaptobrevin family. (121 aa) |
| | spo7 | Meiotically up-regulated gene 79 protein; Appears to have a role in sporulation. (1318 aa) |
| | nsk1 | Kinetochore protein nsk1; Ensures chromosome alignment and accurate chromosome segregation during mitosis. Promotes proper kinetochore-microtubule (k- MT) interactions during anaphase B. The phosphorylation status of nsk1 affects the proper k-MT coupling, ensuring that it interacts stably only at the correct time during mitosis. (462 aa) |
| | dad4 | DASH complex subunit dad4; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (72 aa) |
| | spc19 | DASH complex subunit spc19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (152 aa) |
| | klp9 | Kinesin-like motor protein 9; Kinesin-like motor protein involved in anaphase B spindle elongation; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (633 aa) |
| | pic1 | Inner centromere protein-related protein pic1; Required for chromosome segregation and cytokinesis. Has a role in sister chromatid cohesion and condensation. (1018 aa) |
| | pab1 | Protein phosphatase PP2A regulatory subunit B; Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates. (463 aa) |
| | rhp41 | DNA repair protein rhp41; Has a role in the nucleotide excision repair (NER) pathway. Acts in both transcription-coupled repair (TCR) which removes damage from the transcribed strand of active genes and in global genome repair (GGR) which removes damage in untranscribed DNA. Involved in the repair of UV-induced damages where it is involved in the removal of cyclobutane pyrimidine dimers (CPDs); Belongs to the XPC family. (638 aa) |
| | par1 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation. (548 aa) |
| | cmr2 | Uncharacterized protein C56F8.02. (1517 aa) |
| | alp1 | Tubulin-folding cofactor D; Has a function in the folding of beta-tubulin. Microtubule- associated protein that is essential to direct polarized cell growth and to position the nucleus and septum to the center of the cell during mitosis. (1105 aa) |
| | mal3 | Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2. Belongs to the MAPRE family. (308 aa) |
| | utp11 | Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (249 aa) |
| | snt2 | Lid2 complex component snt2. (1131 aa) |
| | dis1 | Phosphoprotein p93; Has a role in sister chromatid separation. (882 aa) |
| | pcr1 | Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa) |
| | scd1 | Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes. (872 aa) |
| | prp3 | U4/U5/U6 small nuclear ribonucleoprotein prp3; Participates in pre-mRNA splicing and in nuclear mRNA export. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex. (542 aa) |
| | sad1 | Spindle pole body-associated protein sad1; Associates with the spindle pole body and maintains a functional interface between the nuclear membrane and the microtubule motor proteins. Involved in chromosome segregation during meiosis where it associates with the telomeres. (514 aa) |
| | tgs1 | Trimethylguanosine synthase; Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization. (239 aa) |
| | apm4 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential). (446 aa) |
| | gtb1 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (446 aa) |
| | cph2 | Uncharacterized protein C2F7.07c. (607 aa) |
| | SPBC31F10.17c | Uncharacterized protein C31F10.17c. (135 aa) |
| | dad1 | DASH complex subunit dad1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Mediates interaction between the DASH and sim4 complexes leading to loading of DASH onto the kinetochore. (90 aa) |
| | alp16 | Spindle pole body component alp16; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. (759 aa) |
| | mad1 | Spindle assembly checkpoint component mad1; Central component of the spindle assembly checkpoint. Has a role in the correct positioning of the septum. Required for anchoring mad2 to the nuclear periphery. (689 aa) |
| | tip1 | Tip elongation protein 1; Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2. (461 aa) |
| | slp1 | WD repeat-containing protein slp1; Required for mad2-dependent spindle checkpoint activation. Promotes ubiquitin-dependent degradation of cdc13 by the anaphase promoting complex/cyclosome (APC/C). (488 aa) |
| | dad3 | DASH complex subunit dad3; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (86 aa) |
| | exo1 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. (571 aa) |
| | plo1 | Serine/threonine-protein kinase plo1; Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division. Together with moa1, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromer [...] (683 aa) |
| | shk1 | Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (658 aa) |
| | rad24 | DNA damage checkpoint protein rad24; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. Acts as a negative regulator of meiosis by antagonizing the function of mei2. It inhibits the association of meiRNA (a non-coding RNA molecule required for the nuclear mei2 dot formation) to the phosphorylated but not to the unphosphorylated form of mei2 in vitro. (270 aa) |
| | rad54 | DNA repair protein rhp54; Involved in DNA repair. May have a role in the processing of replication structures during late replication that is different from its role in the repair of radiation damage; Belongs to the SNF2/RAD54 helicase family. (852 aa) |
| | rad4 | S-M checkpoint control protein rad4; Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer for establishing the DNA checkpoint. (648 aa) |
| | fib1 | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification [...] (305 aa) |
| | rec8 | Meiotic recombination protein rec8; Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation. Belongs to the rad21 family. (561 aa) |
| | cka1 | Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Plays a role in the translation of cell polarity into polarized growth. The alpha and alpha' chains contain the catalytic site. (332 aa) |
| | ypt3 | GTP-binding protein ypt3; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in the secretory pathway where it has a role in acid phosphatase secretion; Belongs to the small GTPase superfamily. Rab family. (214 aa) |
| | cut1 | Separin; Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the rad21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/cut2 protein. It is also required for pointed nuclear formation. (1828 aa) |
| | cut2 | Securin; Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks separase/cut1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of cut1. (301 aa) |
| | cut7 | Kinesin-like protein cut7; Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation. (1085 aa) |
| | mex67 | mRNA export factor mex67; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family. (596 aa) |
| | alp4 | Spindle pole body component alp4; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. Required for correct septation; Belongs to the TUBGCP family. (784 aa) |
| | dlc1 | Dynein light chain Tctex-type; Acts as a non-catalytic accessory component of a dynein complex. (111 aa) |
| | toe2 | Uncharacterized transcriptional regulatory protein C139.03. (625 aa) |
| | dad2 | DASH complex subunit dad2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (94 aa) |
| | pex8 | Uncharacterized protein C323.03c. (575 aa) |
| | cdh1 | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (307 aa) |
| | alp6 | Spindle pole body component alp6; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles; Belongs to the TUBGCP family. (832 aa) |
| | klf1 | Zinc finger protein klf1; Required for maintaining cell viability in nitrogen-deficient stationary phase (G0) cells. (781 aa) |
| | klp2 | Kinesin-like protein 2; Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle. Required for the polarization of interphase microtubules where it orients the microtubule plus ends toward the cell ends and the minus ends toward the cell center. Mediates minus end-directed sliding of cytoplasmic microtubules relative to each other, thereby promoting mitotic spindle disassembly. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (817 aa) |
| | alp7 | Microtubule protein alp7; Required for bipolar spindle formation and proper chromosome segregation. Has an indirect role in connecting the kinetochores and the plus end of pole to chromosome microtubules by targeting alp14 to the spindle pole body. Involved in the emergence of large microtubule organizing centers (MTOC) in interphase cells. Attaches to the minus ends of microtubules and associates with the sites of microtubule attachment on the nuclear envelope. This leads to the stabilzation of the microtubule bundles. (474 aa) |
| | gfh1 | Gamma-tubulin complex component gfh1; Required for proper anchoring of astral microtubules at the spindle pole bodies (SPBs), during anaphase, ensuring correct cell polarity; Belongs to the TUBGCP family. (577 aa) |
| | clp1 | Tyrosine-protein phosphatase CDC14 homolog; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase cdc2, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintaine [...] (537 aa) |
