Your Input: | |
| | ase1 | Anaphase spindle elongation protein 1; Required for anaphase spindle elongation and microtubule bundling in both interphase and mitosis. Has a role in spatial and temporal regulation of septation and cytokinesis and ensures equal partition of segregating sister chromatids. Ensures correct midzone positioning of protein kinase ark1. Acts as a regulatory component at cytokinesis checkpoint where it inhibits nuclear division when actomyosin ring formation is impaired. (731 aa) |
| | dhc1 | Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for nuclear movement during meiotic prophase. (4196 aa) |
| | rsp1 | DnaJ-related protein rsp1; Has a role in the proper organization of the interphase microtubule cytoskeleton. Required for equatorial microtubule organizing center (eMTOC) disassembly into satellites, contributing to the dynamic redistribution of MTOC components for organization of interphase microtubules. (494 aa) |
| | bir1 | Protein bir1; Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3. (997 aa) |
| | spc34 | DASH complex subunit spc34; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. (164 aa) |
| | klp5 | Kinesin-like protein 5; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (883 aa) |
| | mad2 | Mitotic spindle checkpoint component mad2; Feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. It interacts with the anaphase promoting complex/cyclosome (APC/C) thereby inhibiting APC/C-dependent proteolysis, a step required for exit from mitosis. Belongs to the MAD2 family. (203 aa) |
| | fta1 | Inner kinetochore subunit fta1; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (280 aa) |
| | ssm4 | Microtubule-associated protein ssm4; Binds to nuclear microtubules with the effect of either modifying their structure or function. This then promotes meiotic nuclear division. (670 aa) |
| | peg1 | Protein peg1; Microtubule binding protein that regulates the stability of dynamic microtubules. Required for mitotic spindle formation. Belongs to the CLASP family. (1462 aa) |
| | klp6 | Kinesin-like protein 6; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (784 aa) |
| | ark1 | Serine/threonine-protein kinase ark1; Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis. (355 aa) |
| | bis1 | Stress response protein bis1; Has a role in maintaining cell viability during stationary phase induced by stress response. May be involved in pre-mRNA splicing; Belongs to the ESS2 family. (384 aa) |
| | tea4 | Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] (821 aa) |
| | nud3 | Nuclear movement protein nudc; Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase (By similarity). Belongs to the nudC family. (166 aa) |
| | duo1 | DASH complex subunit duo1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (282 aa) |
| | mmb1 | Microtubule-associated protein mug164; Involved in the cell polarity process and in regulation of microtubule growth. Has a role in meiosis. (517 aa) |
| | fta7 | Inner kinetochore subunit fta7; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (244 aa) |
| | fta3 | Inner kinetochore subunit fta3; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere. (220 aa) |
| | mcp1 | Meiotic coiled-coil protein 1. (661 aa) |
| | mto1 | Microtubule organizer protein 1; Required for cytoplasmic astral microtubule growth during mitosis. Involved in localizing components of the gamma-tubulin complex to the non-spindle pole body (non-SPB) microtubule organizing centers (MTOCs). Required for new microtubule nucleation from non-SPB sites during interphase. (1115 aa) |
| | alp14 | Spindle pole body component alp14; Required for bipolar spindle formation and proper chromosome segregation. Has a role in connecting the kinetochores and the plus end of pole to chromosome microtubules. Also required for the activation of the spindle checkpoint pathway; Belongs to the TOG/XMAP215 family. (809 aa) |
| | mug184 | Meiotically up-regulated gene 184 protein; Has a role in sporulation. (551 aa) |
| | arp1 | Centractin; Core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. Arp1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. Required for proper orientation of the mitotic spindle (By similarity). (379 aa) |
| | fta4 | Inner kinetochore subunit fta4; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere. (233 aa) |
| | nda2 | Tubulin alpha-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (455 aa) |
| | atb2 | Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa) |
| | nda3 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa) |
| | cut7 | Kinesin-like protein cut7; Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation. (1085 aa) |
| | gtb1 | Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. (446 aa) |
| | shk1 | Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (658 aa) |
| | dad3 | DASH complex subunit dad3; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity). (86 aa) |
| | tip1 | Tip elongation protein 1; Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2. (461 aa) |
| | tea1 | Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex. (1147 aa) |
| | alp16 | Spindle pole body component alp16; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. (759 aa) |
| | dad1 | DASH complex subunit dad1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Mediates interaction between the DASH and sim4 complexes leading to loading of DASH onto the kinetochore. (90 aa) |
| | msp1 | Protein msp1, mitochondrial; Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane (By similarity). (903 aa) |
| | dnm1 | Dynamin-related protein dnm1; Microtubule-associated force-producing protein that mediates mitochondrial fission during interphasic growth and at cell division. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. With vps1, acts redundantly in peroxisome biogenesis, which is under cell cycle control. (781 aa) |
| | alp41 | ADP-ribosylation factor-like protein alp41; Has a role in the cofactor-dependent pathway of microtubule biogenesis. Required for growth polarity control. Belongs to the small GTPase superfamily. Arf family. (186 aa) |
| | sad1 | Spindle pole body-associated protein sad1; Associates with the spindle pole body and maintains a functional interface between the nuclear membrane and the microtubule motor proteins. Involved in chromosome segregation during meiosis where it associates with the telomeres. (514 aa) |
| | dis1 | Phosphoprotein p93; Has a role in sister chromatid separation. (882 aa) |
| | mal3 | Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2. Belongs to the MAPRE family. (308 aa) |
| | alp1 | Tubulin-folding cofactor D; Has a function in the folding of beta-tubulin. Microtubule- associated protein that is essential to direct polarized cell growth and to position the nucleus and septum to the center of the cell during mitosis. (1105 aa) |
| | alp11 | Cell polarity protein alp11; Required for microtubule function and cell polarity. Involved in the proper folding of alpha-tubulin. (234 aa) |
| | alp21 | Cell polarity protein alp21; Required for microtubule and spindle assembly. Involved in the proper folding of alpha-tubulin. (511 aa) |
| | tea2 | Kinesin-like protein tea2; Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (628 aa) |
| | klp9 | Kinesin-like motor protein 9; Kinesin-like motor protein involved in anaphase B spindle elongation; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (633 aa) |
| | spc19 | DASH complex subunit spc19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (152 aa) |
| | dad4 | DASH complex subunit dad4; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (72 aa) |
| | pkl1 | Kinesin-like protein 1; Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (832 aa) |
| | dam1 | DASH complex subunit dam1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. (155 aa) |
| | tbc1 | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family. (259 aa) |
| | dli1 | Dynein intermediate light chain dil1; Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Promotes oscillatory nuclear movement and efficient pairing of homologous centromeres during meiotic prophase. Belongs to the dynein light intermediate chain DYN3 family. (360 aa) |
| | ask1 | DASH complex subunit ask1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Plays a role in meiosis. (307 aa) |
| | gfh1 | Gamma-tubulin complex component gfh1; Required for proper anchoring of astral microtubules at the spindle pole bodies (SPBs), during anaphase, ensuring correct cell polarity; Belongs to the TUBGCP family. (577 aa) |
| | dlc2 | Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). (85 aa) |
| | alp7 | Microtubule protein alp7; Required for bipolar spindle formation and proper chromosome segregation. Has an indirect role in connecting the kinetochores and the plus end of pole to chromosome microtubules by targeting alp14 to the spindle pole body. Involved in the emergence of large microtubule organizing centers (MTOC) in interphase cells. Attaches to the minus ends of microtubules and associates with the sites of microtubule attachment on the nuclear envelope. This leads to the stabilzation of the microtubule bundles. (474 aa) |
| | vps1 | Vacuolar protein sorting-associated protein 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (678 aa) |
| | klp2 | Kinesin-like protein 2; Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle. Required for the polarization of interphase microtubules where it orients the microtubule plus ends toward the cell ends and the minus ends toward the cell center. Mediates minus end-directed sliding of cytoplasmic microtubules relative to each other, thereby promoting mitotic spindle disassembly. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily. (817 aa) |
| | fta2 | Inner kinetochore subunit fta2; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Ft [...] (351 aa) |
| | klp3 | Kinesin-like protein 3; Cytoplasmic motor that could play a role in Golgi membrane recycling; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (554 aa) |
| | mto2 | Uncharacterized protein C902.06. (397 aa) |
| | alp6 | Spindle pole body component alp6; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles; Belongs to the TUBGCP family. (832 aa) |
| | mod21 | Gamma-tubulin complex subunit mod21; Component of the gamma-tubulin complex that is required for the regulation of both interphase microtubule organization and nucleation, and mitotic bipolar spindles. Required for correct septation. (677 aa) |
| | dad2 | DASH complex subunit dad2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. May be necessary for growth under high osmotic stress. (94 aa) |
| | klp8 | Kinesin-like protein 8. (511 aa) |
| | fta6 | Inner kinetochore subunit fta6; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (59 aa) |
| | dlc1 | Dynein light chain Tctex-type; Acts as a non-catalytic accessory component of a dynein complex. (111 aa) |
| | alp31 | Tubulin-specific chaperone A; Required for the maintenance of microtubule structures and cell polarity. Beta-tubulin-folding protein; may have a regulatory role in the tubulin-folding pathway. (119 aa) |
| | alp4 | Spindle pole body component alp4; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles. Required for correct septation; Belongs to the TUBGCP family. (784 aa) |
