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| | adl1 | DNA ligase 3; Belongs to the ATP-dependent DNA ligase family. (774 aa) |
| | fml2 | Putative ATP-dependent DNA helicase fml2; Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (783 aa) |
| | pds5 | Sister chromatid cohesion protein pds5; Required for the establishment and maintenance of sister chromatid cohesion during S phase. Prevents their formation until eso1 is present. May also have a role during meiosis. (1205 aa) |
| | pku80 | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (695 aa) |
| | rev3 | DNA polymerase zeta catalytic subunit; Nonessential DNA polymerase. Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites (By similarity). (1480 aa) |
| | slx4 | Structure-specific endonuclease subunit slx4; Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for stem-loop (SL) and splayed arm Y structures. Introduces a single-strand cut in duplex DNA on the 3' side of a double-strand/single-strand junction with respect to the single-strand moving 3' to 5' away from the junction. Plays a critic [...] (419 aa) |
| | wss1 | DNA-dependent metalloprotease WSS1 homolog; Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (top1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped top1 from chromatin. DPC proteolysis enables the repair of the lesions via do [...] (283 aa) |
| | sld5 | DNA replication complex GINS protein sld5; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation and is required for bir1 localization. (214 aa) |
| | xlf1 | Xrcc4-like factor 1; Involved in non-homologous end joining (NHEJ) in the repair of double-strand DNA breaks (DSB). Has a role in meiosis. Belongs to the XLF family. (203 aa) |
| | slx1 | Structure-specific endonuclease subunit slx1; Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for stem-loop (SL) and splayed arm Y structures. Introduces a single-strand cut in duplex DNA on the 3' side of a double-strand/single-strand junction with respect to the single-strand moving 3' to 5' away from the junction. Plays a critica [...] (271 aa) |
| | lub1 | Ubiquitin homeostasis protein lub1; Acts as a negative regulator of vacuole-dependent ubiquitin degradation. (718 aa) |
| | psf2 | DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation and is required for bir1 localization. (183 aa) |
| | pku70 | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. R [...] (607 aa) |
| | mst1 | Histone acetyltransferase mst1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on [...] (463 aa) |
| | rfc4 | Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (342 aa) |
| | pli1 | E3 SUMO-protein ligase pli1; Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats. Belongs to the PIAS family. (727 aa) |
| | mag2 | Probable DNA-3-methyladenine glycosylase 2; Involved in base excision repair of methyl methanesulfonate- damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions. (213 aa) |
| | rsc7 | Chromatin structure-remodeling complex subunit rsc7; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (390 aa) |
| | pob3 | FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (512 aa) |
| | pxd1 | Uncharacterized protein C1322.02. (351 aa) |
| | fum1 | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate. Belongs to the class-II fumarase/aspartase famil [...] (520 aa) |
| | wss2 | Ubiquitin and WLM domain-containing metalloprotease SPCC1442.07c. (282 aa) |
| | rev1 | DNA repair protein rev1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis (By similarity). (935 aa) |
| | sir2 | NAD-dependent histone deacetylase sir2; Involved in silencing within the mating-type region, at the telomeres, and according to also within centromeric DNA regions. Required for the localization of swi6 to the telomeres, silent mating type region, and according to to the centromeric DNA regions. According to not required for the localization of swi6 to centromeric foci. Deacetylates histone H3 on 'Lys-9' and 'Lys-16' of histone H4. This has a direct role in heterochromatin assembly; Belongs to the sirtuin family. Class I subfamily. (475 aa) |
| | nse5 | Non-structural maintenance of chromosome element 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. May prevent formation of excessive Holliday junctions or assist in their resolution. (388 aa) |
| | pmh1 | RNA polymerase II transcription factor B subunit 3; Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity). (318 aa) |
| | rvb2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (465 aa) |
| | rfc5 | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (358 aa) |
| | iec3 | INO80 complex subunit 3; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (168 aa) |
| | hta1 | Histone H2A-alpha; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (132 aa) |
| | hta2 | Histone H2A-beta; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa) |
| | cdc17 | DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. (768 aa) |
| | rad1 | DNA damage checkpoint control protein rad1; Recombinational reparation of DNA damages induced by UV and gamma radiation. (323 aa) |
| | rhp6 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity). Required for obr1 ubiquitination, whi [...] (151 aa) |
| | rad9 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. Repressor of entry into mitosis that is activated by chromosome breaks. (426 aa) |
| | msh3 | DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (993 aa) |
| | rad15 | General transcription and DNA repair factor IIH helicase subunit XPD; ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/rad15 is required for DNA opening. [...] (772 aa) |
| | pol1 | DNA polymerase alpha catalytic subunit; Polymerase alpha in a complex with DNA primase is a replicative polymerase; Belongs to the DNA polymerase type-B family. (1405 aa) |
| | rad13 | DNA repair protein rad13; Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair (Probable). (1112 aa) |
| | mcm4 | DNA replication licensing factor mcm4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (931 aa) |
| | cdc27 | DNA polymerase delta subunit 3. (372 aa) |
| | cdc6 | DNA polymerase delta catalytic subunit; Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Belongs to the DNA polymerase type-B family. (1086 aa) |
| | mcm3 | DNA replication licensing factor mcm3; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (879 aa) |
| | rad21 | Cohesin subunit rad21; Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by cut1 and dissociates from chromatin, allowing sister chromatids to segregate. Also involved in the DNA double-strand-break (DSB) repair system. (628 aa) |
| | rad52 | DNA repair and recombination protein rad22; Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion; Belongs to the RAD52 family. (469 aa) |
| | rad51 | DNA repair protein rhp51; Required both for recombination and for the repair of DNA damage caused by X-rays. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical nucleoprotein filaments. Belongs to the RecA family. RAD51 subfamily. (365 aa) |
| | rad8 | DNA repair protein rad8; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats (By similarity). Plays a role in surviving topoisomerase-mediated DNA damage. (1133 aa) |
| | rad16 | DNA repair protein rad16; Endonuclease that specifically degrades single-stranded DNA and which is involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Required for double strand break-induced interchromosomal gene conversion. Belongs to the XPF family. (877 aa) |
| | rec8 | Meiotic recombination protein rec8; Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation. Belongs to the rad21 family. (561 aa) |
| | rad2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | hhp1 | Casein kinase I homolog hhp1; Involved in DNA repair. Has a probable role in repairing alkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (365 aa) |
| | hhp2 | Casein kinase I homolog hhp2; Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. (400 aa) |
| | mcm2 | DNA replication licensing factor mcm2; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (830 aa) |
| | rec12 | Meiotic recombination protein rec12; Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II. (345 aa) |
| | hus5 | SUMO-conjugating enzyme ubc9; Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins. Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis. This may be as part of a checkpoint independent recovery process; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | mcm5 | DNA replication licensing factor mcm5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa) |
| | rad54 | DNA repair protein rhp54; Involved in DNA repair. May have a role in the processing of replication structures during late replication that is different from its role in the repair of radiation damage; Belongs to the SNF2/RAD54 helicase family. (852 aa) |
| | mcm6 | DNA replication licensing factor mcm6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (892 aa) |
| | apn1 | DNA-(apurinic or apyrimidinic site) lyase 1; DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. Provides back-up AP endonuclease (APE) activity to apn2 together with uve1. (342 aa) |
| | rad17 | Checkpoint protein rad17; Participates in checkpoint pathways arrest of the cell cycle. A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. (606 aa) |
| | hsk1 | Cell cycle serine/threonine-protein kinase hsk1; Required for G1/S transition. Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1. Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21. Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19. Required for genome integrity; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. (507 aa) |
| | smc6 | Structural maintenance of chromosomes protein 6; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the SMC family. SMC6 subfamily. (1140 aa) |
| | exo1 | Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. (571 aa) |
| | pms1 | DNA mismatch repair protein pms1; This protein is involved in the repair of mismatches in DNA. (794 aa) |
| | ddr48 | Uncharacterized protein C23H3.15c. (325 aa) |
| | hus1 | Checkpoint protein hus1; Essential in controlling the S-M checkpoint that couples mitosis to the completion of DNA replication. It is also required for the response to DNA damage. (287 aa) |
| | rhp16 | ATP-dependent helicase rhp16; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation. Belongs to the SNF2/RAD54 helicase family. (861 aa) |
| | nhp6 | Non-histone chromosomal protein 6; DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity). (108 aa) |
| | cdc20 | DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2199 aa) |
| | apn2 | DNA-(apurinic or apyrimidinic site) lyase 2; DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. Provides the majority of the AP-endonuclease (APE) activity. Repairs phleomycin D1-induced DNA damage. Plays a role in oxidative damage repair; Belongs to the DNA repair enzymes AP/ExoA family. (523 aa) |
| | mus81 | Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI). Belongs to the XPF family. (608 aa) |
| | rhp42 | DNA repair protein rhp42; Has a role in the nucleotide excision repair (NER) pathway. Acts in both transcription-coupled repair (TCR) which removes damage from the transcribed strand of active genes and in global genome repair (GGR) which removes damage in untranscribed DNA. Involved in the repair of short-patch mismatch during meiosis; Belongs to the XPC family. (686 aa) |
| | tfb2 | General transcription and DNA repair factor IIH subunit tfb2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (447 aa) |
| | cdc1 | DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression. (462 aa) |
| | rad3 | Protein kinase rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication ; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2386 aa) |
| | pcn1 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | swi10 | Mating-type switching protein swi10; Involved in termination of copy-synthesis during mating-type switching. Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD16 forms an endonuclease that specifically degrades single-stranded DNA; Belongs to the ERCC1/RAD10/SWI10 family. (252 aa) |
| | mre11 | DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family. (649 aa) |
| | pol4 | DNA polymerase type-X family protein pol4; Repair polymerase. Involved in gap-filling in DNA non- homologous end joining (NHEJ) required for double-strand break repair. Can incorporate a ribonucleotide (rNTP) into a primer DNA. Belongs to the DNA polymerase type-X family. (506 aa) |
| | SPAC12G12.16c | Uncharacterized protein C12G12.16c. (496 aa) |
| | mis4 | Sister chromatid cohesion protein mis4; Plays a structural role in chromatin. Chromatid cohesion molecule required for equal sister chromatid separation in anaphase. May form a stable link between chromatids in S phase that is split rather than removed in anaphase. Also required for spindle-kinetochore interaction in early mitosis and inhibit sister chromatid separation until the cleavage of Rad21 in anaphase; Belongs to the SCC2/Nipped-B family. (1587 aa) |
| | bun107 | UBP9-binding protein bun107; Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations. (962 aa) |
| | rdh54 | Meiotic recombination protein rdh54; Acts with rhp54 to repair meiotic double strand breaks via homologous recombination. Involved in meiotic DNA recombination. Belongs to the SNF2/RAD54 helicase family. (811 aa) |
| | rqh1 | ATP-dependent DNA helicase hus2/rqh1; Has a role in the repair of UV-induced DNA damage in G2 via recombination-mediated repair. Also has a role in the repair of infrared-induced double DNA strand breaks. Exhibits an ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction; Belongs to the helicase family. RecQ subfamily. (1328 aa) |
| | rfc2 | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 2 binds ATP and single-stranded DNA. (340 aa) |
| | arp42 | SWI/SNF and RSC complexes subunit arp42; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindi [...] (424 aa) |
| | nth1 | Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8- dihydroguanine (8-oxoG) DNA glycosylas [...] (355 aa) |
| | rsc4 | Chromatin structure-remodeling complex subunit rsc4; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (542 aa) |
| | rev7 | DNA polymerase zeta processivity subunit; Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites (By similarity). (213 aa) |
| | tra2 | Uncharacterized PI3/PI4-kinase family protein C1F5.11c; Belongs to the PI3/PI4-kinase family. (3655 aa) |
| | mms1 | Uncharacterized protein C3H8.05c. (1073 aa) |
| | myh1 | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. Has glycosylase and nicking activities and is active at A/G and A/GO sites. (461 aa) |
| | rmi1 | RecQ-mediated genome instability protein 1; Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with top3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response; Belongs to the RMI1 family. (235 aa) |
| | srs2 | ATP-dependent DNA helicase srs2; ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks. Belongs to the helicase family. UvrD subfamily. (887 aa) |
| | rnh201 | Ribonuclease H2 subunit A; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication. (326 aa) |
| | cmb1 | Mismatch-binding protein cmb1; Binds to cytosines in base mismatches and opposite chemically altered guanines. (223 aa) |
| | pso2 | DNA cross-link repair protein pso2/snm1; Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein may have 5' exonuclease activity on single- stranded and double-stranded DNA, which could be necessary for the processing of DNA double strand breaks prior to religation. (560 aa) |
| | yaf9 | Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity). (217 aa) |
| | rhp1602 | Uncharacterized ATP-dependent helicase C582.10c. (830 aa) |
| | brc1 | BRCT-containing protein 1; Required for mitotic fidelity, specifically in the G2 phase of the cell cycle. Plays a role in chromatin organization. (878 aa) |
| | SPAC1F12.06c | Putative endonuclease C1F12.06c. (252 aa) |
| | rsc58 | Chromatin structure-remodeling complex subunit rsc58; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (403 aa) |
| | rik1 | Chromatin modification-related protein rik1; Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Rik1 has also a function in meiotic telomere clustering. (1040 aa) |
| | rhp41 | DNA repair protein rhp41; Has a role in the nucleotide excision repair (NER) pathway. Acts in both transcription-coupled repair (TCR) which removes damage from the transcribed strand of active genes and in global genome repair (GGR) which removes damage in untranscribed DNA. Involved in the repair of UV-induced damages where it is involved in the removal of cyclobutane pyrimidine dimers (CPDs); Belongs to the XPC family. (638 aa) |
| | uve1 | UV-damage endonuclease; Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway. Functions also in oxidative damage repair in vivo. Provides back-up AP endonuclease activity to apn2 together with apn1. Belongs to the uve1/UvsE family. (599 aa) |
| | nse2 | E3 SUMO-protein ligase nse2; Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the NSE2 family. (250 aa) |
| | nse1 | Non-structural maintenance of chromosomes element 1; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (232 aa) |
| | nse4 | Non-structural maintenance of chromosome element 4; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the NSE4 family. (300 aa) |
| | xrc4 | Uncharacterized protein C6G9.16c. (264 aa) |
| | ssb1 | Replication factor A protein 1; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism; Belongs to the replication factor A protein 1 family. (609 aa) |
| | ssb2 | Replication factor A protein 2; Binds to single-stranded sequences; Belongs to the replication factor A protein 2 family. (279 aa) |
| | ssb3 | Replication factor A protein 3; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (104 aa) |
| | mag1 | DNA-3-methyladenine glycosylase 1; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions. Can release ethylated and propylated bases from DNA in addition to 3-methyladenine; Belongs to the alkylbase DNA glycosidase AlkA family. (228 aa) |
| | rvb1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (456 aa) |
| | eme1 | Crossover junction endonuclease eme1; Interacts with mus81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI). Belongs to the EME1/MMS4 family. (735 aa) |
| | mcl1 | Minichromosome loss protein 1; Has a role in regulating DNA replication complexes. Acts as a regulator of post DNA replication initiation. Associates with chromatin during G1 and S phases of mitosis. Required for the transcriptional repression of the outer repeats of the centromeric region. Acts as a polymerase alpha replication accessory factor and is important for S- phase DNA damage survival. Plays a role in lagging-strand synthesis and Ozaki fragment processing, in addition to DNA repair. (815 aa) |
| | tfb5 | General transcription and DNA repair factor IIH subunit tfb5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (68 aa) |
| | iec5 | INO80 complex subunit 5; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (144 aa) |
| | sws1 | Zinc finger SWIM domain-containing protein sws1; Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. (209 aa) |
| | ubc13 | Ubiquitin-conjugating enzyme E2 13; Has a role in the DNA error-free postreplication repair (PRR) pathway. The ubc13/spm2 heterodimer catalyzes the synthesis of non- canonical poly-ubiquitin chains that are linked through 'Lys-63'. Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | nse6 | Non-structural maintenance of chromosome element 6; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. May prevent formation of excessive Holliday junctions or assist in their resolution. (522 aa) |
| | smc5 | Structural maintenance of chromosomes protein 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (1076 aa) |
| | tfb1 | General transcription and DNA repair factor IIH subunit tfb1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (533 aa) |
| | rrp1 | Uncharacterized ATP-dependent helicase C17A2.12. (897 aa) |
| | ptr8 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ptr8, but not its helicase activity, is required f [...] (804 aa) |
| | ssr1 | SWI/SNF and RSC complexes subunit ssr1; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...] (527 aa) |
| | rdl1 | DNA repair protein rdl1; Involved in homologous recombination where it functions at an early stage of recombination in a pre-recombinogenic complex with rlp1 and sws1. Also has a role at a later stage of recombination in association with the rhp55-rhp57 complex. (230 aa) |
| | ddb1 | DNA damage-binding protein 1; Component of an E3 ubiquitin-protein ligase that includes cul4 (By similarity). Required for ubiquitination and the subsequent degradation of the DNA replication licensing factor cdt1 and of the ribonucleotide reductase inhibitor spd1. Also required for transcription-coupled nucleotide excision repair. (1072 aa) |
| | rfp1 | E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. Has a role in meiosis. (254 aa) |
| | pnk1 | Bifunctional polynucleotide phosphatase/kinase; Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA; In the N-terminal section; belongs to the DNA 3' phosphatase family. (408 aa) |
| | msh1 | MutS protein homolog 1; Involved in mitochondrial DNA repair; Belongs to the DNA mismatch repair MutS family. (941 aa) |
| | alp13 | Chromatin modification-related protein eaf3; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Also involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains; Belongs to the MRG family. (337 aa) |
| | hrq1 | ATP-dependent helicase hrq1; Helicase with 3'-5' helicase activity involved in genome stability. Functions in the nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair. Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (By similarity). Shows both processive helicase and DNA strand annealing activities (By similarity). Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding [...] (1063 aa) |
| | mgs1 | ATPase WRNIP1 homolog C26H5.02c; Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity); Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. (504 aa) |
| | rfc3 | Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 3 binds ATP. Also involved in replication and DNA damage checkpoint controls, probably functioning as a checkpoint sensor. (342 aa) |
| | prp19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair. Belongs to the WD repeat PRP19 family. (488 aa) |
| | ast1 | Asteroid homolog 1. (519 aa) |
| | cul4 | Cullin-4; Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochroma [...] (734 aa) |
| | rad55 | DNA repair protein rhp55; Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways. (350 aa) |
| | rpn15 | 26S proteasome complex subunit rpn15; Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Acts as a ubiquitin receptor of the 26S proteasome, by interacting with ubiquitin chains linked by 'Lys-63' and 'Lys-48'. Involved in nuclear export of specific sets of mRNAs. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC). Involved in recombinational repair of DNA. Plays a critical role in linking [...] (71 aa) |
| | chl1 | ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (844 aa) |
| | ino80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1604 aa) |
| | mus7 | Protein mms22; Involved in protection against replication-dependent DNA damage. May act by restoring active replication forks, repairing unusual DNA structures, and/or preventing aberrant DNA rearrangement at arrested replication forks; Belongs to the MMS22 family. (1888 aa) |
| | ies2 | INO80 complex subunit 2; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (295 aa) |
| | drc1 | DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint; Belongs to the SLD2 family. (337 aa) |
| | eaf6 | Chromatin modification-related protein eaf6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. (138 aa) |
| | swc4 | SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (437 aa) |
| | mgm101 | Mitochondrial genome maintenance protein mgm101; Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity); Belongs to the MGM101 family. (270 aa) |
| | ssr2 | SWI/SNF and RSC complexes subunit ssr2; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...] (503 aa) |
| | dmc1 | Meiotic recombination protein dmc1; Required for meiotic recombination and cell cycle progression. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments. Belongs to the RecA family. DMC1 subfamily. (332 aa) |
| | nht1 | HMG box-containing protein C10F6.08c. (341 aa) |
| | png1 | Chromatin modification-related protein png1; Component of a histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes. (283 aa) |
| | rti1 | DNA repair and recombination protein rti1; Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion. (371 aa) |
| | eso1 | N-acetyltransferase eso1; Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. The relevance of acetyltransferase function remains unclear (By similarity). In the N-terminal section; belongs to the DNA polymerase type-Y family. (872 aa) |
| | eaf7 | Probable chromatin modification-related protein eaf7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (272 aa) |
| | def1 | CUE domain-containing protein C354.10. (963 aa) |
| | nbs1 | DNA repair and telomere maintenance protein nbs1; Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure. (613 aa) |
| | elg1 | Telomere length regulation protein elg1; Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. An RFC-like complex (elg1-RFC) is formed where elg1 replaces rfc1 in the RFC complex. This complex appears to have a role in DNA replication, replication fork re-start, recombination and repair. (920 aa) |
| | rhp14 | DNA repair protein rad14; Involved in nucleotide excision repair (NER). Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance. Binds damaged DNA. Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides. Maintains GT repeat stability. Functions as a part of the short-patch excision repair system. (289 aa) |
| | vid21 | Chromatin modification-related protein vid21; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). (994 aa) |
| | thp1 | G/U mismatch-specific uracil DNA glycosylase; Removes uracil from G/U mispairs in ssDNA. Also corrects G/G mispairs. Does not catalyze the removal of thymine from G/T mispairs. (325 aa) |
| | cdm1 | DNA polymerase delta subunit 4; Appears to have a role in the stabilization of the DNA polymerase delta complex. (160 aa) |
| | abh1 | Alpha-ketoglutarate-dependent dioxygenase abh1; Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity); Belongs to the alkB family. (302 aa) |
| | top3 | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] (622 aa) |
| | rrp2 | Uncharacterized ATP-dependent helicase C23E6.02. (1040 aa) |
| | rfc1 | Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication. (934 aa) |
| | cdc45 | Cell division control protein 45 homolog; Required for initiation of chromosomal DNA replication. May have a role in regulating the MCM proteins nda1 and nda4. Belongs to the CDC45 family. (638 aa) |
| | rlp1 | DNA repair protein rlp1; Required for normal levels of meiotic recombination. Acts in the recombinational pathway of double-strand break (DSB) repair together with rhp51, rhp55 and rad22. Required for the full extent of DNA recombination and cell survival under condition of a replication fork collapse; Belongs to the RecA family. RAD51 subfamily. (363 aa) |
| | tfb4 | General transcription and DNA repair factor IIH subunit tfb4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (297 aa) |
| | msh6 | DNA mismatch repair protein msh6; Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops. (1254 aa) |
| | tel1 | Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length [...] (2812 aa) |
| | rpb9 | DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). Involved in the regulation o [...] (113 aa) |
| | rhp18 | Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity). (387 aa) |
| | pst3 | Paired amphipathic helix protein pst3. (1154 aa) |
| | msh2 | DNA mismatch repair protein msh2; Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA. Required for correct termination of copy synthesis during mating-type switching. Also required for proper chromosome organization during meiosis. (982 aa) |
| | fan1 | Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions (By similarity). (703 aa) |
| | nse3 | Non-structural maintenance of chromosome element 3; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (328 aa) |
| | cnd2 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase in processes such as DNA repair. Belongs to the CND2 (condensin subunit 2) family. (742 aa) |
| | exo5 | Probable exonuclease V, mitochondrial; Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity). (409 aa) |
| | swi1 | Mating-type switching protein swi1; Forms a fork protection complex (FPC) with swi3. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. It is required for programmed fork-pausing which is necessary for mating-type switching. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors. It is involved in termination at the mat1-proximal polar- terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1. (971 aa) |
| | rad57 | DNA repair protein rhp57; Involved in recombination DNA repair and in the repair of gamma-ray-induced damage. (354 aa) |
| | swi5 | Mating-type switching protein swi5; Required for normal mating-type switching. Also involved in the rhp51-dependent recombination DNA repair pathway. (85 aa) |
| | pfh1 | ATP-dependent DNA helicase pfh1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Involved in the maintenance of mitochondrial (mtDNA). Required for both repair of mitochondrial DNA and recognition of a recombinogenic signal characterized by a 26-bp palindromic at sequence in the ery region of mitochondrial DNA. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. Required for the completion of S-phase. Belongs to the helicase family. PIF1 subfamily. (805 aa) |
| | epl1 | Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity). (557 aa) |
| | mms19 | DNA repair/transcription protein mms19; Key component of the cytosolic iron-sulfur protein assembly (CIA) machinery that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. Acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as rad3/xpd and dna2, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription (By similarity). (1018 aa) |
| | arp9 | SWI/SNF and RSC complexes subunit arp9; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...] (523 aa) |
| | SPAC11H11.03c | Smr domain-containing protein C11H11.03c. (206 aa) |
| | atl1 | Alkyltransferase-like protein 1; Involved in DNA damage recognition. Binds DNA containing O(6)-methylguanine and larger O(6)-alkylguanine adducts. The DNA is bent, the damaged base is rotated out of the DNA duplex into a hydrophobic binding pocket (nucleotide flipping), with Arg-39 donating a hydrogen bond to the orphaned cytosine to stabilize the extrahelical DNA conformation. This structural change in DNA presents the lesion to the nucleotide excision repair (NER) pathway. The affinity for O(6)-alkylguanine adducts increases with the size of the alkyl group. Low affinity small O(6)-a [...] (108 aa) |
| | snf21 | Chromatin structure-remodeling complex subunit snf21; Helicase. Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (1199 aa) |
| | hat1 | Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (378 aa) |
| | iec1 | INO80 complex subunit 1; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (249 aa) |
| | SPAC144.05 | Uncharacterized ATP-dependent helicase C144.05. (1375 aa) |
| | rad50 | DNA repair protein rad50; Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance. (1285 aa) |
| | rfp2 | E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. (205 aa) |
| | SPAC824.03c | Uncharacterized protein C824.03c, mitochondrial. (247 aa) |
| | fml1 | ATP-dependent DNA helicase fml1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinantion during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. FANCM-MHF also promotes non- crossover recombination in meiotic cells. (834 aa) |
| | rad60 | DNA repair protein rad60; Required for repair of DNA double strand breaks which occur during replication, or induced by UV or gamma radiation, via recombination between sister chromatids. This has a subsequent role in the maintenance of chromosome structure. May work in conjunction with the Smc5-Smc6 complex. (406 aa) |
| | sfr1 | Swi5-dependent recombination DNA repair protein 1; Involved in DNA recombination repair and meiotic chromosome segregation; Belongs to the SFR1/MEI5 family. (299 aa) |
| | fbh1 | F-box DNA helicase protein 1; Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1. Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase. Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Ubiquitination and D [...] (878 aa) |
| | ckn1 | DNA excision repair protein ckn1; Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair. (404 aa) |
| | sfh1 | Chromatin structure-remodeling complex subunit sfh1; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (418 aa) |
| | tdp1 | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] (536 aa) |
| | arp8 | Probable actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Exhibits low basal ATPase activity, and unable to polymerize. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity). (662 aa) |
| | dna2 | DNA replication ATP-dependent helicase/nuclease dna2; Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for fen1. Is a target of the intra-S phase checkpoint, associating with stalled replication forks when phosphorylated at Ser- 219 and preventing the stalled replication forks from reversing. Also involve [...] (1397 aa) |
| | hst4 | NAD-dependent protein deacetylase hst4; NAD-dependent histone deacetylase, which contributes to both telomeric and centromeric silencing, proper cell cycle progression, DNA damage control, recombination, and genomic maintenance. Belongs to the sirtuin family. Class I subfamily. (415 aa) |
| | rhp26 | DNA repair protein rhp26; Involved in transcription-coupled repair (TCR). (973 aa) |
| | ssr4 | SWI/SNF and RSC complexes subunit ssr4; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...] (395 aa) |
| | alp5 | Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...] (433 aa) |
| | rsc9 | Chromatin structure-remodeling complex subunit rsc9; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (780 aa) |
| | mlh1 | Putative MutL protein homolog 1; This protein is involved in the repair of mismatches in DNA. (684 aa) |
| | ies4 | INO80 complex subunit 4; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (194 aa) |
| | ssr3 | SWI/SNF and RSC complexes subunit ssr3; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...] (425 aa) |
| | pph3 | Putative serine/threonine-protein phosphatase C26H8.05c; Belongs to the PPP phosphatase family. PP-1 subfamily. (348 aa) |
| | rhp23 | UV excision repair protein rhp23; Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. (368 aa) |
| | mhf1 | Inner kinetochore subunit mhf1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance. FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable). FANCM-MHF promotes non-crossover recombination both in mitotic and meiotic cells. Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinet [...] (110 aa) |
| | lig4 | DNA ligase 4; Involved in ds DNA break repair. Belongs to the ATP-dependent DNA ligase family. (913 aa) |
| | ung1 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (322 aa) |
| | hnt3 | Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'- phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, bu [...] (232 aa) |
| | mhf2 | Inner kinetochore subunit mhf2; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance. FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable). FANCM-MHF promotes non-crossover recombination both in mitotic and meiotic cells. Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinet [...] (89 aa) |
| | dbl2 | Uncharacterized protein C553.01c. (715 aa) |
| | kpa1 | DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Has a role in meiosis. (547 aa) |
| | rsc1 | Chromatin structure-remodeling complex subunit rsc1; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (803 aa) |
| | mms2 | Ubiquitin-conjugating enzyme spm2; Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'; Belongs to the ubiquitin-conjugating enzyme family. (139 aa) |
| | ctp1 | DNA endonuclease ctp1; Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection. Required for the repair of programmed meiotic DSBs. Involved also in an rhp51 recombinase-dependent recombinational repair pathway. Belongs to the COM1/SAE2/CtIP family. (294 aa) |
| | ssl1 | General transcription and DNA repair factor IIH subunit ssl1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...] (421 aa) |
| | rhp7 | DNA repair protein rhp7; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp16, after UV irradiation. Belongs to the RAD7 family. (563 aa) |
| | mcm7 | DNA replication licensing factor mcm7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (760 aa) |
| | cdc24 | Cell division control protein 24; Has a role in the progression of DNA replication and in the maintenance of genomic integrity. Acts during S phase, after initiation, where it is essential for completion. (501 aa) |
| | dpb2 | DNA polymerase epsilon subunit B; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family. (594 aa) |
| | spt16 | FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (1019 aa) |
