STRINGSTRING
hbs1 hbs1 rpp0 rpp0 mef2 mef2 tef3 tef3 rps21 rps21 rpp201 rpp201 tef101 tef101 tef102 tef102 tef103 tef103 rpp101 rpp101 tsf1 tsf1 rpp102 rpp102 rpp202 rpp202 SPCC1223.01 SPCC1223.01 tuf1 tuf1 rpp103 rpp103 mef1 mef1 tif512 tif512 rqc2 rqc2 rps1702 rps1702 rps802 rps802 zuo1 zuo1 mrpl3 mrpl3 rps1701 rps1701 eft201 eft201 rpp203 rpp203 efm3 efm3 rps801 rps801 efm6 efm6 rqc1 rqc1 rps2401 rps2401 SPBC460.02c SPBC460.02c SPAC29A4.02c SPAC29A4.02c tif51 tif51 cpc2 cpc2 gcn20 gcn20 rps2402 rps2402 tef5 tef5 rkr1 rkr1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hbs1Elongation factor 1 alpha-like protein; Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs (By similarity). (592 aa)
rpp060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (312 aa)
mef2Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (813 aa)
tef3Elongation factor 3; The main role of EF-3 may be to transduce nucleoside triphosphate energy into mechanical energy for translocation during translation. EF-3 stimulates EF-1-alpha-dependent binding of aminoacyl- tRNA to the ribosome. (1047 aa)
rps2140S ribosomal protein S21; Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability. Belongs to the eukaryotic ribosomal protein eS21 family. (87 aa)
rpp20160S acidic ribosomal protein P2-alpha; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (110 aa)
tef101Elongation factor 1-alpha-A; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (460 aa)
tef102Elongation factor 1-alpha-B; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (460 aa)
tef103Elongation factor 1-alpha-B/C; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (460 aa)
rpp10160S acidic ribosomal protein P1-alpha 1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (109 aa)
tsf1Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (299 aa)
rpp10260S acidic ribosomal protein P1-alpha 3; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (110 aa)
rpp20260S acidic ribosomal protein P2-beta; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (110 aa)
SPCC1223.01E3 ubiquitin-protein ligase hel2; Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation. (732 aa)
tuf1Elongation factor Tu, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (439 aa)
rpp10360S acidic ribosomal protein P1-alpha 5; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (109 aa)
mef1Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (770 aa)
tif512Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity); Belongs to the eIF-5A family. (169 aa)
rqc2Ribosome quality control complex subunit 2; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mtr1/rqc2 is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Mtr1/rqc2 is important for the stable association of rkr1/ltn1 to the complex. Mtr1/rqc2 recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of stalled nascent chains inde [...] (1021 aa)
rps170240S ribosomal protein S17-B. (132 aa)
rps80240S ribosomal protein S8-B. (200 aa)
zuo1Zuotin; Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain (By similarity). (442 aa)
mrpl354S ribosomal protein L3, mitochondrial; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily. (326 aa)
rps170140S ribosomal protein S17-A. (131 aa)
eft201Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (842 aa)
rpp20360S acidic ribosomal protein P2-C; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (110 aa)
efm3Protein-lysine N-methyltransferase efm3; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 2. Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family. (289 aa)
rps80140S ribosomal protein S8-A. (200 aa)
efm6UPF0665 family protein C23C4.06c. (327 aa)
rqc1Ribosome quality control complex subunit 1; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Rqc1 is essential for the recruitment of cdc48 to ribosomal subunits. (656 aa)
rps240140S ribosomal protein S24-A. (134 aa)
SPBC460.02cPutative glutathione S-transferase C460.02c; Involved in the oxidative stress response and detoxification. (220 aa)
SPAC29A4.02cElongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (409 aa)
tif51Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity); Belongs to the eIF-5A family. (157 aa)
cpc2Guanine nucleotide-binding protein subunit beta-like protein; May be a receptor for protein kinase C in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (314 aa)
gcn20Uncharacterized ABC transporter ATP-binding protein C29A3.09c. (736 aa)
rps240240S ribosomal protein S24-B. (134 aa)
tef5Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP; Belongs to the EF-1-beta/EF-1-delta family. (214 aa)
rkr1E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product. (1610 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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