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| | tif310 | Probable eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (274 aa) |
| | pth3 | Uncharacterized peptide chain release factor-like protein C1105.18c, mitochondrial. (162 aa) |
| | tif1102 | S1-like domain-containing protein C146.08c. (127 aa) |
| | tor2 | Serine/threonine-protein kinase tor2; Phosphatidylinositol 3-kinase homolog, component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC1 controls the switch between cell proliferation and differentiation by sensing nutrient availability. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. In nutrient rich conditions, responsible for the phosphorylation of AGC S6 kinase ( [...] (2337 aa) |
| | tuf1 | Elongation factor Tu, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (439 aa) |
| | dph4 | Diphthamide biosynthesis protein 4; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Belongs to the DPH4 family. (139 aa) |
| | puf6 | Pumilio homology domain family member 6; RNA-binding protein involved in post-transcriptional regulation; Belongs to the PUF6 family. (642 aa) |
| | mkt1 | Uncharacterized protein C139.01c. (802 aa) |
| | hri2 | Eukaryotic translation initiation factor 2-alpha kinase 2; Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (639 aa) |
| | tif222 | Probable translation initiation factor eIF-2B subunit beta; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. (393 aa) |
| | tif308 | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (357 aa) |
| | dph3 | Diphthamide biosynthesis protein 3; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Belongs to the DPH3 family. (79 aa) |
| | mef1 | Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (770 aa) |
| | ath1 | Uncharacterized protein C21B10.03c. (791 aa) |
| | tif512 | Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity); Belongs to the eIF-5A family. (169 aa) |
| | ppk26 | PAN2-PAN3 deadenylation complex subunit pan3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (589 aa) |
| | dph6 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor eEF-2 (eft201 or eft202) to diphthamide (By similarity). Has a role in meiosis; In the N-terminal section; belongs to the Diphthine-- ammonia ligase family. (606 aa) |
| | elp4 | Elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs ; Belongs to the ELP4 family. (361 aa) |
| | gcn3 | Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP. (341 aa) |
| | dom34 | Protein dom34; Involved in protein translation. Together with hbs1, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. The complex formed by dom34 and hbs1 has ribonuclease activity towards double-stranded RNA substrates, but does not cleave single-stranded RNA. Acts as endonuclease; has no exonuclease activity. Increases the affinity of hbs1 for GTP, but nor for GDP. Promotes G1 progression and differentiation and is involved in mitotic and meiotic cell divisions [...] (390 aa) |
| | nro1 | Negative regulator of ofd1; Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen. Belongs to the ETT1 family. (393 aa) |
| | itt1 | E3 ubiquitin-protein ligase itt1. (435 aa) |
| | dcp1 | mRNA-decapping enzyme subunit 1; Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body; Belongs to the DCP1 family. (127 aa) |
| | efm4 | Protein-lysine N-methyltransferase efm4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (238 aa) |
| | mtr3 | Exosome complex component mtr3; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (257 aa) |
| | mdv1 | Mitochondrial division protein 1; Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity); Belongs to the WD repeat MDV1/CAF4 family. (651 aa) |
| | nhm1 | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Has no activity towards mRNA molecules longer than 25 nucleotides. May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the do [...] (304 aa) |
| | puf2 | Pumilio domain-containing protein P35G2.14. (1065 aa) |
| | vts1 | Protein vts1; RNA-binding protein involved in post-transcriptional regulation through transcript degradation. May be involved in vacuolar protein transport (By similarity). (713 aa) |
| | set13 | Ribosomal lysine N-methyltransferase 4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42 (rpl42) at 'Lys-55'; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (468 aa) |
| | mmd1 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. (318 aa) |
| | slr1 | Uncharacterized HTH La-type RNA-binding protein C1527.03. (475 aa) |
| | gcn2 | eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/tif211) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the general amino acid control (GAAC) pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/tif211 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a tr [...] (1576 aa) |
| | tsf1 | Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (299 aa) |
| | sum2 | Protein sum2; Required for G2/M phase checkpoint control. (426 aa) |
| | pth4 | Meiotically up-regulated gene 82 protein; Has a role in meiosis; Belongs to the prokaryotic/mitochondrial release factor family. (182 aa) |
| | mpa1 | Uncharacterized protein PB1E7.11c. (319 aa) |
| | rcd1 | Cell differentiation protein rcd1; A differentiation-controlling factor that is essential for the onset of sexual development. Induces ste11 when sexual development is invoked through nitrogen starvation. (283 aa) |
| | puf4 | Pumilio domain-containing protein C6G9.14. (681 aa) |
| | caf16 | ABC transporter domain-containing protein C20G4.01. (280 aa) |
| | SPCC1223.01 | E3 ubiquitin-protein ligase hel2; Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation. (732 aa) |
| | mti3 | Probable translation initiation factor, mitochondrial; May be involved in mitochondrial translation initiation. Belongs to the IF-3 family. (233 aa) |
| | psk1 | Serine/threonine-protein kinase psk1; AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients. Required for phosphorylation of ribosomal protein S6 (rps601/rps602) at 'Ser-235' and 'Ser-236'. (436 aa) |
| | ofd1 | Prolyl 3,4-dihydroxylase ofd1; Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Belongs to the TPA1 family. (515 aa) |
| | tif471 | Eukaryotic translation initiation factor 4 gamma; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family. (1403 aa) |
| | ppr5 | Pentatricopeptide repeat-containing protein 5, mitochondrial; Mitochondrial RNA-binding protein that acts as a general negative regulator of mitochondrial translation. (1261 aa) |
| | tif302 | Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (725 aa) |
| | ppr10 | Uncharacterized protein C106.19. (515 aa) |
| | cpc2 | Guanine nucleotide-binding protein subunit beta-like protein; May be a receptor for protein kinase C in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (314 aa) |
| | upf3 | Nonsense-mediated mRNA decay protein 3; Involved in nonsense-mediated decay of mRNAs containing premature stop codons; Belongs to the RENT3 family. (278 aa) |
| | tif52 | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor [...] (1079 aa) |
| | mpf1 | Meiotic PUF family protein 1; RNA-binding protein essential for meiotic progression. (581 aa) |
| | dph2 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Belongs to the DPH1/DPH2 family. DPH2 subfamily. (503 aa) |
| | rrp43 | Exosome complex component rrp43; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (270 aa) |
| | rrp6 | Exosome complex exonuclease rrp6; Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export t [...] (777 aa) |
| | edc1 | Uncharacterized protein C18G6.09c. (312 aa) |
| | gcn1 | eIF-2-alpha kinase activator gcn1; Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Component of the gcn1- gcn20 complex that forms a complex with gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of gcn2, and hence stimulating gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator gc [...] (2670 aa) |
| | tif224 | Probable translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. (467 aa) |
| | sty1 | Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa) |
| | puf5 | Pumilio domain-containing protein C4G8.03c. (780 aa) |
| | mot2 | Putative general negative regulator of transcription C16C9.04c; May negatively regulate the basal and activated transcription of many genes. (489 aa) |
| | pan2 | PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1088 aa) |
| | rps901 | 40S ribosomal protein S9-A; Belongs to the universal ribosomal protein uS4 family. (191 aa) |
| | trm112 | Multifunctional methyltransferase subunit trm112; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase mtq2, required for the methylation of eRF1 on 'Gln-182'. Together with methyltransferase trm11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase bud23, required for the formation of a 7-methylguanine in 18S rRNA. Involved in biogenesis of both 40S and 60S ribosomal subunits (By similarity). (126 aa) |
| | tif313 | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (402 aa) |
| | rrp4 | Exosome complex component rrp4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (329 aa) |
| | mrf1 | Putative peptide chain release factor 1, mitochondrial; Belongs to the prokaryotic/mitochondrial release factor family. (396 aa) |
| | tif5 | Probable eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity); Belongs to the eIF-2-beta/eIF-5 family. (395 aa) |
| | ste13 | Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (485 aa) |
| | tif213 | Eukaryotic translation initiation factor 2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cat [...] (446 aa) |
| | not2 | General negative regulator of transcription subunit 2; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity); Belongs to the CNOT2/3 [...] (306 aa) |
| | lsm1 | U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends. (140 aa) |
| | not1 | General negative regulator of transcription subunit 1; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). (2100 aa) |
| | sum1 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (328 aa) |
| | erf1 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (433 aa) |
| | sui1 | Protein translation factor sui1; Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation. (109 aa) |
| | tif45 | Eukaryotic translation initiation factor 4E-1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures; Belongs to the eukaryotic initiation factor 4E family. (218 aa) |
| | tif307 | Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (282 aa) |
| | tif212 | Probable eukaryotic translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reac [...] (321 aa) |
| | tif51 | Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity); Belongs to the eIF-5A family. (157 aa) |
| | tif223 | Probable translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP. (458 aa) |
| | tif225 | Probable translation initiation factor eIF-2B subunit epsilon; Subunit of the guanine nucleotide exchange factor for eIF-2. Belongs to the eIF-2B gamma/epsilon subunits family. (678 aa) |
| | tif211 | Eukaryotic translation initiation factor 2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cat [...] (306 aa) |
| | tif11 | Eukaryotic translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). (138 aa) |
| | tif1 | ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (392 aa) |
| | SPAC29A4.02c | Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components. (409 aa) |
| | efm2 | Protein-lysine N-methyltransferase rrg1; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 2 and elongation factor 3A. (303 aa) |
| | pka1 | cAMP-dependent protein kinase catalytic subunit. (512 aa) |
| | dis3 | Exosome complex exonuclease dis3; Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] (970 aa) |
| | byr3 | Cellular nucleic acid-binding protein homolog; Acts in the sexual differentiation pathway. Is required for efficient conjugation. Double-stranded DNA-binding protein. (179 aa) |
| | pabp | Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (653 aa) |
| | ppa1 | Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit; Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor; Belongs to the PPP phosphatase family. PP-2A subfamily. (309 aa) |
| | tef103 | Elongation factor 1-alpha-B/C; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (460 aa) |
| | tef102 | Elongation factor 1-alpha-B; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (460 aa) |
| | tef101 | Elongation factor 1-alpha-A; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (460 aa) |
| | gle1 | Nucleoporin gle1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC (By similarity). (480 aa) |
| | ppr8 | Pentatricopeptide repeat-containing protein 8, mitochondrial; Mitochondrial RNA-binding protein involved in mitochondrial translation. The cox1 mRNA is one target but it is not clear if ppr8 has a single or multiple targets. (481 aa) |
| | sua5 | Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-st [...] (408 aa) |
| | SPBC609.01 | Uncharacterized ribonuclease C609.01. (1157 aa) |
| | int6 | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Required for maintaining the basal level of atf1 and for transcriptional activation of core environmental stress response genes (CESR genes) i [...] (501 aa) |
| | tef3 | Elongation factor 3; The main role of EF-3 may be to transduce nucleoside triphosphate energy into mechanical energy for translocation during translation. EF-3 stimulates EF-1-alpha-dependent binding of aminoacyl- tRNA to the ribosome. (1047 aa) |
| | tif6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (244 aa) |
| | puf3 | mRNA-binding protein puf3; RNA-binding protein involved in post-transcriptional regulation. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology (By similarity); Belongs to the PUF3 family. (732 aa) |
| | mef2 | Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (813 aa) |
| | tri1 | Uncharacterized protein C29A10.09c; Belongs to the CAF1 family. (427 aa) |
| | dys1 | Probable deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (350 aa) |
| | moe1 | Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (567 aa) |
| | eif21 | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner; Belongs to the WD repeat EIF2A family. (576 aa) |
| | mmi1 | YTH domain-containing protein mmi1; RNA-binding protein that recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR) of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region. (488 aa) |
| | rnc1 | RNA-binding protein rnc1; Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion. (398 aa) |
| | rrp45 | Exosome complex component rrp45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (291 aa) |
| | dph5 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. (283 aa) |
| | ccr4 | Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to [...] (690 aa) |
| | dph7 | Diphthine methyltransferase; Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (eft201 and eft202). Belongs to the DPH7 family. (326 aa) |
| | caf1 | Poly(A) ribonuclease pop2; Acts as the catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vivo and in vitro, caf1 has 3'-exoribonuclease activity with a preference for poly(A) RNAs. (335 aa) |
| | rpb4 | DNA-directed RNA polymerase II subunit rpb4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] (135 aa) |
| | hbs1 | Elongation factor 1 alpha-like protein; Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs (By similarity). (592 aa) |
| | tif301 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (932 aa) |
| | tif452 | Eukaryotic translation initiation factor 4E-2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures; Belongs to the eukaryotic initiation factor 4E family. (243 aa) |
| | rrf1 | Putative ribosomal recycling factor, mitochondrial; Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria; Belongs to the RRF family. (244 aa) |
| | sup35 | Eukaryotic peptide chain release factor GTP-binding subunit; Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily. (662 aa) |
| | cbr1 | NADH-cytochrome b5 reductase 1; Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity). (301 aa) |
| | ssp2 | SNF1-like protein kinase ssp2; Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation. Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes. The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation th [...] (576 aa) |
| | cti1 | Exosome complex protein C1739.07; Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites (By similarity); Belongs to the C1D family. (133 aa) |
| | mpf2 | Meiotic coiled-coil protein 2. (703 aa) |
| | eap1 | Uncharacterized protein C14G10.04. (497 aa) |
| | elp6 | Elongator complex protein 6 homolog; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs ; Belongs to the ELP6 family. (249 aa) |
| | tef5 | Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP; Belongs to the EF-1-beta/EF-1-delta family. (214 aa) |
| | ppr2 | Pentatricopeptide repeat-containing protein 2, mitochondrial; Mitochondrial RNA-binding protein that acts as a general translation factor. (432 aa) |
| | rrp42 | Exosome complex component rrp42; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (299 aa) |
| | mrpl23 | 54S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL13 family. (157 aa) |
| | rli1 | Translation initiation factor rli1; Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits (By similarity). (593 aa) |
| | nam9 | 37S ribosomal protein S4-like, mitochondrial. (327 aa) |
| | puf1 | Pumilio domain-containing protein C56F2.08c. (661 aa) |
| | csl4 | Exosome complex component csl4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (181 aa) |
| | dph1 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Belongs to the DPH1/DPH2 family. DPH1 subfamily. (436 aa) |
| | elp1 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs ; Belongs to the ELP1/IKA1 family. (1253 aa) |
| | mti2 | Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (686 aa) |
| | rps902 | 40S ribosomal protein S9-B; Belongs to the universal ribosomal protein uS4 family. (192 aa) |
| | tac1 | Probable transcriptional regulatory protein C8D2.12c. (293 aa) |
| | tif306 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (302 aa) |
| | fes1 | Hsp70 nucleotide exchange factor fes1; Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity). Belongs to the FES1 family. (287 aa) |
| | rpl1603 | 60S ribosomal protein L16-C. (197 aa) |
| | rpl1601 | 60S ribosomal protein L16-B. (197 aa) |
| | pdc2 | DNA topoisomerase 2-associated protein pat1; Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. Stabilizes the 3' terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity); Belongs to the PAT1 family. (754 aa) |
| | tma22 | Translation machinery-associated protein 22. (190 aa) |
| | oga1 | Uncharacterized protein C16A3.08c. (284 aa) |
| | rrp46 | Exosome complex component rrp46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (226 aa) |
| | rrp41 | Exosome complex component ski6; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...] (242 aa) |
| | rpl1602 | 60S ribosomal protein L16-A. (197 aa) |
| | eft201 | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (842 aa) |
| | rpb7 | DNA-directed RNA polymerase II subunit rpb7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] (172 aa) |
| | sce3 | Probable RNA-binding protein sce3. (388 aa) |
| | ppr4 | Pentatricopeptide repeat-containing protein 4, mitochondrial; Mitochondrial RNA-binding protein that specifically activates the translation of the cox1 mRNA. (931 aa) |
| | mtf2 | Uncharacterized protein C5D6.12. (314 aa) |
| | tif303 | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (918 aa) |
| | dis32 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (927 aa) |
| | elp3 | Elongator complex protein 3; Catalytic subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5- methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). Elp3 acts as a tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). (544 aa) |
| | yih1 | Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn2 kinase activity; impairs gcn1-mediated gcn2 activation, and hence gcn2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis. In normal conditions, it resides in a actin complex and has no activity. (280 aa) |
| | jmj1 | JmjC domain-containing protein 1. (464 aa) |
| | not11 | Uncharacterized protein C23H4.16c. (328 aa) |
| | efm6 | UPF0665 family protein C23C4.06c. (327 aa) |
| | rrp40 | Exosome complex component rrp40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...] (240 aa) |
| | hri1 | Eukaryotic translation initiation factor 2-alpha kinase 1; Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme. (704 aa) |
| | not3 | General negative regulator of transcription subunit 3; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Belongs to the CNOT2/3/5 family. (640 aa) |
| | guf1 | Translation factor guf1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (652 aa) |
| | pan3 | PAB-dependent poly(A)-specific ribonuclease subunit pan3-like; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex; Belongs to the protein kinase superfamily. PAN3 family. (681 aa) |
| | cid1 | Terminal uridylyltransferase cid1; Cytoplasmic uridylyltransferase that mediates the terminal uridylation of mRNAs with short poly(A) tails such as such as act1, hcn1 and urg1 mRNAs, hence facilitating global mRNA decay. Uridylates the 3' ends of actin mRNAs upon S-phase arrest. Has also a weak poly(A) polymerase (PAP) activity. Residue His-336 is responsible for the specificity for UTP. Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis. (405 aa) |
| | dcp2 | mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body. (741 aa) |
| | cid16 | Caffeine-induced protein 16. (1202 aa) |
| | ulp2 | Ubiquitin-like-specific protease 2. (638 aa) |
| | mss116 | ATP-dependent RNA helicase mss116, mitochondrial; ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity); Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. (535 aa) |
| | sum3 | ATP-dependent RNA helicase ded1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Inactivation of ded1 blocks mitotic cell cycle progression at G1 and G2/M. Induces sexual development and ascus formation. (636 aa) |
