Your Input: | |
| | rhp1602 | Uncharacterized ATP-dependent helicase C582.10c. (830 aa) |
| | swr1 | Helicase swr1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. (1288 aa) |
| | smc5 | Structural maintenance of chromosomes protein 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (1076 aa) |
| | rrp1 | Uncharacterized ATP-dependent helicase C17A2.12. (897 aa) |
| | psm1 | Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. (1228 aa) |
| | pku70 | ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. R [...] (607 aa) |
| | snf22 | SWI/SNF chromatin-remodeling complex subunit snf22; Helicase. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. (1680 aa) |
| | rfc4 | Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (342 aa) |
| | rvb2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (465 aa) |
| | rfc5 | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (358 aa) |
| | top2 | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1485 aa) |
| | tlh1 | ATP-dependent DNA helicase tlh1; Exhibits ATP-dependent 3' to 5' DNA helicase activity and has a role in telomerase-independent telomere maintenance. Belongs to the helicase family. RecQ subfamily. (1887 aa) |
| | msh3 | DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (993 aa) |
| | rad15 | General transcription and DNA repair factor IIH helicase subunit XPD; ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/rad15 is required for DNA opening. [...] (772 aa) |
| | mcm4 | DNA replication licensing factor mcm4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (931 aa) |
| | mcm3 | DNA replication licensing factor mcm3; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (879 aa) |
| | rad51 | DNA repair protein rhp51; Required both for recombination and for the repair of DNA damage caused by X-rays. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical nucleoprotein filaments. Belongs to the RecA family. RAD51 subfamily. (365 aa) |
| | rad8 | DNA repair protein rad8; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats (By similarity). Plays a role in surviving topoisomerase-mediated DNA damage. (1133 aa) |
| | mcm2 | DNA replication licensing factor mcm2; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (830 aa) |
| | rec12 | Meiotic recombination protein rec12; Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II. (345 aa) |
| | cut14 | Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1172 aa) |
| | cut3 | Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC4 subfamily. (1324 aa) |
| | mcm5 | DNA replication licensing factor mcm5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (720 aa) |
| | rad54 | DNA repair protein rhp54; Involved in DNA repair. May have a role in the processing of replication structures during late replication that is different from its role in the repair of radiation damage; Belongs to the SNF2/RAD54 helicase family. (852 aa) |
| | mcm6 | DNA replication licensing factor mcm6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (892 aa) |
| | rad17 | Checkpoint protein rad17; Participates in checkpoint pathways arrest of the cell cycle. A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes. (606 aa) |
| | smc6 | Structural maintenance of chromosomes protein 6; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the SMC family. SMC6 subfamily. (1140 aa) |
| | pms1 | DNA mismatch repair protein pms1; This protein is involved in the repair of mismatches in DNA. (794 aa) |
| | rhp16 | ATP-dependent helicase rhp16; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation. Belongs to the SNF2/RAD54 helicase family. (861 aa) |
| | fft1 | ATP-dependent helicase fft1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. (944 aa) |
| | rdh54 | Meiotic recombination protein rdh54; Acts with rhp54 to repair meiotic double strand breaks via homologous recombination. Involved in meiotic DNA recombination. Belongs to the SNF2/RAD54 helicase family. (811 aa) |
| | rqh1 | ATP-dependent DNA helicase hus2/rqh1; Has a role in the repair of UV-induced DNA damage in G2 via recombination-mediated repair. Also has a role in the repair of infrared-induced double DNA strand breaks. Exhibits an ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction; Belongs to the helicase family. RecQ subfamily. (1328 aa) |
| | upf1 | ATP-dependent helicase upf1; Required for rapid turnover of mRNAs containing a premature translational termination codon; Belongs to the DNA2/NAM7 helicase family. (925 aa) |
| | rfc2 | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 2 binds ATP and single-stranded DNA. (340 aa) |
| | srs2 | ATP-dependent DNA helicase srs2; ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks. Belongs to the helicase family. UvrD subfamily. (887 aa) |
| | tlh2 | ATP-dependent DNA helicase tlh2; Exhibits ATP-dependent 3' to 5' DNA helicase activity and has a role in telomerase-independent telomere maintenance. Represses ade6 at an ectopic site. (1919 aa) |
| | sen1 | Helicase sen1; ATP-dependent 5'->3' DNA/RNA helicase required for the expression and maturation of diverse classes of non-protein-coding RNAs like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar (snoRNA) RNAs. Directs RNA polymerase II transcription termination on snoRNAs as well as on several short protein-coding genes. May also play a role in transcription-coupled nucleotide excision repair (By similarity). (1687 aa) |
| | rvb1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (456 aa) |
| | fml2 | Putative ATP-dependent DNA helicase fml2; Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily. (783 aa) |
| | pku80 | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. I [...] (695 aa) |
| | mit1 | Chromatin remodeling factor mit1; Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC). (1418 aa) |
| | mlh1 | Putative MutL protein homolog 1; This protein is involved in the repair of mismatches in DNA. (684 aa) |
| | rhp26 | DNA repair protein rhp26; Involved in transcription-coupled repair (TCR). (973 aa) |
| | dna2 | DNA replication ATP-dependent helicase/nuclease dna2; Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape fen1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit dna2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for fen1. Is a target of the intra-S phase checkpoint, associating with stalled replication forks when phosphorylated at Ser- 219 and preventing the stalled replication forks from reversing. Also involve [...] (1397 aa) |
| | hrp1 | Chromodomain helicase hrp1; Seems to play a role in mitotic chromosome segregation and maintenance of chromatin structure. Has ATPase activity. (1373 aa) |
| | fbh1 | F-box DNA helicase protein 1; Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1. Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase. Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Ubiquitination and D [...] (878 aa) |
| | fml1 | ATP-dependent DNA helicase fml1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinantion during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. FANCM-MHF also promotes non- crossover recombination in meiotic cells. (834 aa) |
| | rad50 | DNA repair protein rad50; Involved in DNA double-strand break (DSB) repair. Involved in mating type switching and has a role in choosing the sister chromatid for recombinational repair. Also has a role in telomere length maintenance. (1285 aa) |
| | SPAC144.05 | Uncharacterized ATP-dependent helicase C144.05. (1375 aa) |
| | snf21 | Chromatin structure-remodeling complex subunit snf21; Helicase. Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (1199 aa) |
| | pfh1 | ATP-dependent DNA helicase pfh1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Involved in the maintenance of mitochondrial (mtDNA). Required for both repair of mitochondrial DNA and recognition of a recombinogenic signal characterized by a 26-bp palindromic at sequence in the ery region of mitochondrial DNA. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. Required for the completion of S-phase. Belongs to the helicase family. PIF1 subfamily. (805 aa) |
| | rad57 | DNA repair protein rhp57; Involved in recombination DNA repair and in the repair of gamma-ray-induced damage. (354 aa) |
| | SPCC737.07c | DNA polymerase alpha-associated DNA helicase A; DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication; Belongs to the DNA2/NAM7 helicase family. (660 aa) |
| | mcm7 | DNA replication licensing factor mcm7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (760 aa) |
| | fft2 | ATP-dependent helicase fft2; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. (1284 aa) |
| | msh2 | DNA mismatch repair protein msh2; Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA. Required for correct termination of copy synthesis during mating-type switching. Also required for proper chromosome organization during meiosis. (982 aa) |
| | msh6 | DNA mismatch repair protein msh6; Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops. (1254 aa) |
| | rfc1 | Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication. (934 aa) |
| | rrp2 | Uncharacterized ATP-dependent helicase C23E6.02. (1040 aa) |
| | elg1 | Telomere length regulation protein elg1; Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. An RFC-like complex (elg1-RFC) is formed where elg1 replaces rfc1 in the RFC complex. This complex appears to have a role in DNA replication, replication fork re-start, recombination and repair. (920 aa) |
| | mot1 | Probable helicase mot1; Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its ATPase activity (By similarity). (1953 aa) |
| | fft3 | ATP-dependent helicase fft3; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. Required for maintaining a heterochromatin chromatin structure at centromeres and subtelomeres by protecting these regions from euchromatin assembly. Enhances the nucleotide exchange activity of the pim1 guanine nucleotide exchange factor and abolishes histone-H3- mediated RanGAP inhibition. Involved in the construction of the centromeres. (922 aa) |
| | psm3 | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate; Belongs to the SMC family. SMC3 subfamily. (1194 aa) |
| | dmc1 | Meiotic recombination protein dmc1; Required for meiotic recombination and cell cycle progression. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments. Belongs to the RecA family. DMC1 subfamily. (332 aa) |
| | ino80 | Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair. (1604 aa) |
| | chl1 | ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity). (844 aa) |
| | hrp3 | Chromodomain helicase hrp3; Involved in heterochromatin silencing. Required for transcriptional repression at the silence loci of mat3, where it has a direct role as a chromatin remodeling factor. (1388 aa) |
| | rad55 | DNA repair protein rhp55; Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways. (350 aa) |
| | abo1 | Uncharacterized AAA domain-containing protein C31G5.19. (1190 aa) |
| | rfc3 | Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 3 binds ATP. Also involved in replication and DNA damage checkpoint controls, probably functioning as a checkpoint sensor. (342 aa) |
| | mgs1 | ATPase WRNIP1 homolog C26H5.02c; Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity); Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. (504 aa) |
| | hrq1 | ATP-dependent helicase hrq1; Helicase with 3'-5' helicase activity involved in genome stability. Functions in the nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair. Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (By similarity). Shows both processive helicase and DNA strand annealing activities (By similarity). Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding [...] (1063 aa) |
| | msh1 | MutS protein homolog 1; Involved in mitochondrial DNA repair; Belongs to the DNA mismatch repair MutS family. (941 aa) |
| | ptr8 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ptr8, but not its helicase activity, is required f [...] (804 aa) |
