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gld1 gld1 pfk1 pfk1 gpd3 gpd3 ura6 ura6 pgk1 pgk1 tpi1 tpi1 adk1 adk1 fba1 fba1 tmp1 tmp1 cdc22 cdc22 suc22 suc22 gpm1 gpm1 eno101 eno101 ndk1 ndk1 hxk2 hxk2 gnd1 gnd1 pgi1 pgi1 tdh1 tdh1 pdb1 pdb1 hxk1 hxk1 pyk1 pyk1 idn1 idn1 pda1 pda1 eno102 eno102 pcd1 pcd1 guk1 guk1 ysa1 ysa1 ynd1 ynd1 gda1 gda1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
gld1Glycerol dehydrogenase 1; Glycerol dehydrogenase involved in the assimilation of glycerol; Belongs to the iron-containing alcohol dehydrogenase family. (450 aa)
pfk1ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. May also have a role in cell cycle regulation. (942 aa)
gpd3Glyceraldehyde-3-phosphate dehydrogenase 2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
ura6Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (191 aa)
pgk1Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (414 aa)
tpi1Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (249 aa)
adk1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (220 aa)
fba1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (358 aa)
tmp1Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP. (210 aa)
cdc22Ribonucleoside-diphosphate reductase large chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (811 aa)
suc22Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (391 aa)
gpm1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
eno101Enolase 1-1. (439 aa)
ndk1Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (151 aa)
hxk2Hexokinase-2; Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate. Phosphorylates D-glucose, D-fructose and D-mannose. Compared to hxk1, has a much higher affinity for D-glucose. Constitutes the initial enzyme of glycolysis by catalyzing the phosphorylation of glucose to D-glucose 6- phosphate (Probable). (455 aa)
gnd16-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (492 aa)
pgi1Glucose-6-phosphate isomerase. (550 aa)
tdh1Glyceraldehyde-3-phosphate dehydrogenase 1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pdb1Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (366 aa)
hxk1Hexokinase-1; Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate. Phosphorylates D-fructose, D-mannose and, to a lower extent, D-glucose. Compared to hxk2, has low affinity for D-glucose. (484 aa)
pyk1Pyruvate kinase. (509 aa)
idn1Probable gluconokinase; Belongs to the gluconokinase GntK/GntV family. (193 aa)
pda1Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (409 aa)
eno102Enolase 1-2. (440 aa)
pcd1Probable nudix hydrolase C6G9.05; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. PCD1 subfamily. (285 aa)
guk1Guanylate kinase; Essential for recycling GMP and indirectly, cGMP; Belongs to the guanylate kinase family. (202 aa)
ysa1Uncharacterized Nudix hydrolase P35G2.12. (205 aa)
ynd1Golgi apyrase; Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates. Required for Golgi glycosylation and cell wall integrity. Involved in N-mannosylation of proteins in Golgi. (572 aa)
gda1Guanosine-diphosphatase; After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol; Belongs to the GDA1/CD39 NTPase family. (556 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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