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fin1 fin1 tsc2 tsc2 ckk2 ckk2 paa1 paa1 tip41 tip41 ppk32 ppk32 gad8 gad8 cmk1 cmk1 fnp1 fnp1 ptr2 ptr2 gcn2 gcn2 npr3 npr3 pmk1 pmk1 pab1 pab1 ofd1 ofd1 byr4 byr4 par1 par1 dma1 dma1 ppa3 ppa3 cpc2 cpc2 rga2 rga2 rho2 rho2 pcr1 pcr1 tsc1 tsc1 rgs1 rgs1 SPAC18B11.11 SPAC18B11.11 pom1 pom1 ptc3 ptc3 par2 par2 tif211 tif211 atf1 atf1 sck1 sck1 ssp1 ssp1 ptc1 ptc1 cdc16 cdc16 cgs1 cgs1 cgs2 cgs2 pck2 pck2 gap1 gap1 sxa2 sxa2 pyp2 pyp2 gpa1 gpa1 pyp1 pyp1 rhp6 rhp6 dis2 dis2 fil1 fil1 far8 far8 rga7 rga7 rnc1 rnc1 iml1 iml1 bhd1 bhd1 tel1 tel1 ssp2 ssp2 far10 far10 rga4 rga4 dnt1 dnt1 sid4 sid4 ubr1 ubr1 gnr1 gnr1 spc7 spc7 klp6 klp6 bub3 bub3 npr2 npr2 klp5 klp5 ade3 ade3 plp1 plp1 csc4 csc4 lam2 lam2 sea3 sea3 far11 far11 pmp1 pmp1 ubc11 ubc11
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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fin1G2-specific protein kinase fin1; Promotes chromosome condensation and nuclear envelope dynamics during mitosis. Activity appears at metaphase-anaphase transition; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily. (722 aa)
tsc2Tuberous sclerosis 2 protein homolog; Together with tsc1, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1. (1339 aa)
ckk2Serine/threonine-protein kinase ppk34. (354 aa)
paa1Protein phosphatase PP2A regulatory subunit A; Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates (By similarity). (590 aa)
tip41Type 2A phosphatase activator tip41; Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Activates the PP2A phosphatase ppa2; Belongs to the TIP41 family. (252 aa)
ppk32Protein kinase domain-containing protein ppk32. (749 aa)
gad8Serine/threonine-protein kinase gad8; Involved in a signaling module for sexual development and cell growth under stressed conditions. Required for G1 arrest under nitrogen starvation and for growth at high temperature and osmolarity. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (569 aa)
cmk1Calcium/calmodulin-dependent protein kinase type I; Important in cell cycle regulation; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (335 aa)
fnp1Uncharacterized protein C30C2.07. (842 aa)
ptr2Probable peptide transporter ptr2; Uptake of small peptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (618 aa)
gcn2eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/tif211) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the general amino acid control (GAAC) pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/tif211 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a tr [...] (1576 aa)
npr3Nitrogen permease regulator 3-like protein; Belongs to the NPR3 family. (585 aa)
pmk1Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions. (422 aa)
pab1Protein phosphatase PP2A regulatory subunit B; Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates. (463 aa)
ofd1Prolyl 3,4-dihydroxylase ofd1; Prolyl 3,4-dihydroxylase that catalyzes 3,4-dihydroxylation of 'Pro-62' of small ribosomal subunit uS12 (rps23 and rps2302), thereby regulating protein translation termination efficiency. Negative regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Belongs to the TPA1 family. (515 aa)
byr4Protein byr4; Has an essential role in ensuring cytokinesis and septation occur only once during mitosis. It does so by interacting with the ras1 signaling pathways, thereby suppressing them; To yeast BFA1. (665 aa)
par1Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation. (548 aa)
dma1Probable E3 ubiquitin-protein ligase dma1; Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB. Belongs to the DMA1 family. (267 aa)
ppa3Putative serine/threonine-protein phosphatase C22H10.04. (307 aa)
cpc2Guanine nucleotide-binding protein subunit beta-like protein; May be a receptor for protein kinase C in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (314 aa)
rga2Probable Rho-type GTPase-activating protein 2; GTPase-activating protein for Rho-type proteins. (1275 aa)
rho2GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2. (200 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
tsc1Tuberous sclerosis 1 protein homolog; Together with tsc2, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1. (899 aa)
rgs1Regulator of G-protein signaling 1; Negatively regulates pheromone signaling during mating. Acts in a negative feedback loop that is essential for the mating process. This loop acts to down-regulate cellular sensitivity to pheromone. Activated by ste11. (481 aa)
SPAC18B11.11Uncharacterized protein C18B11.11. (1294 aa)
pom1DYRK-family kinase pom1; Polarity factor involved in localization of polarized growth and cytokinesis. Forms an intracellular gradient that serves to measure cell length and control mitotic entry. Controls the timing of mitotic commitment by regulating the inhibitory impact of cdr1/cdr2 on wee1 activity. Directly phosphorylates the tail of cdr2 which inhibits cdr2 activation by ssp1. Cdr2 phosphorylation by pom1 also modulates cdr2 association with membranes and inhibits cdr2 interaction with mid1, reducing its clustering ability, possibly via the down-regulation of cdr2 kinase activit [...] (1087 aa)
ptc3Protein phosphatase 2C homolog 3; Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase. (414 aa)
par2Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation. (627 aa)
tif211Eukaryotic translation initiation factor 2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cat [...] (306 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
sck1Serine/threonine-protein kinase sck1; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Required for trehalase activation. (696 aa)
ssp1Serine/threonine-protein kinase ssp1; Involved in actin localization and thus in polarized cell growth; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (652 aa)
ptc1Protein phosphatase 2C homolog 1; It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability. (347 aa)
cdc16Cell division control protein 16; Has a dual role in the cell cycle. In mitosis, it is involved in maintenance of cdc2 kinase activity. It is subsequently required for regulation of septum formation. Could be involved in maintenance of cdc2 kinase activity by preventing, directly or indirectly, the degradation of cyclin or the dephosphorylation of 'Thr-167' of cdc2. (299 aa)
cgs1cAMP-dependent protein kinase regulatory subunit. (412 aa)
cgs23',5'-cyclic-nucleotide phosphodiesterase. (346 aa)
pck2Protein kinase C-like 2; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (1016 aa)
gap1GTPase-activating protein; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras1. (766 aa)
sxa2Carboxypeptidase sxa2; Involved in degradation or processing of the mating pheromones. Its loss causes a persistent response to the pheromones. It may be required for stabilization of enzymes that are essential for zygote formation. May degrade the mating pheromone P-factor. (507 aa)
pyp2Tyrosine-protein phosphatase 2; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (711 aa)
gpa1Guanine nucleotide-binding protein alpha-1 subunit; Implicated in the mating and sporulation pathway. Probably coupled to mating-factor receptors. May act in concert with Ras1; Belongs to the G-alpha family. G(q) subfamily. (407 aa)
pyp1Tyrosine-protein phosphatase 1; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2. (550 aa)
rhp6Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity). Required for obr1 ubiquitination, whi [...] (151 aa)
dis2Serine/threonine-protein phosphatase PP1-1; Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis. (327 aa)
fil1GATA zinc finger domain-containing protein C1393.08. (557 aa)
far8Uncharacterized WD repeat-containing protein C1773.01. (612 aa)
rga7Probable Rho-GTPase-activating protein 7. (695 aa)
rnc1RNA-binding protein rnc1; Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion. (398 aa)
iml1Vacuolar membrane-associated protein iml1. (1496 aa)
bhd1Folliculin-like protein bhd1. (367 aa)
tel1Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length [...] (2812 aa)
ssp2SNF1-like protein kinase ssp2; Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation. Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes. The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation th [...] (576 aa)
far10Uncharacterized protein C3H7.13. (301 aa)
rga4Probable Rho-type GTPase-activating protein 4; GTPase-activating protein for Rho-type proteins. (933 aa)
dnt1Nucleolar protein dnt1; Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1. May also have a role in silencing rDNA transcription. Required for maintaining the exclusive nucleolus localization of nuc1. (599 aa)
sid4Septation initiation protein sid4; Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach. (660 aa)
ubr1E3 ubiquitin-protein ligase ubr1; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Belongs to the UBR1 family. (1958 aa)
gnr1Guanine nucleotide-binding protein negative regulator 1; Negatively regulates the pheromone-response pathway. Acts as a structural mimic of the G protein beta subunit thereby interacting with gpa1 which then inhibits gpa1 signaling. (399 aa)
spc7Kinetochore protein spc7; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. (1364 aa)
klp6Kinesin-like protein 6; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (784 aa)
bub3Mitotic checkpoint protein bub3; Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function. Belongs to the WD repeat BUB3 family. (320 aa)
npr2Nitrogen permease regulator 2 homolog; Mediates inactivation of the TORC1 complex in response to amino acid starvation. Post-transcriptional regulator of nitrogen permeases (By similarity); Belongs to the NPR2 family. (409 aa)
klp5Kinesin-like protein 5; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily. (883 aa)
ade3Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family. (1323 aa)
plp1Thioredoxin domain-containing protein plp1; Inhibits early G-protein signaling events following pheromone stimulation. May help create heterodimerizable beta-tubulin by facilitating the efficient transfer of nascent beta-tubulin polypeptides to the folding apparatus (By similarity); Belongs to the phosducin family. (279 aa)
csc4Uncharacterized protein C2C4.10c. (166 aa)
lam2Uncharacterized protein C1778.05c. (160 aa)
sea3Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05; May be involved in telomere capping. (1323 aa)
far11Factor arrest protein 11; Participates in the control of the reentry into the cell cycle following pheromone treatment; Belongs to the FAR11 family. (817 aa)
pmp1Tyrosine-protein phosphatase pmp1; Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (278 aa)
ubc11Ubiquitin-conjugating enzyme E2-20 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (176 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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