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| | SPBP4H10.07 | Uncharacterized RING finger protein P4H10.07. (583 aa) |
| | ubc7 | Ubiquitin-conjugating enzyme E2-18 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradatio [...] (166 aa) |
| | ubc11 | Ubiquitin-conjugating enzyme E2-20 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. (176 aa) |
| | ubc13 | Ubiquitin-conjugating enzyme E2 13; Has a role in the DNA error-free postreplication repair (PRR) pathway. The ubc13/spm2 heterodimer catalyzes the synthesis of non- canonical poly-ubiquitin chains that are linked through 'Lys-63'. Belongs to the ubiquitin-conjugating enzyme family. (148 aa) |
| | sea3 | Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05; May be involved in telomere capping. (1323 aa) |
| | ubr11 | E3 ubiquitin-protein ligase ubr11; Belongs to the UBR1 family. (2052 aa) |
| | SPAC16E8.13 | RING finger protein ETP1 homolog; May act as a cytoplasmic retention protein with a role in regulating nuclear transport. (547 aa) |
| | rrp1 | Uncharacterized ATP-dependent helicase C17A2.12. (897 aa) |
| | cul1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2; Belongs to the cullin family. (767 aa) |
| | ddb1 | DNA damage-binding protein 1; Component of an E3 ubiquitin-protein ligase that includes cul4 (By similarity). Required for ubiquitination and the subsequent degradation of the DNA replication licensing factor cdt1 and of the ribonucleotide reductase inhibitor spd1. Also required for transcription-coupled nucleotide excision repair. (1072 aa) |
| | rfp1 | E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. Has a role in meiosis. (254 aa) |
| | ptr1 | E3 ubiquitin-protein ligase ptr1; Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins such as rae1; Belongs to the UPL family. TOM1/PTR1 subfamily. (3227 aa) |
| | rbx1 | RING-box protein pip1; Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional s [...] (107 aa) |
| | prp19 | Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair. Belongs to the WD repeat PRP19 family. (488 aa) |
| | SPAC2F3.16 | Uncharacterized RING finger protein C2F3.16. (425 aa) |
| | cul4 | Cullin-4; Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochroma [...] (734 aa) |
| | pop2 | WD repeat-containing protein pop2; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. (703 aa) |
| | dsc4 | DSC E3 ubiquitin ligase complex subunit 4; Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. (281 aa) |
| | pqr1 | Uncharacterized RING finger protein C6B12.07c. (470 aa) |
| | pub3 | E3 ubiquitin-protein ligase pub3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (786 aa) |
| | ats1 | RCC1 repeat-containing protein C10F6.04. (351 aa) |
| | ubc6 | Ubiquitin-conjugating enzyme E2 6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. (227 aa) |
| | cut20 | Anaphase-promoting complex subunit 4; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (719 aa) |
| | rnf170 | Uncharacterized RING finger protein C23A1.07. (251 aa) |
| | apc10 | Anaphase-promoting complex subunit 10; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome. Involved in G1 cell cycle arrest in response to n [...] (189 aa) |
| | dsc1 | DSC E3 ubiquitin ligase complex subunit 1; Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. (695 aa) |
| | gid2 | LisH domain-containing protein C29A3.03c. (398 aa) |
| | doa10 | ERAD-associated E3 ubiquitin-protein ligase doa10; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Als [...] (1242 aa) |
| | SPBC14F5.10c | LON peptidase N-terminal domain and RING finger protein C14F5.10c. (486 aa) |
| | mrz1 | Uncharacterized RING finger protein C16G5.03. (268 aa) |
| | SPBC18H10.09 | Uncharacterized protein C18H10.09. (495 aa) |
| | ubr1 | E3 ubiquitin-protein ligase ubr1; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Belongs to the UBR1 family. (1958 aa) |
| | rrp2 | Uncharacterized ATP-dependent helicase C23E6.02. (1040 aa) |
| | rkr1 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product. (1610 aa) |
| | SPBC32F12.07c | Uncharacterized RING finger protein C32F12.07c. (340 aa) |
| | SPCC1739.01 | Uncharacterized protein C1739.01. (547 aa) |
| | brl2 | E3 ubiquitin-protein ligase brl2; E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. (680 aa) |
| | rhp18 | Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity). (387 aa) |
| | ipa1 | Uncharacterized protein C1734.10c. (332 aa) |
| | hrd1 | ERAD-associated E3 ubiquitin-protein ligase hrd1; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER- associated degradation (ERAD). Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolde [...] (677 aa) |
| | btb2 | BTB/POZ domain-containing protein 2; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (284 aa) |
| | ubc1 | Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER- membrane proteins with misfolded transmembrane domains (ERAD-M). (217 aa) |
| | btb1 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (1347 aa) |
| | pep3 | Vacuolar membrane protein pep3; Required for vacuolar biogenesis; Belongs to the VPS18 family. (900 aa) |
| | mms2 | Ubiquitin-conjugating enzyme spm2; Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'; Belongs to the ubiquitin-conjugating enzyme family. (139 aa) |
| | mpe1 | Uncharacterized RING finger protein P8B7.15c. (482 aa) |
| | mug30 | Probable E3 ubiquitin-protein ligase mug30; Probable E3 ubiquitin-protein ligase. Has a role in meiosis. (807 aa) |
| | lub1 | Ubiquitin homeostasis protein lub1; Acts as a negative regulator of vacuole-dependent ubiquitin degradation. (718 aa) |
| | pof13 | F-box protein pof13. (396 aa) |
| | asr1 | PHD and RING finger domain-containing protein C126.07c. (571 aa) |
| | cut23 | Anaphase-promoting complex subunit 8; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates. (565 aa) |
| | ptr3 | Ubiquitin-activating enzyme E1 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. (1012 aa) |
| | pmh1 | RNA polymerase II transcription factor B subunit 3; Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity). (318 aa) |
| | ubi3 | Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (150 aa) |
| | ubi5 | Ubiquitin-40S ribosomal protein S27b; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (150 aa) |
| | ubi4 | Polyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...] (382 aa) |
| | ubi1 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | ubi2 | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa) |
| | nuc2 | Anaphase-promoting complex subunit 3; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Interacts with spindle apparatus, chromosomes, or nuclear envelope, and interconnect nuclear and cytoskeletal functions in mitosis [...] (665 aa) |
| | rhp6 | Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity). Required for obr1 ubiquitination, whi [...] (151 aa) |
| | rad8 | DNA repair protein rad8; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats (By similarity). Plays a role in surviving topoisomerase-mediated DNA damage. (1133 aa) |
| | cps3 | Protein cps3; Responsible for supersensitivity to the spindle poison, isopropyl N-3-chlorophenyl carbamate. Has a role in meiosis. (583 aa) |
| | cut9 | Anaphase-promoting complex subunit cut9; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. May play a pivotal role in the control of anaphase. (671 aa) |
| | ubc4 | Ubiquitin-conjugating enzyme E2 4; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5. (147 aa) |
| | rhp16 | ATP-dependent helicase rhp16; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation. Belongs to the SNF2/RAD54 helicase family. (861 aa) |
| | pop1 | WD repeat-containing protein pop1; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop2, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. Regulates cell-cycle progression under starvation through the rum1 protein. (775 aa) |
| | meu34 | RING finger protein mug145; Has a role in meiosis. (309 aa) |
| | SPAC57A7.09 | Uncharacterized RING finger protein C57A7.09. (372 aa) |
| | slx8 | E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression (By similarity). (269 aa) |
| | SPCC4G3.12c | Uncharacterized RING finger protein C4G3.12c. (821 aa) |
| | SPAC16A10.03c | Pep5-like zinc finger protein C16A10.03c. (847 aa) |
| | mlo2 | Protein mlo2; Not known, interfere with mitotic chromosome segregation when overexpressed. (329 aa) |
| | cul3 | Cullin-3; Probable core component of multiple cullin-RING-based BC3B (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the BC3B complex depends on the substrate recognition component (By similarity). Involved in ubiquitin-mediated degradation of btb3. (785 aa) |
| | mot2 | Putative general negative regulator of transcription C16C9.04c; May negatively regulate the basal and activated transcription of many genes. (489 aa) |
| | pof11 | F-box/WD repeat-containing protein pof11; Has a role in meiosis. (506 aa) |
| | sea4 | Uncharacterized WD repeat-containing protein C12G12.01c; Belongs to the WD repeat mio family. (905 aa) |
| | cyp8 | Peptidyl-prolyl cis-trans isomerase cyp8; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins; Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily. (516 aa) |
| | snt2 | Lid2 complex component snt2. (1131 aa) |
| | btb3 | BTB/POZ domain-containing protein 3; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (523 aa) |
| | dma1 | Probable E3 ubiquitin-protein ligase dma1; Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB. Belongs to the DMA1 family. (267 aa) |
| | SPAC12B10.01c | Probable ubiquitin fusion degradation protein C12B10.01c; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (1647 aa) |
| | cdt2 | Cell division cycle protein cdt2; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for DNA replication during mitosis and meiosis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of cdt1 and spd1. Involved in the regulation of mitotic and pre-meiotic S- phase progression. (490 aa) |
| | hul5 | Probable E3 ubiquitin protein ligase C167.07c; Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. (1029 aa) |
| | brl1 | E3 ubiquitin-protein ligase brl1; E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. (692 aa) |
| | SPBC15C4.06c | Uncharacterized RING finger membrane protein C15C4.06c. (556 aa) |
| | nse1 | Non-structural maintenance of chromosomes element 1; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. (232 aa) |
| | SPCC1223.01 | E3 ubiquitin-protein ligase hel2; Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation. (732 aa) |
| | apc2 | Anaphase-promoting complex subunit 2; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the cullin family. (681 aa) |
| | pex12 | Peroxisome assembly protein 12; Required for protein import into peroxisomes. (343 aa) |
| | pub1 | E3 ubiquitin-protein ligase pub1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Regulates ubiquitination of cdc25. (767 aa) |
| | bop1 | Uncharacterized RING finger protein P32A8.03c. (513 aa) |
| | pof15 | F-box protein pof15; Probable substrate recognition component of a SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (243 aa) |
| | ufd2 | Ubiquitin conjugation factor E4; E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety. (1010 aa) |
| | dsc3 | DSC E3 ubiquitin ligase complex subunit 3; Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. Belongs to the dsc3 family. (250 aa) |
| | pib1 | Putative E3 ubiquitin-protein ligase C36B7.05c; Functions as an E3 ubiquitin-protein ligase. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate. (279 aa) |
| | knd1 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable); Belongs to the CAND family. (1220 aa) |
| | dbl4 | E3 ubiquitin-protein ligase dbl4; Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation. (504 aa) |
| | dbl5 | Uncharacterized RING finger protein C548.05c. (468 aa) |
| | apc5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome; Belongs to the APC5 family. (744 aa) |
| | ubc16 | Ubiquitin-conjugating enzyme E2 16; Catalyzes the covalent attachment of ubiquitin to other proteins. (160 aa) |
| | vps11 | E3 ubiquitin-protein ligase pep5; Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. Acts as component of the CORVET complex that is required for transport between [...] (906 aa) |
| | cwf24 | Pre-mRNA-splicing factor cwf24; Involved in mRNA splicing. (533 aa) |
| | ubc8 | Ubiquitin-conjugating enzyme E2 8; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family. (184 aa) |
| | gid9 | Protein fyv10; Involved in the proteasome-dependent degradation of fructose- 1,6-bisphosphatase; Belongs to the FYV10 family. (404 aa) |
| | cut4 | Anaphase-promoting complex subunit 1; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Mutations to this protein prevent the exit from mitosis; Belongs to the APC1 family. (1458 aa) |
| | itt1 | E3 ubiquitin-protein ligase itt1. (435 aa) |
| | ckn1 | DNA excision repair protein ckn1; Adapter protein for ddb1/cullin 4 ubiquitin ligases involved in transcription-coupled nucleotide excision repair. (404 aa) |
| | fbh1 | F-box DNA helicase protein 1; Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1. Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase. Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Ubiquitination and D [...] (878 aa) |
| | rfp2 | E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. (205 aa) |
| | apc11 | Anaphase-promoting complex subunit 11; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. (94 aa) |
| | pub2 | E3 ubiquitin-protein ligase pub2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Has a role in the G2/M transition. (671 aa) |
| | dsc2 | DSC E3 ubiquitin ligase complex subunit 2; Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation. (372 aa) |
| | SPAC144.05 | Uncharacterized ATP-dependent helicase C144.05. (1375 aa) |
| | ubc14 | Ubiquitin-conjugating enzyme E2 14; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. (155 aa) |
| | pas4 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes. Belongs to the pex2/pex10/pex12 family. (306 aa) |
| | san1 | Uncharacterized RING finger protein C2A9.04c. (741 aa) |
| | ubc15 | Ubiquitin-conjugating enzyme E2 15; Catalyzes the covalent attachment of ubiquitin to other proteins. Has a role in the formation of chromatin structures that influence the localization of transcriptional silencing factors. (167 aa) |
