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| | tif308 | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (357 aa) |
| | gem6 | Uncharacterized protein new12. (93 aa) |
| | rsa3 | Ribosome assembly protein 3; Required for efficient biogenesis of the 60S ribosomal subunit. (80 aa) |
| | new4 | Uncharacterized protein new4. (146 aa) |
| | gem7 | Gem-associated protein 7 homolog. (91 aa) |
| | trt1 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (988 aa) |
| | mrd1 | Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family. (833 aa) |
| | SPBC17A3.06 | Tyrosine-protein phosphatase yvh1; May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate (By similarity). (330 aa) |
| | rsm7 | 37S ribosomal protein S7, mitochondrial. (259 aa) |
| | pof8 | Protein pof8. (402 aa) |
| | usp101 | U1 small nuclear ribonucleoprotein 70 kDa homolog; Involved in nuclear mRNA splicing (By similarity). Essential for growth. (261 aa) |
| | mrps18 | Putative 37S ribosomal protein S18, mitochondrial; Belongs to the universal ribosomal protein uS11 family. (223 aa) |
| | sqt1 | Uncharacterized WD repeat-containing protein C25H1.08c. (399 aa) |
| | smd2 | Small nuclear ribonucleoprotein Sm D2; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (115 aa) |
| | tif303 | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (918 aa) |
| | usp104 | Pre-mRNA-processing protein prp40; Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity). (695 aa) |
| | SPAC4F8.04 | Brix domain-containing protein C4F8.04. (306 aa) |
| | spp42 | Pre-mRNA-splicing factor spp42; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2363 aa) |
| | SPAC1B9.03c | Brix domain-containing protein C1B9.03c. (389 aa) |
| | rps5 | 40S ribosomal protein S5-A. (203 aa) |
| | lsm4 | Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (121 aa) |
| | naf1 | H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex (By similarity). (516 aa) |
| | sce3 | Probable RNA-binding protein sce3. (388 aa) |
| | hit1 | Uncharacterized zinc-finger protein C4F10.19c. (154 aa) |
| | smd1 | Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (117 aa) |
| | prp31 | Pre-mRNA-processing factor 31; Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes. Belongs to the PRP31 family. (518 aa) |
| | rsa1 | Uncharacterized protein C16C6.03c. (207 aa) |
| | tma22 | Translation machinery-associated protein 22. (190 aa) |
| | lsm5 | U6 snRNA-associated Sm-like protein LSm5; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. LSm5 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity). (80 aa) |
| | tif306 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (302 aa) |
| | shq1 | Protein shq1; Involved in the early biogenesis steps of box H/ACA snoRNP assembly; Belongs to the SHQ1 family. (451 aa) |
| | smf1 | Small nuclear ribonucleoprotein F; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (78 aa) |
| | cxr1 | Uncharacterized RNA-binding protein C23E6.01c. (473 aa) |
| | rpl502 | 60S ribosomal protein L5-B; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] (294 aa) |
| | rps27 | 40S ribosomal protein S27. (83 aa) |
| | esf2 | Pre-rRNA-processing protein esf2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (334 aa) |
| | cwf12 | Pre-mRNA-splicing factor cwf12; Involved in mRNA splicing and cell cycle control; Belongs to the ISY1 family. (217 aa) |
| | rpl2502 | 60S ribosomal protein L25-B; This protein binds to a specific region on the 26S rRNA. Belongs to the universal ribosomal protein uL23 family. (141 aa) |
| | lsm8 | U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family. (94 aa) |
| | lsm7 | U6 snRNA-associated Sm-like protein LSm7; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Probable component of the spliceosome; Belongs to the snRNP Sm proteins family. (113 aa) |
| | tif301 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (932 aa) |
| | rpb4 | DNA-directed RNA polymerase II subunit rpb4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] (135 aa) |
| | rsa4 | Ribosome assembly protein 4; Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin, which is essential for the ATP- dependent dissociation of a group of nonribosomal factors from the pre- 60S particle. (502 aa) |
| | rpp0 | 60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (312 aa) |
| | bcd1 | Putative box C/D snoRNA protein SPCC613.07; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Belongs to the BCD1 family. (345 aa) |
| | uri1 | Uncharacterized protein C736.07c. (699 aa) |
| | smg1 | Small nuclear ribonucleoprotein G; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (77 aa) |
| | usp102 | U1 small nuclear ribonucleoprotein usp102; Involved in nuclear mRNA splicing. (249 aa) |
| | usp105 | Pre-mRNA-processing factor 39; Function prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRNP/5'-splice site interaction. Has a direct role in the assembly or function of a catalytically active spliceosome (By similarity); Belongs to the PRP39 family. (612 aa) |
| | moe1 | Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (567 aa) |
| | mdn1 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. (4717 aa) |
| | cwf29 | U2 snRNP component ist3; Required for pre-mRNA splicing and spliceosome assembly. (217 aa) |
| | cwf10 | Pre-mRNA-splicing factor cwf10; Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (984 aa) |
| | rex4 | RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family. (260 aa) |
| | sgf73 | SAGA-associated factor 73; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...] (344 aa) |
| | prp18 | Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing. Belongs to the PRP18 family. (343 aa) |
| | lsm2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa) |
| | tif6 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (244 aa) |
| | int6 | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Required for maintaining the basal level of atf1 and for transcriptional activation of core environmental stress response genes (CESR genes) i [...] (501 aa) |
| | spf30 | Splicing factor spf30; Necessary for spliceosome assembly. (311 aa) |
| | usp109 | U1 snRNP-associated protein usp109. (365 aa) |
| | rrp7 | Ribosomal RNA-processing protein 7; Plays an important role in the synthesis of 18S rRNA but is not required for the 5.8S and 25S pathway. Is necessary for the cleavage at site A2 (By similarity); Belongs to the RRP7 family. (238 aa) |
| | rvb2 | RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (465 aa) |
| | lin1 | LIN1-like protein; Belongs to the LIN1 family. (408 aa) |
| | rps1501 | 40S ribosomal protein S15-A. (153 aa) |
| | rps1401 | 40S ribosomal protein S14-A. (139 aa) |
| | rps1402 | 40S ribosomal protein S14-B. (139 aa) |
| | rps2801 | 40S ribosomal protein S28-A. (68 aa) |
| | rps2802 | 40S ribosomal protein S28-B. (68 aa) |
| | rpl1201 | 60S ribosomal protein L12-A; This protein binds directly to 26S ribosomal RNA. Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | rpl1202 | 60S ribosomal protein L12-B; This protein binds directly to 26S ribosomal RNA. Belongs to the universal ribosomal protein uL11 family. (165 aa) |
| | yip11 | Survival of motor neuron protein-interacting protein yip11; Belongs to the gemin-2 family. (235 aa) |
| | yip12 | Survival of motor neuron protein-interacting protein yip12; Belongs to the gemin-2 family. (235 aa) |
| | dsk1 | Protein kinase dsk1; May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle. (544 aa) |
| | prp2 | Splicing factor U2AF 59 kDa subunit; Necessary for the splicing of pre-mRNA. The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC- 3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns; Belongs to the splicing factor SR family. (517 aa) |
| | rpl301 | 60S ribosomal protein L3-A; Belongs to the universal ribosomal protein uL3 family. (388 aa) |
| | rpl501 | 60S ribosomal protein L5-A; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...] (294 aa) |
| | tif212 | Probable eukaryotic translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reac [...] (321 aa) |
| | rps1901 | 40S ribosomal protein S19-A. (144 aa) |
| | tif307 | Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (282 aa) |
| | rps1902 | 40S ribosomal protein S19-B. (143 aa) |
| | rpl6 | 60S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family. (195 aa) |
| | sum1 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (328 aa) |
| | cwf2 | Pre-mRNA-splicing factor cwf2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...] (388 aa) |
| | tif310 | Probable eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (274 aa) |
| | cwf4 | Pre-mRNA-splicing factor cwf4; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity); Belongs to the crooked-neck family. (674 aa) |
| | tma20 | Translation machinery-associated protein 20; Involved in translation. (181 aa) |
| | rpl1001 | 60S ribosomal protein L10-A. (221 aa) |
| | tif213 | Eukaryotic translation initiation factor 2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cat [...] (446 aa) |
| | tif5 | Probable eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity); Belongs to the eIF-2-beta/eIF-5 family. (395 aa) |
| | tif313 | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (402 aa) |
| | smn1 | Survival motor neuron-like protein 1; Has been implicated indirectly in general cellular RNA processing. Plays a crucial role in the generation of the pre-mRNA splicing machinery and in mRNA biogenesis by interacting with spliceosomal snRNPs. (152 aa) |
| | usp108 | U1 snRNP-associated protein usp108; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. (337 aa) |
| | rpl3802 | 60S ribosomal protein L38-2. (74 aa) |
| | smb1 | Small nuclear ribonucleoprotein-associated protein B; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (147 aa) |
| | prp10 | U2 snRNP component prp10; Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly; Belongs to the SF3B1 family. (1205 aa) |
| | SPAC3F10.16c | Large subunit GTPase 1; GTPase required for the nuclear export of the 60S ribosomal subunit. Acts by mediating the release of nmd3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity). (616 aa) |
| | rpl2501 | 60S ribosomal protein L25-A; This protein binds to a specific region on the 26S rRNA. Belongs to the universal ribosomal protein uL23 family. (141 aa) |
| | tif302 | Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (725 aa) |
| | cdc28 | Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28; Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing (By similarity). Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily. (1055 aa) |
| | prp1 | Pre-mRNA-splicing factor prp1; Involved in pre-mRNA splicing. Interacts with prp6 and prp13. May also be involved in the regulation of the G0-G1/G2 transition. Required for pre-spliceosome formation, which is the first step of pre- mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site- 3' splice 3'-exon region. (906 aa) |
| | nip7 | 60S ribosome subunit biogenesis protein nip7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly. (180 aa) |
| | aar2 | A1 cistron-splicing factor aar2; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth (By similarity); Belongs to the AAR2 family. (346 aa) |
| | usp107 | U1 snRNP-associated protein usp107; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. (695 aa) |
| | rvb1 | RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family. (456 aa) |
| | pwp2 | Periodic tryptophan protein 2 homolog; Belongs to the WD repeat PWP2 family. (854 aa) |
| | brx1 | Ribosome biogenesis protein brx1; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family. (295 aa) |
| | rps502 | 40S ribosomal protein S5-B. (203 aa) |
| | rps002 | 40S ribosomal protein S0-B; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (287 aa) |
| | asc1 | tRNA-aminoacylation cofactor arc1; Binds to tRNA and functions as a cofactor for the methionyl- tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRS). Forms a complex with MetRS and GluRS and increases their affinity for cognate tRNAs due to the presence of a tRNA binding domain in its middle and C- terminal part (By similarity). (450 aa) |
| | rpl1002 | 60S ribosomal protein L10-B. (221 aa) |
| | prp16 | Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing. (1173 aa) |
| | usp103 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. usp103/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (182 aa) |
| | cwf16 | Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. (270 aa) |
| | prp11 | Pre-mRNA-processing ATP-dependent RNA helicase prp11; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1014 aa) |
| | sap62 | Pre-mRNA-splicing factor sap62; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. (217 aa) |
| | cdc123 | Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. (319 aa) |
| | cwf3 | Pre-mRNA-splicing factor cwf3; Involved in pre-mRNA splicing and cell cycle progression. Belongs to the crooked-neck family. (790 aa) |
| | rsm19 | Probable ribosomal protein S19, mitochondrial. (93 aa) |
| | luc7 | U1 snRNP-associated protein usp106; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway. (264 aa) |
| | ubp10 | Probable mRNA-splicing protein ubp10; May play a role in mRNA splicing. It is unsure if the protein really exhibits hydrolase activity. Could be a competitor of ubiquitin C-terminal hydrolases (UCHs) (By similarity); Belongs to the peptidase C19 family. (502 aa) |
| | rpl3801 | 60S ribosomal protein L38-1. (74 aa) |
| | prp24 | Uncharacterized RNA-binding protein C1861.04c. (1014 aa) |
| | gem8 | Uncharacterized protein C16H5.15. (166 aa) |
| | sme1 | Small nuclear ribonucleoprotein E; Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification (By similarity). (84 aa) |
| | mrt4 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (241 aa) |
| | brr2 | Pre-mRNA-splicing factor brr2; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region. (2176 aa) |
| | rps1502 | 40S ribosomal protein S15-B. (154 aa) |
| | hpm1 | Histidine protein methyltransferase 1; Required for histidine methylation of RPL3 at 'His-243'. (339 aa) |
| | prp12 | Pre-mRNA-splicing factor prp12; Involved in mRNA splicing and G2/M transition. (1206 aa) |
| | smd3 | Small nuclear ribonucleoprotein Sm D3; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity). (97 aa) |
| | cdc73 | Cell division control protein 73; The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. It regulates 3'-end formation of snR47 by modulating the recruitment or stable association of nrd1 with RNA polymerase II (By similarity). (371 aa) |
| | rpf2 | Ribosome production factor 2 homolog. (317 aa) |
| | lsm6 | U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2- LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 [...] (75 aa) |
| | sap145 | Pre-mRNA-splicing factor sap145; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). (601 aa) |
| | rrp16 | Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (419 aa) |
| | rps001 | 40S ribosomal protein S0-A; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (292 aa) |
| | prp28 | Pre-mRNA-splicing ATP-dependent RNA helicase prp28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (662 aa) |
| | slu7 | Pre-mRNA-splicing factor slu7; Involved in pre-mRNA splicing. (379 aa) |
