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| | clr4 | Histone-lysine N-methyltransferase, H3 lysine-9 specific; Histone methyltransferase. Catalytic component of the rik1- associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransfer [...] (490 aa) |
| | spc7 | Kinetochore protein spc7; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. (1364 aa) |
| | cut12 | Spindle pole body-associated protein cut12; Required for bipolar spindle formation. May act as a regulator of the p34cdc2/cyclin B kinase. Required for full activation of the plo1 kinase. However, in cut12.1 cells at restrictive temperature the H1 kinase does rise concomitant with entry into mitosis, indicating that cut12 is not required for activation of p34cdc2/cyclin B. The cut12.s11 allele may promote cdc2-independent phosphorylation of SPB proteins thereby overcoming the requirement for cdc25 in cell cycle progression. (548 aa) |
| | mod5 | Cell polarity protein mod5; With tea1, acts in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Involved in the anchoring of tea1 at the cortex as well as the correct localization of tea3. (522 aa) |
| | kms2 | Karyogamy meiotic segregation protein 2. (457 aa) |
| | vac8 | Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole; Belongs to the beta-catenin family. (550 aa) |
| | spa2 | Uncharacterized protein C3G9.05. (659 aa) |
| | sec20 | Protein transport protein sec20; SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. (226 aa) |
| | smi1 | Cell wall biosynthesis/cell cycle regulator smi1; Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis (By similarity). Involved in cellular response to nitrogen starvation and required for quiescence-maintenance by regulating negatively G0 to G1 transition. Belongs to the KNR4/SMI1 family. (504 aa) |
| | ahk1 | UPF0592 membrane protein C7D4.03c. (886 aa) |
| | pof5 | Protein pof5. (348 aa) |
| | fsv1 | Syntaxin-like protein fsv1; Involved in vesicle-mediated protein transport between the Golgi and the vacuole. (247 aa) |
| | epr1 | Meiotically up-regulated gene 185 protein; Has a role in meiosis. (380 aa) |
| | rng2 | Ras GTPase-activating-like protein rng2; Required for cytokinesis. Component of the contractile F- actin ring; required for its construction following assembly of F-actin at the division site. (1489 aa) |
| | stg1 | Transgelin; Has actin-binding and actin-bundling activity and is a component of the actin patch. Stabilizes actin filaments against disassembly. Cross-links F-actin and is required for the formation of the contractile F-actin ring. (174 aa) |
| | pop2 | WD repeat-containing protein pop2; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. (703 aa) |
| | cul4 | Cullin-4; Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochroma [...] (734 aa) |
| | tcb1 | Uncharacterized protein C962.01. (1429 aa) |
| | pex3 | Uncharacterized protein C29A4.14c. (346 aa) |
| | mug56 | Meiotically up-regulated gene 56 protein; Has a role in meiosis. (965 aa) |
| | cut11 | Nuclear envelope protein ndc1; Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope. Involved in the formation of the bipolar mitotic spindle. Anchors the spindle pole body in the nuclear envelope; Belongs to the NDC1 family. (601 aa) |
| | bet1 | Protein transport protein bet1; SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex. (117 aa) |
| | irc6 | Uncharacterized protein C19A8.11c. (246 aa) |
| | cul1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2; Belongs to the cullin family. (767 aa) |
| | use1 | Protein transport protein use1; SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. (222 aa) |
| | syb1 | Synaptobrevin homolog 1; Involved in membrane trafficking during cytokinesis and cell elongation; Belongs to the synaptobrevin family. (121 aa) |
| | sgo2 | Shugoshin-2; Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis. (647 aa) |
| | ain1 | Alpha-actinin-like protein 1; Binds to actin and is involved in actin-ring formation and organization. Plays a role in cytokinesis and is involved in septation. Belongs to the alpha-actinin family. (621 aa) |
| | man1 | Meiotically up-regulated gene 61 protein; Required for correct meiotic chromosome segregation. (844 aa) |
| | atg43 | Uncharacterized protein C14C4.01c. (244 aa) |
| | sea3 | Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05; May be involved in telomere capping. (1323 aa) |
| | csm1 | Monopolin complex subunit pcs1; The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. In contrast to its S.cerevisiae ortholog CSM1, is not required ofr mono-orientation during meiosis I. (261 aa) |
| | sed5 | Integral membrane protein sed5; Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE) (By similarity); Belongs to the syntaxin family. (309 aa) |
| | sbg1 | Uncharacterized protein P22H7.03. (181 aa) |
| | erh1 | Enhancer of rudimentary homolog; May have a role in the cell cycle; Belongs to the E(R) family. (104 aa) |
| | shd1 | Actin cytoskeleton-regulatory complex protein sla1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity). (1420 aa) |
| | pcp1 | Spindle pole body protein pcp1; Spindle pole body component that binds calmodulin. Overexpression of pcp1 causes the formation of supernumerary SPB-like structures and disrupts both mitotic spindle assembly and chromosome segregation. (1208 aa) |
| | aly1 | Putative arrestin-related trafficking adapter SPBC839.02; May regulate endocytosis in response to extracellular stimuli. (504 aa) |
| | hob2 | UPF0648 protein C3H5.09c. (2699 aa) |
| | bqt2 | Telomere bouquet protein 2; Involved in chromosome segregation. During meiotic prophase, connects telomeres to the spindle pole body by forming a bridge between the telomere protein rap1 and the spindle pole body protein sad1. (118 aa) |
| | tcb2 | Meiotically up-regulated gene 190 protein; Has a role in meiosis. (1188 aa) |
| | psy1 | Syntaxin-like protein psy1. (284 aa) |
| | cnp3 | Inner kinetochore subunit cnp3; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. (643 aa) |
| | fbh1 | F-box DNA helicase protein 1; Involved in ATP-dependent DNA-unwinding in a 3' to 5' direction, and ATP-ase activities stimulated by the single-stranded DNA-binding protein ssb1. Essential for viability and normal growth of stationary phase cells and in the absence of either srs2 or rqh1 DNA helicase. Involved in DNA recombination repair of strand breaks and stalled or collapsed replication forks, on the rhp51-dependent pathway: promotes rhp51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Ubiquitination and D [...] (878 aa) |
| | inp2 | Inheritance of peroxisomes protein 2; Required for peroxisome inheritance. Acts as the peroxisome- specific receptor for the myosin V motor myo2 (By similarity). Belongs to the INP2 family. (470 aa) |
| | elc1 | Elongin-C; Prevents degradation of interacting proteins by the proteasome. (97 aa) |
| | tcb3 | Uncharacterized protein PYUK71.03c. (1225 aa) |
| | moa1 | Monopolar attachment protein 1; Plays an important role in chromosome segregation during meiosis I by allowing meiotic rec8 to establish cohesion at the centromeric central core and thereby promote the side-by-side structure of kinetochores at meiosis I. Enables monopolar attachment during meiosis I. Required to facilitate kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Acts in collaboration with plo1. (172 aa) |
| | snf21 | Chromatin structure-remodeling complex subunit snf21; Helicase. Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. (1199 aa) |
| | red1 | Protein red1; Required for elimination of meiosis-specific mRNAs from mitotic cells. Promotes the destabilization of mRNAs containing a degradation signal sequence called determinant of selective removal (DSR) to prevent ectopic expression of meiotic mRNAs in vegetative cells. (712 aa) |
| | apl4 | AP-1 complex subunit gamma-1; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin (By similarity). (865 aa) |
| | mug170 | Meiotically up-regulated gene 170 protein; Has a role in meiosis; Belongs to the arrestin family. (426 aa) |
| | hob3 | Protein hob3; Involved in cytokinesis and septation where it has a role in the localization of F-actin. (264 aa) |
| | skp1 | Suppressor of kinetochore protein 1; Required for cig2 degradation in the G2 and M phases of the cell cycle. Together with pof6, essential for septum processing and cell separation. Involved in mitotic progression, essential for the execution of anaphase B; required for coordinated structural alterations of mitotic spindles and segregation of nuclear membrane structures at anaphase. Involved in the DNA damage checkpoint pathway and maintenance of genome integrity. Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V- ATPase. Belongs to th [...] (161 aa) |
| | lam2 | Uncharacterized protein C1778.05c. (160 aa) |
| | num1 | Meiotic coiled-coil protein 5; Involved in chromosome segregation. Facilitates nuclear oscillation during meiotic prophase I, the 'horsetail' phase, by acting as a dynein anchor. Essential for anchoring dhc1 to the cortex. Required for proper sliding of the microtubules along the cell cortex, which leads to the proper U-turn movement of the nucleus. (968 aa) |
| | sec22 | Protein transport protein sec22; Nonessential SNARE involved in targeting and fusion of ER- derived transport vesicles with the Golgi complex as well as Golgi- derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family. (215 aa) |
| | aps2 | AP-2 complex subunit sigma; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (143 aa) |
| | bye1 | Transcription factor bye1; Negative regulator of transcription elongation. Belongs to the BYE1 family. (721 aa) |
| | nse4 | Non-structural maintenance of chromosome element 4; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the NSE4 family. (300 aa) |
| | psk1 | Serine/threonine-protein kinase psk1; AGC kinase which plays a role in TOR complex 1 (TORC1) signaling pathway which mediates temporal control of cell growth in response to nutrients. Required for phosphorylation of ribosomal protein S6 (rps601/rps602) at 'Ser-235' and 'Ser-236'. (436 aa) |
| | cdt2 | Cell division cycle protein cdt2; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for DNA replication during mitosis and meiosis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of cdt1 and spd1. Involved in the regulation of mitotic and pre-meiotic S- phase progression. (490 aa) |
| | byr4 | Protein byr4; Has an essential role in ensuring cytokinesis and septation occur only once during mitosis. It does so by interacting with the ras1 signaling pathways, thereby suppressing them; To yeast BFA1. (665 aa) |
| | spd1 | S-phase delaying protein 1; Regulates the ribonucleotide reductase activity through its mediation of the nuclear localization of suc22, the small subunit of the ribonucleotide reductase. Delays the progression of the G1-S phase transition, thereby ensuring the G1 phase is complete. Interacts with both p34 and the p34-p56 complex, although no direct inhibitory effect on the bound proteins has been demonstrated. The action of p14 may happen coincidentally with the cdc10 function or may happen downstream of this. (124 aa) |
| | scs22 | Uncharacterized protein C17C9.12. (319 aa) |
| | par1 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation. (548 aa) |
| | any2 | Uncharacterized protein C1F12.05. (377 aa) |
| | git5 | Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Required for adenylate cyclase activation. (305 aa) |
| | ppc89 | Spindle pole body protein ppc89; Has a role in meiosis. (783 aa) |
| | imp2 | Septation protein imp2; Required for normal septation. Involved in the disassembly of the medial ring during septation. (670 aa) |
| | ndc80 | Kinetochore protein ndc80; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NDC80/HEC1 family. (624 aa) |
| | nuf2 | Kinetochore protein nuf2; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NUF2 family. (441 aa) |
| | mal3 | Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2. Belongs to the MAPRE family. (308 aa) |
| | lem2 | Lap-Emerin-Man domain protein 2; Nucleus inner membrane protein involved in meiosis. (688 aa) |
| | rho1 | GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase. Belongs to the small GTPase superfamily. Rho family. (202 aa) |
| | aly3 | Arrestin domain-containing protein C584.15c; Belongs to the arrestin family. (594 aa) |
| | pof11 | F-box/WD repeat-containing protein pof11; Has a role in meiosis. (506 aa) |
| | gos1 | Protein transport protein gos1; Nonessential SNARE involved in retrograde transport within the Golgi complex. (182 aa) |
| | sad1 | Spindle pole body-associated protein sad1; Associates with the spindle pole body and maintains a functional interface between the nuclear membrane and the microtubule motor proteins. Involved in chromosome segregation during meiosis where it associates with the telomeres. (514 aa) |
| | cdc15 | Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability. (927 aa) |
| | nmd3 | 60S ribosomal export protein nmd3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. (498 aa) |
| | bzz1 | Protein BZZ1; Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity); Belongs to the BZZ1 family. (642 aa) |
| | sft1 | Protein transport protein sft1; Vesicle SNARE required for retrograde transport within the Golgi complex. (91 aa) |
| | rod1 | Arrestin domain-containing protein C31A2.12. (596 aa) |
| | apm4 | AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential). (446 aa) |
| | pap1 | AP-1-like transcription factor; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC tansporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'- TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific [...] (552 aa) |
| | SPAC16A10.03c | Pep5-like zinc finger protein C16A10.03c. (847 aa) |
| | mis6 | Inner kinetochore subunit mis6; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Required for the localization of cnp1 to the centromere ; Belongs to the CENP-I/CTF3 family. (672 aa) |
| | mip1 | Target of rapamycin complex 1 subunit mip1; Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcrip [...] (1313 aa) |
| | crb2 | DNA repair protein crb2; Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage. Interaction with rad4 via its phosphorylation sites in the N-terminus couples the DNA checkpoint apparatus to chromatin via interaction of its C-terminal BRCT domains with epigenetic modifications on histones H4 and H2A, respectively, in the G1/S phase of the cell cycle, and facilitates recruitment of the checkpoint kinase chk1. (778 aa) |
| | tea1 | Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex. (1147 aa) |
| | pop1 | WD repeat-containing protein pop1; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop2, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. Regulates cell-cycle progression under starvation through the rum1 protein. (775 aa) |
| | pof1 | F-box/WD repeat-containing protein pof1; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Required for the inactivation of zip1 via ubiquitination. (605 aa) |
| | spg1 | Septum-promoting GTP-binding protein 1; GTP-binding protein essential for the induction of septum formation at G2 and pre-START stages of mitosis. Acts via the cdc7 protein kinase pathway. (198 aa) |
| | mid1 | Division mal foutue 1 protein; At the onset of mitosis, forms a medial ring structure before the arrangement of the medial actin ring. Essential for the central positioning of the division septum before the cell divides. (920 aa) |
| | vti1 | Vesicle transport v-SNARE protein vti1; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers (By similarity); Belongs to the VTI1 family. (214 aa) |
| | tfs1 | Transcription elongation factor S-II; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Belongs to the TFS-II family. (293 aa) |
| | scd2 | Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions. (536 aa) |
| | rad4 | S-M checkpoint control protein rad4; Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer for establishing the DNA checkpoint. (648 aa) |
| | rad9 | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. Repressor of entry into mitosis that is activated by chromosome breaks. (426 aa) |
| | mzt1 | Mitotic-spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC). (64 aa) |
| | hta2 | Histone H2A-beta; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (131 aa) |
| | hta1 | Histone H2A-alpha; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (132 aa) |
| | fic1 | Ingression protein fic1; Involved in the ingression of the plasma membrane during cytokinesis, leading to the separation of the daughter cells. Unlike its S.cerevisiae ortholog INN1, it does not play an essential role, probably because the actinomyosin ring is connected to the cell cortex by many more proteins. (272 aa) |
| | pep12 | Syntaxin pep12; Has a role in vesicle-mediated transport but not with protein transport from Golgi to vesicle; Belongs to the syntaxin family. (263 aa) |
| | ufe1 | Syntaxin ufe1; Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; Belongs to the syntaxin family. (319 aa) |
| | pof13 | F-box protein pof13. (396 aa) |
| | sog2 | Leucine-rich repeat-containing protein sog2. (886 aa) |
| | stc1 | Meiotic chromosome segregation protein P8B7.28c; Required for meiotic chromosome segregation. (215 aa) |
| | pof3 | F-box/TPR repeat protein pof3; Has a role in substrate recognition in the Skp1-Cullin- 1/Cdc53-F-box (SCF) ubiquitin ligase complex. Required for the maintenance of telomere length and transcriptional silencing at the telomere. Also required for chromosome segregation. (577 aa) |
| | mmi1 | YTH domain-containing protein mmi1; RNA-binding protein that recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR) of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region. (488 aa) |
| | ago1 | Protein argonaute; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H [...] (834 aa) |
| | pep3 | Vacuolar membrane protein pep3; Required for vacuolar biogenesis; Belongs to the VPS18 family. (900 aa) |
| | btb1 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (1347 aa) |
| | pof6 | F-box protein pof6; Together with skp1, essential for septum processing and cell separation. (872 aa) |
| | erg28 | Ergosterol biosynthetic protein 28; May have a role in anchoring erg26 and erg27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction (By similarity); Belongs to the ERG28 family. (136 aa) |
| | aly2 | Putative arrestin-related trafficking adapter C2D10.04; May regulate endocytosis in response to extracellular stimuli; Belongs to the ALY1 family. (658 aa) |
| | sec9 | Protein transport protein sec9; Has a role in cell separation, a final step of cytokinesis and in the assembly of the forespore membrane. May have a role in the transport of secretory proteins to these growing sites. (419 aa) |
| | pof2 | SCF E3 ubiquitin ligase complex F-box protein pof2; Involved in substrate recognition in ubiquitin-dependent degradation. (463 aa) |
| | btb2 | BTB/POZ domain-containing protein 2; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (284 aa) |
| | pof7 | F-box protein pof7. (361 aa) |
| | bqt3 | Bouquet formation protein 3; Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase. (255 aa) |
| | vsl1 | Vacuolar morphogenesis protein 7 homolog; Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure (By similarity). (341 aa) |
| | cdc11 | Septation initiation network scaffold protein cdc11; Essential for the onset of septum formation. Involved in the organization of astral microtubules during mitosis. Acts as a bridge between sid4 and the other SIN proteins mediating their association with the spindle pole body (SPB). The sid4-cdc11 complex organizes a signaling hub on the SPB which coordinates cell and nuclear division. (1045 aa) |
| | pof9 | F-box protein pof9. (467 aa) |
| | hob1 | Protein hob1; Has a role in DNA damage signaling as a part of stress response processes. (466 aa) |
| | blt1 | Mitosis inducer protein blt1; At the onset of mitosis, forms a medial ring structure before the arrangement of the medial actin ring. Essential for the central positioning of the division septum before the cell divides. (700 aa) |
| | sid4 | Septation initiation protein sid4; Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach. (660 aa) |
| | bqt4 | Bouquet formation protein 4; Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase. (432 aa) |
| | rcr1 | Uncharacterized protein C19C7.05. (150 aa) |
| | any1 | Uncharacterized protein C18H10.20c. (361 aa) |
| | tea4 | Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] (821 aa) |
| | scs2 | Vesicle-associated membrane protein-associated protein C16G5.05c; Targets proteins containing a FFAT motif to endoplasmic reticulum membranes. (383 aa) |
| | ykt6 | Synaptobrevin homolog ykt6. (197 aa) |
| | pof12 | F-box protein pof12. (440 aa) |
| | apl3 | AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Alpha adaptin is a subunit of the plasma membrane adaptor (By similarity). (878 aa) |
| | rif1 | Telomere length regulator protein rif1; Negatively regulates telomere length. Appears to play no role in transcriptional silencing of telomeric loci. (1400 aa) |
| | mdm12 | Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...] (273 aa) |
| | bqt1 | Telomere bouquet protein 1; Involved in chromosome segregation. During meiotic prophase, connects telomeres to the spindle pole body by forming a bridge between the telomere protein rap1 and the spindle pole body protein sad1. (132 aa) |
| | sin1 | Target of rapamycin complex 2 subunit sin1; Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. (665 aa) |
| | tim18 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (159 aa) |
| | pof10 | F-box/WD repeat-containing protein pof10; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. (662 aa) |
| | mrc1 | Mediator of replication checkpoint protein 1; Component of the replisome and is required for rad3-dependent activation of the checkpoint kinase cds1 in response to replication fork arrest. Phosphorylation allows it to mediate the activation of cds1. (1019 aa) |
| | vas2 | AP-1 complex subunit sigma-1; Component of the AP-1 complex which links clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Belongs to the adaptor complexes small subunit family. (162 aa) |
| | bos1 | Protein transport protein bos1; SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex. (235 aa) |
| | sgo1 | Shugoshin-1; Plays a central role in chromosome cohesion during meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting centromeric rec8 from separase degradation during anaphase I. (319 aa) |
| | tlg2 | t-SNARE affecting a late Golgi compartment protein 2; t-SNARE that functions in transport from the endosome to the late Golgi and on the endocytic pathway; Belongs to the syntaxin family. (301 aa) |
| | vps11 | E3 ubiquitin-protein ligase pep5; Required for vacuolar biogenesis and for trafficking of hydrolase precursors to the vacuole. Mediates transport at the vacuolar membrane where it may be responsible for tethering transport vesicles on the target membranes. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase ypt7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. Acts as component of the CORVET complex that is required for transport between [...] (906 aa) |
| | rng10 | Uncharacterized protein C688.07c. (1038 aa) |
| | end4 | Endocytosis protein end4; Required for cellular morphogenesis and polarization of the cortical cytoskeleton. Required for establishment of new polarized growth zones where it acts in actin organization. Involved plasma membrane internalization and is essential for fluid-phase endocytosis. Belongs to the SLA2 family. (1102 aa) |
| | sec17 | Probable vesicular-fusion protein sec17 homolog; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus; Belongs to the SNAP family. (289 aa) |
| | cdc48 | Cell division cycle protein 48; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. By recruiting and promoting the degradation of ubiquitinated proteins, plays a role in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum- associated degradation (ERAD) pathway which mediates the cytoplasmic elimination of misfolded proteins exported from the ER. Involved in spindle disassembly. Component of the [...] (815 aa) |
| | tlg1 | t-SNARE affecting a late Golgi compartment protein 1. (225 aa) |
| | apm1 | AP-1 complex subunit mu-1; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). (426 aa) |
| | pof15 | F-box protein pof15; Probable substrate recognition component of a SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (243 aa) |
