STRINGSTRING
but1 but1 cmk2 cmk2 SPBC16A3.14 SPBC16A3.14 cip1 cip1 gpx1 gpx1 SPBC3H7.04 SPBC3H7.04 tpx1 tpx1 nce103 nce103 oxs1 oxs1 srk1 srk1 bcp1 bcp1 sro1 sro1 sod1 sod1 wis1 wis1 atf1 atf1 ctt1 ctt1 tdh1 tdh1 pgr1 pgr1 mcs4 mcs4 pap1 pap1 lon1 lon1 uba42 uba42 mxr1 mxr1 cip2 cip2 sty1 sty1 pcr1 pcr1 hsr1 hsr1 snt2 snt2 lkh1 lkh1 pof14 pof14 ccs1 ccs1 eos1 eos1 trr1 trr1 gcn2 gcn2 ubp2 ubp2 gst3 gst3 cmk1 cmk1 sod2 sod2 plg7 plg7 srx1 srx1 grx2 grx2 grx3 grx3 csx1 csx1 pdi2 pdi2 ptc4 ptc4 prr1 prr1 pmp20 pmp20 trx1 trx1 grx1 grx1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
but1Uba3-binding protein but1; Acts as a negative regulator of the NEDD8 pathway. Has a role in meiosis. (243 aa)
cmk2Calcium/calmodulin-dependent protein kinase type II; Has a role in the regulation of G2/M transition during mitosis; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (504 aa)
SPBC16A3.14Putative 37S ribosomal protein S26A, mitochondrial. (268 aa)
cip1RNA-binding post-transcriptional regulator cip1; Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress. (490 aa)
gpx1Glutathione peroxidase-like peroxiredoxin gpx1; Glutathione peroxidase-like protein that protects cells during oxidative stress. Has peroxidase activity reducing hydrogen peroxide, alkyl and phospholipid hydroperoxides using preferentially thioredoxin as a reducing power. May act as a scavenger of H(2)O(2). Belongs to the glutathione peroxidase family. (158 aa)
SPBC3H7.04Putative 37S ribosomal protein S26B, mitochondrial. (220 aa)
tpx1Peroxiredoxin tpx1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Relays hydrogen peroxide as a signal to the transcription factor pap1 by inducing the formation of intramolecular disulfide bonds in pap1, which causes its nuclear accumulation and activation. Reduced by srx1 and this regulation acts as a molecular switch controlling the transcriptional [...] (192 aa)
nce103Carbonic anhydrase; Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate- dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase (By similarity); Belongs to the beta-class carbonic anhydrase family. (328 aa)
oxs1Coiled-coil domain-containing protein 124 homolog. (207 aa)
srk1Serine/threonine-protein kinase srk1; Has a role in the regulation of meiosis via the sty1 stress- activated MAPK pathway. Inhibits nitrogen-limitation induced arrest at G1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (580 aa)
bcp1Peroxiredoxin bcp1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (By similarity). Acts as a scavenger of H(2)O(2). (195 aa)
sro1Stress-responsive protein 1; Stress-responsive protein that may play a role in regulation of cell cycle. (106 aa)
sod1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
wis1Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1. (605 aa)
atf1Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26. (566 aa)
ctt1Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa)
tdh1Glyceraldehyde-3-phosphate dehydrogenase 1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgr1Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. (464 aa)
mcs4Response regulator mcs4; Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle. (522 aa)
pap1AP-1-like transcription factor; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC tansporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'- TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific [...] (552 aa)
lon1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1067 aa)
uba42Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] (401 aa)
mxr1Probable peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity). (170 aa)
cip2RNA-binding post-transcriptional regulator cip2; Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress. (576 aa)
sty1Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...] (349 aa)
pcr1Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26. (171 aa)
hsr1Hydrogen peroxide stress regulator 1; Transcription factor that globally supports gene expression in response to hydrogen peroxide. (582 aa)
snt2Lid2 complex component snt2. (1131 aa)
lkh1Dual specificity protein kinase lkh1; Protein kinase that may act as a negative regulator of filamentous growth and flocculation. Appears to have a role in normal cell wall and septum formation and in cell separation. May have antagonistic function in the regulation of beta-glucan distribution between the sites for cell wall and septum assembly. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. (690 aa)
pof14F-box protein pof14; Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9. (431 aa)
ccs1Superoxide dismutase 1 copper chaperone; Copper chaperone for superoxide dismutase 1 (sod1). Binds copper ions and delivers them specifically to sod1. Also has a role in cell protection against copper ion toxicity during conditions of copper excess. The C-terminal region is thought to act specifically in this sequestration role; Belongs to the CCS1 family. (297 aa)
eos1N-glycosylation protein eos1; Involved in N-glycosylation; Belongs to the EOS1 family. (209 aa)
trr1Thioredoxin reductase. (322 aa)
gcn2eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/tif211) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the general amino acid control (GAAC) pathway required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/tif211 either to a competitive inhibitor of translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a tr [...] (1576 aa)
ubp2Probable ubiquitin carboxyl-terminal hydrolase 2. (1141 aa)
gst3Glutathione S-transferase 3; May have a role in the detoxification of various heavy metals. (242 aa)
cmk1Calcium/calmodulin-dependent protein kinase type I; Important in cell cycle regulation; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (335 aa)
sod2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (218 aa)
plg7Putative phospholipase A2; Belongs to the serine esterase family. (438 aa)
srx1Sulfiredoxin; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in a peroxiredoxin. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. (124 aa)
grx2Glutaredoxin-2; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase. Thioltransferase catalyzes cellular thiol-disulfide transhydrogenation reactions. It transfers reducing equivalents to cytosolic protein and nonprotein disulfides (By similarity). (110 aa)
grx3Monothiol glutaredoxin-3; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (By similarity). (166 aa)
csx1RNA-binding post-transcriptional regulator csx1; Regulates global gene expression after oxidative stress. Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover. (632 aa)
pdi2Protein disulfide-isomerase C17H9.14c; Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer; Belongs to the protein disulfide isomerase family. (359 aa)
ptc4Protein phosphatase 2C homolog 4; Has a role in the regulation of vacuole fusion. (383 aa)
prr1Transcription factor prr1; Involved in oxidative stress. Transcription factor that acts upon trr1 and ctt1; In the N-terminal section; belongs to the HSF family. (539 aa)
pmp20Peroxisomal membrane associated protein 20; May act as a chaperone rather than a peroxidase. Has no thioredoxin-dependent peroxidase activity. Shows weak chaperone activity; Belongs to the peroxiredoxin family. Prx5 subfamily. (156 aa)
trx1Thioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. (103 aa)
grx1Glutaredoxin-1; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase. Thioltransferase catalyzes cellular thiol-disulfide transhydrogenation reactions. It transfers reducing equivalents to cytosolic protein and nonprotein disulfides (By similarity). (101 aa)
Your Current Organism:
Schizosaccharomyces pombe
NCBI taxonomy Id: 284812
Other names: S. pombe 972h-, Schizosaccharomyces pombe 972h-
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